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		题名	作者	年代	出处	被引量
	1	Characterization and phylogenetic analysis of novel polyene type antimicrobial metabolite producing actinomycetes from marine sediments:Bay of Bengal India显示文摘Objective:To isolate and indentify the promising antimicrobial metabolite producing Streptomyces strains from marine sediment samples from Andraprudesh coast of India.Methods:Antagonistic aetinomycetes were isolated by starch casein agar medium and modified nutrient agar medium with 1%glucose used as a base for primary screening.Significant antimicrobial metabolite producing strains were selected and identified by using biochemical and 16S rDNA level.Minimum inhibitory concentrations of the organic extracts were done by using broth micro dilution method.Results:Among the 210 actinomyeetes,64.3%exhibited activity against Gram positive bacteria,48.5%showed activity towards Cram negative bacteria,38.8%exhibited both Cram positive and negative bacteria and 80.85%isolates revealed significant antifungal activity.However,five isolates AP-5,AP-18,AP-41 and AP-70 showed significant antimicrobial activity.The analysis of cell wall hydrolysates showed the presence of LL-diaminopimelic acid and glycine in all the isolates.Sequencing analysis indicated that the isolates shared 98.5%-99.8%sequence identity to the 16S rDNA gene sequences of the Streptomyces taxons.The antimicrobial substances were extracted using hexane and ethyl acetate from spent medium in which strains were cultivated at 30X for five days.The antimicrobial activity was assessed using broth micro dilution technique.Each of the culture extracts from these five strains showed a typical polyenelike property.The lowest minimum inhibitory concentrations of ethyl acetate extracts against Escherichia coli and Cumularia lunula were 67.5 and 125.0μg/mL,respectively.Conclusions:It can be concluded that hexane and ethyl acetate soluble extracellular products of novel isolates are effective against pathogenic bacteria and fungi.	Valan Arasu M Asha KRT Duraipandiyan V Ignacimuthu S Agastian P	2012	Asian Pacific Journal of Tropical Biomedicine2012，2，10：	5
	2	Travelling-wave ther-moacoustic bigh-temperature heat pump for industrial waste heat re~covery 显示文摘	Zhao Yang Yang Zhuo Luo Krt^ang	2014	Energy2014，77，1：	1
	3	Seroprevalence of paratuberculosis in Slovenia between 1999~2000显示文摘	M Ocepek B krt M pate	2002	Slo Vet Res2002，39，34：	1
	4	IS1245RFLP-basedgenotyping study of Mycobacterium avium subsp hominissuis i-solates from pigs and humans显示文摘	Pate M Zolnir-Dovc M Krt B	2008	Comp Immunol Microb2008，31，6：	1
	5	Screening for Down's syndrome by fetal nuchal translucency measurement in a general obstetric population显示文摘	krt E van Lith JM Mol BW		0，，03：	1
	6	Targeting t umor associated fibroblasts improves cancer chemotherapy by increas ing intratumoral drug uptake显示文摘	Loeffler M Krt~ger A Nietbammer AG	2006	J Clin Invest2006，116，19：	1
	7	Cell transduction pathways of transportans显示文摘	KRT P PILLE S MATS H	2005	Bioconjugate Chem2005，16，6：	1
	8	The technology ac- ceptance model: past, present, and future 显示文摘	LEE Y KOZAR KA LARSEN KRT	2003	Communica- tions of the Association for Information System2003，，12：	1

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