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| 1 | Enhanced oxygen reduction reaction performance of Co@N–C derived from metal-organic frameworks ZIF-67 via a continuous microchannel reactor显示文摘Traditional methods of preparing metal-organic frameworks(MOFs)compounds have the disadvantages such as poor dispersion,inefficient and discontinuous process.In this work,microchannel reactor is used to prepare MOFs-derived zeolite-imidazole material via flash nanoprecipitation to form ZIF-67+PEI(FNP),which reduces the MOF synthesis time down to millisecond time interval while keeping the synthesized ZIF-67+PEI(FNP)highly dispersed.The Co@N–C(FNP)catalyst obtained by flash nanoprecipitation and carbonization has a higher Co content and thus more active sites for oxygen reduction reaction than the Co@N–C(DM)catalyst prepared by direct mixing method.Electrochemical tests show that the Co@N–C(FNP)catalyst prepared by this method has excellent oxygen reduction performance,good methanol resistance and high stability.The onset potential and half-wave potential of Co@N–C(FNP)are 0.92 VRHE and 0.83 VRHE,respectively,which are higher than that of Co@N–C(DM)(Eonset=0.90 VRHEand E1/2=0.83VRHE).Moreover,the Zn-air battery assembled with Co@N–C(FNP)as the cathode catalyst has high open circuit voltage,high power density and large specific capacity.The performance of these batteries has been comparable to that of Pt/C assembled batteries.Density functional theory(DFT)calculations confirm that the Co(220)crystal plane present in Co@N–C(FNP)have stronger adsorption energy than that of Co(111)crystal plane in Co@N–C(DM),leading to better electrocatalytic performance of the former. | Chenxu Wang Huifang Yuan Feng Yu Jie Zhang Yangyang Li Wentao Bao Zhimou Wang Ke Lu Jie Yu Ge Bai Gang Wang Banghua Peng Lili Zhang | 2023 | Chinese Chemical Letters2023，34，1： | 2 |
| 2 | Research on Speeding up the Internationalization of Private Higher Vocational Education显示文摘 | Jiangtao Geng Zengyi Kuang Zhimou Yu | 2017 | International Journal of Technology Management2017，，4： | 2 |
| 3 | Supramolecular Hydrogels of Indole-Capped Short Peptides as Vaccine Adjuvants显示文摘 | Zhongyan Wang Yanbin Cai Linan Yi Jie Gao Zhimou Yang | 2017 | Chinese Journal of Chemistry2017，35，7： | 2 |
| 4 | Aflatoxin B1: Toxicity, bioactivation and detoxification in the polyphagous caterpillar Trichoplusia ni显示文摘Trichoplusia ni 毛虫是杂食的 foliage-feeders 并且很少可能遇到黄麴毒素 B1 (AFB1 ) , mycotoxin 由曲霉属菌 flavus 和 A 生产了。parasiticus,在他们的主人植物。决定怎么 T。ni 应付 AFB1,我们评估了 AFB1 的毒性到 T。在不同发展阶段的 ni 毛虫并且发现忍耐显著地与幼虫的开发增加的那 AFB1。在 1 g/g 的 AFB1 的食谱加入完全禁止了最新孵的幼虫,而是 3 g/g 的幼虫的生长和 AFB1 没有的化蛹首先消费这的毛虫的幼虫的生长和化蛹上的明显的有毒的效果在孵化以后加重 10 天。Piperonyl butoxide,细胞色素 P450 monooxygenases (P450s ) 的一个一般禁止者,减少了 AFB1 的毒性,建议那 AFB1 是在 T 的 bioactivated。ni 和这 bioactivation 被 P450s 调停。某植物 allelochemicals 包括象黄酮,象 xanthotoxin 和 imperatorin 那样的 furanocoumarins,和象 visnagin 那样的 furanochromones 那样的 flavonoids,在另外的鳞翅类的幼虫导致 P450s 改善 AFB1 毒性,建议那 P450s 也在 T 涉及 AFB1 detoxification。ni。 | Ren Sen Zeng Zhimou Wen Guodong Niu R. Berenbaum | 2013 | Insect Science2013，20，3： | 1 |
| 5 | Tandem Molecular Self-Assembly Selectively Inhibits Lung Cancer Cells by Inducing Endoplasmic Reticulum Stress显示文摘The selective formation of nanomaterials in cancer cells and tumors holds great promise for cancer diagnostics and therapy.Until now,most strategies rely on a single trigger to control the formation of nanomaterials in situ.The combination of two or more triggers may provide for more sophisticated means of manipulation.In this study,we rationally designed a molecule(Comp.1)capable of responding to two enzymes,alkaline phosphatase(ALP),and reductase.Since the A549 lung cancer cell line showed elevated levels of extracellular ALP and intracellular reductase,we demonstrated that Comp.1 responded in a stepwise fashion to those two enzymes and displayed a tandem molecular self-assembly behavior.The selective formation of nanofibers in the mitochondria of the lung cancer cells led to the disruption of the mitochondrial membrane,resulting in an increased level of reactive oxygen species(ROS)and the release of cytochrome C(Cyt C).ROS can react with proteins,resulting in endoplasmic reticulum(ER)stress and the unfolded protein response(UPR).This severe ER stress led to disruption of the ER,formation of vacuoles,and ultimately,apoptosis of the A549 cells.Therefore,Comp.1 could selectively inhibit lung cancer cells in vitro and A549 xenograft tumors in vivo.Our study provides a novel strategy for the selective formation of nanomaterials in lung cancer cells,which is powerful and promising for the diagnosis and treatment of lung cancer. | Debin Zheng Yumiao Chen Sifan Ai Renshu Zhang Zhengfeng Gao Chunhui Liang Li Cao Yaoxia Chen Zhangyong Hong Yang Shi Ling Wang Xingyi Li Zhimou Yang | 2019 | Research2019，，1： | 1 |
