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1Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo显示文摘The hepatic sinusoids are lined by a unique population of hepatic sinusoidal endothelial cells (HSEC), which is one of the first hepatic cell populations to come into contact with blood components. However, HSEC are not simply barrier cells that restrict the access of blood- borne compounds to the parenchyma. They are func- tionally specialised endothelial cells that have complex roles, including not only receptor-mediated clearance of endotoxin, bacteria and other compounds, but also the regulation of inflammation, leukocyte recruitment and host immune responses to pathogens. Thus understand- ing the differentiation and function of HSEC is critical for the elucidation of liver biology and pathophysiology. This article reviews methods for isolating and studying human hepatic endothelial cell populations using in vitro models. We also discuss the expression and functions of phe- notypic markers, such as the presence of fenestrations and expression of VAP-1, Stabilin-1, L-SIGN, which can be used to identify sinusoidal endothelium and to permit discrimination from vascular and lymphatic endothelial cells.PF Lalor SM Curbishley S Shetty DH Adams 2006World Journal of Gastroenterology2006,12,34:11
2Plasma N terminal probrain natriuretic peptide and cardiotrophin are raised in unstable anginal 显示文摘Talwar S Squire IB Downie PF 2000Heart2000,84,4:1
3Daytime functional bladder capacity as a predictor of response to desmopressin in monosymptomatic nocturnal enuresis显示文摘Eller DA Austin PF Tanguay S 1998Eur Urol1998,33,3:1
4Antioxidant and free radical scavenging activities of 5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia 显示文摘PF REZ G R M VARGAS S R MARTINEZ M F J 2004Phytother Res2004,18,5:1
5Requisite role of angiopoietin-1 a ligand for the TIE2 receptor during embryonic angiogenesis显示文摘Suri C Jones PF Patan S 1996Cell1996,87,:1
6The effect of human proinsulin C-peptide on erythrocyte deformability in patients with type 1 diabetes mellitus显示文摘Kunt T Schneider S Pfützner A 1999Diabetologia1999,42,4:1
7Experimental valida- tion of a new ultrasound method for the simultaneous assessment of radial and longitudinal myocardial deformation independent of inso- nation angle显示文摘Langeland S D'hooge J Wouters PF 2005Circulation2005,112,14:1
8Telephone nursecounseling for medication adherence in ulcerative colitis : apreliminary study 显示文摘Cook PF Emiliozzi S El-Hajj D 2010Patient Educ Couns2010,81,2:1
9Lesions in the cerebellar fastigial nucleus have a small effect on the hyperpnea needed to meet the gas exchange' requirements of submaximal exercise 显示文摘Martino PF Davis S Opansky C 2006Appl Physiol2006,101,4:1
10Elevated circulating cardiotro- phin - 1 in heart failure : Relationship with parameters of left ventricular systolic dysfunction显示文摘Talwar S Squire IB Downie PF 2000Clin Sci2000,99,1:1
11Emergence of dengue virus type 4 genotype ⅡA in Malaysia 显示文摘AbuBakar S Wong PF Chan YF 2002J Gen Virol2002,83,:1
12Plasma N - terminal pro - brain natriuretic peptide and cardiotrophin 1 are raised in unstable angina显示文摘Talwar S Squire IB Downie PF 2004Heart2004,84,:1
13Safety and efficacy of subcutaneous and continuous intravenous itffusion rlL-2 in patients with metastatic renal cell carcinoma 显示文摘Geertsen PF Gore ME Negrier S 2004Br J Cancer2004,90,6:1
14Aduh bone marrow stromal cells differentiate into neural cells m vitro 显示文摘Sanchez RJ Song S Cardozo PF 2000Exp neurol2000,164,2:1
15Upregulation of L-type Ca^2+ channels in mesenteric and skeletal arteries of SHR显示文摘Pratt PF Bonnet S Ludwig LM 2002Hypertension2002,40,:1
16NgLL Plasma N-terminal pro-brain natriure tiepeptide and cardiotrophinl are raise dinun stableangina显示文摘Talwar S Squire IB Downie PF 2000Heart2000,84,:1
17Requisite role of angiopoietin-1, a ligand for the tie2 receptor, during embryonic angiogenesis显示文摘Suri C Jones PF Patan S 1996Cell1996,87,7:1
18Delayed umbilical cord clamping for reducing anaemia in low birthweight infants: impli- cations for developing countries 显示文摘van Rheenen PF Gruschke S Brabin BJ 2006Ann Trop Paediatr2006,26,:1
19Towards new understanding of the heart structure and function 显示文摘Langeland S Wouters PF Claus P 2005Eur J Cardiol Thorac Surg2005,27,2:1
20Intraoperative local an- aesthesia for reduction of postoperative pain following general an- aesthesia for dental treatment in children and adolescents显示文摘Parekh S Gardener C Ashley PF 2014Co- chrane Database Syst Rev2014,12,00:1
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