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| 1 | Direct generation of an ultrafast vortex beam in a CVD-graphene-based passively mode-locked Pr:LiYF4 visible laser显示文摘We report on the direct generation of passively mode-locked vortex lasers in the visible spectral region, for the first time to the best of our knowledge, using a Pr :Li YF4(Pr:YLF) crystal as the gain medium. A stable mode-locked TEM00 mode has been achieved with a maximum average output power of 75 m W using a graphene saturable absorber mirror. The mode-locked pulse width is measured to be as short as about 73.4 ps at a repetition rate of about 140 MHz, and the laser wavelength is at about 721 nm with spectral width of about 0.5 nm. By slightly misaligning the laser resonator, a first-order Laguerre-Gaussian mode(LG0,1) has also been obtained with output power reduced to about 22 m W. The achieved LG0,1 mode has been verified via a home made improved Fizeau interferometer. This work provides a simple and universal method for direct generation of an ultrafast vortex laser,which can be readily extended to other spectral regions by using different laser gain mediums. | Nan Li Junjie Huang Bin Xu Yaqi Cai Jie Lu Linjie Zhan Zhengqian Luo Huiying Xu Zhiping Cai Weiwei Cai | 2019 | Photonics Research2019,7,11: | 9 |
| 2 | Nonlinear optical absorption of few-layer molybdenum diselenide (MoSe2) for passively mode-locked soliton fiber laser [Invited]显示文摘In this paper,both nonlinear saturable absorption and two-photon absorption(TPA) of few-layer molybdenum diselenide(MoSe2) were observed at 1.56 μm wavelength and further applied to mode-locked ultrafast fiber laser for the first time to our knowledge.Few-layer MoSe2 nanosheets were prepared by liquid-phase exfoliation method and characterized by x ray diffractometer,Raman spectroscopy,and atomic force microscopy.The obtained fewlayer MoSe2 dispersion is further composited with a polymer material for convenient fabrication of MoSe2 thin films.Then,we investigated the nonlinear optical(NLO) absorption property of the few-layer MoSe2 film using a balanced twin-detector measurement technique.Both the saturable absorption and TPA effects of the few-layer MoSe2 film were found by increasing the input optical intensity.The saturable absorption shows a modulation depth of 0.63% and a low nonsaturable loss of 3.5%,corresponding to the relative modulation depth of 18%.The TPA effect occurred when the input optical intensity exceeds 260 MW∕cm2.Furthermore,we experimentally exploit the saturable absorption of few-layer MoSe2 film to mode lock an all-fiber erbium-doped fiber laser.Stable soliton mode locking at 1558 nm center wavelength is achieved with pulse duration of 1.45 ps.It was also observed that the TPA process suppresses the mode-locking operation in the case of higher optical intensity.Our results indicate that layered MoSe2,as another two-dimensional nanomaterial,can provide excellent NLO properties(e.g.,saturable absorption and TPA) for potential applications in ultrashort pulse generation and optical limiting. | Zhengqian Luo Yingyue Li Min Zhong Yizhong Huang Xiaojiao Wan Jian Peng Jian Weng | 2015 | Photonics Research2015,3,3: | 8 |
| 3 | Neurological manifestations of patients with COVID-19:potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has caused a global pandemic in only 3 months.In addition to major respiratory distress,characteristic neurological manifestations are also described,indicating that SARS-CoV-2 may be an underestimated opportunistic pathogen of the brain.Based on previous studies of neuroinvasive human respiratory coronaviruses,it is proposed that after physical contact with the nasal mucosa,laryngopharynx,trachea,lower respiratory tract,alveoli epithelium,or gastrointestinal mucosa,SARS-CoV-2 can induce intrinsic and innate immune responses in the host involving increased cytokine release,tissue damage,and high neurosusceptibility to COVID-19,especially in the hypoxic conditions caused by lung injury.In some immunecompromised individuals,the virus may invade the brain through multiple routes,such as the vasculature and peripheral nerves.Therefore,in addition to drug treatments,such as pharmaceuticals and traditional Chinese medicine,non-pharmaceutical precautions,including facemasks and hand hygiene,are critically important. | Zhengqian Li Taotao Liu Ning Yang Dengyang Han Xinning Mi Yue Li Kaixi Liu Alain Vuylsteke Hongbing Xiang Xiangyang Guo | 2020 | Frontiers of Medicine2020,14,5: | 5 |
