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| 1 | Petrogenesis of the Neopro-terozoic bimodal volcanic rocks along the western margin of the Yangtze Block:New constraints from Hf isotopes and Fe/Mn ratios显示文摘High-precision major element and Hf isotope data are reported for the Neoproterozoic Suxiong volcanic rocks along the western margin of the Yangtze Block. These volcanic rocks have variable εHf(T) values and Fe/Mn ratios. The relatively primitive basalts have high Fe/Mn ratios and high Hf-Nd isotopic compositions, indicating that they were generated by partial melting of garnet clinopyroxene in mantle plume at high pressure. Thus, the Suxiong basalts are genetically related to the proposed Neoproterozoic super-plume. On the contrary, a few differentiated basalts have low Fe/Mn ratios and low Hf-Nd isotopic compositions. They are likely to experience assimilation-fractional crystallization process. The Suxiong rhyolites have consistent Hf and Nd model ages of 1.3―1.4 Ga. They are likely generated by shallow dehydration melting of pre-existing young arc igne-ous rocks associated with the basaltic underplating/intrusion in a continental rift. | LI Xianhua QI Changshi LIU Ying LIANG Xirong TU Xianglin XlE Liewen YANG Yueheng | 2005 | Chinese Science Bulletin2005，50，21： | 91 |
| 2 | MAPK signal pathways in the regulation of cell proliferation in mammalian cells显示文摘MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPI(families have been characterized: extracellular signal-regulated kinase (ERK), Jun kinase (JNK/SAPK) and p38 MAPK. The above effects are fulfilled by regulation of cell cycle engine and other cell proliferation related proteins. In this paper we discussed their functions and cooperation with other signal pathways in regulation of cell proliferation. | WEI ZHANG, Hui Tu LIU The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China | 2002 | Cell Research2002，12，1： | 107 |
| 3 | Heavy metal pollution in intertidal sediments from Quanzhou Bay, China显示文摘The concentrations of eight heavy metals (Cu, Zn, Pb, Cd, Cr, Ni, Hg, and As) in the intertidal surface sediments from Quanzhou Bay were determined to evaluate their levels and spatial distribution due to urbanization and economic development of Quanzhou region, southeast China. The ranges of the measured concentrations in the sediments are as follows: 24.8–119.7 mg/kg for Cu, 105.5–241.9 mg/kg for Zn, 34.3–100.9 mg/kg for Pb, 0.28–0.89 mg/kg for Cd, 51.1–121.7 mg/kg for Cr, 16.1–45.7 mg/kg for Ni, 0.17–0.74 mg/kg for Hg, and 17.7–30.2 mg/kg for As. The overall average concentrations of above metals exceed the primary standard criteria but meet the secondary standard criteria of the Chinese National Standard of Marine Sediment Quality. Several contents of Cu and Hg exceed the secondary standard criteria at some stations. The results of geoaccumulation index (Igeo) show that Cd causes strong pollution in most of the study area. There are no significant correlations among most of these heavy metals, indicating they have different anthropogenic and natural sources. Some locations present severe pollution by heavy metals depending on the sources, of which sewage outlets, aquatic breeding, and commercial ports are the main sources of contaminants to the area. | YU Ruilian YUAN Xing ZHAO Yuanhui HU Gongren TU Xianglin | 2008 | Journal of Environmental Sciences2008，20，6： | 73 |
