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| 1 | Could sport be part of pediatric obesity prevention and treatment? Expert conclusions from the 28th European Childhood Obesity Group Congress显示文摘The prevalence of pediatric obesity continues to increase worldwide,bringing with it various metabolic,functional,social,and psychological complications.1 Both the prevention and treatment of childhood obesity must be based on multidisciplinary approaches combining nutrition,physical activity(PA),and psychological support.2 As an essential element of these multicomponent strategies,regular physical activity has been acknowledged as having beneficial effects on children's and adolescents,body composition,physical fitness,and metabolic profile,as well as on their health-related quality of life,social and psychological health,and academic achievement.3,4 Given that only a relatively small proportion of children and adolescents meet the public health recommendations for PA,5 and given that weight loss exercise-based interventions suffer from a high attrition rate,there is a clear need for appropriate PAs. | Susanne Ring-Dimitriou Peter Krustrup Manuel J Coelho-E-Silva Jorge Mota Andera Seabra Carla Rego Artur Mazur Elpis Vlachopapadopoulou Margerita Caroli Marie-Laure Frelut Eva Erhardt Anders Forslund Ema Boyland Daniel Weghuber David Thivel | 2019 | Journal of Sport and Health Science2019，8，4： | 3 |
| 2 | Macroscopic appearance of TypeⅣand giant Type Ⅲ is a high risk for a poor prognosis in pathological stage Ⅱ/Ⅲ advanced gastric cancer with postoperative adjuvant chemotherapy显示文摘AIM To evaluate whether a high risk macroscopic appearance(Type Ⅳ and giant Type Ⅲ) is associated with a dismal prognosis after curative surgery, because its prognostic relevance remains elusive in pathological stage Ⅱ/Ⅲ(p Stage Ⅱ/Ⅲ) gastric cancer.METHODS One hundred and seventy-two advanced gastric cancer(defined as pT2 or beyond) patients with p Stage Ⅱ/Ⅲ who underwent curative surgery plus adjuvant S1 chemotherapy were evaluated, and the prognostic relevance of a high-risk macroscopic appearance was examined. RESULTS Advanced gastric cancers with a high-risk macroscopic appearance were retrospectively identified by preoperative recorded images. A high-risk macroscopic appearance showed a significantly worse relapse free survival(RFS)(35.7%) and overall survival(OS)(34%) than an average risk appearance(P = 0.0003 and P < 0.0001, respectively). A high-risk macroscopic appearance was significantly associated with the 13^(th) Japanese Gastric Cancer Association(JGCA) pT(P = 0.01), but not with the 13^(th) JGCA pN. On univariate analysis for RFS and OS, prognostic factors included 13^(th) JGCA p Stage(P < 0.0001)and other clinicopathological factors including macroscopic appearance. A multivariate Cox proportional hazards model for univariate prognostic factors identified highrisk macroscopic appearance(P = 0.036, HR = 2.29 for RFS and P = 0.021, HR = 2.74 for OS) as an independent prognostic indicator. CONCLUSION A high-risk macroscopic appearance was associated with a poor prognosis, and it could be a prognostic factor independent of 13^(th) JGCA stage in p Stage Ⅱ/Ⅲ advanced gastric cancer. | Keishi Yamashita Akira Ema Kei Hosoda Hiroaki Mieno Hiromitsu Moriya Natsuya Katada Masahiko Watanabe | 2017 | World Journal of Gastrointestinal Oncology2017，9，4： | 2 |
