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| 1 | Luminescent metal nanoclusters for biomedical applications显示文摘Luminescent metal nanoclusters (NCs) have recently emerged as a novel class of luminescent nanomaterials and hold significant potential in biomedicine owing to their ultrasmall (<2nm) size,excellent photostability,and good biocompatibility.The recent rapid advances in the synthesis and functionalization of luminescent metal NCs have enabled scientists to develop colorful nanomaterials and nanodevices for a wide range of biomedical applications.In this review,we summarize the characteristics and advantages of luminescence from metal NCs,and highlight their applications in biomedicine.We focus on the research in biomedical detection,bio-imaging,drug delivery,and therapy,especially for the advances in the last five years.Luminescent metal NCs display a series of unique superiorities in biomedical applications,and the recent achievements have brought a lot of benefits to the diagnosis and treatment of clinical diseases,especially for tumors and cancers.Finally,we put forward the main challenges that currently still hinder the basic science studies and the practical development of luminescent metal NCs in biomedical applications.Overall,we expect that luminescent metal NCs will play a much more important role in future biomedicine and clinical applications. | Yu Su Tiantian Xue Yuxin Liu Jinxia Qi Rongchao Jin Zhenkun Lin | 2019 | Nano Research2019，12，6： | 6 |
| 2 | Machine Learning-Based Multi-Modal Information Perception for Soft Robotic Hands显示文摘This paper focuses on multi-modal Information Perception(IP)for Soft Robotic Hands(SRHs)using Machine Learning(ML)algorithms.A flexible Optical Fiber-based Curvature Sensor(OFCS)is fabricated,consisting of a Light-Emitting Diode(LED),photosensitive detector,and optical fiber.Bending the roughened optical fiber generates lower light intensity,which reflecting the curvature of the soft finger.Together with the curvature and pressure information,multi-modal IP is performed to improve the recognition accuracy.Recognitions of gesture,object shape,size,and weight are implemented with multiple ML approaches,including the Supervised Learning Algorithms(SLAs)of K-Nearest Neighbor(KNN),Support Vector Machine(SVM),Logistic Regression(LR),and the unSupervised Learning Algorithm(un-SLA)of K-Means Clustering(KMC).Moreover,Optical Sensor Information(OSI),Pressure Sensor Information(PSI),and Double-Sensor Information(DSI)are adopted to compare the recognition accuracies.The experiment results demonstrate that the proposed sensors and recognition approaches are feasible and effective.The recognition accuracies obtained using the above ML algorithms and three modes of sensor information are higer than 85 percent for almost all combinations.Moreover,DSI is more accurate when compared to single modal sensor information and the KNN algorithm with a DSI outperforms the other combinations in recognition accuracy. | Haiming Huang Junhao Lin Linyuan Wu Bin Fang Zhenkun Wen Fuchun Sun | 2020 | Tsinghua Science and Technology2020，25，2： | 4 |
| 3 | Clinical relevance of angiographic coronary collaterals during primary coronary intervention for acute ST-elevation myocardial infarction显示文摘 | Shen Ying Wu Feng Pan Chunzang Zhu Tianqi Zhang Qi Zhang Ruiyan Ding Fenghua Lu Lin Hu Jian Yang Zhenkun Shen Weifeng Wu Zonggui | 2014 | Chinese Medical Journal2014，，1： | 2 |
| 4 | Wavelength-swept fiber laser based on bidirectional used linear chirped fiber Bragg grating显示文摘A wavelength-swept fiber laser is proposed and successfully demonstrated based on a bidirectional used linear chirped fiber Bragg grating(LC-FBG). The wavelength-swept operation principle is based on intracavity pulse stretching and compression. The LC-FBG can introduce equivalent positive and negative dispersion simultaneously, which enables a perfect dispersion matching to obtain wide-bandwidth mode-locking. Experimental results demonstrate a wavelength-swept fiber laser that exhibits a sweep rate of about 5.4 MHz over a 2.1 nm range at a center wavelength of 1550 nm. It has the advantages of simple configuration and perfect dispersion matching in the laser cavity. | LIN WANG MINGGUI WAN ZHENKUN SHEN XUDONG WANG YUAN CAO XINHUAN FENG BAI-OU GUAN | 2017 | Photonics Research2017，5，3： | 1 |
| 5 | A novel superparamagnetic surface mo- lecularly imprinted nanoparticle adopting dummy template: An efficient solid-phase extraction adsorbent for bisphenol A 显示文摘 | Lin Zhenkun | 2012 | Anal Chim Acta2012，720，： | 1 |
| 6 | Preparation of magnetic multi-functional molecularly imprinted polymer beads for determining environmental estrogens in water samples显示文摘 | Lin Zhenkun He Qiaoya Wang Lituo | 2013 | Journal of Hazardous Materials2013，25，15： | 1 |