| 6 | Enzyme-instructed and mitochondria-targeting peptide self-assembly to efficiently induce immunogenic cell death显示文摘Immunogenic cell death(ICD) plays a major role in cancer immunotherapy by stimulating specific T cell responses and restoring the antitumor immune system.However,effective type Ⅱ ICD inducers without biotoxicity are still very limited.Herein,a tentative drug-or photo sensitizer-free strategy was developed by employing enzymatic self-assembly of the peptide F-pY-T to induce mitochondrial oxidative stress in cancer cells.Upon dephosphorylation catalyzed by alkaline phosphatase overexpressed on cancer cells,the peptide F-pY-T self-assembled to form nanoparticles,which were subsequently internalized.These affected the morphology of mitochondria and induced serious reactive oxygen species production,causing the ICD characterized by the release of danger-associated molecular patterns(DAMPs).DAMPs enhanced specific immune responses by promoting the maturation of DCs and the intratumoral infiltration of tumor-specific T cells to eradicate tumor cells.The dramatic immunotherapeutic capacity could be enhanced further by combination therapy of F-pY-T and anti-PD-L1 agents without visible biotoxicity in the main organs.Thus,our results revealed an alternative strategy to induce efficient ICD by physically promoting mitochondrial oxidative stress. | Debin Zheng Jingfei Liu Limin Xie Yuhan Wang Yinghao Ding Rong Peng Min Cui Ling Wang Yongjie Zhang Chunqiu Zhang Zhimou Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 1 |
| 7 | Enzymatic hydrogelation of small molecules 显示文摘 | Yang Zhimou Liang Gaolin Xu Bing | 2008 | Accounts of Chemical Research2008，41，： | 1 |
| 8 | Facet-Selective 2D Self-Assembly of TiO2 Nanoleaves via Supramolecular Interactions显示文摘 | Cheng Yang Zhimou Yang Hongwei Gu | 2008 | Chemistry of Materials2008，20，： | 1 |
| 9 | 显示文摘 | Zhang Yah Gu Hongwei Yang Zhimou | 2003 | Am Chem Soc2003，125，13： | 1 |
| 10 | Organelle-inspired supramolecular nanomedicine to precisely abolish liver tumor growth and metastasis显示文摘Organelles are responsible for the efficient storage and transport of substances in living systems.A myriad of extracellular vesicles(EVs)acts as a bridge to exchange signaling molecules in cell-cell communication,and the highly dynamic tubulins and actins contribute to efficient intracellular substance transport.The inexhaustible cues of natural cargo delivery by organelles inspire researchers to explore the construction of biomimetic architectures for“smart”delivery carriers.Herein,we report a 10-hydroxycamptothecin(HCPT)-peptide conjugate HpYss that simulates the artificial EV-to-filament transformation process for precise liver cancer therapy.Under the sequential stimulus of extracellular alkaline phosphatase(ALP)and intracellular glutathione(GSH),HpYss proceeds via tandem self-assembly with a morphological transformation from nanoparticles to nanofibers.The experimental phase diagram elucidates the influence of ALP and GSH contents on the self-assembled nanostructures.In addition,the dynamic transformation of organelle-mimetic architectures that are formed by HpYss in HepG2 cells enables the efficient delivery of the anticancer drug HCPT to the nucleus,and the size-shape change from extracellular nanoparticles(50-100 nm)to intracellular nanofibers(4-9 nm)is verified to be of key importance for nuclear delivery.Nuclear targeting of HpYss amplifies apoptosis,thus significantly enhancing the inhibitory effect of HCPT(>10-fold)to HepG2 cells.Benefitting from the spatiotemporally controlled nanostructures,HpYss exhibited deep penetration,enhanced accumulation,and long-term retention in multicellular spheroid and xenograft models,potently abolishing liver tumor growth and preventing lung metastasis.We envision that our organelle-mimicking delivery strategy provides a novel paradigm for designing nanomedicine to cancer therapy. | Jie Zhan Yuhan Wang Shaodan Ma Qin Qin Ling Wang Yanbin Cai Zhimou Yang | 2022 | Bioactive Materials2022，7，3： | 1 |
