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| 1 | Glucagonoma synd- rome: a case report 显示文摘 | Castro PG de Leon AM Trancon JG | 2011 | J Med Case Rep2011，5，： | 1 |
| 2 | Potential for cross- contamination from use of a needleless injector显示文摘 | Weintraub AM Ponce de Leon MP | 1998 | Am J Infect Control1998，26，4： | 1 |
| 3 | Maximal hyperemia in the assessment of fractional flow reserve: intracoronary adenosine versus intracoronary sodium nitroprusside versus intravenous adenosine: the NASCI (Nitroprussiato versus Adenosina nelle Stenosi Coronariche Intermedie) study显示文摘 | Leone AM Porto I De Caterina AR | 2012 | JACC Cardiovasc Interv2012，5，4： | 1 |
| 4 | Sodium bicarbonate plus N-acetylcysteine to prevent contrast-induced nephropathy inprimnary and rescue percutaneous coronary interventions:the BINARIO (Blcarbonato e N-Acetil-cisteina nell'infaRto mlocardico acutO) study显示文摘 | Leone AM De Caterina AR Sciahbasi A | | 0，，： | 1 |
| 5 | Maximal hyperemia in the assessment of fractional flow reserve : intracoronary adenosine versus intracomnary sodium ni- troprusside versus intravenous adenosine: the NASCI (nitroprussiato versus a- denosine nelle stenosi coronariche intermedie) study 显示文摘 | Leone AM Porto l de Caterina AR | 2012 | JACC Cardiovasc In- terv2012，5，： | 1 |
| 6 | A longitudinal study of parkinsonism and disability in a community population of older people显示文摘 | Murray AM Bennett DA Mendes de Leon CF | 2004 | J Gerontol A Biol SCi Med Sci2004，59，8： | 1 |
| 7 | Sodium bicarbon- ate plus N - acetylcysteine to prevent contrast - induced nephrop- athy in primary and rescue percutaneous coronary interventions: The BINARIO(bicarbonatoe nacetil- cisteina nell' infarto mio- cardico acuto) study显示文摘 | Leone AM De Caterina AR Sciahbasi A | 2012 | Euro Intervention2012，8，7： | 1 |
| 8 | Delayed stentlng of a thrombotic saphenous vein graft after intravenous tirofiban pretreatment 显示文摘 | Niccoli G De Vita M Leone AM | 2006 | Int J Cardiol2006，110，1： | 1 |
| 9 | A longitudinal study of parkinsonism and disability in a community population of ol- der people 显示文摘 | Murray AM Bennett DA Mendes de Leon CF | 2004 | J Gerontol A Biol Sci Med Sci2004，59，8： | 1 |
| 10 | A Longitudinal Study of Parkinsonism and Disability in a Community Population of Older People显示文摘 | Murray AM Bennett DA Mendes de Leon CF | 2004 | J Gerontol A Biol Sci Med Sci2004，59，8： | 1 |
| 11 | The role of Beta-blockers as first-line therapy in hypertension 显示文摘 | De Caterina AR Leone AM | 2011 | Curr Atheroscler Rep2011，13，2： | 1 |
| 12 | Sodium bicarbonate plus N - acetylcysteine to prevent contrast - induced nephropathy in primary and rescue percutaneous coronary interventions:the BI- NARIO ( BIcarbonato e N - Acetil - cisteina nelllnfaRto mIocardi- co acutO) study 显示文摘 | Leone AM De Caterina AR Sciahbasi A | 2012 | EuroIntervention2012，8，7： | 1 |
| 13 | Endothelial pro genitor cells, microvascular obstruction, and left ven tricular remodeling in patients with ST elevation myo cardial infarction undergoing primary percutaneous cot onary intervention显示文摘 | Porto I De Maria GL Leone AM | 2013 | Am J Cardiol2013，112，6： | 1 |
| 14 | A longitudinal study of parkinsonism and disability in a community population of older people 显示文摘 | Murray AM Bennett DA Mendes de Leon CF | 2004 | J Gerontol A Biol Sci Med Sci2004，59，： | 1 |
| 15 | Sodium bicarbon- ate plus N - acetylcysteine to prevent contrast - induced nephrop- athy in primary and rescue percutaneous coronary interventions: the BINARIO ( BIcarbonato e N - Acetil - cisteina nell 'infaRto mIocardico acutO) study 显示文摘 | Leone AM De Caterina AR Sciahbasi A | 2012 | Crea F EuroIntervention2012，8，7： | 1 |
| 16 | The C807T/G873A polymorphism in the platelet glycoprotein Ia gene and the risk of acute coronary syndrome in the Italian population显示文摘 | Casorelli I De Stefano V Leone AM Chiusolo P | 2001 | Br J Haematol2001，114，1： | 1 |
