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| 1 | Results of Carbon Ion Radiotherapy for Skin Carcinomas in 33 Patients显示文摘Purpose: To evaluate outcome and toxicity after carbon ion radiotherapy (RT) in skin carcinomas. Patients and Methods: Between November 2006 to September 2008, | H.Zhang1,2, S.Li3, X.H.Wang 4, Q.Li1,2, S.H.Wei3, L.Y.Gao4, W.P.Zhao1,2, Z.G.Hu1, R.S.Mao1, H.S.Xu1, H.Y.Cai 4, Y.Y.Yue3, G.Q.Xiao1 1Institute of Modern Physics, CAS, Lanzhou 730000, China 2 Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China 3 The General Hospital of Lanzhou Command, Lanzhou 730050, China 4 Tumor Hospital of Gansu Province, Lanzhou 730050, China | 2009 | 生物物理学报2009，25，S1： | 23 |
| 2 | Noninvasive investigations for non alcoholic fatty liver disease and liver fi brosis显示文摘Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of diseases that have insulin resistance in common and are associated with metabolic conditions such as obesity, type 2 diabetes mellitus, and dyslipidemia. NAFLD ranges from simple liver steatosis, which follows a benign course, to nonalcoholic steatohepatitis (NASH), a more severe entity, with necroinflmmation and f ibrosis, which can progress to cryptogenic cirrhosis and end-stage liver disease. Liver biopsy remains the gold standard for evaluating the degree of hepatic necroinflammation and f ibrosis; however, several noninvasive investigations, such as serum biomarkers, have been developed to establish the diagnosis and also to evaluate treatment response. These markers are currently neither available in all centers nor validated in extensive studies. Examples include high-sensitivity C reactive protein and plasma pentraxin 3, which are associated with extensive liver f ibrosis in NASH. Interleukin-6 correlates with inflammation, and cytokeratin-18 represents a marker of hepatocyte apoptosis (prominent in NASH and absent in simple steatosis). Tissue polypep-tide specif ic antigen seems to have a clinical utility in the follow-up of obese patients with NASH. | Carmen Fierbinteanu-Braticevici Ion Dina Ana Petrisor Laura Tribus Lucian Negreanu Catalin Carstoiu | 2010 | World Journal of Gastroenterology2010，16，38： | 21 |
| 3 | Nonalcoholic fatty liver disease, metabolic risk factors, and hepatocellular carcinoma: An open question显示文摘Non-alcoholic liver disease(NAFLD) defines liver abnormalities ranging from simple steatosis to nonalcoholic steatohepatitis with or without cirrhosis development, occurring in the absence of significant alcohol consumption, use of teratogenic medication, or hereditary disorders.The association between NAFLD and metabolic syndrome is well documented and widely recognized.Obesity, type 2 diabetes mellitus(T2DM), and dyslipidemia are the most common metabolic risk factors associated with NAFLD.Among the components of metabolic syndrome, current evidence strongly indicates obesity and diabetes as hepatocellular carcinoma(HCC) risk factors.There is also growing evidence that suggests an increased risk of HCC in NAFLD patients, even surpassing other etiologies in some high-income countries.Epidemiologic data demonstrate a parallel rise in prevalence of obesity, diabetes, NAFLD, and HCC.As obesity and its related diseases have steadily afflicted larger populations, HCC incidence is expected to increase in the future.Pathophysiologic mechanisms that underlie NAFLD development and subsequent progression to nonalcoholic steatohepatitis and cirrhosis(insulin resistance and hyperinsulinemia, oxidative stress, hepatic stellate cell activation, cytokine/adipocytokine signaling pathways, and genetic and environmental factors) appear to play a significant role in the development of NAFLD-related HCC.However, a comprehensive view of molecular mechanisms linking obesity, T2 DM, and NAFLD-related HCC, as well as the exact sequence of molecular events, is still not understood in its entirety.Good-quality data are still necessary, and efforts should continue towards better understanding the underlying carcinogenic mechanisms of NAFLD-related HCC.In this paper, we aimed to centralize the most important links supporting these relationships, focusing on obesity, T2 DM, and NAFLD-related HCC, as well as point out the major gaps in knowledge regarding the underlying molecular mechanisms behind them. | Letitia Adela Maria Streba Cristin Constantin Vere Ion Rogoveanu Costin Teodor Streba | 2015 | World Journal of Gastroenterology2015，21，14： | 15 |