| 11 | 显示文摘 | Yang Zhimou Wang Ling Xu Bing | 2010 | Matter Chem2010，20，11： | 1 |
| 12 | Dietary Litsea cubeba essential oil supplementation improves growth performance and intestinal health of weaned piglets显示文摘This paper was to determine the effects of dietary Litsea cubeba essential oil(LEO)supplementation on growth performance,immune function,antioxidant level,intestinal morphology and microbial composition in weaned piglets.One hundred and ninety-two piglets(Duroc×[Large White×Landrace])with 6.85±0.22 kg mean body weight weaned at 21 d of age were randomly assigned to 4 treatment groups with 8 replicates and were fed with a basal diet(CON)or CON diet containing 100(LLEO),200(MLEO)and 400(HLEO)mg/kg LEO.The results revealed that HLEO supplementation(P<0.05)increased the average daily gain on d 28 compared with CON.MLEO and HLEO supplementation decreased(P<0.05)feed conversion ratio.LEO-containing diets had a lower(P<0.05)diarrhea rate.Supple-mentation with HLEO increased(P<0.05)total antioxidant capacity(T-AOC)both in the serum and liver.Meanwhile,the supplementation of MLEO and HLEO resulted in higher(P<0.05)glutathione peroxidase(GPx)activities both in serum and liver.Supplementation of HLEO increased(P<0.05)serum immu-noglobulin A,immunoglobulin G and interleukin-10,whereas supplementation with MLEO and HLEO decreased(P<0.05)tumor necrosis factor-α.Villus height in the duodenum or jejunum was increased(P<0.05)in the HLEO group,and the villus height to crypt depth ratio in the jejunum was also improved(P<0.05)in the MLEO group.The addition of LEO increased(P<0.05)the richness and diversity of the microbial community in the cecum,which mainly increased the relative abundance of Oscillospir-aceae_UCG-005,Faecalibacterium,Blautia and Coprococcus.Piglets supplemented with HLEO increased(P<0.05)the concentration of short chain fatty acids(SCFA),including acetic acid in the cecum and propionic acid in the colon.In conclusion,these findings indicated that LEO supplementation improved growth performance and intestinal health in weaned piglets. | Zhe Yang Fang Wang Yexin Yin Peng Huang Qian Jiang Zhimou Liu Yulong Yin Jiashun Chen | 2023 | Animal Nutrition2023，，2： | 1 |
| 13 | Zirconium phosphate / Nation 115 composite membrane for high-concentration DMFC显示文摘 | Hou Hongying Sun Gongquan Wu Zhimou | 2008 | Int J Hydrogen Energy2008，33，： | 1 |
| 14 | CYP9E2,CYP4C21and related pseudogenes from German cockroaches,Blattella ger-manica:implications for molecular evolution,expression studies and nomenclature of P450s显示文摘 | Zhimou Wen C E H Jeffrey G Scott | 2001 | Gene2001，272，12： | 1 |
| 15 | Characterization and luminescence properties of a novel green emitting CaB 2 O 4 :Tb 3+ , Li + phosphor显示文摘 | Wenning Zhao Zhimou Xu Tangyou Sun Xinghui Wu Sisi Liu Zhichao Ma | 2014 | Solid State Communications2014，，： | 1 |
| 16 | Preorganization boosts the artificial esterase activity of a self-assembling peptide显示文摘The creation of artificial enzymes to mimic natural enzymes remains a great challenge owing to the complexity of the structural arrangement of the essential amino acids in catalytic centers.In this study,we used the phosphatase-based enzyme-instructed self-assembly(EISA)to supervise artificial esterases'final structures and catalytic activities.We reported that peptide precursors containing different phosphorylation sites could preorganize into alternated nanostructures and undergo dephosphorylation in the presence of alkaline phosphatase(ALP)with variation in kinetic and thermodynamic profiles.Although identical self-assembly compositions were formed after dephosphorylation,precursors with more enhanced preorganized states tended to better promote ALP dephosphorylation,facilitate further self-assembly,and strengthen the catalytic activities of the final assemblies.We envisioned that our strategy would be useful for further construction and manipulation of various artificial enzymes with superior catalytic activities. | Yaoxia Chen Wenwen Zhang Yinghao Ding Chunhui Liang Yang Shi Zhi-Wen Hu Ling Wang Zhimou Yang | 2021 | Science China Chemistry2021，64，9： | 1 |