| 4 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 5 | Immune suppression in chronic hepatitis B infection associated liver disease: A review显示文摘Hepatitis B virus(HBV) infection is one the leading risk factors for chronic hepatitis, liver fibrosis, cirrhosis and hepatocellular cancer(HCC), which are a major global health problem. A large number of clinical studies have shown that chronic HBV persistent infection causes the dysfunction of innate and adaptive immune response involving monocytes/macrophages, dendritic cells, natural killer(NK) cells, T cells. Among these immune cells, cell subsets with suppressive features have been recognized such as myeloid derived suppressive cells(MDSC),NK-reg, T-reg, which represent a critical regulatory system during liver fibrogenesis or tumourigenesis. However, the mechanisms that link HBVinduced immune dysfunction and HBV-related liver diseases are not understood.In this review we summarize the recent studies on innate and adaptive immune cell dysfunction in chronic HBV infection, liver fibrosis, cirrhosis, and HCC, and further discuss the potential mechanism of HBV-induced immunosuppressive cascade in HBV infection and consequences. It is hoped that this article will help ongoing research about the pathogenesis of HBV-related hepatic fibrosis and HBV-related HCC. | Tian-Yang Li Yang Yang Guo Zhou Zheng-Kun Tu | 2019 | World Journal of Gastroenterology2019，25，27： | 69 |
| 6 | 慢性炎症、肿瘤微环境与癌变显示文摘某些肿瘤发生前或发生时常有慢性炎症。抗炎疗法在癌症的预防及治疗中也显现出一定的疗效。创伤愈合演变为癌症前兆的具体机理已成为当前研究的热点。已有研究证实,炎症介质、炎症相关基因多态性与癌变之间存在病原学关系。潜在的炎症过程可通过不同的机理影响肿瘤间室与癌症分期, | Tamas A. Gonda Shuiping Tu Timothy C. Wang 丁燕(翻译) 南娟(翻译) 刘谦(校对) | 2009 | 中国肺癌杂志2009，12，9： | 55 |
| 7 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 8 | Combined Pollution and Pollution Index of Heavy Metals in Red Soil显示文摘A field experiment was conducted to study the effects of Pb, Cd, Cu, Zn and As coexisting in red soilon growth of rice (Oryza sativa L.), mung bean (Vigna rabiata (Linn.) Wilczek), alfalfa (Medicago sativaL.), slash pine (Pinus elliottii Engelm.) and aspen (Populus L.). Results showed that rice, mung bean andalfalfa were significantly innuenced by combined pollution of the heavy metals. The contents of Pb, cd andAs in rice grains greatly exceeded the National Standards for Food Hygiene of China. Heavy metals at ahigh concentration seriously retarded growth of mung bean and alfalfa, but not so obviously with slash pineand aspen. The composite index is suggested for evaluating the relativity of combined pollution witll heavymetals in soil. | CHEN HUAIMAN ZHENG CHUNRONG WANG SHENQIANG and TU CONG(Institute of Soil Science, the Chinese Academy of Sciences, P.O. Box 821, Naroing 210008 China) | 2000 | Pedosphere2000，10，2： | 56 |
| 9 | Induction of apoptosis by arsenic trioxide and hydroxycamptothecin in gastric cancer cells in vitro显示文摘AIM To study the effects of arsenic trioxide andHCPT on different degrees of differentiated gastriccancer cells(SGC-7901,MKN-45,MKN-28)withrespect to both cytotoxicity and induction ofapoptosis in vitro.METHODS The cytotoxicity of As2O3 and HCPTon gastric cancer cells was determined by MTTassay.Morphologic changes of apoptosis ofgastric cancer cells were observed by lightmicroscopy and transmission electron microscopy.Apoptosis and cell cycle changes of gastric cancercells induced by HCPT and As2O3 were investigatedby TUNEL method and flow cytometry.RESULTS As2O3 and HCPT had remarkablecytotoxic effects on different degrees ofdifferentiated gastric cancer cells.The IC50ofAs2O3 on well differentiated gastric cancer cellMKN-28,moderately differentiated gastric cancercell SGC-7901,and