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| 1 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 2 | A Facile Way to Large-scale Production of Few-layered Graphene via Planetary Ball Mill显示文摘In the field of polymer/graphene nanocomposites, massive production and commercial availability of graphene are essential. Exfoliation of graphite to obtain graphene is one of the most promising ways to large-scale production at extremely low cost. In this work we illustrate a facile strategy for mass production of few-layered(≤ 10) graphene(FLG) via the newly explored ball milling. The achieved FLG concentration was determined by UV/Vis spectroscopy. The formation of FLG was proved by measuring the flake thickness by atomic force microscopy(AFM). Further Raman spectral studies indicated that the crystal structure of exfoliated flakes was preserved satisfactorily during this shear-force dominating process. To increase the maximum concentration obtainable, it's critical to make a good parameter assessment. N-methylpyrrolidone(NMP) was used as a dispersing medium and the effect of milling parameters was systematically and quantitatively investigated, thus providing a criterion to optimize the milling process. We established the optimal values for solvent volume and initial weight of graphite. As for milling time, the production of FLG was enhanced with continuous milling according to the power law,but not linearly with increasing milling time. Moreover, the possible mechanism involved in milling process was also explored. Our work provides a simple method for graphite exfoliation and has great potential for improving thermal and electrical conductivity of polymer composites in the fields of engineering. | sha deng xiao-dong qi yan-ling zhu hong-ju zhou feng chen 傅强 | 2016 | Chinese Journal of Polymer Science2016，34，10： | 10 |
| 3 | 基于状态图的对象行为建模显示文摘状态图(State Chart)是对对象的行为的一种描述的方法,并是UML(Unified ModelingLanguage)可视化建模的一部分.文中分析了状态图建模的规则,以及如何用状态图对对象的行为进行建模的方法. | 刘忠 邓苏 沙基昌 张维明 LIU Zhong DENG Su Sha Jichang ZHANG Weiming | 2001 | 计算机工程与设计2001，22，2： | 9 |
| 4 | Gastric motility functional study based on electrical bioimpedance measurements and simultaneous electrogastrography显示文摘For some time now,the research on gastric motility and function has fallen behind in the amount of research on gastric endocrine,exocrine secretion,and gastric morphology.In this paper,a noninvasive method to study gastric motility was developed,taking bioimpedance measurements over the gastric area simultaneously with the electrogastrography(EGG).This is based on the concept of observing and analyzing simultaneously the intrinsic electrical gastric activity(basic electric rhythm) and the mechanical gastric activity.Additionally,preliminary clinical studies of healthy subjects and subjects with functional dyspepsia(FD) and gastritis were carried out.The impedance gastric motility(IGM) measurements of the healthy and FD subjects were compared,along with the studies of the FD subjects before treatment and after one week and three weeks of treatment.We also compared IGM measurements of healthy subjects and subjects with erosive gastritis,along with the studies of the subjects with erosive gastritis before treatment and after one week of treatment.Results show that FD subjects have poor gastric motility(P<0.01).After a week of treatment,the gastric motility of FD subjects was not yet improved although the EGG had returned to normal by this time.By three weeks of treatment,the regular IGM rhythm returned in FD subjects.There was a significant difference of IGM parameters between the gastritis and healthy subjects(P<0.05).The EGG rhythm of the gastritis subjects returned to normal at one week post-treatment,while IGM parameters showed a trend to improvement(P>0.05),These results suggest the possibility of clinic application of the proposed method. | Zhang-yong LI Chao-shi REN Shu ZHAO Hong SHA Juan DENG | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，12： | 9 |