| 3 | 造血干细胞功能异质性研究的“金标准”--单细胞移植技术的建立和优化显示文摘造血干细胞(HSC)是发现最早、在临床中广泛应用并一直发挥范式作用的一类重要的成体组织干细胞.HSC是一个由不同功能亚群组成的高度异质性群体,其自我更新和多向分化潜能主要通过HSC移植这一'金标准'的实验流程来评估和判断.细胞群体水平的研究无法深入探讨其生物学功能,从而使HSC单细胞水平的研究成为必需.为了更好地研究HSC的异质性,本文将详细介绍HSC单细胞移植实验流程及结果检测和分析,旨在促进相关科研人员对于单细胞移植适用性的了解以及具体实验操作的掌握,客观评判具有高度异质性干细胞群体功能,为其他具有高度异质性的干细胞群体的功能研究和评价提供例举和参考. | 王晓芳 董芳 郝莎 程涛 Hideo Ema | 2017 | 中国科学:生命科学2017，47，12： | 2 |
| 4 | 欧盟采取措施控制氟喹诺酮和喹诺酮类药品的严重风险显示文摘欧洲药品管理局(EMA)于2018年10月5日发布信息,称其药物警戒和风险评估委员会(PRAC)通过对使用氟喹诺酮和喹诺酮类药物发生致残性和潜在长期性不良反应报告的评估,建议限制这些抗生素(口服制剂、注射制剂和吸入剂)的使用。评估综合了EMA于2018年6月召开的关于氟喹诺酮和喹诺酮听证会上患者、医务人员以及学术界的观点。使用氟喹诺酮和喹诺酮类药物患者发生了罕见的长期性和致残性不良反应,主要涉及肌肉、肌腱、骨骼和神经系统。 | EMA网站 | 2018 | 中国医药导刊2018，20，11： | 2 |
| 5 | Potential adverse effects of phthalic acid esters on human health: A review of recent studies on reproduction显示文摘 | Mariko Matsumoto Mutsuko Hirata-Koizumi Makoto Ema | 2007 | Regulatory Toxicology and Pharmacology2007，，1： | 2 |
| 6 | Non - side - population hematopoietic stem cells in mouse bone marrow 显示文摘 | MORITA Y EMA H YAMAZAKI S | 2006 | Blood2006，108，8： | 1 |
| 7 | MRI macromolecular contrast agents as indicators of changed tumor blood flow显示文摘 | Katarina Beravs Maja emaar | 2001 | Radiol Oncol2001，35，2： | 1 |
| 8 | A fundamental study on impact dampers 显示文摘 | Ema S Marui E | 1996 | International Journal of Machine Tools and Manufacturers1996，36，： | 1 |
| 9 | A method for automated nomenclature of bronchial branches extracted from CT imag-ines 显示文摘 | Mori K Ema S Kitasaka T | 2005 | International Congress Series2005，1281，： | 1 |
| 10 | Molecular mechanisms of transcription activation by HLF and HIF1 alpha in response to hypoxia:their stabilization and redox signal-induced interaction with CBP/p300显示文摘 | Ema M Himta K Mimura J | 1999 | EMBO J1999，18，7： | 1 |
| 11 | Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction显示文摘 | Seita J Ema H Ooehara J | 2007 | Proc Natl Acad Sci U S A2007，104，7： | 1 |
| 12 | In vitro and in vivo anti-allergic effects of ‘benifuuki’ green tea containing O -methylated catechin and ginger extract enhancement显示文摘 | Mari Maeda-Yamamoto Kaori Ema Ikuo Shibuichi | 2007 | Cytotechnology2007，，2： | 1 |
| 13 | cDNA cloning and tissue-specific expression of a novel basic helix-loop-he- lix/PAS factor (Amt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Amt)显示文摘 | Hirose K Morita M Ema M | 1996 | Mol Cell Biol1996，16，4： | 1 |
| 14 | Activated Fps/Fes partially rescues the in vivo developmental potential of Flkl-deficient vascular progenitor cells显示文摘 | Haigh JJ Ema M migh K | 2004 | Blood2004，103，3： | 1 |
| 15 | Hematopoietie stem cells express Tie-2 receptor in the murine fetal liver 显示文摘 | Hsu HC Ema H Osawa M | 2000 | Blood2000，96，： | 1 |
| 16 | Potential adverse effects of phthalic acid esters on human health:a review of recent studies on reproduction 显示文摘 | Matsumoto M Hirata-Koizumi M Ema M | 2008 | Regulatory Toxicol Pharmacol2008，50，： | 1 |
| 17 | Copper corrosion inhibitors in near neutral media显示文摘 | Helena Otmacic Ema Stupnisek- Lisac | 2003 | Electrochemical Acta2003，48，8： | 1 |
| 18 | Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival显示文摘 | Haigh J J Ema M | 2006 | J Neurosci2006，26，25： | 1 |
| 19 | The efficacyof early treatment of seasonal allergic rhinitis withBenifuuki green tea containing O-methylated catechinbefore pollen exposure:an open randomized显示文摘 | Maeda-Yamamoto M Ema K Monobe M | 2009 | AllergologyInternational2009，58，3： | 1 |
| 20 | Microwave driven wood liquefaction with glycols显示文摘 | Andrej Kr(z)an Ema(z)agar | | 0，，12： | 1 |
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