| 4 | Direct generation of watt-level yellow Dy^(3+)-doped fiber laser显示文摘Yellow lasers(∼565–590 nm)are of tremendous interest in biomedicine,astronomy,spectroscopy,and display technology.So far,yellow lasers still have relied heavily on nonlinear frequency conversion of near-infrared lasers,precluding compact and low-cost yellow laser systems.Here,we address the challenge through demonstrating,for the first time,to the best of our knowledge,watt-level high-power yellow laser generation directly from a compact fiber laser.The yellow fiber laser simply consists of a Dy^(3+)-doped ZBLAN fiber as gain medium,a fiber end-facet mirror with high reflectivity at yellow and a 450-nm diode laser as the pump source.We comprehensively investigated the dependence of the yellow laser performance on the output coupler reflectivity and the gain fiber length and demonstrated that the yellow fiber laser with an output coupler reflectivity of 4% and a gain fiber length of∼1.8 m yields a maximum efficiency of 33.6%.A maximum output power of 1.12 W at 575 nm was achieved at a pump power of 4.20 W.This work demonstrated the power scaling of yellow Dy^(3+)-doped ZBLAN fiber lasers,showing their promise for applications in ophthalmology,astronomical exploration,and high-resolution spectroscopy. | Jinhai Zou Tianran Li Yanbo Dou Jin Li Nan Chen Yikun Bu Zhengqian Luo | 2021 | Photonics Research2021,9,4: | 5 |
| 5 | Mid‐infrared all‐fiber gain‐switched pulsed laser at 3μm显示文摘Mid-infrared(MIR)fiber pulsed lasers are of tremendous application interest in eye-safe LIDAR,spectroscopy,chemical detection and medicine.So far,these MIR lasers largely required bulk optical elements,complex free-space light alignment and large footprint,precluding compact all-fiber structure.Here,we proposed and demonstrated an all-fiberized structured gain-switched Ho3+-doped ZBLAN fiber laser operating around 2.9μm.A home-made 1146 nm Raman fiber pulsed laser was utilized to pump highly concentrated single-cladding Ho3+-doped ZBLAN fiber with different lengths of 2 m or 0.25 m.A home-made MIR fiber mirror and a perpendicular-polished ZBLAN fiber end construct the all-fiberized MIR cavity.Stable gain-switched multiple states with a sub-pulse number tuned from 1 to 8 were observed.The effects of gain fiber length,pump power,pump repetition rate and output coupling ratio on performance of gain-switched pulses were further investigated in detail.The shortest pulse duration of 283 ns was attained with 10 kHz repetition rate.The pulsed laser,centered at 2.92μm,had a maximum average output power of 54.2 mW and a slope efficiency of 10.12%.It is,to the best of our knowledge,the first time to demonstrate a mid-infrared gain-switched Ho3+:ZBLAN fiber laser with compact all-fiber structure. | Xiaojin Zhang Weiwei Li Jin Li Huiying Xu Zhiping Cai Zhengqian Luo | 2020 | Opto-Electronic Advances2020,3,5: | 4 |
| 6 | The brain,another potential target organ,needs early protection from SARS-CoV-2 neuroinvasion显示文摘With the outbreak and rapid spread of the novel coronavirus disease(COVID-19)around the world,humans are engaged in a life-and-death battle with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),formerly known as 2019-Novel Coronavirus(2019-nCoV). | Zhengqian Li Yuguang Huang Xiangyang Guo | 2020 | Science China(Life Sciences)2020,63,5: | 3 |
| 7 | 3.6 W compact all-fiber Pr3+-doped green laser at 521 nm显示文摘Green semiconductor lasers are still undeveloped,so high-power green lasers have heavily relied on nonlinear frequency conversion of near-infrared lasers,precluding compact and low-cost green laser systems.Here,we report the first Watt-level all-fiber CW Pr3t-doped laser operating directly in the green spectral region,addressing the aforementioned difficulties.The compact all-fiber laser consists of a double-clad Pr3t-doped fluoride fiber,two homemade fiber dichroic mirrors at visible wavelengths,and a 443-nm fiber-pigtailed pump source.Benefitting from>10 MW∕cm2 high damage intensity of our designed fiber dielectric mirror,the green laser can stably deliver 3.62-W of continuous-wave power at∼521 nm with a slope efficiency of 20.9%.To the best of our knowledge,this is the largest output power directly from green fiber lasers,which is