| 5 | Gold nanoflowers for 3D volumetric molecular imaging of tumors by photoacoustic tomography显示文摘By binding molecular probes that target tumor cells, gold nanoparticles (AuNPs) with superior characteristics have shown great potential in tumor molecular imaging studies. The non-invasive, high-resolution, and three-dimensional imaging of the targeted AuNPs within the tumor is desirable for both diagnosis and therapy. In this study, gold nanoflowers (AuNFs) are presented as a novel contrast agent for photoacoustic tomography (PAT). By binding to folic acid, the molecular probe, the tail-vein injected AuNFs concentrated within the tumor site in mice; this was clearly visualized by three-dimensional (3D) PAT imaging. In addition, toxicity assay proved that AuNFs were harmless to living cells and animals. Our results demonstrate that AuNFs have great potential in tumor molecular imaging. | Yuanyuan Jiang Zijian Deng Dan Yang Xin Deng Qi Li Yinlin Sha Changhui Li Dongsheng Xu | 2015 | Nano Research2015，8，7： | 8 |
| 6 | Stratigraphy of the Triassic-Jurassic Boundary Successions of the Southern Margin of the Junggar Basin,Northwestern China显示文摘The Triassic-Jurassic(Tr-J) boundary marks a major extinction event,which(~200 Ma) resulted in global extinctions of fauna and flora both in the marine and terrestrial realms.There prevail great challenges in determining the exact location of the terrestrial Tr-J boundary,because of endemism of taxa and the scarcity of fossils in terrestrial settings leading to difficulties in linking marine and terrestrial sedimentary successions.Investigation based on palynology and bivalves has been carried out over a 1113 m thick section,which is subdivided into 132 beds,along the Haojiagou valley on the southern margin of the Junggar Basin of the northern Xinjiang,northwestern China.The terrestrial Lower Jurassic is conformably resting on the Upper Triassic strata.The Upper Triassic covers the Huangshanjie Formation overlaid by the Haojiagou Formation,while the Lower Jurassic comprises the Badaowan Formation followed by the Sangonghe Formation.Fifty six pollen and spore taxa and one algal taxon were identified from the sediments.Based on the key-species and abundance of spores and pollen,three zones were erected:the Late Triassic(Rhaetian) Aratrisporites-Alisporites Assemblage,the Early Jurassic(Hettangian) Perinopollenites-Pinuspollenites Assemblage,and the Sinemurian Perinopollenites-Cycadopites Assemblage.The Tr-J boundary is placed between bed 44 and 45 coincident with the boundary between the Haojiagou and Badaowan formations.Beds with Ferganoconcha(?),Unio-Ferganoconcha and Waagenoperna-Yananoconcha bivalve assemblages are recognized.The Ferganoconcha(?) bed is limited to the upper Haojiagou Formation, Unio-Ferganoconcha and Waagenoperna-Yananoconcha assemblages are present in the middle and upper members of the Badaowan Formation.The sedimentary succession is interpreted as terrestrial with two mainly lake deposit intervals within Haojiagou and Badaowan formations,yielding fresh water algae and bivalves.However,the presence of brackish water algae Tasmanites and the marine-littoral facies bivalve Waagenoperna from the Badaowan Formation indicate that the Junggar Basin was influenced by sea water caused by transgressions from the northern Tethys,during the Sinemurian. | SHA Jingeng Vivi VAJDA PAN Yanhong Linda LARSSON YAO Xiaogang ZHANG Xiaolin WANG Yaqiong CHENG Xiansheng JIANG Baoyu DENG Shenghui CHEN Siwei PENG Bo | 2011 | Acta Geologica Sinica(English Edition)2011，85，2： | 7 |
| 7 | Surface Partial Discharge Characteristics of Oil-paper Insulation Under Combined AC-DC Voltage显示文摘The valve side windings of converter transformers bear AC, DC, impulse, and reversal-polarity voltages during operation, which could result in serious insulation problems of the equipment. By performing experiments with surface discharge model of oil-paper insula- tion at 80 ℃ under combined AC-DC voltage for 200 h, we studied the spectrums and statistical parameters of partial discharges at different discharge stages. Furthermore, some fingerprint parameters were calculated in order to estimate the development situation of par- tial discharge, while the characteristic gases dissolved in the transformer oil were measured by gas chromatography. The surface discharges in the experiments were observed using a high speed camera, and a full discharge process could be marked off into four stages as follows. ①The elementary stage. When a partial discharge occurs near electrodes, electrical charges are injected into the region near electrodes and causing bubble generation. ②Due to their high resistivity and low dielectric constant, the bubbles would bare the major part of the voltage applied to samples. Therefore, discharge happens inside the small bubbles, and it emits a lot of light. ③Micromolecules of gas are produced in discharge, and further ionization in the transformer oil takes place simultaneously when high-energy electrons collide with oil molecules. ④The carrier charge moves forward to electrodes driven by the applied electric field, till they neutralize with the charge from electrodes, and hence discharge channels are formed subsequently. | SHA Yanchao ZHOU Yuanxiang NIE Dexin WU Zhirong DENG Jiangang LU Licheng | 2013 | 高电压技术2013，39，8： | 5 |
