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| 1 | Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy显示文摘Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has been extensively investigated into the context of neurodegenerative diseases. Alzheimer's disease and Parkinson's disease show changes in the regulation of specific neurotrophic factors and their receptors, which appear to be critical for neuronal degeneration. Indeed, neurotrophic factors prevent cell death in degenerative processes and can enhance the growth and function of affected neurons in these disorders. Based on recent reports, this review discusses the main findings related to the neurotrophic factor support – mainly brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor – in the survival, proliferation and maturation of affected neurons in Alzheimer's disease and Parkinson's disease as well as their putative application as new therapeutic approach for these diseases management. | Tuane Bazanella Sampaio Anne Suely Savall Maria Eduarda Ziani Gutlerrez Simone Proton | 2017 | Neural Regeneration Research2017，12，4： | 16 |
| 2 | Use of edible films based on whey protein isolate to protect foods rich in polyunsaturated fatty acids显示文摘 | OSES J FERNANDEZ-Pan I ZIANI K | 2008 | Eur Food Res Technol2008，227，2： | 1 |
| 3 | Influence of surfactant charge on antimicrobial efficacy of surfactant-stabilized thyme oil nanoemulsions 显示文摘 | ZIANI K CHANG Y McLandsborough L | 2011 | Journal of Agricultural and Food Chemistry2011，59，11： | 1 |
| 4 | Potato Starch Edible Films to Control Oxidative Rancidity of Polyunsaturated Lipids:Effects of Film Composition,Thickness and Wa- ter Activity显示文摘 | OSES J NIZA S ZIANI K | 2009 | International Journal of Food Science and Technology2009，4，： | 1 |
| 5 | Application of bioactive coatings based on chitosan for artichoke seedprotection显示文摘 | Ziani K Ursfla B Mats J I | 2010 | Crop Protection2010，29，8： | 1 |
| 6 | Removal of lead ions byhydroxyapatite prepared from the egg shell显示文摘 | MESKI S ZIANI S KHIREDDINE H | 2010 | Journal of Chemical &Engineering Data2010，55，： | 1 |
| 7 | Potato starch edible films to control oxidative rancidity ofpolyunsaturated lipids:effects of film composition,thick-ness and water activity显示文摘 | JAVIER OS S SANDRA NIZA KHALID ZIANI | 2009 | International Journal of FoodScience and Technology2009，，44： | 1 |
| 8 | Structural and dielectric properties of oxynitride perovskite LaTiO x N y thin films显示文摘 | A. Ziani C. Le Paven-Thivet L. Le Gendre D. Fasquelle J.C. Carru F. Tessier J. Pinel | 2008 | Thin Solid Films2008，，2： | 1 |
| 9 | On simplit~cing allometlic analyses oftbrest biomass显示文摘 | Zianis D Mencuccini M | 2004 | Forest EcoloK~ and Management2004，187，2： | 1 |
| 10 | Combined effect of plasticizers and surfactants on the physical properties of starch based edible films显示文摘 | Rodriguez M Oses J Ziani K | 2006 | Food Res Int2006，39，： | 1 |
| 11 | An autoadaptative limited memory Broyden' s method to solve systems of nonlinear equations 显示文摘 | ZIANI M GUYOMARC' H F | 2008 | Applied Mathematics and Computation2008，205，1： | 1 |
| 12 | Antibioresistance of Escherichia coli strains isolated in Morocco from chickens with colibacillosis 显示文摘 | Abdelkader Amara Zakia Ziani Khalid Bouzoubaa | 1995 | Veterinary Microbiology1995，43，： | 1 |
| 13 | Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice显示文摘Alzheimer’s disease is a progressive brain disorder and complex mechanisms are involved in the physiopathology of Alzheimer’s disease.However,there is data suggesting that inflammation plays a role in its development and progression.Indeed,some non-steroidal antiinflammatory drugs,such as meloxicam,which act by inhibiting cyclooxygenase-2 have been used as neuroprotective agents in different neurodegenerative disease models.The purpose of this study was to investigate the effects of co-nanoencapsulated curcumin and meloxicam in lipid core nanocapsules(LCN)on cognitive impairment induced by amyloid-beta peptide injection in mice.LCN were prepared by the nanoprecipitation method.Male Swiss mice received a single intracerebroventricular injection of amyloid-beta peptide aggregates(fragment 25–35,3 nmol/3μL)or vehicle and were subsequently treated with curcumin-loaded LCN(10 mg/kg)or meloxicam-loaded LCN(5 mg/kg)or meloxicam+curcumin-co-loaded LCN(5 and 10 mg/kg,respectively).Treatments were given on alternate days for 12 days(i.e.,six doses,once every 48 hours,by intragastric gavage).Our data showed that amyloid-beta peptide infusion caused long-term memory deficits in the inhibitory avoidance and object recognition tests in mice.In the inhibitory avoidance test,both meloxicam and curcumin formulations(oil or co-loaded LCN)improved amyloid-beta-induced memory impairment in mice.However,only meloxicam and curcumin-co-loaded LCN attenuated non-aversive memory impairment in the object recognition test.Moreover,the beneficial effects of meloxicam and curcuminco-loaded LCN could be explained by the anti-inflammatory properties of these drugs through cortical cyclooxygenase-2 downregulation.Our study suggests that the neuroprotective potential of meloxicam and curcumin co-nanoencapsulation is associated with cortical cyclooxygenase-2 modulation.This study was approved by the Committee on Care and Use of Experimental Animal Resources,the Federal University of Pampa,Brazil(approval No.02-2015)on April 16,2015. | Maria Eduarda Ziani Gutierrez Anne Suély Pinto Savall Edina da Luz Abreu Kelly Ayumi Nakama Renata Bem Dos Santos Marina Costa Monteiro Guedes Daiana SilvaÁvila Cristiane Luchese Sandra Elisa Haas Caroline Brandão Quines Simone Pinton | 2021 | Neural Regeneration Research2021，16，4： | 1 |
| 14 | Biomass and stem volume equations for tree species in Europe 显示文摘 | ZIANIS D MUUKKONEN P MAKIPAA R | 2005 | Silva Fennica2005，，4： | 1 |
| 15 | On simplifying allometric analyses of forest biomass显示文摘 | Zianis D Mencuccini M | 2004 | Forest Ecology and Management2004，187，23： | 1 |
| 16 | Biomass and slem volume equations for tree species in Europe 显示文摘 | Zianis D Munkkonen P Makiapaa R | 2005 | Silva Fenniea2005，，4： | 1 |
| 17 | Comparis on between empirical and theoretical biomass allometrie models and sta- tistical implications for stem volume predictions 显示文摘 | Zianis D Radoglou K | 2006 | Forestry2006，79，4： | 1 |
| 18 | Comparison between Empirical and Theoreti- cal Biomass Allometric Models and Statistical Implications for Stem Volume Predictions 显示文摘 | Zianis D Radoglou K | 2006 | Forestry2006，79，4： | 1 |
| 19 | Combined effect of plasticizers and surfactants on the physical properties of starch based edible films 显示文摘 | Rodriguez M Oses J Ziani K | 2006 | Food Research International2006，39，8： | 1 |
| 20 | Application of bioactive coatings based on chitosan for artichoke seed protection显示文摘 | Ziani K Ursúa B Maté J I | 2010 | Crop Protection2010，29，8： | 1 |
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