| 4 | A view of cloud computing显示文摘 | Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia | 2010 | Communications of the ACM2010，，4： | 13 |
| 5 | Contrast-enhanced ultrasonography parameters in neural network diagnosis of liver tumors显示文摘AIM:To study the role of time-intensity curve(TIC) analysis parameters in a complex system of neural networks designed to classify liver tumors.METHODS:We prospectively included 112 patients with hepatocellular carcinoma(HCC)(n = 41),hypervascular(n = 20) and hypovascular(n = 12) liver metastases,hepatic hemangiomas(n = 16) or focal fatty changes(n = 23) who underwent contrast-enhanced ultrasonography in the Research Center of Gastroenterology and Hepatology,Craiova,Romania.We recorded full length movies of all contrast uptake phases and post-processed them offline by selecting two areas of interest(one for the tumor and one for the healthy surrounding parenchyma) and consecutive TIC analysis.The difference in maximum intensities,the time to reaching them and the aspect of the late/portal phase,as quantified by the neural network and a ratio between median intensities of the central and peripheral areas were analyzed by a feed forward back propagation multi-layer neural network which was trained to classify data into five distinct classes,corresponding to each type of liver lesion.RESULTS:The neural network had 94.45% training accuracy(95% CI:89.31%-97.21%) and 87.12% testing accuracy(95% CI:86.83%-93.17%).The automatic classification process registered 93.2% sensitivity,89.7% specificity,94.42% positive predictive value and 87.57% negative predictive value.The artificial neural networks(ANN) incorrectly classified as hemangyomas three HCC cases and two hypervascular metastases,while in turn misclassifying four liver hemangyomas as HCC(one case) and hypervascular metastases(three cases).Comparatively,human interpretation of TICs showed 94.1% sensitivity,90.7% specificity,95.11% positive predictive value and 88.89% negative predictive value.The accuracy and specificity of the ANN diagnosis system was similar to that of human interpretation of the TICs(P = 0.225 and P = 0.451,respectively).Hepatocellular carcinoma cases showed contrast uptake during the arterial phase followed by wash-out in the portal and first seconds of the late phases.For the hypovascular metastases did not show significant contrast uptake during the arterial phase,which resulted in negative differences between the maximum intensities.We registered wash-out in the late phase for most of the hypervascular metastases.Liver hemangiomas had contrast uptake in the arterial phase without agent wash-out in the portallate phases.The focal fatty changes did not show any differences from surrounding liver parenchyma,resulting in similar TIC patterns and extracted parameters.CONCLUSION:Neural network analysis of contrastenhanced ultrasonography-obtained TICs seems a promising field of development for future techniques,providing fast and reliable diagnostic aid for the clinician. | Costin Teodor Streba Mihaela Ionescu Dan Ionut Gheonea Larisa Sandulescu Tudorel Ciurea Adrian Saftoiu Cristin Constantin Vere Ion Rogoveanu | 2012 | World Journal of Gastroenterology2012，18，32： | 11 |
