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| 1 | 老年人的甲状腺疾病显示文摘老年人的甲状腺疾病并不少见,因症状可不典型,故易漏诊。本文对老年人的甲状腺机能减退症(甲减)、亚临床甲状腺机能减退症、甲状腺机能亢进症(甲亢)、甲状腺癌从流行病学、病因、治疗等方面作了较为详细的介绍。 | Levy EG 苏代泉 | 1992 | 国外医学(老年医学分册)1992，13，1： | 11 |
| 2 | Antibacterial activity of leaves and inter-nodal callus extracts of Mentha arvensis L显示文摘Objective:To determine the anti-bacterial efficacy of chloroform,ethanol,ethyl acetate and water extracts of inter-nodal and leaves derived calli extracts from Mentha arvensis(M.arvensis) against Salmonella typhi(S.typhi),Streptococcus pyogenes(S.pyogenes),Proteus vulgaris(P. vulgaris) and Bacillus subtilis(B.subtilis).Methods:The inter-nodal and leaves segments of M.arvensis were cut into 0.5-0.7 cm in length and cultured on Murashige and Skoog solid medium supplemented with 3%sucrose,gelled with 0.7%agar and different concentration of 2,4-Dichlorophenoxyacetie acid(2,4-D) either alone or in combinations.The preliminary phytochemical screening was performed by Brindha et al method.Antibacterial efficacy was performed by disc diffusion method and incubated for 24 h at 37℃.Results:Maximum percentage of callus formation(inter-nodal segments 84.3±0.78;leaves segments 93.8±1.27) was obtained on Murashige and Skoog’s basal medium supplemented with 3%sucrose and 1.5 mg/L of 2,4-D.The ethanol extracts of leaves derived calli showed the maximum bio-efficacy than other solvents.The leaves and stem derived calli extracts on Proteus sp.showed that the plants can be used in the treatment of urinary tract infection associated with Proteus sp.Through the bacterial efficacy studies,it is confirmed that the in vitro raised calli tissue was more effective compared to in vivo tissue.Conclusions:The bio-efficacy study confirmed that the calli mediated tissues showed the maximum zone of inhibition.The present study paved a protocol to establish high potential cell lines by in vitro culture. | Johnson M Wesely EG Kavitha MS Uma V | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，3： | 9 |
| 3 | In vivo and in vitro phytochemical and antibacterial efficacy of Baliospermum montanum (Willd.) Muell.Arg.显示文摘Objective:To evaluate the phytochemical and anti-bacterial potential of mother plants in vivo and in vitro derived callus of Baliospermum montanum(B.montanum)(Willd.) Muell.-Arg. leaves and root.Methods:The in vitro derived rootlets and leaves segments of B.montanum were cut into 0.5-0.7 cm in length and cultured on Murashige and Skoog solid medium supplemented with 3%sucrose,gelled with 0.7%agar and different concentration of 2,4-D either alone or in combinations.The preliminary phytochemical screening was performed by Harborne method.Antibacterial efficacy was performed by well diffusion method and incubated for 24 h at 37℃.Results:The highest percentage of callus formation(leaves segments 86.9±0.56:root segments 78.7±0.51) was obtained on Murashige and Skoog’s basal medium supplemented with 3%sucrose and 2.0 mg/L of 2.4-Dichlorophenoxy acetic acid.The phytochemical study revealed the high quantity presence of steroids,triterpenoids,glycosides,saponins,alkaloids,flavanoids, phenolic compounds,tannins,sugars etc of root and leaves derived calli.The