| 7 | Preparation of magnetic multi-functional molecularly imprinted polymer beads for determining environmental estrogens in water samples显示文摘 | Zhenkun Lin Qiaoya He Lituo Wang Xuedong Wang Qiaoxiang Dong Changjiang Huang | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 8 | Polybrominated diphenyl ethers in water, sediment, soil, and biological samples from different industrial areas in Zhejiang, China 显示文摘 | WANG Junxia LIN Zhenkun LIN Kuangfei | 2011 | J Hazard Mater2011，197，： | 1 |
| 9 | A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors显示文摘Poly(ADP-ribose)polymerase(PARP)inhibitors are one of the most exciting classes of targeted therapy agents for cancers with homologous recombination(HR)deficiency.However,many patients without apparent HR defects also respond well to PARP inhibitors/cisplatin.The biomarker responsible for this mechanism remains unclear.Here,we identified a set of ribosomal genes that predict response to PARP inhibitors/cisplatin in HR-proficient patients.PARP inhibitor/cisplatin selectively eliminates cells with high expression of the eight genes in the identified panel via DNA damage(ATM)signaling-induced pro-apoptotic ribosomal stress,which along with ATM signaling-induced pro-survival HR repair constitutes a new model to balance the cell fate in response to DNA damage.Therefore,the combined examination of the gene panel along with HR status would allow for more precise predictions of clinical response to PARP inhibitor/cisplatin.The gene panel as an independent biomarker was validated by multiple published clinical datasets,as well as by an ovarian cancer organoids library we established.More importantly,its predictive value was further verified in a cohort of PARP inhibitor-treated ovarian cancer patients with both RNA-seq and WGS data.Furthermore,we identified several marketed drugs capable of upregulating the expression of the genes in the panel without causing HR deficiency in PARP inhibitor/cisplatin-resistant cell lines.These drugs enhance PARP inhibitor/cisplatin sensitivity in both intrinsically resistant organoids and cell lines with acquired resistance.Together,our study identifies a marker gene panel for HR-proficient patients and reveals a broader application of PARP inhibitor/cisplatin in cancer therapy. | Chao Zhang Qiang Guo Lifeng Chen Zheming Wu Xiao-Jian Yan Chengyang Zou Qiuxue Zhang Jiahong Tan Tian Fang Qunxian Rao Yang Li Shizhen Shen Min Deng Liewei Wang Huanyao Gao Jia Yu Hu Li Cheng Zhang Somaira Nowsheen Jake Kloeber Fei Zhao Ping Yin Chunbo Teng Zhongqiu Lin Kun Song Shuzhong Yao Liangqing Yao Lingying Wu Yong Zhang Xiaodong Cheng Qinglei Gao Jian Yuan Zhenkun Lou Jin-San Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 10 | Facile Modification on Buried Interface for Highly Efficient and Stable FASn_(0.5)Pb_(0.5)I_(3) Perovskite Solar Cells with NiOx Hole-Transport layers显示文摘Formamidinium(FA)-based Sn-Pb perovskite solar cells(FAPb_(0.5)Sn_(0.5)I_(3) PSCs)with ideal bandgap and impressive thermal stability have caught enormous attention recently.However,it still suffers from the challenge of realizing high efficiency due to the surface imperfections of the transport materials and the energy-level mismatch between functional contacts.Herein,it is demonstrated that the modification on buried interface with alkali metal salts is a viable strategy to alleviate these issues.We systematically investigate the role of three alkali metal bromide salts(NaBr,KBr,CsBr)by burying them between the NiOx hole transport layer(HTL)and the perovskite light-absorbing layer,which can effectively passivate interface defects,improve energy-level matching and release the internal residual strain in perovskite layers.The device with CsBr buffer layer exhibits the best power conversion efficiency(PCE)approaching 20%,which is one of the highest efficiencies for FA-based Sn-Pb PSCs employing NiO_(x) HTLs.Impressively,the long-term storage stability of the unencapsulated device is also greatly boosted.Our work provides an efficient strategy to prepare desired FA-based ideal-bandgap Sn-Pb PSCs which could be applied in tandem solar cells. | Hui Zhang Yuan Zhou Tonghui Guo Xiang Zhang Zhenkun Zhu Junjun Jin Xiaxia Cui Dan Zhang Zhen Wang Lin Li Nai Wang Guanqi Tang Qidong Tai | 2023 | Chinese Journal of Chemistry2023，41，23： | 0 |
