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| 1 | 中耳炎显示文摘中耳炎是儿童的高发病。中耳炎的病因病理是多因素的,包含免疫反应、咽鼓管功能障碍、细菌和病毒的感染、遗传以及环境因素等。早期的观察适用于大多数中耳炎儿童;对于被确诊为急性中耳炎的两岁以内的患儿,建议使用抗生素。手术方法的选择取决于合并症、儿童的生长发育状况以及对自发性渗出液的预期估计。推荐的手术方法有鼓室置管术、腺样体刮除术等。然而,到目前还没有理想的治疗方法,需要探索新的、基于现代中耳炎的病因病理理论的有创意性的治疗方法。 | Rovers MM Schilder AG Zielhuis GA Rosenfeld RM 张江平 杨妙丽 张全安 | 2005 | 国外医学(耳鼻咽喉科学分册)2005，29，3： | 427 |
| 2 | QUADAS的制定:用于系统评价中评价诊断性研究质量的工具显示文摘背景在以系统评价为基石的循证医学时代,需要有恰当的质量评价工具。对诊断性研究的评价目前尚缺乏系统开发且经过验证的评价工具。本研究的目的是采用共识决策法整合经验证据和专家意见,制定在系统评价时用于评价原始诊断性研究质量的工具。方法按照循证原则,我们在之前发表的3篇诊断性研究文献的综述的基础上,初选出一些条目形成列表,然后通过Delphi流程逐步调整列表,形成质量评价工具。参与Delphi流程的都是诊断性研究领域的专家。结果共有9位诊断学领域的专家参与Delphi流程。经过4轮Delphi流程后,专家们对哪些条目应纳入评价工具达成共识,我们把这个评价工具命名为QUADAS。纳入条目从最初的28个减少到14个,涵盖了疾病谱、金标准、疾病进展偏倚(disease progression bias)、证实偏倚(verification bias)、评价偏倚、临床评价偏倚、合并偏倚、试验的实施、病例退出以及不确定结果。QUADAS工具中的每个条目都配有评分细则。结论本研究项目开发出了用于诊断性试验系统评价的循证质量评价工具。下一步工作是确定其适用性和有效性。 | Penny Whiting Anne WS Rutjes Johannes B Reitsma Patrick MM Bossuyt Jos Kleijnen 刁骧(译) 艾昌林(译) 秦莉(审校) 姚巡(审校) | 2007 | 中国循证医学杂志2007，7，4： | 67 |
| 3 | Induction of apoptosis by arsenic trioxide and hydroxycamptothecin in gastric cancer cells in vitro显示文摘AIM To study the effects of arsenic trioxide andHCPT on different degrees of differentiated gastriccancer cells(SGC-7901,MKN-45,MKN-28)withrespect to both cytotoxicity and induction ofapoptosis in vitro.METHODS The cytotoxicity of As2O3 and HCPTon gastric cancer cells was determined by MTTassay.Morphologic changes of apoptosis ofgastric cancer cells were observed by lightmicroscopy and transmission electron microscopy.Apoptosis and cell cycle changes of gastric cancercells induced by HCPT and As2O3 were investigatedby TUNEL method and flow cytometry.RESULTS As2O3 and HCPT had remarkablecytotoxic effects on different degrees ofdifferentiated gastric cancer cells.The IC50ofAs2O3 on well differentiated gastric cancer cellMKN-28,moderately differentiated gastric cancercell SGC-7901,and poorly differentiated gastriccancer cell MKN-28 were 8.91 μmol/L,10.57μmol/L,and 11.65 μmol/L,respectively.The IC50of HCPT on MKN-28,SGC-7901,and MKN-45 were9.35 mg/L,10.21 mg/L,and 12.63 mg/Lrespectively after 48 h treatment.After 12 h ofexposure to both drugs,gastric cancer cellsexhibited morphologic features of apoptosis,including cell shrinkage,nuclear condensation, and formation of apoptotic bodies.A typicalsubdiploid peak before G0/G1 phase was observedby flow cytometry.The apoptotic rates of SGC-7901,MKN-45,and MKN-28 were 13.84%,22.52%,and 9.68%,respectively after 48 hexposure to 10 μmol/L As2O3.The apoptotic ratesof SGC-7901,MKN-45,and MKN-28 were 21.88%,12.35%,and 30.26%,respectively after 48 hexposure to 10 mg/L HCPT.The apoptotic indicewere 7%-15% as assessed by TUNEL method.The effect of As2O3 on SGC-7901 showedremarkable cell cycle specificity,which inducedcell death in G1 phase,and blocked G2/M phase.HCPT also showed a remarkable cell cyclespecificity,by inducing cell death and apoptosis inG1 phase and arrest of proliferation at S phase.CONCLUSION As2O3 and HCPT exhibitsignificant cytotoxicity on gastric cancer cells byinduction of apoptosis.As2O3 and HCPT mighthave a promising prospect in the treatment ofgastric cancer,which needs to be further studied. | Tu SP Zhong J Tan JH Jiang XH Qiao MM Wu YX Jiang SH | 2000 | World Journal of Gastroenterology2000，6，4： | 43 |
