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| 1 | Pediatric functional constipation treatment with Bifi dobacterium-containing yogurt:A crossover,double-blind,controlled trial显示文摘AIM: To evaluate the treatment of pediatric functional chronic intestinal constipation (FCIC) with a probiotic goat yogurt. METHODS: A crossover double-blind formula-controlled trial was carried out on 59 students (age range: 5-15 years) of a public school in Belo Horizonte, MG, Brazil, presenting a FCIC diagnostic, according to Roma Ⅲ criteria. The students were randomized in two groups to receive a goat yogurt supplemented with 109 colony forming unit/mL Bifidobacterium longum (B.longum) (probiotic) daily or only the yogurt for a period of 5 wk (formula). Afterwards, the groups were intercrossed for another 5 wk. Defecation frequency, stool consistency and abdominal and defecation pain were assessed.RESULTS: Both treatment groups demonstrated improvement in defecation frequency compared to baseline. However, the group treated with probiotic showed most signif icant improvement in the f irst phase of the study. An inversion was observed after crossing over, resulting in a reduction in stool frequency when this group was treated by formula. Probiotic and formula improved stool consistency in the f irst phase of treatment, but the improvement obtained with probiotic was significantly higher (P = 0.03). In the second phase of treatment, the group initially treated with probiotic showed worseningstool consistency when using formula. However, the difference was not signif icant. A signif icant improvement in abdominal pain and defecation pain was observed with both probiotic and formula in the first phase of treatment, but again the improvement was more signif icant for the group treated with B. longum during phase I (P < 0.05). When all data of the crossover study were analyzed, significant differences were observed between probiotic yogurt and yogurt only for defecation frequency (P = 0.012), defecation pain (P = 0.046) and abdominal pain (P = 0.015). | Paula VP Guerra Luiza N Lima Tassia C Souza Vanessa Mazochi Francisco J Penna Andreia M Silva Jacques R Nicoli Elizabet V Guimares | 2011 | World Journal of Gastroenterology2011，17，34： | 25 |
| 2 | Factors associated with incomplete small bowel capsule endoscopy studies显示文摘AIM:To identify patient risk factors associated with incomplete small bowel capsule endoscopy(CE) studies.METHODS:Data from all CE procedures performed at St.Paul's Hospital in Vancouver,British Columbia,Canada,between December 2001 and June 2008 were collected and analyzed on a retrospective basis.Data collection for complete and incomplete CE study groups included patient demographics as well as a number of potential risk factors for incomplete CE including indication for the procedure,hospitalization,diabetes mellitus with or without end organ damage,limitations in mobility,renal insufficiency,past history of bowel obstruction,abdominal surgery,abdominal radiation therapy and opiate use.Risk factors were analyzed using a univariable and multivariable logistic regression model.RESULTS:From a total of 535 CE procedures performed,158 were incomplete(29.5%).The univariable analysis showed that CE procedures performed for overt gastrointestinal bleeding(P = 0.002),and for patients with a prior history of abdominal surgery(P = 0.023) or bowel obstruction(P = 0.023) were significantly associated with incomplete CE studies.Patients on opiate medications(P = 0.094) as well as hospitalized patients(P = 0.054) were not statistically significant,but did show a trend towards incomplete CE.The multivariable analysis showed that independent risk factors for an incomplete CE procedure include prior history of bowel obstruction [odds ratios(OR) 2.77,P = 0.02,95% confidence intervals(CI):1.17-6.56] and procedures performed for gastrointestinal bleeding(Occult OR 2.04,P = 0.037,95% CI:1.04-4.02 and Overt OR 2.69,P = 0.002,95% CI:1.44-5.05).Patients with a prior history of abdominal surgery(OR 1.46,P = 0.068,95% CI:0.97-2.19),those taking opiate medications(OR 1.54,P = 0.15,95% CI:0.86-2.76) and hospitalized patients(OR 1.82,P = 0.124,95% CI:0.85-3.93) showed a trend towards statistical significance.CONCLUSION:We have identified a number of risk factors for incomplete CE procedures that can be used to risk-stratify patients and guide interventions to improve completion rates. | Mitchell M Lee Andrew Jacques Eric Lam Ricky Kwok Pardis Lakzadeh Ajit Sandhar Brandon Segal Sigrid Svarta Joanna Law Robert Enns | 2010 | World Journal of Gastroenterology2010，16，42： | 10 |
