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| 1 | PM_(2.5) in China:Measurements,sources,visibility and health effects,and mitigation显示文摘Concern over the health effects of fine particles in the ambient environment led the U.S. Environmental Protection Agency to develop the first standard for PM2.5(particulate matter less than 2.5 jxm) in 1997. The Particle Technology Laboratory at the University of Minnesota has helped to establish the PM2.5 standard by developing many instruments and samplers to perform atmospheric measurements. In this paper, we review various aspects of PM2.5, including its measurement, source apportionment, visibility and health effects, and mitigation. We focus on PM2.5 studies in China and where appropriate, compare them with those obtained in the U.S. Based on accurate PM2.5 sampling, chemical analysis, and source apportionment models, the major PM2.5 sources in China have been identified to be coal combustion, motor vehicle emissions, and industrial sources. Atmospheric visibility has been found to correlate well with PM2.5concentration. Sulfate, ammonium, and nitrate carried by PM2.5, commonly found in coal burning and vehicle emissions, are the dominant contributors to regional haze in China. Short-term exposure to PM2.5 is strongly associated with the increased risk of morbidity and mortality from cardiovascular and respiratory diseases in China. The strategy for PM2.5 mitigation must be based on reducing the pollutants from the two primary sources of coal-fired power plants and vehicle emissions. Although conventional Particulate Emission Control Devices(PECD) such as electrostatic precipitators in Chinese coal-fired power plants are generally effective for large particles, most of them may not have high collection efficiency of PM2.5.Baghouse filtration is gradually incorporated into the PECD to increase the PM2.5 collection efficiency.By adopting stringent vehicle emissions standard such as Euro 5 and 6, the emissions from vehicles can be gradually reduced over the years. An integrative approach, from collaboration among academia,government, and industries, can effectively manage and mitigate the PM2.5 pollution in China. | David Y.H.Pui Sheng-Chieh Chen Zhili Zuo | 2014 | Particuology2014，12，2： | 171 |
| 2 | Antitumor Research on Artemisinin and Its Bioactive Derivatives显示文摘Cancer is the leading cause of human death which seriously threatens human life.The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties.Simultaneously,a variety of target-selective artemisinin-related compounds with high efficiency have been discovered.Many researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects,including inhibiting the proliferation of tumor cells,promoting apoptosis,inducing cell cycle arrest,disrupting cancer invasion and metastasis,preventing angiogenesis,mediating the tumor-related signaling pathways,and regulating tumor microenvironment.More importantly,artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients.Therefore,we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 years.It is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents. | Yunqin Zhang Guowei Xu Shuqun Zhang Dong Wang PSaravana Prabha Zhili Zuo | 2018 | Natural Products and Bioprospecting2018，8，4： | 8 |
| 3 | Pharmacophore-directed Homology Modeling and Molecular Dynamics Simulation of G Protein-coupled Receptor: Study of Possible Binding Modes of 5-HT_(2C) Receptor Agonists显示文摘一个新基于 pharmacophore 的建模过程包括相同建模, pharmacophore 学习,灵活分子的停靠,并且长期的分子的动力学(MD ) 模拟,被采用构造人的 5-HT_(2C ) 的结构受体并且决定 5-HT_(2C ) 的有约束力的模式的特征受体收缩筋。基于一些高活跃的混合物基于当模特儿的相同和一个 pharmacophore 假设模型构造的收缩筋受体建筑群过时的人或物。然后,在明确的膜环境的 ligand 受体建筑群的 MD 模拟被执行。5-HT_(2C ) 的符合构造受体在 MD 模拟期间被探索,并且学习收缩筋的稳定的有约束力的模式是坚定的。几在结构上的灵活分子的停靠人的 5-HT_(2C ) 的多样的收缩筋受体被执行,并且这些收缩筋的一般有约束力的模式被调查。根据在这个工作和Flexi船坞的结果介绍的模型的意见,氨基酸残余毒蛇 134 的参与, Serl38 , Asn210 , Asn331 , Tyr358 , Ile131 , Serl32 , Vall35 , Thrl39 , Ilel89 , Val202 , Val208 , Leu209 , Phe214 , Val215 , Gly218 , Ser219 ,在收缩筋识别的 Phe223 , Trp324 , Phe327 ,和 Phe328 被学习。对指导地点的傻瓜发育不全数据和其它的好同意学习的受体收缩筋有的人的 5-HT_(2C ) 的获得的有约束力的模式。 | Zhili ZUO Gang CHEN Xiaomin LUO Chummok PUAH Weiliang ZHU Kaixian CHEN Hualiang JIANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，6： | 1 |
| 4 | Quebrachitol:Global Status and Basic Research显示文摘Recently,there has been a renewed interest in the natural-products-inspired drugs.Quebrachitol(QCT)is one of naturally occurring optically active cyclitols that has now received considerable attention.Until the last decade,it came to be a starting point for the lead discovery.In this review,we had a discussion on the basic research of QCT,including its source,structure,properties,and the recent advances on its application.The biological activities and QCT-inspired leads that are potentially effective for treating human diseases were also discussed. | Dong Wang Shuqun Zhang Zhe Chang De-Xin Kong Zhili Zuo | 2017 | Natural Products and Bioprospecting2017，7，1： | 1 |