ethanol extract of leaves segment derived calli of B.montanum showed the maximum solubility and antimicrobial activity with the MIC ranged from 100 to 200μL.Conclusions:The preliminary phytochemical study confirmed that the calli mediated tissues showed the higher percentage of metabolite constituents and extraction value compared to the in vivo leaves and roots.The present study observation suggested that a possibility to establish high yielding genotypes by in vitro culture for production of medicinally important bioactive compounds. | Johnson M Wesely EG Zahir Hussain MI Selvan N | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，11： | 6 |
| 4 | Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer显示文摘Colorectal cancer(CRC) is the third most frequent cancer type and the incidence of this disease is increasing gradually per year in individuals younger than 50 years old. The current knowledge is that early-onset CRC(EOCRC) cases are heterogeneous population that includes both hereditary and sporadic forms of the CRC. Although EOCRC cases have some distinguishing clinical and pathological features than elder age CRC, the molecular mechanism underlying the EOCRC is poorly clarified. Given the significance of CRC in the world of medicine, the present review will focus on the recent knowledge in the molecular basis of genetic and epigenetic mechanism of the hereditary forms of EOCRC, which includes Lynch syndrome, Familial CRC type X, Familial adenomatous polyposis, Mut YH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers Syndrome and sporadic forms of EOCRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach. | gulcin tezcan berrin tunca secil ak gulsah cecener unal egeli | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 5 |
| 5 | Colorectal mucosal histamine release by mucosa oxygenation in comparison with other established clinical tests in patients with gastrointestinally mediated allergy显示文摘瞄准:评估的这研究作为一个新诊断过程响应挑战积极的使失明的食物和否定食物抗原渲染表面的粘膜组织安版本。方法:受不了胃肠地调停的过敏症由使失明的口头的挑衅证实了的 19 个病人在他们的病历,皮肤刺测试,浆液 IgE 察觉和颜色的根据上被调查由前 vivo 粘膜氧化的表面的粘膜组织安版本。未经触动的织物粒子为 30 min 与不同食物抗原在一种氧化文化被孵化 / 刺激。与反人的免疫球蛋白 E 并且没有任何刺激质问的标本分别地用作积极、否定的控制。粘膜组织安版本(全部的活体检视组织安内容的 %) 被认为成功(积极) ,从响应抗原的活体检视的组织安版本的率什么时候到达了多于两次自发的版本的。组织安测量被放射性免疫测定执行。结果:从全部的活体检视组织安内容的表面的粘膜被发现是 3.2 的颜色(0.1%-25.8%) 的自发的组织安版本的 median (范围) 。食物抗原由口头的挑衅容忍了没得到桅杆房间去粒 3.4 (0.4%-20.7% , P = 0.4 ) 当 anti-IgE 和原因的食物变应原导致了 5.4 的一个重要组织安版本时(1.1%-25.6% , P = 0.04 ) 并且 8.1 (1.5%-57.9% , P = 0.008 ) 分别地。19 个病人(63.1%) 中的 12 个显示出积极颜色根据对一样的抗原(s) 作出回应的使失明的口头的挑战的表面的粘膜组织安版本,当功能的组织安版本的特性容忍了精确地认出时,食品被发现是 78.6% 。与历史(30.8% 和 57.1%) 的使失明的食物挑战测试,敏感和特性的结果比较,皮肤试验(47.4% 和 78.6%) 或抗原特定的浆液 IgE 决心(57.9% 和 50%) 被发现具有在胃肠地调停的过敏症的更低的诊断精确性。结论:颜色的反应的功能的测试在在有胃肠地调停的过敏症的病人的遗传因子的刺激具有更高诊断的功效的反之上的表面的粘膜。 | M Raithel M Weidenhiller R Abel HW Baenkler EG Hahn | 2006 | World Journal of Gastroenterology2006，12，29： | 4 |
| 6 | The MAPK signaling cascade显示文摘 | Seger R Krebs EG | 1995 | FASEBJ1995，9，： | 3 |
| 7 | 限制卡路里摄入可抑制大鼠促进动脉衰老的炎症反应,保持年轻的表型显示文摘老化呈指数性增加典型心血管病的发病率和死亡率,这主要是由于动脉壁内分子、细胞和组织水平的动脉促炎变化。动物实验中,大鼠的卡路里限制(calorie restriction,CR)改善了动脉功能并延长了健康跨度和寿命。然而,CR如何影响大鼠动脉壁内分子,细胞和组织表型促炎变化仍有待阐明。该文选取随意喂食的344只年轻(6个月大)和老(24个月大)的Fischer大鼠,获取主动脉;另外选取1组在1个月大时开始只维持40%CR。 | 刘青 叶鹏 Wang MY Zhang L Zhu WQ Zhang J Kim SH Wang YS Ni L Telljohann R Monticone RE McGraw K Liu LJ Rafael de Cabo Lakatta EG | 2018 | 中华高血压杂志2018，26，11： | 3 |