| 8 | Clinicopathologic characteristics and therapeutic responses of Chinese patients with non-small cell lung cancer who harbor an anaplastic lymphoma kinase rearrangement显示文摘Introduction: The rearrangement of the anaplastic lymphoma kinase(ALK) gene accounts for approximately 1%–6% of lung adenocarcinoma cases and deines a molecular subgroup of tumors characterized by clinical sensitivity to ALK inhibitors such as crizotinib. This study aimed to identify the relationship between ALK rearrangement and the clinico?pathologic characteristics of non?small cell lung cancer(NSCLC) and to analyze the therapeutic responses of crizotinib and conventional chemotherapy to ALK rearrangement in NSCLC patients.Methods: A total of 487 lung cancer patients who underwent testing for ALK rearrangement in our department were included in this study. ALK rearrangement was examined by using fluorescence in situ hybridization(FISH) assay.Results: Among the 487 patients, 44(9.0%) were diagnosed with ALK rearrangement by using FISH assay. In 123 patients with adenocarcinoma who were non?smokers and of a young age(≤58 years old), the frequency of ALK rearrangement was 20.3%(25/123). Short overall survival(OS) was associated with non?adenocarcinoma tumor type(P = 0.006), poorly diferentiated tumors(P al growth factor rece= 0.001), advanced?stage tumors(P < 0.001), smoking history(P ptor(EGFR)(P = 0.008), and wild?type epidermrter time to cancer p= 0.008). Moreover, patients with poorly diferentiated and advanced?stage tumors had a shorogression compared with those with well diferentiated(P = 0.023) and early?stage tumors(P = 0.001), respectively.Conclusions: ALK?rearranged NSCLC tends to occur in younger individuals who are either non?smokers or light smokers with adenocarcinoma. Patients with ALK rearrangement might beneit from ALK inhibitor therapy. | Sha Fu Hai‑Yun Wang Fang Wang Ma‑Yan Huang Ling Deng Xiao Zhang Zu‑Lu Ye Jian‑Yong Shao | 2015 | Chinese Journal of Cancer2015，34，9： | 3 |
| 9 | 冷冻干燥更适合土壤活性氮气体(HONO和NO)排放的研究?显示文摘土壤活性氮气体(HONO和NO)排放是全球氮循环的关键过程,对大气化学具有重要意义。本研究采集了农田,草地和森林三种不同土地利用类型的土壤样品,分别对样品进行了风干,冻干和烘干三种处理,并与未处理的新鲜土壤进行比较研究。结果表明,三种类型土壤的冻干土与新鲜土样品的p H值差异最小。总的来说,三种干燥处理都能提高新鲜土壤NH4+-N, NO3--N和溶解态有机N的含量。与新鲜土壤相比,冻干土壤HONO和NO的最大排放通量及完整干湿交替循环的总排放量没有显著增加,而风干和烘干土壤显著增加。因此,冷冻干燥方法可能更适合涉及土壤活性氮气体排放通量的研究。这一发现的重要启示是,我们需要慎重评价以往基于不同干燥方法得到的有关陆地–大气界面活性氮交换过程和生物地球化学氮循环机制的认识。 | WU Dianming DENG Lingling LIU Yanzhuo XI Di ZOU Huilan WANG Ruhai SHA Zhimin PAN Yuepeng HOU Lijun LIU Min | 2020 | Atmospheric and Oceanic Science Letters2020，13，3： | 3 |
| 10 | Preconcentration of Ultra-trace Cadmium with Nanometer-size TiO_2 Colloid and Determination by GFAAS with Slurry Sampling显示文摘A novel method of ultra-trace Cd(II) preconcentration with nanometer-size TiO2 colloid and determination by graphite furnace atomic adsorption spectrometry(GFAAS) with slurry sampling was first advanced in this paper. The adsorption efficiency of nanometer-size TiO2 colloid for ultra-trace Cd(II) could reach above 96% in a short time when the pH value was between 5 and 6. Other problems were also studied,such as adsorption capacity,nanometer-size TiO2 colloid dosage,effect of coexistent ions. The detection limit(3σ) and the relative standard deviation (R.S.D) of this method were 4.46?10-3 μg/L and 1.30%(n=7),respectively. The method was successfully applied to the analysis of environmental samples with recoveries between 93.8% and 96.4%. | Sha Hua QIAN Xue Qin LI Han LIN Mei XIAO Hong Bing DENG Luo Jing XIANG | 2006 | Chinese Chemical Letters2006，17，7： | 2 |