| 5 | Towards growth of pure AB-stacked bilayer graphene single crystals显示文摘Given its intriguing band structure and unique tunable bandgap,AB-stacked bilayer graphene has great potentials in the applications of high-end electronics,optoelectronics and semiconductors.The epitaxial growth of AB-stacked single-crystal bilayer graphene films requires a strict AB-stacked lattice,identical orientations and seamless stitching of bilayer graphene islands.However,the particles inevitably present on the metal surface that produced during high temperature growth would induce random orientations,twisted stacking islands,and uncontrollable multilayers,which is a great challenge to overcome.Here,we propose a heat-resisting-box assisted strategy to produce nearly pure AB-stacked bilayer graphene single-crystal films on Cu/Ni(111)foils.With our technique,the particles on the Cu/Ni(111)surface are effectively eliminated,which greatly minimizes the occurrence of randomly twisted islands and uncontrollable multilayers.The as-grown AB-stacked bilayer graphene films show>99%alignment and>99%AB stacking order.Our work provides a promising method towards the growth of pure AB-stacked bilayer graphene single crystals and would accelerate its device applications. | Xiaowen Zhang Tao Zhou Yunlong Ren Zuo Feng Ruixi Qiao Qinghe Wang Bin Wang Jinxia Bai Muhong Wu Zhilie Tang Xu Zhou Kaihui Liu Xiaozhi Xu | 2024 | Nano Research2024，17，5： | 0 |
| 6 | Screening of Host Proteins Interacting with PorcineEpidemic Diarrhea Virus (PEDV) N Protein by YeastTwo-hybrid System显示文摘[Objective] The paper was to obtain host proteins interacting with porcine epidemic diarrhea virus(PEDV) N protein. [Method] The recombinant vector pGBKT7-N of PEDV N gene was constructed and used as the bait plasmid to screen the proteins interacting with N protein of PEDV from the cDNA library of porcine alveolar macrophage(PAM) by yeast two-hybrid method. [Result] There was no toxicity and self activation of bait protein in yeast hybridization system, and six proteins(FTH1, LGALS3, CORO1C, SNRPG, KRTAP5-3, ZNF598) interacting with N protein were indentified. It was confirmed that LGALS3 and SNRPG had specific interaction with N protein by return experiment and co-immunoprecipitation(CoIP) test. [Conclusion] The study lays a foundation for further studying the function of PEDV N protein and the pathogenic mechanism of PEDV. | Wang Zhongze Qin Cuili Kong Ning Zuo Yewen Wang Meng Zheng Hao Tong Wu Li Liwei Yu Hai Li Zhili Shan Tongling Tong Guangzhi Li Xue | 2018 | Animal Husbandry and Feed Science2018，10，4： | 0 |
| 7 | Roles of trichomes in tea plant resistance against multiple abiotic and biotic stresses显示文摘Tea trichomes contribute significantly to tea flavors by providing diverse and specific flavor-determining metabolites,including catechins,caffeine,theanine,and volatiles.However,not much is known about the physiological functions of tea trichomes in tea plant adaptation to complex environments,nor the trichome development.Tea trichomes not only build up chemical defenses,but also act as the first physical barrier protecting herbivore attacks,reflecting high light and UV-B radiation,and preventing water loss.Moreover,transcriptome profiling on the tea trichomes compared with the trichome-removed leaves also showed that tea trichomes highly expressed numerous defense-related genes involved in protection from high light and UV-B radiation,cold stress,disease resistance signal transduction,anti-herbivore or anti-abiotic peptide biosynthesis,and other defense responses.Several pieces of experimental evidence supported the notes,highlighting the roles of tea trichomes in plant defenses against both abiotic and biotic stresses.The study provides fresh insights into the multiple protective functions of tea trichome for tea plant adaptation to harsh environments.The new understanding on tea trichomes could benefit the development of better breading strategy for new tea varieties with greater adaption and tolerance to changing environmental challenges. | Penghui Li Yanrui Zhang Zhili Ye Hao Zuo Ping Li Xuecheng Zhao Zhihui Chen Changsong Chen Jian Zhao | 2022 | Beverage Plant Research2022，2，1： | 0 |
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