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| 1 | Performances of improved Tent chaos-based FM radar signal显示文摘A novel algorithm is proposed to solve the poor performance problem of the Tent chaos-based frequency modulation(FM) signal for range-Doppler imaging,which takes it into complex multi-segment system by increasing its segments.The simulation results show that the effectiveness of the proposed algorithm,as well as the performance of the improved Tent FM signal is obvious in a multipath or noise propagation environment. | Shaobin Xie Zishu He Jinfeng Hu Lidong Liu Jichun Pan | 2012 | Journal of Systems Engineering and Electronics2012，23，3： | 6 |
| 2 | Chimeric classical swine fever (CSF)-Japanese encephalitis (JE) viral replicon as a non-transmissible vaccine candidate against CSF and JE infections显示文摘 | Zhenhua Yang Rui Wu Robert W. Li Ling Li Zhongliang Xiong Haizhong Zhao Deyin Guo Zishu Pan | 2012 | Virus Research2012，，1： | 2 |
| 3 | Construction of cytopathic PK-15 cell model of classical swine fever virus显示文摘No cytopathic effect (CPE) can be observed on classical swine fever virus (CSFV) infected cell culture in vitro. This brings an obstacle to the researches on reciprocity between CSFV and host cells. Based on the construction of full-length genomic infectious Cdna clone of Chinese CSFV standard virulent Shimen strain, partial deletion is intro- duced into genomic Cdna to obtain a 7.5 kb subgenomic Cdna. A new subgenomic CSFV is derived from transfection with the subgenomic Cdna on PK-15 cells pre-infected by CSFV Shimen virus. Typical CPE induced by this subgenomic virus is observed on PK-15 cells. Coexistence of wild- type and subgenomic virus in cytopathic cell culture is dem- onstrated by RT-PCR detection in cytopathic cells. For conclusion, the construction of cytopathic cell model exploited a new way for researches on the molecular mechanism of CSFV pathogenesis. | WU Haixiang, ZHANG Chuyu, ZHENG Congyi, WANG Jiafu, PAN Zishu, LI Lei, CAO Shen & Yl GuanghuiInstitute of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaCorrespondence should be addressed to Zhang Chuyu (e-mail: avlab@ whu.edu.cn) | 2003 | Chinese Science Bulletin2003，48，9： | 1 |
| 4 | Core fungal species strengthen microbial cooperation in a food-waste composting process显示文摘In ecosystem engineering research,the contribution of microbial cooperation to ecosystem function has been emphasized.Fungi are one of the predominant decomposers in composting,but thus far,less attention has been given to fungal than to bacterial cooperation.Therefore,network and cohesion analyses were combined to reveal the correlation between fungal cooperation and organic matter(OM)degradation in ten composting piles.Positive cohesion,reflecting the cooperation degree,was positively linked to the degradation rate of OM.From the community perspective,core species(i.e.,Candida tropicalis,Issatchenkia orientails,Kazachstania exigua,and Dipodascus australiensis)with high occurrence frequency and abundance were the key in regulating positive cohesion.These species were highly relevant to functional genera associated with OM degradation in both fungal and bacterial domains.Therefore,focusing on these core fungal species might be an appropriate strategy for targeted regulation of functional microbes and promotion of degradation rates. | Yuxiang Zhao Jingjie Cai Pan Zhang Weizhen Qin Yicheng Lou Zishu Liu Baolan Hu | 2022 | Environmental Science and Ecotechnology2022，，4： | 0 |
| 5 | Dynamic Host Immune and Transcriptomic Responses to Respiratory Syncytial Virus Infection in a Vaccination-Challenge Mouse Model显示文摘Respiratory syncytial virus(RSV) is the major cause of lower respiratory tract infections in children. Inactivated RSV vaccine was developed in the late 1960’s, but the vaccine-enhanced disease(VED) occurred to vaccinated infants upon subsequent natural RSV infection. The excessive inflammatory immunopathology in the lungs might be involved in the VED, but the underlying mechanisms remain not fully understood. In this study, we utilized UV-inactivated RSV in the prime/boost approach followed by RSV challenge in BALB/c mice to mimic RSV VED. The dynamic virus load,cytokines, histology and transcriptome profiles in lung tissues of mice were investigated from day 1 to day 6 post-infection.Compared to PBS-treated mice, UV-RSV vaccination leads to a Th2 type inflammatory response characterized by enhanced histopathology, reduced Treg cells and increased IL4^(+)CD4 T cells in the lung. Enhanced production of several Th2 type cytokines(IL-4, IL-5, IL-10) and TGF-b, reduction of IL-6 and IL-17 were observed in UV-RSV vaccinated mice. A total of 5582 differentially expressed(DE) genes between PBS-treated or vaccinated mice and na?ve mice were identified by RNA-Seq. Eleven conserved high-influential modules(HMs) were recognized, majorly grouped into regulatory networks related to cell cycle and cell metabolism, signal transduction, immune and inflammatory responses. At an early time post-infection, the vaccinated mice showed obvious decreased expression patterns of DE genes in 11 HMs compared to PBS-treated mice. The extracellular matrix(HM5) and immune responses(HM8) revealed tremendous differences in expression and regulation characteristics of transcripts between PBS-treated and vaccinated mice at both early and late time points. The highly connected genes in HM5 and HM8 networks were further validated by RT-qPCR.These findings reveal the relationship between RSV VED and immune responses, which could benefit the development of novel RSV vaccines. | Yu Zhao Chen Ma Jie Yang Xiufen Zou Zishu Pan | 2021 | Virologica Sinica2021，36，6： | 0 |
| 6 | Correction to: Dynamic Host Immune and Transcriptomic Responses to Respiratory Syncytial Virus Infection in a Vaccination-Challenge Mouse Model显示文摘Correction to:Virologica Sinica http://gffzzd3cc09b8251d45dfsxvc0kf6vwn6v6xf5.ffgz.tsg.suse.edu.cn/10.1007/s12250-021-00418-3 The original version of this article,published online on June 17,2021,contained a mistake in Supplementary Table S5.The correct Supplementary Table S5 is given below. | Yu Zhao Chen Ma Jie Yang Xiufen Zou Zishu Pan | 2021 | Virologica Sinica2021，36，6： | 0 |
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