| 6 | Proteomic analysis of mitochondria reveals a metabolic switch from fatty acid oxidation to glycolysis in the failing heart显示文摘This work characterizes the mitochondrial proteomic profile in the failing heart and elucidates the molecular basis of mitochondria in heart failure. Heart failure was induced in rats by myocardial infarction, and mitochondria were isolated from hearts by differential centrifugation. Using two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry, a system biology approach was employed to investigate differences in mitochondrial proteins between normal and failing hearts. Mass spectrometry identified 27 proteins differentially expressed that involved in energy metabolism. Among those, the up-regulated proteins included tricarboxylic acid cycle enzymes and pyruvate dehydrogenase complex subunits while the down-regulated proteins were involved in fatty acid oxidation and the OXPHOS complex. These results suggest a substantial metabolic switch from free fatty acid oxidation to glycolysis in heart failure and provide molecular evidence for alterations in the structural and functional parameters of mitochondria that may contribute to cardiac dysfunction during ischemic injury. | WANG Jun1,2, BAI Ling1,2, LI Jing3, SUN ChaoFeng1,2, ZHAO Jin1, CUI ChangCong1,2, HAN Ke1,2, LIU Yu1,2, ZHUO XiaoZhen1,2, WANG TingZhong1,2, LIU Ping1,2, FAN FenLing1,2, GUAN YouFei3 & MA AiQun1,2 1 Department of Cardiology, First affiliated hospital of medical college of Xi’an Jiaotong University, Xi’an 710061, China 2 Ion Channel Disease Laboratory, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry, Xi’an 710061, China 3 Department of Physiology and Pathophysiology Key Laboratory of Molecular Cardiovascular Sciences of the Ministry of Education, Peking University Health Science Center, Beijing 100083, China | 2009 | Science China(Life Sciences)2009，52，11： | 10 |
| 7 | Ground-state and Pairing Properties of Pr Isotopes in RMF Theory显示文摘The ground-state and pairing properties of Pr (Z=59) isotopes have been investigated in therelativistic mean-field (RMF). The pairing correlation is studied in Bardeen-Cooper-Schrieffer (BCS) approximation and the pairingforces are taken to be isospin dependent. The ’blocking’ method is adopted to deal with unpaired | LI Jun-qing, MA Zhong-yu, CHEN Bao-qiu, ZHOU Yong(Research Center of Nuclear Theory of National Laboratory of Heavy Ion Accelerator of Lanzhou, Institute of Modem Physics, Lanzhou, 730000) | 2002 | Annual Report of China Institute of Atomic Energy2002，，0： | 9 |
| 8 | Optical coherence tomography and Doppler optical coherence tomography in the gastrointestinal tract显示文摘Optical coherence tomography(OCT) is a noninvasive,high-resolution,high-potential imaging method that has recently been introduced into medical investigations.A growing number of studies have used this technique in the field of gastroenterology in order to assist classical analyses.Lately,3D-imaging and Doppler capabilities have been developed in different configurations,which make this type of investigation more attractive.This paper reviews the principles and characteristics of OCT and Doppler-OCT in connection with analyses of the detection of normal and pathological structures,and with the possibility to investigate angiogenesis in the gastrointestinal tract. | Eugen Osiac Adrian Sǎftoiu Dan Ionut Gheonea Ion Mandrila Radu Angelescu | 2011 | World Journal of Gastroenterology2011，17，1： | 8 |
| 9 | Hybrid ultrasound imaging techniques(fusion imaging)显示文摘Visualization of tumor angiogenesis can facilitate noninvasive evaluation of tumor vascular characteristics to supplement the conventional diagnostic imaging goals of depicting tumor location,size,and morphology.Hybrid imaging techniques combine anatomic [ultrasound,computed tomography(CT),and/or magnetic resonance imaging(MRI)] and molecular(single photon emission CT and positron emission tomography) imaging modalities.One example is real-time virtual sonography,which combines ultrasound(grayscale,colour Doppler,or dynamic contrast harmonic imaging) with contrast-enhanced CT/MRI.The benefits of fusion imaging include an increased diagnostic confidence,direct comparison of the lesions using different imaging modalities,more precise monitoring of interventional procedures,and reduced radiation exposure. | Daniela Larisa Sandulescu Daniela Dumitrescu Ion Rogoveanu Adrian Saftoiu | 2011 | World Journal of Gastroenterology2011，17，1： | 7 |