| 11 | Rectified Ion Transport in Ultra-thin Membrane Governed by Outer Membrane Electric Double Layer显示文摘of main observation and conclusion The outstanding combination of selectivity and permeability observed in ultra-thin nanoporous mem-branes atracts broad interest from both fundamental research and practical application aspects.t is reported that the asymmetrical ion transport can berealized through the modfication of polyelectrolytes on the outer membranes surface.However,the related mechanisms are til nclear which hinderstheir applications.Herein,we systematclly investigate the origin of the ion current rectification in heterogeneously charged ultra-thin nanopores.Thecalcuated resuts based on the contiuity model suggest that,the ion transport across the ulra-thin membrane is dominated by the charge on the outermembrane surfoce rather than the pore wal.the overlap of electric double layer outside the pore entrance is essential fpr the ion asymmetric transport.And t acordingly results in the fact that the ion concentration enrichment and depletion effect ocurring outside the nanopore orifices governs the highand low ionic conductance states under the applied bias.These features can be regulated by the membrane surface state,which is truly attractive be.Ccause the surfaces of the outer membrane can be easily modified by experimental approaches.These findings provide the renew inspiration for the design of high-performance 2D nanofluidic devices. | Zhenkun Zhang Chao Wang Lingxin Lin Mengyi Xu Yichun Wu Liuxuan Cao | 2020 | Chinese Journal of Chemistry2020，38，12： | 0 |
| 12 | Volumetric Imaging of Neural Activity by Light Field Microscopy显示文摘Recording the highly diverse and dynamic activities in large populations of neurons in behaving animals is crucial for a better understanding of how the brain works.To meet this challenge,extensive efforts have been devoted to developing functional fluorescent indicators and optical imaging techniques to optically monitor neural activity.Indeed,optical imaging potentially has extremely high throughput due to its non-invasive access to large brain regions and capability to sample neurons at high density,but the readout speed,such as the scanning speed in two-photon scanning microscopy,is often limited by various practical considerations.Among different imaging methods,light field microscopy features a highly parallelized 3D fluorescence imaging scheme and therefore promises a novel and faster strategy for functional imaging of neural activity.Here,we briefly review the working principles of various types of light field microscopes and their recent developments and applications in neuroscience studies.We also discuss strategies and considerations of optimizing light field microscopy for different experimental purposes,with illustrative examples in imaging zebrafish and mouse brains. | Lu Bai Zhenkun Zhang Lichen Ye Lin Cong Yuchen Zhao Tianlei Zhang Ziqi Shi Kai Wang | 2022 | Neuroscience Bulletin2022，38，12： | 0 |
| 13 | Dysregulation of PLOD2 Promotes Tumor Metastasis and Invasion in Hepatocellular Carcinoma显示文摘Background and Aims:Metastasis is a major factor associated with high recurrence and mortality in hepatocellular carcinoma(HCC)patients while the underlying mechanism of metastasis remains elusive.In our study,procollagen-lysine,2-oxoglutarate 5-dioxygenase 2(PLOD2)was shown to be involved in the process of metastasis in HCC.Methods:The Cancer Genome Atlas(TCGA)database and HCC tissue microarrays were used to evaluate the expression of genes.In vitro migration,invasion,in vivo subcutaneous tumor model and in vivo lung metastasis assays were used to determine the role of PLOD2 in tumor growth and metastasis in HCC.RNA sequencing and gene set enrichment analysis were performed to uncover the downstream factor of PLOD2 in HCC cells.A luciferase reporter assay was performed to evaluate the interaction between PLOD2 and interferon regulatory factor 5(IRF5).Results:The expression of PLOD2 in HCC tissues was higher than that in adjacent tissues,and increased PLOD2 expression was often found in advanced tumors and was correlated with poor prognosis in HCC patients.In vitro experiments,knockdown of PLOD2 reduced the migration and invasion of human HCC cells.Loss of PLOD2 suppressed human HCC growth and metastasis in a subcutaneous tumor model and a lung metastasis model.Baculoviral IAP repeat containing 3(BIRC3)was proven to be the downstream factor of PLOD2 in human HCC cells.In addition,PLOD2 was transcriptionally regulated by IRF5 in HCC cells.Conclusions:High expression of PLOD2 was regulated by IRF5,which was correlated with the poor survival of HCC patients.PLOD2 enhanced HCC metastasis via BIRC3,suggesting that PLOD2 might be a valuable prognostic biomarker for HCC treatment. | Keren Li Yi Niu Kai Li Chengrui Zhong Zhiyu Qiu Yichuan Yuan Yunxing Shi Zhu Lin Zhenkun Huang Dinglan Zuo Yunfei Yuan Binkui Li | 2023 | Journal of Clinical and Translational Hepatology2023，11，5： | 0 |
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