| 4 | COVID-19中肝脏检查异常:对美国一家主要医院网络的1827例患者的一项回顾性观察队列研究显示文摘【据Hepatology 2020年7月报道】题:COVID-19中肝脏检查异常:对美国一家主要医院网络的1827例患者的一项回顾性观察队列研究(作者Hundt MA等)由SARS-CoV-2病毒引起的COVID-19大流行与肺炎、急性呼吸窘迫综合征(ARDS)和多器官衰竭的发病率及病死率相关。据报道,肝损伤为COVID-19的一种非肺部表现,但肝脏检查异常及其与临床结果相关性的描述尚不完整。 | 万敏婕 高普均 HUNDT MA DENG Y CIARLEGLIO MM | 2020 | 临床肝胆病杂志2020，36，10： | 27 |
| 5 | Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death显示文摘 | Jiang H Gomez-Manzano C Aoki H Alonso MM Kondo S McCormick F Xu J Kondo Y Bekele BN Colman H Lang FF Fueyo J | 2007 | 中国神经肿瘤杂志2007，5，3： | 24 |
| 6 | Fluorescence enhancement effect and the interaction between donor and acceptor显示文摘A new theoretical equation for fluorescence enhancement effect between donor and acceptor has been introduced.By using it we determined the binding constants and numbers of binding sites of five medicines,including chlorogenic acid,forsythiaside norfloxacin,Ciprofloxacin and fluorenone,to γ-globulin. | Yang, P Yang, MM Yang, BS | 1996 | Chinese Journal of Chemistry1996，14，2： | 23 |
| 7 | Microbiota-host interactions in irritable bowel syndrome: Epithelial barrier, immune regulation and brain-gut interactions显示文摘Irritable bowel syndrome(IBS) is a common, sometimes debilitating, gastrointestinal disorder worldwide. While altered gut motility and sensation, as well as aberrant brain perception of visceral events, are thought to contribute to the genesis of symptoms in IBS, a search for an underlying aetiology has, to date, proven unsuccessful. Recently, attention has been focused on the microbiota as a possible factor in the pathogenesis of IBS. Prompted by a number of clinical observations, such as the recognition of the de novo development of IBS following enteric infections, as well as descriptions of changes in colonic bacterial populations in IBS and supported by clinical responses to interventions, such as antibiotics and probiotics, that modify the microbiota, various approaches have been taken to investigating the microbiota-host response in IBS, as well as in animal models thereof. From such studies a considerable body of evidence has accumulated to indicate the activation or upregulation of both factors involved in bacterial engagement with the host as well host defence mechanisms against bacteria. Alterations in gut barrier function, occurring in response, or in parallel, to changes in the microbiota, have also been widely described and can be seen to play a pivotal role in generating and sustaining host immune responses both within and beyond the gut. In this manner a plausible hypothesis, based on an altered microbiota and/or an aberrant host response, for the pathogenesis, of at least some instances of IBS, can be generated. | Niall P Hyland Eamonn MM Quigley Elizabeth Brint | 2014 | World Journal of Gastroenterology2014，20，27： | 22 |