| 10 | Coexistence of normal, super-, and hyper-deformation in nuclei: A study with angular momentum projection method显示文摘Angular-momentum-projected energy surface calculations for A ≈ 110 nuclei indicate three distinct energy minima occurring at different angular-momenta. These correspond to normal, super-, and hy- per-deformed shapes coexisting in one nucleus. 110Pd is studied in detail, with a quantitative prediction on super- and hyper-deformed spectra by the Projected Shell Model calculation. It is found that several other neighboring nuclei in the A-110 mass region, with the neutron number around 64, also exhibit clear super- and hyper-deformation minima in the projected calculation. | SUN Yang1,2, ZHANG JingYe3, LONG GuiLu4,5 & WU ChengLi6,7 1 Department of Physics, Shanghai Jiao Tong University, Shanghai 200240, China 2 Joint Institute for Nuclear Astrophysics, University of Notre Dame, Notre Dame, Indiana 46556, USA 3 Department of Physics and Astronomy, University of Tennessee, Knoxville, Tennessee 37996, USA 4 Department of Physics, Tsinghua University, Beijing 100084, China 5 Center of Nuclear Theory, Lanzhou National Laboratory of Heavy Ion Accelerator, Lanzhou 730000, China 6 Department of Physics, Xiamen University, Xiamen 361005, China 7 Department of Physics, Chung Yuan Christian University, Chung-Li, Taiwan 32023, China | 2009 | Chinese Science Bulletin2009，54，3： | 7 |
| 11 | Studies of low-lying states of even-even Xe isotopes within the nucleon pair approximation显示文摘We study the relevance of nucleon pairs with higher spins, in addition to spin-zero and spin-two pairs (i.e., S D pairs), in low-lying states of even-even Xe nuclei. By including those higher-spin pairs in our configuration, we recalculate energy level schemes, elec trical quadrupole moments, magnetic moments and electric quadrupole transition rates, for low-lying states of even-even 128-142Xe nuclei. The agreement between our calculated results and the experimental data is substantially improved in comparison with previous studies. | ZHANG LiHua1, JIANG Hui1,2 & ZHAO YuMin1,3,4 1Institute of Nuclear, Particle, Astrophysics and Cosmology, Department of Physics, Shanghai Jiao Tong University, Shanghai 200240, China 2School of Arts and Sciences, Shanghai Maritime University, Shanghai 200135, China 3Center of Theoretical Nuclear Physics, National Laboratory of Heavy Ion Accelerator, Lanzhou 730000, China 4CCAST, World Laboratory, P.O. Box 8730, Beijing 100080, China | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S1： | 5 |
| 12 | A view of cloud computing显示文摘 | Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia | 2010 | Communications of the ACM2010，，4： | 5 |
| 13 | Diagnostic challenges in non-cirrhotic portal hypertension-porto sinusoidal vascular disease显示文摘Non-cirrhotic portal hypertension consists of a group of diseases characterized by signs and complications of portal hypertension,which differ from cirrhosis through histological alterations,hemodynamic characterization and,clinical outcome.Because of the similarities in clinical presentation and imaging signs,frequently these patients,and particularly those with porto-sinusoidal vascular disease(PSVD),are misdiagnosed as having liver cirrhosis and thus raising difficulties in their diagnosis.The most challenging differentiation to be considered is between PSVD and cirrhosis and,although not pathognomonic,liver biopsy is still the standard of diagnosis.Although they still require extended validation before being broadly used,new non-invasive methods for the diagnosis of porto-sinusoidal vascular disease,like transient elastography,contrast-enhanced ultrasound or metabolomic profiling,have shown promising results.Another issue is the differentiation between PSVD and chronic extrahepatic portal vein obstruction,especially now when it is known that 40%of patients suffering from PSVD develop portal vein thrombosis.In this particular case,once the portal vein thrombosis occurred,the diagnosis of PSVD is impossible according to the current guidelines.Moreover,so far,the differentiation between PSVD and sinusoidal obstruction syndrome has not been clear so far in particular circumstances.In this review we highlighted the diagnostic challenges regarding the PSVD,as well as the current techniques used in the evaluation of these patients. | Oana Nicoara-Farcau Ioana Rusu Horia Stefanescu Marcel Tanțau Radu Ion Badea Bogdan Procopet | 2020 | World Journal of Gastroenterology2020，26，22： | 4 |