poorly differentiated gastriccancer cell MKN-28 were 8.91 μmol/L,10.57μmol/L,and 11.65 μmol/L,respectively.The IC50of HCPT on MKN-28,SGC-7901,and MKN-45 were9.35 mg/L,10.21 mg/L,and 12.63 mg/Lrespectively after 48 h treatment.After 12 h ofexposure to both drugs,gastric cancer cellsexhibited morphologic features of apoptosis,including cell shrinkage,nuclear condensation, and formation of apoptotic bodies.A typicalsubdiploid peak before G0/G1 phase was observedby flow cytometry.The apoptotic rates of SGC-7901,MKN-45,and MKN-28 were 13.84%,22.52%,and 9.68%,respectively after 48 hexposure to 10 μmol/L As2O3.The apoptotic ratesof SGC-7901,MKN-45,and MKN-28 were 21.88%,12.35%,and 30.26%,respectively after 48 hexposure to 10 mg/L HCPT.The apoptotic indicewere 7%-15% as assessed by TUNEL method.The effect of As2O3 on SGC-7901 showedremarkable cell cycle specificity,which inducedcell death in G1 phase,and blocked G2/M phase.HCPT also showed a remarkable cell cyclespecificity,by inducing cell death and apoptosis inG1 phase and arrest of proliferation at S phase.CONCLUSION As2O3 and HCPT exhibitsignificant cytotoxicity on gastric cancer cells byinduction of apoptosis.As2O3 and HCPT mighthave a promising prospect in the treatment ofgastric cancer,which needs to be further studied. | Tu SP Zhong J Tan JH Jiang XH Qiao MM Wu YX Jiang SH | 2000 | World Journal of Gastroenterology2000，6，4： | 43 |
| 10 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 11 | Definition, theory, methods, and applications of the safe and efficient simultaneous extraction of coal and gas显示文摘 | Yuanping Cheng Liang Wang Hongyong Liu Shengli Kong Jintuo Zhu Qingyi Tu | 2015 | International Journal of Coal Science & Technology2015，2，1： | 36 |
| 12 | Rural restructuring in China: Theory, approaches and research prospect显示文摘农村重构是在内核系统和农村开发的外部系统两个都响应元素的变化在农村领土重塑社会经济的形态学和空间模式的进程,由最佳地分配并且高效地设法在二个系统的材料和非物质的元素。它瞄准最终优化结构并且象认识到结构的协作和在城市、农村的领土的系统之间的功能的互补一样在农村领土的系统以内支持功能。这篇论文建立通过象分析推基于 elements-structure-function 的进化的向前农村的重构的机制一样详细描述这个概念和涵义的农村重构的一个理论框架,并且从空间重构,经济重构并且社会重构的三个方面探查途径。而且,作者主张在未来的在中国的农村重构的学习需要集中于长期、多尺度的过程和模式的方面,机制,地区性的模型,农村计划技术系统和标准,有关在农村重构上的象全球化的影响一样的农村重构的政策和机构的革新,以便提供当前的公民战略要求并且在 urba | TU Shuangshuang LONG Hualou | 2017 | Journal of Geographical Sciences2017，27，10： | 36 |
| 13 | Drift and deposition of ultra-low altitude and low volume application in paddy field显示文摘Field trials were performed to evaluate various techniques for measuring spray deposition and aerial drift during spray application to paddy field.The application of a spraying agent containing the fluorescent dye Rhodamine-B was applied by an unmanned aerial vehicle(UAV)which flew at a height of 5 m,a speed of 3 m/s,and the wind speed of 3 m/s.The results showed that because the downdraft produced by a helicopter rotor increased the penetrability of crops,there is a higher deposition on the upper layer and the under layer than the traditional spraying.The average deposition on the upper layer accounts for 28% of the total spraying,the deposition on the under layer accounts for 26% of the total spraying.The deposition on the under layer takes up 92.8% of the deposition on the upper layer.Droplets drift data showed that the drift of non-target area took up 12.9% of the total liquid spray.The 90% drifting droplets were located within a range of 8 m of the target area;the drift quantity was almost zero at a distance of 50 m away from the treated area. | Xue Xinyu Tu Kang Qin Weicai Yubin Lan Huihui Zhang | 2014 | International Journal of Agricultural and Biological Engineering2014，7，4： | 40 |