| 8 | Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma显示文摘INTRODUCTIONSialyl Lewis-X antigen ,correlated with carcinoma, is a group of carbohydrate antigen containing oligosaccharide expressed of embryonic tisue and glycoproteins on cell surface of embryonic tissue[1].The SLeX antigen located on cell surface is synthesized principally by two enzymes ,al ,3fucosyltransfrease and a2, 3sialyctransferase.In adults ,SLeX antigen is expressed principally on the surfaces of granulocytic cells and some tumor cells . | Xiao Wei Li~1 Yan Qing Ding~1 Jun Jie Cai~1 Shao Qing Yang~2 Lian Bing An~3 Dong Fang Qiao~3 ~1Department of Pathology,Nanfang Hospital of the First Military Medical University,Guangzhou 510515,Guangdong Province,China ~2The Northern Hospital of PLA,Shenyang 110015,Liaoning Province,China ~3Department of Electronmicroscopy,First Military Medical University,Guangzhou 510515,Gangdong Province,ChinaDr.Xiao Wei Li graduated from the First Military Medical University with a MM degree in 1999.Physician in Charge of pathology,having 6 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 19 |
| 9 | 接受治疗的老年高血压患者的血压、抗高血压药物应用、衰弱指标与严重摔伤风险的关系显示文摘一些研究表明,降压药物、低收缩压和舒张压与跌倒风险增加相关。许多老年人表现出衰弱的指征,这可能会增加跌倒的风险。该研究纳入脑卒中地区和种族差异原因(the reasons for geographic and racial differences in stroke,REGARDS)研究中年龄≥65岁的受试者5236例,探索收缩压、舒张压、抗高血压药物类别数量以及衰弱指标与严重跌倒损伤风险的关系, | 刘莉 叶鹏 Bromfield SG Ngameni CA Colantonio LD Bowling CB Shimbo D Reynolds K Safford MM Banach M Toth PP Muntner P | 2017 | 中华高血压杂志2017，25，8： | 19 |
| 10 | 空气污染对中小学生呼吸系统健康状况影响显示文摘目的研究空气污染对中小学生呼吸系统健康影响,筛选主要影响因素。方法运用环境流行病学方法,在兰州市大气污染程度不同的3个区整群抽样选取8~20岁共约1200名中小学生为研究对象,以面询式调查问卷进行呼吸系统疾病和症状调查,并对其影响因素进行回顾性分析。结果2005年采暖期,兰州市污染水平与中小学生咳嗽及咳痰、喷嚏及流涕症状发生率及上呼吸道感染发病率均表现为西固区〉城关区〉榆中区,且差异均有统计学意义(P〈0.05)。非条件Logistic回归分析表明,引起呼吸道不适症状和发病的主要因素有大气污染、吸烟、室内空气污染,呈显著正相关。结论大气污染、主动及被动吸烟、室内空气污染是中小学生呼吸系统症状和疾病发生的主要因素。 | 王燕侠 牛静萍 丁国武 Noordin MM 陈晓燕 | 2007 | 中国公共卫生2007，23，6： | 17 |
| 11 | 兰州市大气污染对青春期青少年肺功能的影响显示文摘目的探讨兰州市大气污染对青春期发育阶段青少年肺功能的影响。方法于2005年12月15日—2006年2月15日(采暖期)对兰州市大气污染程度不同的3个区(西固区、城关区、榆中区)的部分大气污染物(PM2.5、SO2、NO2)进行为期15d的监测。采用整群抽样的方法在上述3个区各选取8~18岁青少年近500名作为研究对象,进行肺功能指标测定[最大肺活量(FVC)、第1秒最大呼气量(FEV1.0)、最大肺活量百分比(/FVC)、第1秒最大呼气量占最大肺活量百分比(FEV1.0/)、75/的容量率(V75)、50/的容量率(V50)、25/的容量率(V25)]。结果大气环境质量指数表现为西固区(5.595)>城关区(3.312)>榆中区(0.897)。城关区和西固区的PM2.5日平均浓度分别为0.120和0.233mg/m3,超过美国制定的PM2.5日均值标准(PM2.5≤0.065mg/m3),西固区NO2日平均浓度(0.085mg/m3)超过GB3095—1996二级标准(0.080mg/m3)。青少年各项肺功能指标(FVC,FEV1.0,/FVC,FEV1.0/,V25,V50,V75)均表现为西固区<城关区<榆中区,FVC,FEV1.0,/FVC,FEV1.0/在各调查点间比较,差异有统计学意义(P<0.05)。青春发育前、中、后期各项肺功能指标表现为西固区<城关区<榆中区。肺通气功能阻塞型(FEV1.0/<70/)异常率(西固区、城关区、榆中区依次为12.4/、11.1/和5.7/)在3个区间比较,差异有统计学意义(P<0.05)。偏相关性分析显示,FVC与PM2.5、SO2、NO2的日平均浓度间呈显著负相关(P<0.01),偏相关系数分别为-0.087、-0.097和-0.122。结论兰州市大气污染物PM2.5、SO2、NO2的综合作用对青春期青少年肺功能产生了危害,表现为肺通气功能阻塞性障碍,年龄越小影响越大,并表现出长期慢性的影响过程。 | 王燕侠 牛静萍 丁国武 Noordin MM 陈晓燕 | 2007 | 环境与健康杂志2007，24，6： | 16 |
| 12 | Current medical treatment of estrogen receptor-positive breast cancer显示文摘Approximately 80% of breast cancers(BC) are estrogen receptor(ER)-positive and thus endocrine therapy(ET) should be considered complementary to surgery in the majority of patients. The advantages of oophorectomy, adrenalectomy and hypophysectomy in women with advanced BC have been demonstrated many years ago, and currently ET consist of(1) ovarian function suppression(OFS), usually obtained using