| 17 | Optimal culture conditions and toxicity assessment of Fomitopsis feei(Fr.):a newly documented macro fungus from Philippines显示文摘Mushrooms are known to be utilized by ethnic communities and Paracelis,Mountain Province is one of the places in Philippines inhabited by several of these native groups.Many studies have been conducted on various macrofungi,however no studies have been reported about Fomitopsis feei in the Philippines particularly in Paracelis,Mountain Province.It is a brown-rot bracket fungus,belonging to the family Fomitopsidaceae,characterized by a sessile effuse-reflexed basidiomata,with its color ranging from white to pinkish or brown.This mushroom has been reported to have antimicrobial properties,hence optimization of its culture condition could lead to its mass production for its biopharmaceutical potential.In order to develop a mass cultivation protocol of this mushroom,this study was conducted to determine the optimum conditions for its mycelial growth.The effect of different culture media using local substrates and evaluating environmental factors such as pH,aeration,illumination,and temperature were assessed.Optimum conditions for the secondary mycelial growth of F.feei produced very thick and largest radial growth on coconut water gelatin(CWG)medium(83.57 mm)at pH 6.5(83.13 mm),in sealed(85 mm),dark conditions(85.00 mm)at room temperature(28-32℃)(81.96 mm).The most abundant mycelial growth was found in cracked corn as grain spawning material.This study also determined the teratogenic and cytotoxic activity of the ethanol extract of F.feei against the zebra fish(Danio rerio)embryos and brine shrimp(Artemia salina)nauplii.Fomitopsis feei exhibited teratogenic effects against the developing D.rerio embryos wherein growth retardation,malformation of tail,yolk deformity,pericardial edema,curved body,scoliosis and little pigmentation were the notable teratogenic effects of the ethanol extract to the developing embryos.Embryos treated with≥1000 ppm recorded high mortality rate.Hatchability was most evident at lower concentrations≤750 ppm.In terms of heartbeat,as the concentration of the extract increased,the heartbeat rate significantly decreased.For the cytotoxicity,1250 ppm has the highest mortality rate with 73.33%.Using probit analysis,the LC_(50)is 534.676 ppm which is considered as mildly toxic.Thus,F.feei in higher concentrations exhibit toxic effect.These results indicate that F.feei has a pharmaceutical potential and could be harnessed for its bioactivities. | De Leon AM Dulay AR Villanueva AL Kalaw SP | 2020 | Studies in Fungi2020，5，1： | 0 |
| 18 | Cultivation of different strains of Lentinus tigrinus from selected areas of Luzon Island,Philippines显示文摘Lentinus tigrinus is a wood-decaying species of macrofungi that belongs to family Polyporaceae.This mushroom is known to be edible and with medicinal attributes.In this study,cultivation of different strains of Lentinus tigrinus using rice straw-sawdust based substrate is reported.Results showed that the shortest incubation period was observed in strain 10(16.60 days),and the longest was noted in strain 1(40.50 days).However,strain 10 showed the earliest appearance of fruiting initials(20.70 days),and strain 1 had the longest period(44 days).In terms of fruiting body size,strain 6 recorded the widest mean pileus diameter(72.2 mm),and strain 10 had the longest mean stipe length(41.22 mm).Moreover,strain 6 produced the highest yield of 81.83 g and biological efficiency of 16.37%.Interestingly,although they belong to the same species,cultivation phase and fruiting body performance of different strains of L.tigrinus may also vary depending on geographical origin,which is very important to consider in strain selection. | Kalaw SP De Leon AM Damaso JrEJ Ramos JC del Rosario MAG Abon MD Undan JR Dulay RMR Reyes RG | 2021 | Studies in Fungi2021，6，1： | 0 |