| 11 | Potential involvement of heat shock proteins in pancreaticduodenal homeobox-1-mediated effects on the genesis of gastric cancer: A 2D gel-based proteomic study显示文摘AIM To identify functional proteins involved in pancreaticduodenal homeobox-1(PDX1)-mediated effects on gastric carcinogenesis.METHODS A PDX1-overexpressed model was established by transfecting gastric cancer cell line SGC7901 with pcDNA3.1(+)-PDX1 vector(SGC-PDX1). Transfection with empty pcDNA3.1 vector(SGC-pcDNA) served as control. Comparative protein profiles of the two groups were analyzed by two-dimensional electrophoresis basedproteomics(2 DE gel-based proteomics). The differential proteins identified by 2 DE were further validated by qRTPCR and immunoblotting. Finally, co-immunoprecipitation was used to determine any direct interactions between PDX1 and the differential proteins.RESULTS2 DE gel proteomics identified seven differential proteins in SGC-PDX1 when compared with those in SGC-pcDNA. These included four heat shock proteins(HSPs; HSP70 p1 B, HSP70 p8, HSP60, HSP27) and three other proteins(ER60, laminin receptor 1, similar to epsilon isoform of 14-3-3 protein). Immunoblotting validated the expression of the HSPs(HSP70, HSP60, HSP27). Furthermore, their expressions were lowered to 80%, 20% and 24%, respectively, in SGC-PDX1, while PDX1 exhibited a 9-fold increase, compared to SGC-pcDNA. However, qRT-PCR analysis revealed that mRNA levels of the HSP s were increased in SGC-PDX1, suggesting that the expression of the HSP s was post-translationally regulated by the PDX1 protein. Finally, co-immunoprecipitation failed to identify any direct interaction between PDX1 and HSP70 proteins.CONCLUSION This study demonstrates the potential involvement of HSPs in PDX1-mediated effects on the genesis of gastric cancer. | Juan Ma Bei-Bei Wang Xiao-Yan Ma Wei-Ping Deng Li-Shu Xu Wei-Hong Sha | 2018 | World Journal of Gastroenterology2018，24，37： | 2 |
| 12 | Visualizing DC morphology and T cell motility to characterize DC-T cell encounters in mouse lymph nodes under mTOR inhibition显示文摘Mammalian target of rapamycin(mTOR),a serine/threonine kinase orchestrating cellular metabolism,is a crucial immune system regulator.However,it remains unclear how mTOR regulates dendritic cell(DC) function in vivo,especially DC-T cell encounters,a critical step for initiating adaptive immune responses.We dynamically visualized DC-T contacts in mouse lymph node using confocal microscopy and established an encounter model to characterize the effect of mTOR inhibition on DC-T cell encounters using DC morphology.Quantitative data showed mTOR inhibition via rapamycin altered DC shape,with an increased form factor(30.17%) and decreased cellular surface area(20.36%) and perimeter(22.43%),which were associated with Cdc42 protein downregulation(52.71%).Additionally,DCs adopted a similar morphological change with Cdc42 inhibition via ZCL278 as that observed with mTOR inhibition.These morphologically altered DCs displayed low encounter rates with T cells.Time-lapse imaging data of T cell motility supported the simulated result of the encounter model,where antigen-specific T cells appeared to reduce arrest in the lymph nodes of rapamycin-pretreated mice relative to the untreated group.Therefore,mTOR inhibition altered DC morphology in vivo and decreased the DC-T cell encounter rate,as well as Cdc42 inhibition.By establishing an encounter model,our study provides an intuitive approach for the early prediction of DC function through morphological quantification of form factor and area. | Qiaoya Lin Zheng Liu Meijie Luo Hao Zheng Sha Qiao Chenlu Han Deqiang Deng Zhan Fan Yafang Lu Zhihong Zhang Qingming Luo | 2019 | Science China(Life Sciences)2019，62，9： | 2 |
| 13 | Potential therapeutic effects and applications of Eucommiae Folium in secondary hypertension显示文摘Eucommiae Folium(EF),a traditional Chinese medicine,has been used to treat secondary hypertension,including renal hypertension and salt-sensitive hypertension,as well as hypertension caused by thoracic aortic endothelial dysfunction,a high-fat diet,and oxidized low-density lipoprotein.The antihypertensive components of EF are divided into four categories:flavonoids,iridoids,lignans,and phenylpropanoids,such as chlorogenic acid,geniposide acid and pinoresinol diglucoside.EF regulates the occurrence and development of hypertension by regulating biological processes,such as inhibiting inflammation,regulating the nitric oxide synthase pathway,reducing oxidative stress levels,regulating endothelial vasoactive factors,and lowering blood pressure.However,its molecular antihypertensive mechanisms are still unclear and require further investigation.In this review,by consulting the relevant literature on the antihypertensive