| 3 | 内镜下射频消融术治疗范围广泛的0-Ⅱb型早期食管鳞状细胞癌及癌前病变的临床效果显示文摘目的探讨内镜下应用HALO射频消融系统(Radiofrequency Ablation,RFA)治疗范围广泛的早期表浅平坦型(0-Ⅱb)食管鳞状细胞癌及癌前病变的治疗效果。方法对中国医学科学院肿瘤医院自2008年10月至2011年6月应用HALO射频消融系统治疗的33例早期食管鳞状细胞癌(early esophageal squamous cell cancer,EESCC)、重度不典型增生(high grade dysplasia,HGD)及中度不典型增生(middle grade dysplasia,MGD)患者的临床资料进行分析,观察治疗后1年病变组织学上完全缓解率(CR)及并发症情况。结果33例患者中,男26例,女7例,年龄平均61岁,MGD10例,HGD17例,EESCC6例,病变长度3~12(平均7.9)cm,治疗区域长度5~14(平均9.9)cm,累及食管周径平均11/12周。33例患者首次治疗手术时间11~57(平均30)min,平均住院时间3天。首次治疗后3个月内镜随访CR达69.7%(23/33),随访期间追加治疗1—4(平均2.7)次,12个月内镜随访时CR达93.9%(31/33)。4例(12%)术后出现重度狭窄,行内镜下水囊扩张术3—12(平均7)次,扩张后均缓解。无其他并发症发生。结论RFA治疗范围广泛的0-Ⅱb型早期食管鳞状细胞癌和癌前病变是安全的、有效的且是一项对于操作者技术要求较低的技术,扩大了内镜微创治疗的适应证。 | 张月明 贺舜 吕宁 薛丽燕 David E Fleischer Bas Weusten Sanford M Dawsey 窦利州 Jacques JGHM Bergman 王贵齐 | 2015 | 中华消化内镜杂志2015，32，9： | 8 |
| 4 | Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chemo-radiation?显示文摘AIM To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) performed in a highvolume tertiary cancer center. METHODS A retrospective review of patients undergoing esophagectomy was performed and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to compare variables. Logistic regression analysis was used to determine if clinical variables such as tumor location and tumor histology were associated with EUS accuracy.RESULTS Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectomy were identified. There were 25(18%) female and 114(82%) male patients. The tumor location included the middle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinoma. Preoperative EUS matched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron emission tomography(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom both EUS and PET were negative for nodal involvement. CONCLUSION EUS is less accurate in early EC and endoscopic mucosal resection might be useful in certain settings. The addition of PET to EUS improves staging accuracy. | Carrie Luu Marisa Amaral Jason Klapman Cynthia Harris Khaldoun Almhanna Sarah Hoffe Jessica Frakes Jose M Pimiento Jacques P Fontaine | 2017 | World Journal of Gastroenterology2017，23，46： | 8 |
| 5 | Pulse pressure and aortic pulse wave are markers of cardiovascular risk in hypertensive populations显示文摘 | Roland Asmar Annie Rudnichi Jacques Blacher Gérard M London Michel E Safar | 2001 | American Journal of Hypertension2001，，2： | 3 |
| 6 | A combined analysis of the cystic fibrosis transmembrane conductance regulator: implications for structure and diease models显示文摘 | Chen J M Cutler C Jacques C | 2001 | Mol Biol Evol2001，18，9： | 2 |
| 7 | Modulation of HIV-1 replication by RNAi显示文摘 | Triques K Stevenson M | 2002 | Nature2002，418，： | 1 |
| 8 | Continuous production of aligned carbon nanotubes:A step closer to commercial realization显示文摘 | Andrews R Jacques D Rao A M | 1999 | Chemical Physics Letters1999，303，： | 1 |
| 9 | C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study显示文摘 | Wilson PW Pencina M Jacques P | 2008 | Circ Cardiovasc Qual Outcomes2008，1，2： | 1 |
| 10 | computer analysis of the tonic,phasic,and kinesthetic activity of pallidal discharges in parkinson patients显示文摘 | Jacques F Jamal M Thomas B | 1999 | Surg Neurol1999，51，： | 1 |
| 11 | Modulation of HIV-1 replication by RNA interference显示文摘 | Jacque JM Triques K Stevenson M | 2002 | Nature2002，418，： | 1 |
| 12 | Localization of laminin,fibronectin,E-caderin,and integrins in endometrium and endometriosis显示文摘 | Aude Beliard M D Jacques Donnez P H D | 1997 | Fertil Steril1997，67，： | 1 |
| 13 | Biofilm formation in bacterial pathogens of veterinary importance 显示文摘 | JACQUES M ARAGON V TREMBLAY Y D | 2010 | Anita Health Res Rev2010，11，2： | 1 |
| 14 | The three dimensions of species diversity显示文摘 | YOU M S LIETTE V JACQUES R | 2009 | The Open Conservation Biology Journal2009，，3： | 1 |
| 15 | Interactions of Haemophilus parasuis and its LOS with porcine brain microvascular endothelial cells显示文摘 | Bouchet B Vanier G Jacques M | 2008 | Vet Res2008，39，5： | 1 |
| 16 | Use of the 3,H2AX assay for assessing the genotoxicity of polycyclic aromatic hydro- carbons in human cell lines显示文摘 | AUDEBERT M RIU A JACQUES C | 2010 | Toxicol Lett2010，199，2： | 1 |
| 17 | Proinflammatory ac- tions of visfatin/nicotinamide phosphoribosyhransferase (Nampt) in- volve regu-lation of insulin signaling pathway and Nampt enzymatic ac- tivity显示文摘 | Jacques C Holzenberger M Mladenovic Z | 2012 | J Biol Chem2012，287，15： | 1 |
| 18 | The role of IL - 1 and IL -1Ra in joint inflammation and cartilage degradation 显示文摘 | Jacques C Gosset M Berenbaum F | 2006 | Vitam Horm2006，74，： | 1 |
| 19 | Continues production of aligned carbon nanotubes: A step closer to commercial realization 显示文摘 | Andrews R Jacques D Rao A M | 1999 | Chemical Physics Letters1999，303，56： | 1 |
| 20 | Steinman,dendritic cells and the control of inmmunity显示文摘 | Ralph M | 1998 | Nature1998，392，： | 1 |
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