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| 1 | Metastasis-associated protein 1 induces VEGF-C and facilitates lymphangiogenesis in colorectal cancer显示文摘AIM:To study the correlation between high metastasisassociated protein 1(MTA1)expression and lymphangiogenesis in colorectal cancer(CRC)and its role in production of vascular endothelial growth factor-C(VEGF-C). METHODS:Impact of high MTA1 and VEGF-C expression levels on disease progression and lymphovasculardensity(LVD,D2-40-immunolabeled)in 81 cases of human CRC was evaluated by immunohistochemistry. VEGF-C mRNA and protein expressions in human LoVo and HCT116 cell lines were detected by real-time polymerase chain reaction and Western blotting,respectively,with a stable expression vector or siRNA. RESULTS:The elevated MTA1 and VEGF-C expression levels were correlated with lymph node metastasis and Dukes stages(P<0.05).Additionally,high MTA1 expression level was correlated with a large tumor size(P< 0.05).A significant correlation was found between MTA1 and VEGF-C protein expressions in tumor cells(r=0.371, P<0.05).Similar to the VEGF-C expression level,high MTA1 expression level was correlated with high LVD in CRC(P<0.05).Furthermore,over-expression of MTA1 significantly enhanced the VEGF-C mRNA and protein expression levels,whereas siRNAs-knocked down MTA1 decreased the VEGF-C expression level. CONCLUSION:MTA1,as a regulator of tumor-associated lymphangiogenesis,promotes lymphangiogenesis in CRC by mediating the VEGF-C expression. | Bin Du Zhen-Yu Yang Xue-Yun Zhon Mao Fang Yong-Rong Yan Guo-Long Qi Yun-Long Pan Xu-Long Zhou | 2011 | World Journal of Gastroenterology2011，17，9： | 23 |
| 2 | Chemical induction of settlement and metamorphosis in two Babylonia (Gastropoda) larvae显示文摘By exposure to 12 x 10 3 mol/dm3 K+ for 24 h, more than 90% of planktonic larvae of Babylonia formosae and B. areolata were effectively induced to metamorphose completely. 15 x 10 - 3 mol/dm3 K+ exerted toxic effect on larval B. areolata over a 24-h period, but produced better results of induction by 12 h exposure. Metamorphosed juveniles induced by increased by K’ could move and feed normally. Percent metamorphosis increased with average shell height for K + -induced larvae. L-DOPA, epinephrine and norepinephrine ranging from 5. 5 x 10 -- 6 to 5. 5 x 10 - 5 mol/dm3 had no inductive activity to metamorphosis in larval B. areolata, whereas the rate of metamorphosis induced by dopamine at a concentration of 10--4 mol/dm3 was approximately half less than that by 12 x 10 3 mol/dm3 K+. TEA (a K+ -channel blocker) did not inhibit metamorphosis in the two Babylonia larvae by induction of K+. Based on the results of K+ -induced experiments, it is preliminarily suggested that shell height of larvae achieving metamorphic competence was in the range of 860. 2 - 1 009. 8μm for B. formosae, and 849. 6- 956. 0 um for B. areolata. In addition, planktonic larvae of the two Babylonia had delayed metamorphosis. | Ke Caihuan Li Shaojing Li Fuxue Zheng Zhon Liu Weibin (1. Department of Oceanography and Institute of Subtropical Oceanography, Xiamen University, Xiamen 361005, China 2. Fujian Fisheries Research Institute, Xiamen 361012, China) | 2000 | Acta Oceanologica Sinica2000，19，1： | 4 |
| 3 | Gene-environment interaction for the ERCC2 polymorphisms and cmnulative cigarette smoking exposure in lung cancer显示文摘 | Zhon W Lin G Miller DP | 2002 | Cancer Res2002，62，5： | 1 |
| 4 | A study on convergence of canonical genetic algorithms with natural selection显示文摘 | Liang Yanchun Zhon Chunguang Wang Zaishen | 1997 | Chinese Journal of Electronics1997，6，3： | 1 |
| 5 | Serological thymidine kinase 1 indicates el-evated risk for the development of malignant tumors显示文摘 | Chen Z Zhon H Li S et ai | 2008 | Anticancer Reson-reh2008，28，2： | 1 |
| 6 | Role of interleukin-1 in hypoxia-indueed depression of glutamate uptake in retinal Miiller cells 显示文摘 | Chen C Chen H Xtt C Zhon Y Shert X | 2014 | Graefes Arch Clin Exp Ophthalmol2014，252，1： | 1 |
| 7 | Apigonin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells:implication of chemoprevention of lung cancer显示文摘 | Liu LZ Fang J Zhon Q | 2005 | Mol Pharmacol2005，68，3： | 1 |
| 8 | Identifying markers for panoreatic cancer by geue expression analysis显示文摘 | Zhon W Sokoll LJ Bruzek DJ | 1998 | Cancer Epidemiol Biomarkers Prev1998，7，2： | 1 |
| 9 | Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control cell cycle progression and gene expression显示文摘 | Jiang W Kahn SM Zhon P | 1993 | Oncogene1993，8，12： | 1 |
| 10 | Comparison of FEM and BEM for interactive object simulation显示文摘 | TANG Y M ZHON A F HUI K C | 2006 | Computer Aided Design2006，38，8： | 1 |
| 11 | Maeular abnormality observed by optical coherence tomography in children with amblyopia failing to achieve normal visual acuity after long-term treatment 显示文摘 | Liu H Zhong L Zhon X | 2010 | J Pediatr Ophthalmol Strabismus2010，47，1： | 1 |
| 12 | Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components 显示文摘 | Zhon Q Amar S | 2007 | J Immunol2007，179，11： | 1 |
| 13 | Evaluation of Treated Black Liquor Used as Dispersant of Concentrated Coal - water Slurry 显示文摘 | Zhon M S Kong Q Pan B | 2010 | Fu- el2010，89，3： | 1 |
| 14 | Effects of lanthanum and neodymium hydroxides on secondary alkaline inc electrode显示文摘 | Zhu J L Zhon Y H Yang H X | 1997 | J Power Sources1997，69，12： | 1 |
| 15 | Diagonal Convexity Conditions for Problems in Convex Analysis and Quasi-Variational Ineqnalities显示文摘 | Zhon J X Chen G | 1988 | J Math Anal Appl1988，，132： | 1 |
| 16 | Ensembling neural networks: many could be better than all显示文摘 | Zhon Z H Wu J X Tang W | 2002 | Artificial Intelligence2002，17，12： | 1 |
| 17 | A current statistical model and adaptive algorithm for estinating maneuvering targets显示文摘 | Zhon H R Kumar K S P | 1984 | Journal of Cuidance Control and Dynamics1984，7，5： | 1 |
| 18 | Eiemene displays anti-cancer ability on laryngeal cancer cells in vitro and in vivo显示文摘 | Tao L Zhon L Zheng L | 2006 | Cancer Chemother Pharmacol2006，58，1： | 1 |
| 19 | Realized Jumps on Financial Mar- kets and Predicting Credit Spreads 显示文摘 | Tauchen G H Zhon | 2011 | Journal of Econ- ometrics2011，，160： | 1 |
| 20 | Neuropeptide Y stimulates hypertrophy of adult ventricular cardiomyocytes显示文摘 | Millar BC Schlueterk D Zhon XJ | 1994 | Am J Physiol1994，266，51： | 1 |
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