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| 1 | Impact of Helicobacter pylori on the healing process of the gastric barrier显示文摘AIM To determine the impact of selected well defined Helicobacter pylori(H. pylori) antigens on gastric barrier cell turnover.METHODS In this study,using two cellular models of gastric epithelial cells and fibroblasts,we have focused on exploring the effects of well defined H. pylori soluble components such as glycine acid extract antigenic complex(GE),subunit A of urease(Ure A),cytotoxin associated gene A protein(Cag A) and lipopolysaccharide(LPS) on cell turnover by comparing the wound healing capacity of the cells in terms of their proliferative and metabolic activity as well as cell cycle distribution. Toxic effects of H. pylori components have been assessed in an association with damage to cell nuclei and inhibition of signal transducer and activator of transcription 3(STAT3) phosphorylation. RESULTS We showed that H. pylori GE,Cag A and Ure A promoted regeneration of epithelial cells and fibroblasts,which is necessary for effective tissue healing. However,in vivo increased proliferative activity of these cells may constitute an increased risk of gastric neoplasia. In contrast,H. pylori LPS showed a dose-dependent influence on the process of wound healing. At a low concentration(1 ng/m L) H. pylori LPS accelerated of healing epithelial cells,which was linked to significantly enhanced cell proliferation and MTT reduction as well as lack of alterations in cell cycle and downregulation of epidermal growth factor(EGF) production as well as cell nuclei destruction. By comparison,H. pylori LPS at a high concentration(25 ng/m L) inhibited the process of wound repair,which was related to diminished proliferative activity of the cells,cell cycle arrest,destruction of cell nuclei and downregulation of the EGF/STAT3 signalling pathway.CONCLUSION In vivo H. pylori LPS driven effects might lead to the maintenance of chronic inflammatory response and pathological disorders on the level of the gastric mucosal barrier. | Eliza Mnich Magdalena Kowalewicz-Kulbat Paulina Sicińska Krzysztof Hinc Michal Obuchowski Adrian Gajewski Anthony P Moran Magdalena Chmiela | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
| 2 | Comparative Analysis of the Safety and Efficacy of Transcatheter Arterial Chemoembolization and Yttrium-90 Radioembolization in Patients with Unresectable Hepatocellular Carcinoma显示文摘 | Craig Lance Gordon McLennan Nancy Obuchowski Grace Cheah Abraham Levitin Mark Sands James Spain Shyam Srinivas Sankaran Shrikanthan Federico N. Aucejo Richard Kim K.V. Narayanan Menon | 2011 | Journal of Vascular and Interventional Radiology2011，，12： | 3 |
| 3 | 肝脏肿瘤经皮冰冻消融术后生物化学和血液学的变化:48次治疗报告显示文摘目的回顾分析肝脏肿瘤经皮冰冻消融术后实验室化验值出现异常的频度和严重程度,估计实验室化验值与肿瘤及消融体积的相关性。方法这项符合HIPAA要求的研究得到了伦理委员会的批准,可免除知情同意书。对39例病人(男性18例,女性21例;年龄29—86岁)的65个肝脏肿瘤(62个转移瘤和3个肝细胞癌)进行了48次MRI引导下经皮冰冻消融术,回顾分析其生物化学和血液学方面的实验室检查数据。分析术前基础化验值与术后0-6h、1~2周化验值相对于肿瘤和消融带边界体积的变化。肿瘤与消融边界体积用一般性估计方程计算。 | R.T. Nair S.G. Silverman K. Tuncali N.A. Obuchowski E. van Sonnenberg S. Shankar. 叶锦棠(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 2 |
| 4 | Magnetic resonance imaging of the lumbar spine in people without back pain显示文摘 | Jensen MC Brant-Zawadzki MN Obuchowski N | 1994 | N Engl J Med1994，331，2： | 1 |
| 5 | Receiver operating characteristic curves and their use in radiology 显示文摘 | Obuchowski NA | 2003 | Radiology2003，229，1： | 1 |
| 6 | MR evaluation of epidural fibrosis:proposed grading system with intra-and inter-obserer variability显示文摘 | Ross JS Obuchowski N Modic MT | 1999 | Neurol Res1999，21，1： | 1 |
| 7 | Optimizing patient selection in percutaneous vertebroplasty显示文摘 | STALLMEYER M J ZOARSKI G H OBUCHOWSKI A M | 2003 | J Vase Interv Radiol2003，14，： | 1 |
| 8 | Brain computed tomogaphy angiographic scans as the sole diagnostic examination for excluding aneurysms in patients with perimesencephalic subarachnoid hemorrhage 显示文摘 | Turner R Obuchowski N Gonagunta V | 2007 | Neurosurgery2007，61，6： | 1 |
| 9 | Mag- netic resonance imaging of the lumbar spine in people with- out back pain显示文摘 | Jensen MC Brant-Zawadzki MN Obuchowski N | 1994 | N Engl J Med1994，331，2： | 1 |
| 10 | Magnetic Magnetic resonance imaging of the lumbar spine in people with- out back pain显示文摘 | Jesen M C Brant-Zawadzki M N Obuchowski N | 1994 | N Engl J Med1994，331，2： | 1 |
| 11 | Receiver operating characteristic curves and their use in radiology显示文摘 | Obuchowski NA | 2003 | Radiology2003，229，1： | 1 |
| 12 | Mural attenuation in normal small bowel and active inflammatory Crohn's disease on CT enterography:location,absolute attenuation,relative attenuation,and the effect of wall thickness显示文摘 | Baker ME Walter J Obuchowski NA | | 0，，02： | 1 |
| 13 | Comparative analysis of the development of swarming communities of Bacillus subtilis 168 and a natural wild type: critical effects of surfactin and the composition of the medium 显示文摘 | JULKOWSKA D OBUCHOWSKI M HOLLAND B I | 2005 | Journal of Bacteriology2005，187，1： | 1 |
| 14 | Acute low back pain and radiculopatby: MR imaging findings and their prognostic role and effect on outcome显示文摘 | Modic MT Obuchowski NA RossJS et 01 | 2005 | Radiology2005，237，2： | 1 |
| 15 | ROC analysis显示文摘 | Obuchowski NA | 2005 | A JR2005，184，： | 1 |
| 16 | The postoperative lumbar spine:evaluation of epidural scar over a1year period显示文摘 | Ross J S Obuchowski N Zepp R | 1998 | Am J Neuroradiol1998，19，1： | 1 |
| 17 | The postoperative lumbar spine:evaluation of epidural scar over 1-year显示文摘 | Ross JS Obuchowski N Zepp R | 1998 | Am J Neuoradiol1998，19，： | 1 |
| 18 | Characterization of PrpC from Bacillus subtilis , a member of the PPM phos phatase family显示文摘 | Obuchowski M Madec E Delattre D | 2000 | J Bacteriol2000，182，： | 1 |
| 19 | Magnetic resonance imaging of the lumbar spine in people without back pain显示文摘 | Jensen MC Brant-Zawadzki MN Obuchowski N | 1994 | N Engl J Med1994，331，： | 1 |
| 20 | Clinical evaluation of di- agnostic tests 显示文摘 | Weinstein S Obuchowski NA Lieber ML | 2005 | A JR Am J Roentgeno12005，184，： | 1 |
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