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| 1 | Mesenchymal stem cells for cartilage regeneration in osteoarthritis显示文摘Osteoarthritis(OA) is a slowly progressive disease where cartilage of the synovial joint degenerates. It is most common in the elderly where patients experience pain and reduce physical activity. In combination with lack of conventional treatment, patients are often left with no other choices than arthroplasty. Over the last years, multipotent stromal cells have been used in efforts to treat OA. Mesenchymal stem/progenitor cells(MSCs) are stromal cells that can differentiate into bone, fat, and cartilage cells. They reside within bone marrow and fat. MSCs can also be found in synovial joints where they affect the progression of OA. They can be isolated and proliferated in an incubator before being applied in clinical trials. When it comes to treatment, emphasis has hitherto been on autologous MSCs, but allogenic cells from healthy donors are emerging as another source of the cells. The first adaptations of MSCs revolved in the use of cellrich matrix, delivered as invasive surgical procedure, which resulted in production of hyaline cartilage and fibrocartilage. However, the demand for less invasive delivery of cells has prompted the use of direct intraarticular injections, wherein a large amount of suspended cells are implanted in the cartilage defect. | Baldur Kristjánsson Sittisak Honsawek | 2017 | World Journal of Orthopedics2017,8,9: | 9 |
| 2 | Acromioclavicular dislocations treated by coracoacromial ligament transfer显示文摘 | J. Karlsson H. árnarson K. Sigurjónsson | 1986 | Archives of Orthopaedic and Traumatic Surgery1986,,1: | 6 |
| 3 | 虹鳟鱼鳃及肝脏多种CYP1基因表达模式作为生物标志物监测海河水污染状况显示文摘以虹鳟鱼为受试生物,以鳃与肝脏多种CYP1基因为生物标志物,在天津境内开展了野外监测实验,分析多种CYP1转录物的表达量变化及它们在不同监测位点的表达模式.实验通过鱼类吊网在特定水域进行野外监测.结果表明,葛沽与海河入海口的6种CYP1基因表达模式很相近,但表达量不同,表明两地的污染成分相近似但水中污染物负荷不同.除了在马厂减河外,CYP1C1/C3在葛沽与入海口受到明显诱导作用,表明马厂减河中存在的污染物种类不同于其它监测位点.因此,利用虹鳟鱼鳃与肝脏中多种CYP1基因表达模式作为生物标志物监测污染物有着很好的前景,不仅可以作为研究环境污染物对水环境和鱼类健康影响的重要手段,还可以为进一步解释化学混合物成分与多种生物反应之间关系提供理论基础. | 高锴 闫佩 檀翠玲 罗彦鹤 孙静 Maria E.Jnsson Ingvar Brandt 唐运平 | 2015 | 环境科学2015,36,10: | 3 |
| 4 | Effect of cyclodextrins on topical drug delivery to the eye 显示文摘 | Loftsson I Stefànsson E | 1997 | Drug Devel Ind Pharm Sci1997,23,: | 2 |
| 5 | Topically effective acetazolamide eye-solution in man 显示文摘 | Thorsteinn Loftsson Stefànsson E Kristinsson JK | 1996 | Pharm Sci1996,6,: | 2 |
| 6 | 优于黑箱模型的海洋生态系统模型方法:利用GIS研究沿海生态系统碳通量显示文摘海洋生态系统碳通量研究常用方法包括盆地尺度黑箱模型和高分辨率的三维模型,都强调生态系统中的浮游部分。这些方法适用于海洋研究,但应用于沿海生态系统时会出现相当多的问题,这是因为某些生态位尺度的不同而且底栖生物是该生态系统功能的主导群体。此外,三维模型需要大量的建模工作。该项目基于大量样地调查,应用高分辨率(20m×20m)GIS数据网格对(瑞典波罗的海)Laxemar地区的海岸生态系统进行了研究。该模型在核废料埋藏点安全评估工程背景下发展起来,对假想的从计划中的埋藏点中释放的放射性核素的去向加以估计。该评估项目不仅需要深入了解该地生态系统动态,而且需要定量描述系统中物质的储量和通量。通过数据网格建立对生物量的空间分布、初级生产量和净生态系统产量(NEP)等碳收支状况的描述,从而对该地区碳源和碳汇进行定位。结果表明,在盆地内生态系统特征有较大变异;大尺度上,内部盆地为净生产,而外部盆地为净呼吸,甚至包括浅海底栖植物群落。内部盆地区域的底栖过程较之平流过程对碳通量有较大或类似的影响,而外部盆地则相反。预期放射性核素遵循环境中有机物循环路线,这些研究结果切实增强了我们描述和预测它们在生态系统中去向的能力。 | Erik Wijnbladh Bror Fredrik Jnsson Linda Kumblad 马泽清 | 2006 | AMBIO-人类环境杂志2006,35,8: | 2 |