effects of EF and using network pharmacology,we summarized the active ingredients and pharmacological mechanisms of EF in the treatment of hypertension to clarify how EF is associated with secondary hypertension,the related components,and underlying mechanisms.The results of the network pharmacology analysis indicated that EF treats hypertension through a multicomponent,multi-target and multi-pathway mechanism.In particular,we discussed the role of EF targets in the treatment of hypertension,including epithelial sodium channel,heat shock protein70,rhoassociated protein kinase 1,catalase,and superoxide dismutase.The relevant signal transduction pathways,the ras homolog family member A(RhoA)/Rho-associated protein kinase(ROCK)and nicotinamide adenine dinucleotide phosphate(NADPH)oxidase/eNOS/NO/Ca^(2+)pathways,are also discussed. | Mengyuan Li Yanchao Zheng Sha Deng Tian Yu Yucong Ma Jiaming Ge Jiarong Li Xiankuan Li Lin Ma | 2022 | Journal of Pharmaceutical Analysis2022，12，5： | 2 |
| 14 | Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities显示文摘Six new triterpenoid saponins,aesculusosides A-F(1-6),together with 19 known ones,were isolated from the seeds of Aesculus chinensis.The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data.Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay,and compounds 15,16,19,and 23-25 exhibited inhibitory activities against MCF-7 with IC50 values ranging from 7.1 to 31.3μM. | Jin-Tang Cheng Shi-Tao Chen Cong Guo Meng-Jiao Jiao Wen-Jin Cui Shu-Hui Wang Zhe Deng Chang Chen Sha Chen Jun Zhang An Liu | 2018 | Natural Products and Bioprospecting2018，8，1： | 2 |
| 15 | Development and Application of DC Partial Discharge Test System显示文摘Direct current (DC) partial discharge (PD) test has drawn extensive attention from world-wide electric power research institutes in recent years. However, presently, no DC PD detection device on the market has the statistical function. Thus, we developed a test system for PD detection under DC voltage, which is characterized by strong anti-jamming capability, continuous high-speed real-time data acquisi- tion and effective, complete detection of DC PD signals. The DC PD mechanism, as well as the measuring principles, software system, and hardware design of the test equipment were introduced. Adopting typical electrode pairs, we tested the statistical spectrum of PD under DC voltage. The main difference in statistical spectrums between parallel plate electrodes and needle-plate electrodes was that the time interval between two consecutive discharges for needle-plate electrodes has obviously larger variation range than that for parallel plate electrodes, which could be the convincing proof for distinguishing the type of electrodes under DC PD. Practical results indicate that the proposed sys- tem can measure time domain signals of DC PD of oil-paper insulation effectively and promptly, and it can be used to determine and detect defects in DC power transmission equipment. | NIE Dexin SHA Yanchao ZHOU Yuanxiang WU Zhirong DENG Jiangang | 2013 | 高电压技术2013，39，8： | 2 |
| 16 | Development of C~8- funetionalized magnetic silica nanoparticles as sample preparation technique for the determination of ergosterol in cigarettes by microwave- assisted derivatization and gas chromatography/mass spectrometry显示文摘 | SHA Yunfei DENG Chunhui LIU Baizhan | 2008 | Journal of Chromatography A2008，1198，： | 1 |
| 17 | A new ent-labdane eiterpenoid lactone from Andrographis paniculata显示文摘有一个新自然产品的新 ent-labdane diterpenoid 内酯从 Andrographis paniculata 被孤立。他们的结构被阐明根据光谱证据包括 2D NMR。 | Xiao Chi Ma Bao Jing Zhang Sha Deng Shan Shan Huang Ke Xin Liu Jing Ming Jia | 2009 | Chinese Chemical Letters2009，20，3： | 1 |
| 18 | Micro-crack tip fracture of commercial grade aluminum under mixed mode loading显示文摘 | SHA J B SUN J DENG Z J | 1999 | Theoretical and Applied Fracture Mechanics1999，31，： | 1 |
| 19 | Quality assessment of Flos Chrysanthemi Indici from different growing areas in China by solid - phase microextraction - gas chromatography - mass spectrometry 显示文摘 | Shen S Sha YF Deng CH | 2004 | Journal of Chromatography2004，1047，： | 1 |
| 20 | Systematic qualitative and quantitative assessment of anthocyanins, flavones and flavonols in the petals of 108 lotus (Nelumbo nucifera) cultivars显示文摘 | DENG Jiao CHEN Sha YIN Xiaojian | 2013 | Food Chemistry2013，139，1234： | 1 |
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