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| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | Comparison of pumpdriven and spontaneous continuous hemofiltration in postoperative acute renal failure 显示文摘 | Storck M Hartl WH Zimmerer E | 1991 | Lancet1991，23，： | 2 |
| 3 | Use of DNA barcodes to identify flowering plants 显示文摘 | Kress W J Wurdack K J Zimmer E A | 2005 | Proceedings of the National Academy of Sciences USA2005，102，： | 1 |
| 4 | Evidence for a role of toll-like receptor 4 in development of chronic allograft rejection after cardiac transplantation显示文摘 | Methe H Zimmer E Grimm C | 2004 | Transplantation2004，78，： | 1 |
| 5 | Preparation of uranium kernels by an external gelation process显示文摘 | NAEFE P ZIMMER E | 1979 | Nu- clear Technology1979，42，2： | 1 |
| 6 | The physcomitrella genome reveals evolutionary insights into the conquest of land by plants 显示文摘 | Rensing S A Lang D Zimmer A D Terry A Salamov A Shapiro H Nishiyama T Perroud P F Lindquist E A Kamisugi Y | 2008 | Science2008，319，5859： | 1 |
| 7 | Use of DNA barcodes to identify flowering plants 显示文摘 | KRESS W J WURDACK K J ZIMMER E A | 2005 | Proceedings of the National Academy of Sciences of the United States of America2005，102，23： | 1 |
| 8 | Use of DNA barcodes to identify flowering plants 显示文摘 | Kress W J Wurdeck K J Zimmer E A | 2005 | PNAS2005，102，23： | 1 |
| 9 | Going beyond: Target selec- tion and mission analysis of human exploration missions to Near-Earth Asteroids显示文摘 | Zimmer A K Messerschmid E | 2011 | ActaAstronautica2011，69，11： | 1 |
| 10 | Altered NKG2D func- tion in NK cells induced by chronic exposure to NKG2D ligand-ex- pressing tumor cells显示文摘 | Coudert JD Zimmer J Tomasello E | 2005 | Blood2005，106，15： | 1 |
| 11 | High binaural coherence determines successful sound localization and increased activity in posterior auditory areas显示文摘 | U Zimmer E Macaluso | 2005 | Neuron2005，47，： | 1 |
| 12 | Cell-specific nuclear import of plasmid DNA显示文摘 | Vacik J Dean B S Zimmer W E | 1999 | Gene Ther1999，6，6： | 1 |
| 13 | Teaching Effectively with Multimedia显示文摘 | Zimmer J E | | 0，，09： | 1 |
| 14 | Effective management of complex heart failure显示文摘 | Kosseim L M Pifer A E Zimmer R R | 1999 | Postgrad Med1999，105，6： | 1 |
| 15 | A study of the inhibition/promotion effects of sodium-copper chlorophyllin (SCC)-mediated mutagenesis in somatic cells of Drosophila显示文摘 | Pimentel E Cruces MP Zimmering S | | 0，，： | 1 |
| 16 | Integration of morphological and ribosomal RNA data on the origin of angiosperms显示文摘 | Doyle J A Donoghue M J Zimmer E A | 1994 | Ann Missouri Bot Gard1994，81，： | 1 |
| 17 | Idiosyncratic drug-induced agxanulocytosis: update of an old disorder 显示文摘 | Andres E Zimmer J Affenberger S | 2006 | Eur J Intern Med2006，17，8： | 1 |
| 18 | Base of tongue schwannoma: a case report显示文摘 | YING Y L ZIMMER L A MYERS E N | 2006 | Laryngo scope2006，116，： | 1 |
| 19 | Inaduate IL-2 synthesis and IL-2 messenger expression following thermal and mechanical trauma in human is caused by defective transmemhrane signaling 显示文摘 | Faisitert E Schinkel C Zimmer S | 1993 | Criet Care Meed1993，21，： | 1 |
| 20 | Idiopathic thrombocytopenic purpura: A retrospective analysis in 139 patients of the influence of age on the response to corticosteroids, splenectomy and danazol 显示文摘 | ANDRES E ZIMMER J NOEL E | 2003 | Drugs Aging2003，20，： | 1 |
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