gonadotropinreleasing hormone agonists(Gn RHa);(2) selective estrogen receptor modulators or down-regulators(SERMs or SERDs); and(3) aromatase inhibitors(AIs), or a combination of two or more drugs. For patients aged less than 50 years and ER+ BC, there is no conclusive evidence that the combination of OFS and SERMs(i.e., tamoxifen) or chemotherapy is superior to OFS alone. Tamoxifen users exhibit a reduced risk of BC, both invasive and in situ, especially during the first 5 years of therapy, and extending the treatment to 10 years further reduced the risk of recurrences. SERDs(i.e., fulvestrant) are especially useful in the neoadjuvant treatment of advanced BC, alone or in combination with either cytotoxic agents or AIs. There are two types of AIs: type Ⅰ are permanent steroidal inhibitors of aromatase, while type Ⅱ are reversible nonsteroidal inhibitors. Several studies demonstrated the superiority of the third-generation AIs(i.e., anastrozole and letrozole) compared with tamoxifen, and adjuvant therapy with AIs reduces the recurrence risk especially in patients with advanced BC. Unfortunately, some cancers are or became ET-resistant, and thus other drugs have been suggested in combination with SERMs or AIs, including cyclin-dependent kinase 4/6 inhibitors(palbociclib) and mammalian target of rapamycin(m TOR) inhibitors, such as everolimus. Further studies are required to confirm their real usefulness. | Franco Lumachi Davide A Santeufemia Stefano MM Basso | 2015 | World Journal of Biological Chemistry2015，6，3： | 16 |
| 13 | Antifungal activities and action mechanisms of compounds from Tribulus terrestris L.显示文摘 | Zhang JD Xu Z Cao YB Chen HS Yan L An MM Gao PH Wang Y Jia XM Jiang YY | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 14 | Review on Partial Discharge Detection Techniques Related to High Voltage Power Equipment Using Different Sensors显示文摘当在高电压操作一台设备或一个功率系统时,与部分分泌物(PD ) 联系的问题能被追踪到象臭氧和氧化氩氮气体的形成那样的电磁的排放,声学的排放或化学反应。高电压设备和高电压安装主人与对在象力量变压器,煤气的绝缘的变电所(GIS ) ,和电报安装那样的设备监视 PD 的过程的条件的需要达成协议。这份报纸考察象电的察觉,化学察觉,声学的察觉,和光察觉那样的可得到的 PD 察觉方法(包含的高电压设备) 。每个方法的优点和劣势被探索了并且比较。评论建议光察觉技术为应用在精确性和适用性的考虑提供许多优点什么时候与另外的技术相比。 | MM YAACOB MA ALSAEDI JR RASHED AM DAKHIL SF ATYAH | 2014 | Photonic Sensors2014，4，4： | 14 |
| 15 | Biliary microlithiasis,sludge,crystals, microcrystallization,and usefulness of assessment of nucleation time显示文摘BACKGROUND:The process of microcrystallization,its sequel and the assessment of nucleation time is ignored.This systematic review aimed to highlight the importance of biliary microlithiasis,sludge,and crystals,and their association with gallstones,unexplained biliary pain,idiopathic pancreatitis, and sphincter of Oddi dysfunction.DATA SOURCES:Three reviewers performed a literature search of the PubMed database.Key words used were'biliary microlithiasis','biliary sludge','bile crystals','cholesterol crystallisation','bile microscopy','microcrystal formation of bile','cholesterol monohydrate crystals','nucleation time of cholesterol','gallstone formation','sphincter of Oddi dysfunction'and'idiopathic pancreatitis'.Additional articles were sourced from references within the studies from the PubMed