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| 1 | TGF-β signaling in cancer metastasis显示文摘转变生长因素(TGF )- 发信号的事件是众所周知的控制多样的进程和众多的回答例如房间增长,区别, apoptosis,和移植。在癌症的 TGF- 发信号戏上下文依赖者角色:在 pre 恶意的房间, TGF- 首先作为肿瘤 suppressor 工作,当在癌症的以后的阶段发信号的 TGF- 支持侵略和转移时。最近的研究也建议了在 TGF- 发信号和另外的发信号的小径之间的串音例如河马, Wnt, EGFR/RAS,和 PI3K/AKT 小径,可以实质地贡献我们 TGF- 发信号和癌症的当前的理解。由于 TGF- 的广阔效果, TGF- 和它的下游的发信号部件的封锁提供多重治疗学的机会。因此,为为众多的疾病表明治疗的 anti-TGF- 的眼界显得明亮并且将提供珍贵信息并且想在这药上分子的设计。在这评论,我们集中于最近的卓见进在可以贡献新奇指向癌症的治疗的发展的癌症转移发信号的 TGF- 的规定。 | Feng Xie Li Ling Hans van Dam Fangfang Zhou Long Zhang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 36 |
| 2 | ;he regulation of TGF-β/SMAD signaling by protein deubiquitination显示文摘 | Juan Zhang Xiaofei Zhang Feng Xie Zhengkui Zhang Hans van Dam Long Zhang Fangfang Zhou | 2014 | Protein & Cell2014，5，7： | 27 |
| 3 | UBE20 negatively regulates TRAF6-mediated NF-kB activation by inhibiting TRAF6 polyubiquitination显示文摘 | Xiaofei Zhang Juan Zhang Long Zhang Hans van Dam Peter ten Dijke | 2013 | Cell Research2013，23，3： | 8 |
| 4 | A review on the best practices in concrete pavement design and materials in wet-freeze climates similar to Michigan显示文摘The research presented in this paper aims to identify best practices of design and materials for concrete pavements in wet-freeze climates similar to the Michigan State. For the purposes of this paper, a best practice is a procedure that has been shown by field-validated research or experience to produce improved results and that is established or proposed as a standard suitable for widespread implementation. The local wet-freeze climate makes the requirements for Michigan's pavement system different from many other regions. Wetfreeze climates can result in various concrete pavement distress mechanisms such as thermally-induced cracking, freeze-thaw deterioration, accelerated cracking due to loss of support, frost heave, and material degradation. Therefore, appropriate procedures for design and material selection need to be selected to withstand high precipitation and freezing winter temperatures. Failure to take into account the climatic conditions may lead to inadequate or reduced pavement performance. However, utilizing appropriate techniques and materials could potentially improve the quality and increase the service life of the concrete pavement. Three design methods and five materials have been identified, and examples of their successful performance in wet-freeze climates are provided. In addition, the reasons that give them the superior performance in wet-freeze climates are discussed in detail. | Naser P. Sharifi Siyu Chen Zhanping You Thomas Van Dam Christopher Gilbertson | 2019 | Journal of Traffic and Transportation Engineering(English Edition)2019，6，3： | 3 |
| 5 | Sentinel node mapping with indocyanine green (ICG) and infrared ray detection in early gastric cancer: An accurate method that enables a limited lymphadenectomy显示文摘 | W. Kelder H. Nimura N. Takahashi N. Mitsumori G.M. van Dam K. Yanaga | 2010 | European Journal of Surgical Oncology2010，，6： | 2 |
| 6 | Broad-spectrum antimicrobial activity of human intestinal defensin 5显示文摘 | Porter EM van Dam E Valre EV | 1997 | J Immunol1997，65，6： | 2 |
| 7 | CT colonography for colon cancer screening显示文摘 | Subhas Banerjee Jacques Van Dam | 2006 | Gastrointestinal Endoscopy2006，，1： | 2 |
| 8 | Phasar-Based WDM- Devices:Principles, Design and Applications 显示文摘 | Smit MK van Dam C | 1996 | Quantum Electronics1996，2，2： | 1 |
| 9 | Effects of coffe consumption on fasting buod glucose and insulin conoentra- tions 显示文摘 | ROB M VAN DAM CARLSSON S DOTEVALL A | 2009 | Diabetes Care2009，27，6： | 1 |
| 10 | Troear implantation metastasis after laparoscopy in patients with advanced ovarian caneer:ean the risk be reduced显示文摘 | Van Dam PA DeCtoedt J Tjalma WA | 1999 | Am J Obstet Gyneeol1999，181，3： | 1 |
| 11 | Parameter estimation of soil hydraulic functions using inverse modeling of transient outflow experiments显示文摘 | Hopmans J W Dam J C van Eching S O | 1994 | Trends in Hydrology1994，1，： | 1 |
| 12 | Transplantation and sub-sequent recovery of small amounts of isolated Leydig cells 显示文摘 | van Dam JH Teerds KJ Rommerts FF | 1989 | Arch Androl1989，22，2： | 1 |
| 13 | Efficient Characteristics of Crescent-shaped Wings and Caudal Fin显示文摘 | C P Van Dam | | 0，，： | 1 |
| 14 | Cognitive deficits after postoperative adjuvant chemotherapy for breast carci noma显示文摘 | SCHAGEN S B VAN DAM F S MULLER M J | 1999 | Cancer1999，85，3： | 1 |
| 15 | Displacement of the Earth's surface due to atmospheric loading: Effects on gravity and baseline measurements显示文摘 | Van Dam T M Wahr J | 1987 | J Geophys Res1987，92，： | 1 |
| 16 | Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency显示文摘 | Brooks-Wilson A Marcil M Clee SM Zhang LH Roomp K van Dam M | 1999 | Nat Genet1999，22，4： | 1 |
| 17 | The effect of a multimodal fast-track programme on outcomes in laparoscopic liver surgery: a multicentre pilot study 显示文摘 | Stoot JH van Dam RM Busch OR | 2009 | HPB(Oxford)2009，11，2： | 1 |
| 18 | A pain education program for Chronic cancer pain: follow up results from a randomized controlled trial显示文摘 | de Wit R van Dam F Zandbeh | 1997 | Pain1997，73，1： | 1 |
| 19 | Experimental analysis of thick blunt trailing-edge wind turbine airfoils显示文摘 | Baker J P Mayda E A van Dam C P | 2006 | Journal of Solar Energy Engineering2006，128，4： | 1 |
| 20 | A construct-driven investigation of gender differences in a leadership-role assessment center显示文摘 | Anderson N Lievens F van Dam K Born M | | 0，，： | 1 |
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