| 14 | 福建省社区产后访视质量调查研究显示文摘目的:研究社区产后访视服务现状,提高社区护理质量,促进母婴健康.方法:定量与定性研究相结合,定量研究随机抽取福州市5区内产后42 d左右的产妇776例问卷调查,定性研究采用专题小组讨论和半结构性访谈.产妇12人参加专题讨论,半结构性访谈9人.结果:产后访视率为62.9%,按3~4次标准进行的仅4.3%~48.2%.社区产后访视内容中,询问母子一般情况达98.4%;对产妇及新生儿体检的内容欠缺多;进行母乳喂养指导为94.7%;认为对产妇心理情绪状况'关心与非常关心'的占28.7%,对预防产后抑郁症的保健建议率占9.9%;对社区产后访视满意率不高为33.6%.结论:与产后访视的次数和内容的标准对照,实际操作中的偏差是由于缺乏规范化的管理,因此今后既要加快产后访视人员刘产褥期护理与保健知识的更新,拓展提供保健知识的内容,又要在现有社区产后访视过程中,加强规范化管理,区级妇幼保健机构应对辖区内的社区产妇的产后访视工作实行面对面的质量评估问卷,达到规范化管理的目的,并采取针对性措施提高产后访视中的护理与保健质量. | 陈起燕 陈烈平 张荣莲 叶宝凤 翁云钦 卓秀云 Yu liana Da tu Bua | 2005 | 中国妇幼保健2005，20，5： | 33 |
| 15 | Alpine wetlands in the Lhasa River Basin, China显示文摘拉萨河盆是西藏的高原上的高山的沼泽地的典型分发区域之一。为监视,保护和利用得到背景的更好的理解和高山的沼泽地的特征是很重要的。在盆的沼泽地建设和分发包括域调查数据, CBERS 遥感数据和 3S 技术提供的另外的题目的数据基于多来源数据被分析。结果是(1 ) 沼泽地的全部的区域是 209,322.26 hm2,为盆的 6.37% 全部的陆地区域的财务。沼泽地被自然沼泽地主要统治,与仅仅占据 1.09% 沼泽地区域的人工的沼泽地;沼泽地沼泽地是自然沼泽地的主要部分,由 Kobresia littledalei 统治了在河来源区域分布式的沼泽的草地并且 Chali, Damshung 和 Medro 在上游 Gongkar 县。在不同的县的沼泽地的比率和类型显著地不同,它在 Chali 和 Damshung 县(为 62% 全部的沼泽地区域的财务) 是广泛地分布式的。(2 ) 沼泽地的集中的垂直分发在 36005100 m 的举起。沼泽地广泛地从河来源在整个 Yarlung Zangbo 河山谷被散布到河嘴进 Yarlung Zangbo 河。沼泽地沼泽地在来源区域是主导的并且河在上游与湖的马赛克分发, Kobresia littledalei 和 Carex moorcroftii 沼泽的草地,灌木状的沼泽地和河;至于中间下面流,主要类型是河沼泽地并且充满沼泽地。分发在河,小而淡的 Kobresia 和 Carex moorcroftii 的一个马赛克模式沼泽的草地, Phragmites 南极光和辅助的草沼泽地,充满的沼泽地和人工的沼泽地。 | ZHANG Yili WANG Chunlian BAI Wanqi WANG Zhaofeng TU Yanli YANGJAEN Dor Gka | 2010 | Journal of Geographical Sciences2010，20，3： | 32 |
| 16 | Vascular endothelial dysfunction, cardiomyopathy a major mediator in diabetic cardiomyopathy显示文摘Diabetes mellitus is currently a major public health problem.A common complication of diabetes is cardiac dysfunction,which is recognized as a microvascular disease that leads to morbidity and mortality in diabetic patients.While ischemic events are commonly observed in diabetic patients,the risk for developing heart failure is also increased,independent of the severity of coronary artery disease and hypertension.This diabetes-associated clinical entity is considered a distinct disease process referred to as 'diabetic cardiomyopathy'.However,it is not clear how diabetes promotes cardiac dysfunction.Vascular endothelial dysfunction is thought to be one of the key risk factors.The impact of diabetes on the endothelium involves several alterations,including hyperglycemia,fatty acid oxidation,reduced nitric oxide (NO),oxidative stress,inflammatory activation,and altered barrier function. The current review provides an update on mechanisms that specifically target endothelial dysfunction,which may lead to diabetic cardiomyopathy. | Maura Knapp Xin Tu Rongxue Wu | 2019 | Acta Pharmacologica Sinica2019，40，1： | 34 |
| 17 | Rural vitalization in China:A perspective of land consolidation显示文摘The core objective of rural vitalization is to systemically establish a coupling pattern of various rural development elements including population,land and industry.As one of the prerequisites,land resources is required to be optimally allocated via land consolidation.Con seque ntly,la nd con solidati on con tributes greatly to population agglomeration,industrial developme nt and resources support under the con text of combati ng rural decline.Based on the key eleme nts affecting rural development,this paper elaborates the con no tation of rural vitalization and land consolidation in the new era as well as their relationships.Furthermore,the paper analyzes the alternative paths for achieving rural vitalization via land consolidation,and discusses the future directions of land consolidation and rural vitalization.The conclusions are drawn as follows:(1)To cope with the loss and decline of the intrinsic elements in rural areas,rural vitalization is a development strategy aimed at realizing economic,political,cultural and ecological rejuvenation in rural area by reshaping socio?economic morphology and spatial pattern in rural territory.