| 8 | Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings显示文摘 | Hannu JA Inna EG David NL | 1994 | Radiology1994，191，1： | 2 |
| 9 | Knowledge, perception and practices about malaria, climate change, livelihoods and food security among rural communities of central Tanzania显示文摘Background:Understanding the interactions between malaria and agriculture in Tanzania is of particular significance when considering that they are the major sources of illness and livelihoods.The objective of this study was to determine knowledge,perceptions and practices as regards to malaria,climate change,livelihoods and food insecurity in a rural farming community in central Tanzania.Methods:Using a cross-sectional design,heads of households were interviewed on their knowledge and perceptions on malaria transmission,symptoms and prevention and knowledge and practices as regards to climate change and food security.Results:A total of 399 individuals(mean age=39.8±15.5 years)were interviewed.Most(62.41%)of them had attained primary school education and majority(91.23%)were involved in crop farming activities.Nearly all(94.7%)knew that malaria is acquired through a mosquito bite.Three quarters(73%)reported that most people get sick from malaria during the rainy season.About 50%of the respondents felt that malaria had decreased during the last 10 years.The household coverage of insecticide treated mosquito nets(ITN)was high(95.5%).Ninety-six percent reported to have slept under a mosquito net the previous night.Only one in four understood the official Kiswahili term(Mabadiliko ya Tabia Nchi)for climate change.However,there was a general understanding that the rain patterns have changed in the past 10 years.Sixty-two percent believed that the temperature has increased during the same period.Three quarters of the respondents reported that they had no sufficient production from their own farms to guarantee food security in their household for the year.Three quarters(73.0%)reported to having food shortages in the past five years.About half said they most often experienced severe food shortage during the rainy season.Conclusion:Farming communities in Kilosa District have little knowledge on climate change and its impact on malaria burden.Food insecurity is common and community-based strategies to mitigate this need to be established.The findings call for an integrated control of malaria and food insecurity interventions. | Benjamin K Mayala Carolyn A Fahey Dorothy Wei Maria M Zinga Venera M Bwana Tabitha Mlacha Susan F Rumisha Grades Stanley Elizabeth H Shayo Leonard EG Mboera | 2015 | Infectious Diseases of Poverty2015，4，1： | 2 |
| 10 | Ability of a phase shift us contrast agent to improve imaging of the main renal arteries显示文摘 | Melay MI Grant EG Duerinckx AJ | 1997 | Radiology1997，205，： | 2 |