| 7 | 药物不良反应的药物经济学显示文摘药物不良反应(ADRs)是引起住院的常见原因,往往造成极大的社会成本。然而,由于大多数ADRs从未引起过临床的重视,所以住院治疗的成本仅仅是由ADRs所造成的社会总成本中的一部分。与ADRs相关的成本主要有两项:为治疗由ADRs引起的疾病而产生的成本以及为避免发生ADRs而产生的成本。本文主要从经济学的角度来讨论ADRs的社会成本。通过文献回顾并对其中有关ADRs发生和其成本的研究文献进行总结后,得出如下3种评价ADRs成本的不同方法:第一种方法是成本研究,必须通过以下三步来估算ADRs的成本:(1)定义ADRs;(2)判断是否为ADRs;(3)测算ADRs的成本。大多数有关成本的研究主要集中在由ADRs所引起的住院治疗上,并且文献显示所有住院治疗中约有3%~7%是由ADRs引起的。第二种方法是关于安全性的成本和效益。对处方、使用、调剂或者生产某药物,在决策涉及到成本和效益时,决策者必须对如下两方面成本进行权衡:(1)为治疗由ADRs引起的疾病而产生的成本;(2)为避免发生ADRs而产生的成本。第三种方法是讨论使药物治疗的成本和效益之间达到最佳平衡所需的法规和机制。从经济学的角度讲,ADRs的问题不是最小化而是最优化问题,是在成本和效益之间找到恰当的平衡关系。 | Jonas Lundkvist Bengt Jnsson 张力 | 2008 | 中国药物经济学2008,3,2: | 2 |
| 8 | A simple method for reconstructing a high-quality NDVI time-series data set based on the Savitzky–Golay filter显示文摘 | Jin Chen Per. J?nsson Masayuki Tamura Zhihui Gu Bunkei Matsushita Lars Eklundh | 2004 | Remote Sensing of Environment2004,,3: | 2 |
| 9 | Ocular Oxygenation and the Treatment of Diabetic Retinopathy显示文摘 | Einar Stefánsson | 2006 | Survey of Ophthalmology2006,,4: | 2 |
| 10 | TIMESAT—a program for analyzing time-series of satellite sensor data显示文摘 | Per J?nsson Lars Eklundh | 2004 | Computers and Geosciences2004,,8: | 2 |
| 11 | Metastatic disease in the liver from colorectal cancer: An appraisal of liver surgery显示文摘 | Stig Bengmark M.D. Ph.D. Larsolof Hafstr?m M.D. Ph.D. Bengt Jeppsson M.D. Per-Ebbe J?nsson M.D. Ph.D. Stefan Rydén M.D. Kaj Sundqvist M.D. Ph.D | 1982 | World Journal of Surgery1982,,1: | 2 |
| 12 | Acromioclavicular dislocations treated by coracoacromial ligament transfer显示文摘 | J. Karlsson H. árnarson K. Sigurjónsson | 1986 | Archives of Orthopaedic and Traumatic Surgery1986,,1: | 2 |
| 13 | 一次成功的应力预测地震显示文摘在冰岛成功地“应力预测”了1次5级地震,做法是根据S波分裂的时间延迟变化来估计地震的时间和强度,即估计在受应力作用的体积(也是地震释放应变的体积)内微裂隙在应力作用下达到破裂临界点的时间和强度。当地的研究提供了大致的震中位置。本文叙述了应力预测依据的准则。 | S.Crampin T.Volti R.Stefánsson 阮爱国 | 2000 | 世界地震译丛2000,31,2: | 2 |
| 14 | The optics of vitreous surgery显示文摘 | Landers MB 3rd Stefánsson E Wolbarsht ML | | 0,,05: | 1 |
| 15 | The hematopoietic stem cell niche:low in oxygen but a nice place to be显示文摘 | Eliasson P J?nsson JI | | 0,,: | 1 |
| 16 | Photopolymerization of acrylates using Naliphaticmaleimides as photoinitiators 显示文摘 | CLARK S C HOYLE C E J NSSON S | 1999 | Polymer1999,40,18: | 1 |
| 17 | Acromioclavicular dislocations treated by coracoacromial ligament transfer显示文摘 | Karlsson J Arnarson H Sigurjónsson K | 1986 | Arch Orthop Trauma Surg1986,106,1: | 1 |
| 18 | Cost-effectiveness of extended prophylaxis with fondaparinux compared with low molecular weight heparin against venous thromboembolism in patients undergoing hip fracture surgery显示文摘 | Lundkvist J Bergqvist D J(o) nsson B | 2007 | Eur J Health Econ2007,8,4: | 1 |
| 19 | 查看详情显示文摘 | Evilevitch A Rescic J J?nsson B Olsson U | | 0,,45: | 1 |
| 20 | A fast and robust algorithm for Bader decomposition of charge density显示文摘 | Graeme Henkelman Andri Arnaldsson Hannes Jónsson | 2005 | Computational Materials Science2005,,3: | 1 |