| 14 | Systematic study of survival probability of excited superheavy nuclei显示文摘The stability of excited superheavy nuclei (SHN) with 100 Z 134 against neutron emission and fission is investigated by using a statistical model. In particular, a systematic study of the survival probability against fission in the 1n-channel of these SHN is made. The present calculations consistently take the neutron separation energies and shell correction energies from the calculated results of the finite range droplet model which predicts an island of stability of SHN around Z = 115 and N = 179. It turns out that this island of stability persists for excited SHN in the sense that the calculated survival probabilities in the 1n-channel of excited SHN at the optimal excitation energy are maximized around Z = 115 and N = 179. This indicates that the survival probability in the 1n-channel is mainly determined by the nuclear shell effects. | XIA ChengJun1, SUN BaoXi1, ZHAO EnGuang2,3 & ZHOU ShanGui2,3 1College of Applied Sciences, Beijing University of Technology, Beijing 100124, China 2Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China 3Center of Theoretical Nuclear Physics, National Laboratory of Heavy Ion Accelerator, Lanzhou 730000, China | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S1： | 4 |
| 15 | CALCULATION OF 3-D TRANSIENT TEMPERATURE FIELD DURING LASER TRANSFORMATION HARDENING PROCESS显示文摘A three-dimensional transient heat transfer model for laser transformation hardening process has been developed in this paper. The finite size of the laser treated sample, the surface heat loss of the sample, the latent heat of phase transformation and the temperature dependence of thermal properties of materials were considered. The heat source was considered as a moving Gaussian heat flux with a constant velocity. Three-dimension unequally spatial grid explicit finite difference equations, alternating direction implicit finite difference equations and implicit finite difference equations were deduced respectively. Three programs to calculate the temperature field were developed using Fortran language. The transient temperature fields of C22, 42CrMo, C60 steel samples during laser transformation hardening process were calculated using these programs, and the widths and depths of laser transformation hardening zones were also predicted. C22, 42CrMo, C60 steel samples were treated by CO2 laser,the widths and depths of laser transformation hardening zones of these samples were also measured experimentally. The calculated widths and depths of laser transformation hardening zones are in good agreement with the experimental results. | L. W Zhang, R.S. Wang, J. Th.M.De Hosson, Y.L. Xia and F. G. Wang 1) The State Key Lab. for Materials Modification by Laser, Ion and Electron Beams, Dalian University of Technology, Dalian 116023, China 2) Department of Applied Physics, University of Gro | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 4 |
| 16 | Improving DNA damage repair ability of E. coli to UV-radiosensitivity by DNA-mediated gene transfer of low energy ion beam显示文摘Using calcium chloride method of transfer gene as control, a new technique of transferring gene by low energy ion beam has been applied to the study of improving DMA damage repair ability of E. coli to UV-radiosensitivity. The genome DMA pieces of Deinococcus radio-durans, as 'foreign' genetic materials, were introduced into the UV-radiosensitive strains of E. | SONG Daojun and YU XunCenter of Ion Beam Bioengineering, Institute of Plasma Physics , Chinese Academy of Sciences , Hefei 230031, China College of Life Science , University of Science and Technology of China , Hefei 230026, China | 1999 | Chinese Science Bulletin1999，44，19： | 4 |