one order higher than previously reported.Moreover,these green all-fiber laser designs are optimized by using experiments and numerical simulations.Numerical results are in excellent agreement with our experimental results and show that the optimal gain fiber length,output mirror reflectivity,and doping level should be considered to obtain higher power and efficiency.This work may pave a path toward compact high-power green all-fiber lasers for applications in biomedicine,laser display,underwater detection,and spectroscopy. | Jinhai Zou Jinfen Hong Zhuang Zhao Qingyuan Li Qiujun Ruan Hang Wang Yikun Bu Xianchao Guan Min Zhou Zhiyong Feng Zhengqian Luo | 2022 | Advanced Photonics2022,4,5: | 2 |
| 8 | Regional Metabolic Patterns of Abnormal Postoperative Behavioral Performance in Aged Mice Assessed by XH-NMR Dynamic Mapping Method显示文摘Abnormal postoperative neurobehavioral performance(APNP)is a common phenomenon in the early postoperative period.The disturbed homeostatic status of metabolites in the brain after anesthesia and surgery might make a significant contribution to APNP.The dynamic changes of metabolites in different brain regions after anesthesia and surgery,as well as their potential association with APNP are still not well understood.Here,we used a battery of behavioral tests to assess the effects of laparotomy under isoflurane anesthesia in aged mice,and investigated the metabolites in 12 different sub-regions of the brain at different time points using proton nuclear magnetic resonance('H-NMR)spectroscopy.The abnormal neurobehavioral performance occurred at 6 h and/or 9 h,and recovered at 24 h after anesthesia/surgery.Compared with the control group,the altered metabolite of the model group at 6 h was aspartate(Asp),and the difference was mainly displayed in the cortex;while significant changes at 9 h occurred predominantly in the cortex and hippocampus,and the corresponding metabolites were Asp and glutamate(Glu).All changes returned to baseline at 24 h.The altered metabolic changes could have occurred as a result of the acute APNP,and the metabolites Asp and Glu in the cortex and hippocampus could provide preliminary evidence for understanding the APNP process. | Taotao Liu Zhengqian Li Jindan He Ning Yang Dengyang Han Yue Li Xuebi Tian Huili Liu Anne Manyande Hongbing Xiang Fuqiang Xu Jie Wang Xiangyang Guo | 2020 | Neuroscience Bulletin2020,36,1: | 2 |
| 9 | 212-kHz-linewidth,transform-limited pulses from a single-frequency Q-switched fiber laser based on a few-layer Bi_2Se_3 saturable absorber显示文摘Conventional Q-switched fiber lasers operating at multi-longitudinal-mode oscillation usually suffer from selfmode-locking-induced temporal instability, relatively strong noise, and low coherence. Here, we address the challenge through demonstrating, for the first time, to the best of our knowledge, a single-longitudinal-mode(SLM)Er-doped fiber(EDF) laser passively Q-switched by a few-layer Bi_2Se_3 saturable absorber(SA). The Bi_2Se_3 SA prepared by the liquid-phase exfoliation method shows a modulation depth of ~5% and saturation optical intensity of 1.8 MW∕cm^2. A section of 1-m unpumped EDF together with a 0.06-nm-bandwidth fiber Bragg grating is used as an ultra-narrow autotracking filter to realize SLM oscillation. Stable SLM Q-switching operation at 1.55 μm is successfully achieved with the spectral linewidth as narrow as 212 kHz and the pulse duration of2.54 μs, manifesting near-transform-limited pulses with a time-bandwidth product of 0.53. In particular, we found that the SLM Q-switching possesses the higher signal-to-noise ratios of 62 dB(optical) and 48 dB(radio frequency), exhibiting its advantages of low noise and high stability. Such an SLM Q-switched fiber laser could gain great interest for some applications in coherent detection, coherent optical communications, and high-sensitivity optical sensing. | WEIWEI LI JINHAI ZOU YIZHONG HUANG KAIJIE WANG TUANJIE DU SHUISEN JIANG ZHENGQIAN LUO | 2018 | Photonics Research2018,6,10: | 1 |
| 10 | A new fluorescence “turn-on” type chemosensor for Fe 3+ based on naphthalimide and coumarin显示文摘 | Zhengqian Li Ying Zhou Kai Yin Zhu Yu Yan Li Jun Ren | 2014 | Dyes and Pigments2014,,: | 1 |