(2)From the perspective of rural vitalization,land consolidation is endowed with new connotation,which should not only target at activating the key elements of rural development,but also place emphasis on coordimating material space and spirit core as well as integrating the restructuring of the physical space and the rural gov?ernance system.(3)Land consolidation should be compatible with regional natural conditions and the current stage of socio-economic development.According to the principle of regional planning and classification strategy,the appropriate models and paths should be adopted to promote the benign interactions of population,land and industry based on engineering techniques and ecological means.(4)Under the background of national strategy of rural vitaliza?tion,it is n ecessary to reshape the value orientati on of la nd con solidation based on a scie tific understanding of urban-rural relations and rural territorial functions,coordinate land consolidation planning and rural vitalization planning under the unified spatial planning system,and explore the new model combining land consolidation and multifunctional agriculture. | LONG Hualou ZHANG Yingnan TU Shuangshuang | 2019 | Journal of Geographical Sciences2019，29，4： | 33 |
| 18 | Laparoscopic vs open left hepatectomy for hepatolithiasis显示文摘AIM: To explore the feasibility and therapeutic effect of total laparoscopic left hepatectomy (LLH) for hepatolithiasis. METHODS: From June 2006 to October 2009, 61 consecutive patients with hepatolithiasis who met the inclusion criteria for LLH were treated in our institute. Of the 61 patients with hepatolithiasis, 28 underwent LLH (LLH group) and 33 underwent open left hepatectomy (OLH group). Clinical data including operation time, intraoperative blood loss, postoperative complication rate, postoperative hospital stay time, stone clearance and recurrence rate were retrospectively analyzed and compared between the two groups. RESULTS: LLH was successfully performed in 28 patients. The operation time of LLH group was longer than that of OLH group (158 ± 43 min vs 132 ± 39 min, P < 0.05) and the hospital stay time of LLH group was shorter than that of OLH group (6.8 ± 2.8 d vs 10.2 ± 3.4 d, P < 0.01). No difference was found in intraoperative blood loss (180 ± 56 mL vs 184 ± 50 mL), postoperative complication rate (14.2% vs 15.2%), and stone residual rate (intermediate rate 17.9% vs 12.1% and final rate 0% vs 0%) between the twogroups. No perioperative death occurred in either group. Fifty-seven patients (93.4%) were followed up for 2-40 mo (mean 17 mo), including 27 in LLH group and 30 in OLH group. Stone recurrence occurred in 1 patient of each group. CONCLUSION: LLH for hepatolithiasis is feasible and safe in selected patients with an equal therapeutic effect to that of traditional open hepatectomy. | Tu, Jin-Fu Jiang, Fei-Zhao Zhu, Heng-Liang Hu, Ru-Ying Zhang, Wei-Jian Zhou, Zhen-Xu | 2010 | World Journal of Gastroenterology2010，16，22： | 30 |
