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| 1 | Repurposing metformin for the treatment of gastrointestinal cancer显示文摘Diabetes mellitus type 2 and cancer share many risk factors.The pleiotropic insulin-dependent and insulin-independent effects of metformin might inhibit pathways that are frequently amplified in neoplastic tissue.Particularly,modulation of inflammation,metabolism,and cell cycle arrest are potential therapeutic cancer targets utilized by metformin to boost the anti-cancer effects of chemotherapy.Studies in vitro and in vivo models have demonstrated the potential of metformin as a chemo-and radiosensitizer,besides its chemopreventive and direct therapeutic activity in digestive system(DS)tumors.Hence,these aspects have been considered in many cancer clinical trials.Case-control and cohort studies and associated meta-analyses have evaluated DS cancer risk and metformin usage,especially in colorectal cancer,pancreatic cancer,and hepatocellular carcinoma.Most clinical studies have demonstrated the protective role of metformin in the risk for DS cancers and survival rates.On the other hand,the ability of metformin to enhance the actions of chemotherapy for gastric and biliary cancers is yet to be investigated.This article reviews the current findings on the anti-cancer mechanisms of metformin and its apparatus from pre-clinical and ongoing studies in DS malignancies. | Ademar Dantas Cunha Júnior Arinilda Campos Bragagnoli Felipe Osório Costa JoséBarreto Campello Carvalheira | 2021 | World Journal of Gastroenterology2021，27，17： | 5 |
| 2 | Immunocytochemistry:Its evolution and criteria for its application in the study of epon-embedded cells and tissues显示文摘 | Gosselin E J Cate CC Pettengill OS | 1986 | Am J Anat1986，175，： | 1 |
| 3 | Effects of triterpenes on the immune system显示文摘 | R i os J L | 2010 | Journal of ethnopharmacology2010，128，1： | 1 |
| 4 | Use of edible films based on whey protein isolate to protect foods rich in polyunsaturated fatty acids显示文摘 | OSES J FERNANDEZ-Pan I ZIANI K | 2008 | Eur Food Res Technol2008，227，2： | 1 |
| 5 | l Comparison of nebu lized budeson ide and oral predn iso lone with p lacebo in th e treatment of acu te exacerbations of chron ic obstructive pulmon ary disease:a randomized controlled tria显示文摘 | Maltais F Os tinelli J Bou rbeau J et a | 2002 | l Am J Resp ir Crit CareM ed2002，165，： | 1 |
| 6 | Potato Starch Edible Films to Control Oxidative Rancidity of Polyunsaturated Lipids:Effects of Film Composition,Thickness and Wa- ter Activity显示文摘 | OSES J NIZA S ZIANI K | 2009 | International Journal of Food Science and Technology2009，4，： | 1 |
| 7 | Schizophrenia显示文摘 | Van Os J Kapur S | 2009 | Lancet2009，374，9690： | 1 |
| 8 | Geneticpolymorphism at codon 10 of the transforming growthfactor-jS, gene in patients with alcoholic liver cirrhosis显示文摘 | Lee J J Park S K Kwon OS | 2011 | Korean J Hepatol2011，17，1： | 1 |
| 9 | Heritability of structural brain traits an endophenotype approach to deconstruct schizophrenia显示文摘 | Kaymaz N van Os J | 2009 | Int Rev Neurobiol2009，89，： | 1 |
| 10 | Effect of zirconia addition on crystalline, hardness, and microstructure of gel-derived barium aluminosilicate, BaAl2 Si2O8 显示文摘 | Debsikdar J C Sowemimo OS | 1992 | J Mater Sci1992，27，： | 1 |
| 11 | Mito-chondrial respiratory chain and free radical generationin stroke 显示文摘 | Moro M A Almeida A Bola os J P Lizasoain I | 2005 | Free Radic Biol Med2005，39，： | 1 |
| 12 | Schizophrenia 显示文摘 | van Os J Kapur S | 2009 | Lancet2009，374，9690： | 1 |
| 13 | The epithelial calcium channel,ECaC1:molecular details of a novel player in renal calcium handling显示文摘 | Müller D Hoenderop J G van Os C H | 2001 | Nephrol Dial Transplant2001，16，7： | 1 |
| 14 | Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver isclaemia/reperfusion 显示文摘 | Leon Fema'n OS Ajamieh HH Berlanga J | 2007 | Transplant Intl2007，14，： | 1 |
| 15 | The value of fluoro-2-D -Glucose positron emission tomography in the selection of patients with stage IN A-N2 non-small cell lung cancer for combined modality treatment 显示文摘 | Hoekstra C J Stroobants SG Hoekstra OS | 2003 | Lung Cancer2003，39，： | 1 |
| 16 | C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester acute myocardial infarction peptide (LAMP) study显示文摘 | Khan SQ Dhillon OS O Brien R J | 2007 | Circulation2007，115，： | 1 |
| 17 | Welsh citizens in South-Eastern Spain:a study of attitude toward organ donation显示文摘 | A Ríos L Martínez-Alarcón J Sánchez | | 0，，05： | 1 |
| 18 | Cortical excitatory amino acid release and cell function during hypotension in near-term born lambs显示文摘 | van Os S Ruitenbeek W Hopmau J | 2006 | Biol Neonate2006，90，2： | 1 |
| 19 | Size of burden of schizophrenia and psychotic disorders显示文摘 | Rossler W Salize HJ Van Os J | 2005 | Eur Neuropsychopharmacol2005，15，： | 1 |
| 20 | Where does the interplay between cholesterol absorption and synthesis in the context of statin and/or ezetimibe treatment stand today? 显示文摘 | Descamps OS De Sutter J Guillaume M | 2011 | Atherosclerosis2011，217，： | 1 |
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