| 17 | Recovery of Cu(Ⅱ) from aqueous solution by induced crystallization in a long-term operation显示文摘The feasibility of copper recovery by induced crystallization in a long period(174 days) was investigated in a seeded fluidized bed reactor(FBR). The process was divided into 3 periods according to different influent conditions, and the period III was separated into III-a and IIIb due to the adjustment of the molar ratio of CO_3^(2-)concentration to copper concentration([CT]/[Cu^(2+)]). The removal efficiency could exceed 95% and the average effluent copper concentration decreased to 3.0 mg/L. The mean particle size of seed grains with copper crystals coating on, raised to 0.36 mm from initial 0.18 mm. During period III-a, the supersaturation exceeded 2.88 × 104, the removal efficiency decreased to 60%–80% and the particle size dropped to 0.30 mm, due to the generation of fines by homogeneous crystallization and seeds breaking. And the morphology of the crystals on the seed grains changed from rod-like to spherical which lead to the particle size decreasing. In period III-b,the supersaturation was modified by adjusting the molar ratio of [CT]/[Cu2+] to 1.2 from 2.The efficiency was back to 95% and the mean particle size grew to 0.36 mm at the end of IIIb, the crystals coating on the seeds turned back to rod-like products of good stability. This study illustrated that the copper salt crystal could keep on growing on the seed grains for over 150 days, the feasibility and controllability of copper recovery by induced crystallization process in FBR were satisfactory, even under the dramatic changes in influent conditions. | Zhimou Wei Ya Xiong Jian Chen Jing Bai Jing Wu Jiane Zuo Kaijun Wang | 2018 | Journal of Environmental Sciences2018，30，7： | 1 |
| 18 | Enhanced Multi-phosphopeptide Enrichment and Nano LC-ESI-qTOF-MS Detection Strategy Using Click OEG-CD Matrix显示文摘 | ZHAO Yanyan WANG Liheng GUO Zhimou CHI Xiaofei MA Xiaochi QI Yan FANG Shinong LI Xiuling LIANG Xinmiao | 2015 | Chemical Research in Chinese Universities2015，31，1： | 1 |
| 19 | Seamless and early gap healing of osteochondral defects by autologous mosaicplasty combined with bioactive supramolecular nanofiber-enabled gelatin methacryloyl(BSN-GelMA)hydrogel显示文摘Autologous mosaicplasty is a common approach used to treat osteochondral defects in clinical practice.Gap integration between host and transplanted plugs requires bone tissue reservation and hyaline cartilage regeneration without uneven surface,graft necrosis and sclerosis.However,poor gap integration is a serious concern,which eventually leads to deterioration of joint function.To deal with such complications,this study has developed a strategy to effectively enhance integration of the gap region following mosaicplasty by applying injectable bioactive supramolecular nanofiber-enabled gelatin methacryloyl(GelMA)hydrogel(BSN-GelMA).A rabbit osteochondral defect model demonstrated that BSN-GelMA achieved seamless osteochondral healing in the gap region between plugs of osteochondral defects following mosaicplasty,as early as six weeks.Moreover,the International Cartilage Repair Society score,histology score,glycosaminoglycan content,subchondral bone volume,and collagen II expression were observed to be the highest in the gap region of BSN-GelMA treated group.This improved outcome was due to bio-interactive materials,which acted as tissue fillers to bridge the gap,prevent cartilage degeneration,and promote graft survival and migration of bone marrow mesenchymal stem cells by releasing bioactive supramolecular nanofibers from the GelMA hydrogel.This study provides a powerful and applicable approach to improve gap integration after autologous mosaicplasty.It is also a promising off-the-shelf bioactive material for cell-free in situ tissue regeneration. | Hongwei Wu Yuna Shang Wei Sun Xinyi Ouyang Wenyan Zhou Jieji Lu Shuhui Yang Wei Wei Xudong Yao g Xiaozhao Wang Xianzhu Zhang Yishan Chen Qiulin He Zhimou Yang Hongwei Ouyang | 2023 | Bioactive Materials2023，，1： | 1 |
| 20 | Metabolism of liner and angular furanocoumarins by Papilio polyxenes CYP6B1 co-expressed with NADPH cytochrome P450 reductase显示文摘 | Zhimou Wen Liping Pan Berenbaum M R | 2003 | Insect Biochemistry and Molecular Biology2003，33，： | 1 |
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