search.RESULTS:We found that biliary microcrystals account for almost all patients with gallstone disease,7%to 79%with idiopathic pancreatitis,83%with unexplained biliary pain, and 25%to 60%with altered biliary and pancreatic sphincter function.Overall,the detection of biliary microcrystals in gallstone disease has a sensitivity ranging from 55%to 87%and a specificity of 100%.In idiopathic pancreatitis,the presence of microcrystals ranges from 47%to 90%.A nucleation time less than 10 days in hepatic bile or ultra-filtered gallbladder bile has a specificity of 100%for cholesterol gallstone disease.CONCLUSIONS:Biliary crystals are associated with gallstone disease,idiopathic pancreatitis,sphincter of Oddi dysfunction, unexplained biliary pain,and post-cholecystectomy biliary pain.Pathways of cholesterol super-saturation,crystallisation, and gallstone formation have been described with scientificsupport.Bile microscopy is a useful method to detect microcrystals and the assessment of nucleation time is a good method of predicting the risk of cholesterol crystallisation. | Vasitha Abeysuriya Kemal I Deen Navarathne MM Navarathne | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，3： | 13 |
| 16 | Effects of soil moisture and plant interactions on the soil microbial community structure显示文摘 | Chen MM Zhu YG Su YH Chen BD Fu BJ Marschner P | 2007 | 中国生物学文摘2007，21，6： | 13 |
| 17 | 好莱坞霸权与民族电影显示文摘 | MM萨马蒂 PJ索特林 徐建生 | 2000 | 世界电影2000，，3： | 13 |
| 18 | Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report显示文摘 | Pierre-Alain Clavien Mickael Lesurtel Patrick MM Bossuyt Gregory J Gores Bernard Langer Arnaud Perrier | 2012 | Lancet Oncology2012，，1： | 13 |
| 19 | TENSILE STRENGTH AND CREEP RESISTANCE OF Mg-9Al-1Zn BASED ALLOYS WITH CALCIUM ADDITION显示文摘Small amount of calcium addition to the Mg-9A1-0.8Zn-0.2Mn (AZ91) alloy resulted in the obvious influence on mechanical properties. The yield strength of the alloys increased with the increase of Ca addition and maximum strength was obtained from the alloy containing 0.15% of Ca. The creep resistance at the temperatures between 150-200℃ was also significantly increased with Ca addition. The creep rate (at 200℃, 50MPa) of the alloy with00.15% of Ca addition was one order of magnitude lower than that of the base alloy (AZ91). Microstructural observations revealed that the addition of calcium refined the microstructure and enhanced the thermal stability of the β precipitates, which accounted for the improvement of creep resistance at high temperatures. | Y.S. Sun, W.M. Zhang and X.G. Mm Department of Materials Science and Engineering, Southeast University, Nanjing 210096, China | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，5： | 12 |
| 20 | 人血浆硫氧化还原蛋白80随着年龄增长而增加,并在载脂蛋白E基因敲除小鼠中诱导炎症、血管生成和动脉粥样硬化显示文摘硫氧化还原蛋白(thioredoxin,TRX)1是一种普遍存在的12kD的蛋白质,可产生抗氧化和抗炎作用。由巨噬细胞产生的截断形式称为TRX80,其可诱导促炎细胞因子的上调。TRX80还促进小鼠腹膜和人巨噬细胞向促炎M1表型的分化。方法:使用特异性酶联免疫吸附试验测定血浆TRX1和TRX80水平。 | 刘莉 叶鹏 Couchie D Vaisman B Abderrazak A Mahmood DFD Hamza MM Canesi F Diderot V El Hadri K Nègre-Salvayre AE Le Page A Fulop T Remaley AT Rouis M | 2017 | 中华高血压杂志2017，25，6： | 9 |
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