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| 1 | Ursodeoxycholic acid as a means of preventing atherosclerosis,steatosis and liver fibrosis in patients with nonalcoholic fatty liver disease显示文摘BACKGROUND Atherosclerotic cardiovascular disease(ASCVD)is the leading cause of mortality in patients with nonalcoholic fatty liver disease(NAFLD).Weight loss is a key factor for successful NAFLD and CVD therapy.Ursodeoxycholic acid(UDCA),which is one of the first-line therapeutic agents for treatment of NAFLD,is reported to have a beneficial effect on dyslipidemia and ASCVD risk because of antioxidant properties.AIM To evaluate the effects of 6 mo of UDCA treatment on hepatic function tests,lipid profile,hepatic steatosis and fibrosis,atherogenesis,and ASCVD risk in men and women with NAFLD,as well as to assess the impact of>5%weight reduction on these parameters.METHODS An open-label,multicenter,international noncomparative trial was carried out at primary health care settings and included 174 patients with ultrasound-diagnosed NAFLD who received 15 mg/kg/d UDCA for 6 mo and were prescribed lifestyle modification with diet and exercise.The efficacy criteria were liver enzymes,lipid profile,fatty liver index(FLI),noninvasive liver fibrosis tests(nonalcoholic fatty liver disease fibrosis score and liver fibrosis index),carotid intima-media thickness(CIMT),and ASCVD risk score.To test statistical hypotheses,the Wilcoxon test,paired t-test,Fisher’s exact test,and Pearson's chi-squared test were used.RESULTS The alanine aminotransferase(ALT)level changed by-14.1 U/L(-31.0;-5.3)from baseline to 3 mo and by-6.5 U/L(-14.0;0.1)from 3 to 6 mo.The magnitude of ALT,aspartate transaminase,and glutamyltransferase decrease was greater during the first 3 mo of treatment compared to the subsequent 3 mo(P<0.001,P<0.01,P<0.001,respectively).At 6 mo,in the total sample,we observed a statistically significant decrease in body weight and levels of FLI:84.9±10.4 vs 72.3±17.6,P<0.001,total cholesterol:6.03±1.36 vs 5.76±1.21,Р<0.001,lowdensity lipoprotein:3.86±1.01 vs 3.66±0.91,Р<0.001,and triglyceride:3.18(2.00;4.29)vs 2.04(1.40;3.16),Р<0.001.No effect on nonalcoholic fatty liver disease fibrosis score or liver fibrosis index was found.The CIMT decreased significantly in the total sample(0.985±0.243 vs 0.968±0.237,P=0.013),whereas the highdensity lipoprotein(Р=0.036)and 10-year ASCVD risk(Р=0.003)improved significantly only in women.Fifty-four patients(31%)achieved>5%weight loss.At the end of the study,the FLI decreased significantly in patients with(88.3±10.2 vs 71.4±19.6,P<0.001)and without>5%weight loss(83.5±10.3 vs 72.8±16.7,P<0.001).The changes in ALT,aspartate transaminase,glutamyltransferase,total cholesterol,and low-density lipoprotein levels were similar between the subgroups.CONCLUSION UDCA normalizes liver enzymes greatly within the first 3 mo of treatment,improves lipid profile and hepatic steatosis independent of weight loss,and has a positive effect on CIMT in the total sample and 10-year ASCVD risk in women after 6 mo of treatment. | Maria Nadinskaia Marina Maevskaya Vladimir Ivashkin Khava Kodzoeva Irina Pirogova Evgeny Chesnokov Alexander Nersesov Jamilya Kaibullayeva Akzhan Konysbekova Aigul Raissova Feruza Khamrabaeva Elena Zueva | 2021 | World Journal of Gastroenterology2021，27，10： | 4 |
| 2 | Muller细胞在增殖性糖尿病性视网膜病变中的作用显示文摘目的评价Muller细胞在糖尿病性视网膜病变(DR)视网膜新生血管形成中的作用。方法对239例(478只眼)非增殖期、增殖前期及早期增殖期DR病人进行了闪光视网膜电图(ERG)、局部ERG以及12、32、40赫兹闪烁光ERG检查,并计算纤维指数:闪光ERG的b波幅值/12赫兹闪烁光ERG幅值。此外,对37例增殖前期DR病人每间隔2~4个月进行动态电生理观察1-1.5年。结果非增殖期DR的32、40赫兹闪烁光ERGb波幅值位于正常低限,闪光ERG的a波幅值中度降低,为(54+9.6)μv,b波幅值正常;12赫兹闪烁光ERG幅值明显降低,为(25.8±9.4)μv,纤维指数平均为(9.3±1.4)单位。增殖前期DR的所有视网膜电反应均中度下降,闪光ERG的b波幅值为(179+19)μv,12赫兹闪烁光ERG幅值为(13.0±6.4)μv,纤维指数为10,16单位,平均(13.8+1.3)单位,有极显著增高(P〈0.001)。早期增殖期DR的闪光视网膜电图的a波和32、40赫兹闪烁光视网膜电图幅值继续下降,分别为(30.0±12.2)μv、(8.8±2.7)μv和(4.0±2.1)μv,纤维指数平均为:(13.5±2.2),有极显著增高(P〈O.001)。动态观察表明,原来增高的纤维指数突然下降,说明近期出现视网膜新生血管的可能性极大。结论纤维指数增高是视网膜缺血缺氧的共同特点,表明Muller细胞的代谢活性代偿性增高,证实其在视网膜新生血管形成中起重要作用。 | 刘红 谷万章 陶源 周丽霞 Zueva M.V. | 2009 | 中国实用眼科杂志2009，27，9： | 4 |