| 17 | A mechanism for enhanced photocatalytic activity of nano-size silver particle modified titanium dioxide thin films显示文摘Ag-TiO2 nanostructured thin films with silver volume fraction of 0–20% were deposited on silicon and quartz substrates by RF magnetron sputtering and annealed in ambient air at 950°C for 1 h. The phase structure and surface topography of the films were characterized by X-ray diffractometer and transmission electron microscope. Photocatalytic activity of the films was evaluated by light induced degradation of methyl orange (C14H14N3NaO3S) solution using a high pressure mercury lamp as lamp-house. The relation of photocatalytic activity and silver content was studied in detail. It was found that silver content influences phase structure of TiO2 thin films, and silver in the films is metallic Ag (Ag0). With increasing silver content from 0 to 20 vol%, photocatalytic activity of the films increases first and then decreases. A suitable amount (2.5–5 vol%) silver addition can significantly enhance the photocatalytic activity of TiO2 films. The enhanced photocatalytic activity was mainly attributed to the extension of visible light absorption region of the films, the presence of anatase phase, the increase of oxy-gen anion radicals O2? and reactive center of surface Ti3+, and the better separation between electrons and holes on the films surface. | MENG FanMing1,2,3*, LU Fei1,3, SUN ZhaoQi1,3 & Lü JianGuo1,2,4 1 School of Physics and Materials Science, Anhui University, Hefei 230039, China 2 Key Laboratory of Materials Modification by Laser, Ion and Electron Beams (Dalian University of Technology), Ministry of Education, Dalian 116024, China 3 Anhui Key Laboratory of Information Materials and Devices, Anhui University, Hefei 230039, China 4 Department of Physics and Electronic Engineering, Hefei Normal University, Hefei 230061, China | 2010 | Science China(Technological Sciences)2010，53，11： | 4 |
| 18 | Synthesis of superheavy nuclei with ^(238)U target显示文摘The production of superheavy nuclei with Z=108-116 via hot fusion reactions of the neutron-rich projectiles with 238U target is systematically studied.The results show that the production cross sections of superheavy nuclei do not decrease monotonously as the atomic number Z increasing.The cross sections of the superheavy nuclei at Z = 112 and 115 are enhanced as compared with the whole Z-trend in synthesis of the superheavy nuclei,which clearly illustrates that the reactions with large negative Q-value and shell correction are more favorable to synthesize superheavy nuclei. | LIU ZuHua1,3 & BAO JingDong2,4 1 Key Laboratory of Beam Technology and Material Modification of Ministry of Education,Beijing Normal University,Beijing 100875,China 2 Department of Physics,Beijing Normal University,Beijing 100875,China 3 China Institute of Atomic Energy,Beijing 102413,China 4 Center of Theoretical Nuclear Physics,National Laboratory of Heavy Ion Accelerator of Lanzhou,Lanzhou 730000,China | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，10： | 3 |
| 19 | 加强电力需求侧管理工作的指导意见显示文摘 | National Development And Reform Commission,State Electricity Regulatory Commiss ion | 2004 | 电力需求侧管理2004，6，4： | 3 |
| 20 | Growing applications of FDG PET-CT imaging in non-oncologic conditions显示文摘As the number of clinical applications of 2-[fluorine 18]fluoro-2-deoxy-D-glucose(FDG) positron emission tomography/computed tomography(PET-CT) grows,familiarity with the conditions that can be diagnosed by this modality and when relevant pieces of additional information can be obtained becomes increasingly important for both requesting physicians and nuclear medicine physicians or radiologists who interpret the findings.Apart from its heavy use in clinical oncology,FDG PET-CT is widely used in a variety of non-oncologic conditions interconnecting to such disciplines as general internal medicine,infectious diseases,cardiology,neurology,surgery,traumatology,orthopedics,pediatrics,endocrinology,rheumatology,psychiatry,neuropsychology,and cognitive neuroscience.The aim of this review was to summarize the current evidence of FDG PET-CT applications in evaluating non-oncologic pathologies and the relevant information it can add to achieve a final diagnosis. | Hongming Zhuang Ion Codreanu | 2015 | The Journal of Biomedical Research2015，29，3： | 3 |
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