| 19 | Responses of Soil Microbial Community Structure and Diversity to Agricultural Deintensification显示文摘Using a scheme of agricultural fields with progressively less intensive management (deintensification), different manage- ment practices in six agroecosystems located near Goldsboro, NC, USA were tested in a large-scale experiment, including two cash-grain cropping systems employing either tillage (CT) or no-tillage (NT), an organic farming system (OR), an integrated cropping system with animals (IN), a successional field (SU), and a plantation woodlot (WO). Microbial phos- pholipid fatty acid (PLFA) profiles and substrate utilization patterns (BIOLOG ECO plates) were measured to examine the effects of deintensification on the structure and diversity of soil microbial communities. Principle component analyses of PLFA and BIOLOG data showed that the microbial community structure diverged among the soils of the six systems. Lower microbial diversity was found in lowly managed ecosystem than that in intensive and moderately managed agro- ecosystems, and both fungal contribution to the total identified PLFAs and the ratio of microbial biomass C/N increased along with agricultural deintensification. Significantly higher ratios of C/N (P < 0.05) were found in the WO and SU systems, and for fungal/bacterial PLFAs in the WO system (P < 0.05). There were also significant decreases (P < 0.05) along with agricultural deintensification for contributions of total bacterial and gram positive (G+) bacterial PLFAs. Agricultural deintensification could facilitate the development of microbial communities that favor soil fungi over bacteria. | ZHANG Wei- Jian RUI Wen-Yi C. TU H. G. DIAB F. J. LOUWS J. P. MUELLER N. CREAMER M. BELL M.G. WAGGER S. HU | 2005 | Pedosphere2005，15，4： | 29 |
| 20 | An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure显示文摘Acute hepatic failure (AHF) is a severe liver injury accompanied by hepatic encephalopathy which causes multiorgan failure with an extremely high mortality rate, even if intensive care is provided. Management of severe AHF continues to be one of the most challenging problems in clinical medicine. Liver transplantation has been shown to be the most effective therapy, but the procedure is limited by shortage of donor organs. Although a number of clinical trials testing different liver assist devices are under way, these systems alone have no significant effect on patient survival and are only regarded as a useful approach to bridge patients with AHF to liver transplantation. As a result, reproducible experimental animal models resembling the clinical conditions are still needed. The three main approaches used to create an animal model for AHF are: surgical procedures, toxic liver injury and infective procedures. Most common models are based on surgical techniques (total/partial hepatectomy, complete/transient devascularization) or the use of hepatotoxic drugs (acetaminophen, galactosamine, thioacetamide, and others), and very few satisfactory viral models are available. We have recently developed a viral model of AHF by means of the inoculation of rabbits with the virus of rabbit hemorrhagic disease. This model displays biochemical and histological characteristics, and clinical features that resemble those in human AHF. In the present article an overview is given of the most widely used animal models of AHF, and their main advantages and disadvantages are reviewed. | María Jesús Tuón Marcelino Alvarez Jesús M Culebras Javier González-Gallego | 2009 | World Journal of Gastroenterology2009，15，25： | 29 |
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