| 3 | Synthesis and properties of modified melamine formaldehyde impregnating oligomers 显示文摘 | Tsvetkov V E Zueva M Y | 2011 | Polymer Science series D Glues and Sealing Materials2011，4，3： | 1 |
| 4 | Stability of basalt fibers in a medium of hydrating cement显示文摘 | Rabinovich F N Zueva V N Makeeva L V | 2001 | Glass and Ceramics2001，58，： | 1 |
| 5 | Stability of basah fibres in a medium of hydrating in a medium of hydrating cement显示文摘 | Rabinovich F N Zueva V N Makeeva L V | 2001 | Glass and Ceramics2001，58，1112： | 1 |
| 6 | Temperature-induces selective death of the C-domain within angiotensin-converting enzyme molecule显示文摘 | Voronov S Zueva N Orlov V | 2002 | FEBS Letters2002，52，2： | 1 |
| 7 | Stability of basalt fibers in a medium of hydrating cement 显示文摘 | RABINOVICH F N ZUEVA V N MAKEEVA L V | 2001 | Glass Ceram2001，58，1112： | 1 |
| 8 | Stability of Basalt Fibers in a Medium of Hydrating Cement显示文摘 | F. N. Rabinovich V. N. Zueva L. V. Makeeva | 2001 | Glass and Ceramics (-)2001，，11： | 1 |
| 9 | Stability of basalt fibers in a medium of hydrating cement显示文摘 | RABINOVICH F N ZUEVA V N MAKEEVA L V | 2001 | Glass and Ceramics2001，58，1112： | 1 |
| 10 | Muller细胞在非增殖性糖尿病视网膜病变中的作用显示文摘目的:评价Muller细胞在非增殖期糖尿病视网膜病变中的作用。方法:对46例(92只眼)非增殖期糖尿病视网膜病变病人进行了闪光视网膜电图(ERG)、局部ERG以及12、32、40赫兹闪烁光ERG检查,并计算纤维指数:闪光ERG的b波幅值/12赫兹闪烁光ERG幅值。结果:非增殖期糖尿病视网膜病变的32、40赫兹闪烁光ERG b波幅值位于正常低限,闪光ERG的a波幅值中度降低,为(54±9.6)μv,b波幅值正常,12赫兹闪烁光ERG幅值明显降低,为(25.8±9.4)μv,纤维指数平均为(9.3±1.4)单位。结论:纤维指数增高是视网膜缺血缺氧的共同特点,表明Muller细胞的代谢活性代偿性增高。 | 刘红 谷万章 陶源 周丽霞 Zueva M.V. | 2010 | 航空航天医药2010，21，5： | 1 |
| 11 | An epigenetic silencing pathway controlling T helper 2 cell lineage commitment 显示文摘 | Allan RS Zueva E Cammas F | 2012 | Nature2012，487，7406： | 1 |
| 12 | Stability of basalt fibers in a medium of hydrating cement显示文摘 | Rabinovich F N Zueva V N Makeeva L V | 2001 | Glass and Ceramics2001，58，： | 1 |
| 13 | Synthesis and properties of modified melamine formaldehyde impregnating oligomers 显示文摘 | TSVETKOV V E ZUEVA M Y | 2011 | Polymer Scienee Series D Glues and Sealing Materials2011，4，5： | 1 |
| 14 | Complex mathematical description of heat and mass transfer in the drying of an infinite cylindrical body with analytical methods of heat-conduction theory显示文摘 | Padokhin V A Zueva G A Kokurina G N | 2015 | Theoretical Foundations of Chemical Engineer- ing2015，49，1： | 1 |
| 15 | Mathematical model of heat transfer in a solar collector and its experimental validation 显示文摘 | Zueva G A Magiera J | 2001 | Theoretical Foundations of Chemical Engineering2001，35，6： | 1 |
| 16 | Properties,production,and practical uses of alkaline Phosphatase显示文摘 | Zueva NN Dalev PG Lazarova DL | | 0，，： | 1 |
| 17 | Stability of basalt fibers in a medium of hydrating cement显示文摘 | RABINOVICH F N ZUEVA V N MAKEEVA L V | 2001 | Glass and Ceramics2001，58，1112： | 1 |
| 18 | Stability of basalt fibres in a medium of hydrating cement 显示文摘 | RABINOVICH F N ZUEVA V N MAKEEVA L V | 2001 | Glass and Ceramics2001，58，11： | 1 |
| 19 | Stability of basalt fibers in a medium of hydrating cement显示文摘 | RAB NOV ICH F N ZUEVA V N MAKEEVA L V | 2001 | Glass and Ceramics2001，，58： | 1 |
| 20 | Licorice preparations improve efficiency of chemotherapy and surgical treatment of transplanted tumors 显示文摘 | Goldberg E D Amosova E N Zueva E P | 2008 | Bull Exp Biol Med2008，145，2： | 1 |
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