| 11 | 缺氧对HRE-TK/GCV系统杀伤骨肉瘤细胞的增强作用显示文摘目的:探讨缺氧条件下,缺氧反应元件启动子-胸苷激酶/丙氧鸟苷(HRE-TK/GCV)系统对骨肉瘤细胞系MG63靶向性杀伤作用。方法:构建由HRE启动子驱动的含潮霉素磷酸转移酶-单纯疱疹病毒胸腺嘧啶激酶(Hygromycinphosphotransferase-thymidinekinase,HyTK)融合基因的真核表达质粒pBI-HRE-HyTK,并将其转染入骨肉瘤细胞系MG63。应用PCR和RT-PCR方法检测TK基因的整合及表达;用MTT法和混合共培养实验分别检测转基因细胞在缺氧或不缺氧状态下对GCV的敏感性以及HRE-TK/GCV系统的“旁观者效应”;流式细胞仪检测细胞周期改变及电镜观察细胞超微结构变化探讨其作用机制。结果:成功构建了真核表达质粒pBI-HRE-HyTK,得到转基因细胞系MG63TK。检测到MG63TK细胞内TK基因的DNA和mRNA。MG63TK细胞在不缺氧状态下对GCV不敏感,当GCV浓度达50μg/ml时,仅30%左右细胞被杀死;而缺氧状态下,GCV浓度1μg/ml时,50%左右细胞被杀死,GCV浓度50μg/ml时,90%以上细胞被杀死。混合共培养实验中,缺氧状态下,HRE-TK/GCV系统旁观者效应明显增强,MG63细胞存活率显著低于不缺氧状态下。缺氧和GCV共同作用使转基因细胞DNA合成抑制,细胞周期阻滞于G0G1期,细胞发生凋亡和坏死。结论:缺氧可以增强HRE-TK/GCV系统对体外培养骨肉瘤细胞系选择性的杀伤作用? | 王燕 丘钜世 乔慧 汪睿 彭挺生 李扬 EG Van Meir | 2005 | 中国肿瘤临床2005，32，2： | 2 |
| 12 | Comparison of Milan and UCSF criteria for liver transplantation to treat hepatocellular carcinoma显示文摘AIM:To assess the validity of the Milan and University of California San Francisco(UCSF) criteria and examine the long-term outcome of orthotopic liver transplantation(OLT) in patients with hepatocellular carcinoma(HCC) in a single-center study.METHODS:This study is a retrospective review of prospectively collected data.Between 1998 and 2009,56 of 356 OLTs were performed in patients with HCC.Based on pathological examination of liver explants,patients were retrospectively categorized into 3 groups:Milan +(n = 34),Milan-/UCSF +(n = 7) and UCSF-(n = 14).RESULTS:Median follow-up period was 39.5(1-124) mo.The 5-year overall survival rates in the Milan +,Milan-/UCSF + and UCSF-groups were 87.7%,53.6% and 33.3%,respectively(P < 0.000).Within these groups,tumor recurrence was determined in 5.8%,14.3% and 40% of patients,respectively(P < 0.011).Additionally,the presence of microvascular invasion within the explanted liver had a negative effect on the 5-year disease free survival(74.7% vs 46.7%,P < 0.044).CONCLUSION:The Milan criteria are reliable in the selection of suitable candidates for OLT for the treatment of HCC.For cases of OLT involving living donors,the UCSF criteria may be applied. | Tarkan Unek Sedat Karademir Naciye Cigdem Arslan Tufan Egeli Gulsen Atasoy Ozgul Sagol Funda Obuz Ibrahim Astarcioglu | 2011 | World Journal of Gastroenterology2011，17，37： | 2 |
| 13 | Bwta2 - microglobulin clearance in neonates: Index of tubular maturation显示文摘 | Assadi FK John EG Justice JP | 1985 | Kidney Int1985，28，4： | 2 |
| 14 | The structure of psychological processes in relation to cerebral organization 显示文摘 | Luria AR Simernitskaya EG Tubylevich B | 1970 | Neurpsychocogia1970，8，： | 2 |
| 15 | Dendritic cells in cancer immunotherapy显示文摘 | Fong L Engleman EG | | 0，，： | 2 |
| 16 | Iatrogenic limbal stem cell deficiency显示文摘 | Schwartz GS Holland EG | 1998 | Cornea1998，17，1： | 2 |
| 17 | Damaging and protective cell signalling in the untargeted effects of ionizing radiation显示文摘 | Coates PJ Lorimore SA Wright EG | 2004 | Mutat Res2004，568，1： | 1 |
| 18 | Role of cyclic ADP-ribose in Ca2+-induced Ca2+release and vasoconstriction in small renal arteries显示文摘 | Teggatz EG Zhang G Zhang AY | 2005 | Microvasc Res2005，70，12： | 1 |
| 19 | Effect of atrial fibrillation on atrial refractoriness in humans 显示文摘 | Daoud EG Bogun F Goyal R | 1996 | Circulation1996，94，7： | 1 |
| 20 | Hepatic fibrosis therapeutic strategies显示文摘 | Suchuppan D Strobel D Hann EG | 1998 | Digestion1998，59，4： | 1 |
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