| 19 | Evaluation of angiosuppressive activity of Pleurotus florida on developing chick embryo using chorioallantoic membrane assay显示文摘Angiogenesis is the proliferation of new blood vessels that enable the normal embryonic development and may also induce growth of numerous pathologies like tumor growth and cancer metastasis.The assays were used for both pro and anti-angiogenic agents.This study evaluated the angiosuppressive activity of Pleurotus florida on the developing chick embryo using chorioallantoic membrane(CAM)assay and used destructive sampling into four different treatment concentrations and a control.The result revealed a decrease in the number of blood vessels branch points formed after 24,48,and 72 hours at higher treatment concentrations(0.50%and 1%).Statistical analysis showed that 24 hours and 48 hours of exposure to various concentrations have no significant difference.Nevertheless,after 72 hours of exposure,the mean blood vessel branch points formed showed a significant difference among the treatment means between the highest concentration of P.florida(1%)and the control treatment(sterile water).In terms of the percentage of angiosuppressive activity of P.florida with the greatest angiogenic effect,which was the 1%P.florida treatment concentration possesses 35.69%and 36.85%angiosuppressive rate after 48 and 72 hours of exposure respectively.Thus,this study showed that P.florida lyophilized hot water extract exhibits angiosuppressive activity on the developing chick embryo using chorioallantoic membrane assay and is concentration and time exposure dependent. | Zacarias RC Kalaw SP De Leon AM | 2021 | Studies in Fungi2021，6，1： | 0 |
| 20 | Optimization of Mycelial Culture Conditions and Fructification of Lentinus Species Using Rice Straw and Sawdust Based Substrates显示文摘Lentinus(Basidiomycota,Polyporaceae)species are naturally-occurring mushrooms with nutritional and pharmacological importance.Unlike shiitake Lentinula edodes,a widely cultivated mushroom,Lentinus species are often ignored because they are underutilized and unpopular.However,like shiitake,Lentinus spp.could also be valuable resources of functional food and bioactive compounds.It is therefore of high interest to understand their cultural requirements leading to their efficient biomass production.Thus,this study established the optimal culture conditions for the maximum mycelial growth of seven wild strains under four Lentinus species.Their cultivation potentials were also determined using rice straw and sawdust(7:3 v/v)substrate formulation.Mycelia of all Lentinus strains evaluated favorably grew on coconut water gulaman(local crude agar)and other culture media for specific strain with suitable pH ranging from 5.0 to 8.0.Aeration was not a major physical factor for all Lentinus strains except L.squarrosulus strain 1,which favored sealed condition.Both lighted and dark conditions were found suitable for both strains of L.sajor-caju,L.strigosus strain 2 and L.swartzii whereas both strains of L.squarrosulus and L.strigosus strain 1 favorably grew in lighted condition.However,all Lentinus strains evaluated recorded the highest mycelial growth rates and thick mycelia at 30℃.In terms of fruiting body production,all Lentinus strains demonstrated cultivation potential.The seven Lentinus strains completely colonized the substrate for 18.0-25.6 days and initiated primordia for 21.6-33.5 days.The highest yield(52.5 g bag^(-1))and biological efficiency(10.5%)was recorded in L.strigosus strain 1,whereas the lowest was noted in L.strigosus strain 2 with 21.1 g bag^(-1) yield and 4.2%biological efficiency.L.sajor-caju strain 2 and L.squarrosulus strain 1 showed the widest cap diameter and longest stipe,respectively.The mycelial growth and fruiting body performance of Lentinus may vary depending on species and strains.Altogether,the seven new wild strains of Lentinus can be artificially cultivated by providing the nutritional and physical requirements. | Kalaw SP Dulay RMR Damaso EJ Ramos JC del Rosario MAG Abon MD De Leon AM Undan JR Reyes RG | 2021 | Studies in Fungi2021，6，1： | 0 |
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