| 11 | Direct generation of 3.17 mJ green pulses in a cavity-dumped Ho^(3+)-doped fiber laser at 543 nm显示文摘High-energy pulsed lasers in the green spectral region are of tremendous interest for applications in space laser ranging,underwater detection,precise processing,and scientific research.Semiconductor pulsed lasers currently are difficult to access to the so-called“green gap,”and high-energy green pulsed lasers still heavily rely on the nonlinear frequency conversion of near-IR lasers,precluding compact and low-cost green laser systems.Here,we address this challenge by demonstrating,for the first time to the best of our knowledge,millijoule-level green pulses generated directly from a fiber laser.The green pulsed fiber laser consists of a 450 nm pump laser diode,a Ho^(3+)-doped ZBLAN fiber,and a cavity-dumping module based on a visible wavelength acousto-optic modulator.Stable pulse operation in the cavity-dumping regime at 543 nm is observed with a tunable repetition rate in a large range of 100 Hz–3 MHz and a pulse duration of 72–116 ns.The maximum pulse energy of 3.17 mJ at 100 Hz is successfully achieved,which is three orders of magnitude higher than those of the rare-earth-doped fiber green lasers previously reported.This work provides a model for compact,high-efficiency,and high-energy visible fiber pulsed lasers. | TIANRAN LI ZIYU WANG JINHAI ZOU JINFEN HONG QIUJUN RUAN HANG WANG ZHIPENG DONG ZHENGQIAN LUO | 2023 | Photonics Research2023,11,3: | 1 |
| 12 | Latest assessment methods for mitochondrial homeostasis in cognitive diseases显示文摘Mitochondria play an essential role in neural function,such as supporting normal energy metabolism,regulating reactive oxygen species,buffering physiological calcium loads,and maintaining the balance of morphology,subcellular distribution,and overall health through mitochondrial dynamics.Given the recent technological advances in the assessment of mitochondrial structure and functions,mitochondrial dysfunction has been regarded as the early and key pathophysiological mechanism of cognitive disorders such as Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,mild cognitive impairment,and postoperative cognitive dysfunction.This review will focus on the recent advances in mitochondrial medicine and research methodology in the field of cognitive sciences,from the perspectives of energy metabolism,oxidative stress,calcium homeostasis,and mitochondrial dynamics(including fission-fusion,transport,and mitophagy). | Wei You Yue Li Kaixi Liu Xinning Mi Yitong Li Xiangyang Guo Zhengqian Li | 2024 | Neural Regeneration Research2024,19,4: | 0 |
| 13 | 3-80 Heavy-ion Irradiation Drug Development in Retrospect and Prospect显示文摘The world is facing severe challenges of sustainable development, which requires the joint effort of the globalscience community to solve. As China continues to grow at a very impressive pace, the state appears acutely awareof the need to expand the Chinese science and technology portfolio to help fuel its growth and keep it sustainable.China also needs to continue on the path to innovations and modernization, focusing on endogenous growth torealize full, coordinated, and sustainable development. | Zhou Xiang Liang Jianping Lu Xihong Li Xuehu Xin Zhijun Wang Liang Du Wenyue Wu Zhengqian | 2014 | IMP & HIRFL Annual Report2014,,1: | 0 |
| 14 | 3-81 Enhancement of Bioproduction of Butyrate by Heavy-ion Irradiation显示文摘Butyric acid as a renewable resource has become an increasingly attractive alternative to petroleum based fuels.Clostridium tyrobutyricum is well documented as a fermentation strain for the production of acids. However, it hasbeen reported that butyrate inhibits its growth, and the accumulation of acetate also inhibits biomass synthesis,making production of butyric acid from conventional fermentation processes economically challenging. The presentstudy aimed to identify whether irradiation of C. tyrobutyricum cells makes them more tolerant to butyric acidinhibition and increases the production of butyrate compared with wild type. | Zhou Xiang Liang Jianping Lu Xihong Li Xuehu Xin Zhijun Wang Liang Du Wenyue Wu Zhengqian | 2014 | IMP & HIRFL Annual Report2014,,1: | 0 |
| 15 | Correction to:Regional Metabolic Patterns of Abnormal Postoperative Behavioral Performance in Aged Mice Assessed by^1H-NMR Dynamic Mapping Method显示文摘 | Taotao Liu Zhengqian Li Jindan He Ning Yang Dengyang Han Yue Li Xuebi Tian Huili Liu Anne Manyande Hongbing Xiang Fuqiang Xu Jie Wang Xiangyang Guo | 2020 | Neuroscience Bulletin2020,36,5: | 0 |