|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 2 | Lipopolysaccharide Activates Human Mast Cells To Induce Intestinal Epithelial Barrier Dysfunction显示文摘 | Yang PC Zheng PY Wang CS | 2005 | Int J Gastroenterology2005，4，1： | 1 |
| 3 | 查看详情显示文摘 | Zheng J Guo M Song CS | | 0，，： | 1 |
| 4 | Correlation of hypoxi- ainducible factor lalpha with angiogenesis in liver tumors after transcatheter arterial embolization in an animal mod- el 显示文摘 | Liang B Zheng CS Feng GS | 2010 | Cardiovase Intervent Radiol2010，，： | 1 |
| 5 | Generation of APLP2 KO mice and early postnatal lethality in APLP2/ APP double KO mice显示文摘 | von Koch CS Zheng H Chen H | 1997 | Neurohiol Aging1997，18，6： | 1 |
| 6 | Correlation of hypoxiainducible factor 1alpha with angiogenesis in liver tumors after transcatheter arterial embolization in an animal mode显示文摘 | Liang B Zheng CS Feng GS | 2010 | Cardiovasc Intervent Radiol2010，，4： | 1 |
| 7 | (10S,13R,14R)-17-(2-Hydroxy-1,5-dimethylhex-4 -enyl) -4,4,10,13,14 -pentamethy1-2,3,4,5,6,7,10,11, 12,13,14,15,16,17-tetradecahydro-1H-cyclopenta phenanthren-3-ol显示文摘 | Zheng WF Liu T Yao CS | 2006 | Acta Crystallographica2006，62，2： | 1 |
| 8 | Stereotactic radiosurgery for primary trigeminal neuralgia using the Leksell Gamma unit显示文摘 | Zheng LG Xu DS Kang CS | 2001 | Stereotact Funct Neurosurg2001，76，1： | 1 |
| 9 | A general method for the solidphase synthesis of unsymmetrical tri- and tetrasubstituted ureas 显示文摘 | Zheng CS Combs AP | 2002 | J Comb Chem2002，4，1： | 1 |
| 10 | The -174 G to C polymorphism of interleukin-6 gene is very rare in Koreans显示文摘 | Lira CS Zheng S Kim YS Ahn C Han JS Kim S | 2002 | Cytokine2002，19，10： | 1 |
| 11 | Acetylation of retinal histones in diabetes increases inflammatory proteins:effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC)显示文摘 | Kadiyala CS Zheng L Du Y | | 0，，： | 1 |
| 12 | Permanent and peripheral embolization : temperature-sensitive p(n-isopropylacrylamide-cobutyl methylacrylate)nanogel as a novel blood- vessel- embolic material in the interventional therapy of liver tumors 显示文摘 | Zhao YB Zheng CS Wang Q | 2011 | Adv Funct Mater2011，21，： | 1 |
| 13 | CTLA4 engagement is required for induction of murine liver transplant sponta-neous tolerance显示文摘 | Li W Zheng XX Kuhr CS | 2005 | Am J Transplant2005，5，5： | 1 |
| 14 | Correlation of hypoxia-inducible factor 1alpha with angiogenesis in liver tumors after transcatheter arterial embolization in an animal model显示文摘 | Liang B Zheng CS Feng GS | | 0，，04： | 1 |
| 15 | Topoisomerase Ⅰ and Ⅱ inhibitory constituents from the bark of Tilia amurensis显示文摘 | Choi JY Seo CS Zheng MS | 2008 | Archives of Pharmacal Research2008，31，11： | 1 |
| 16 | Thuricin CD,a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile 显示文摘 | Rea MC Sit CS Clayton E O’Connor PM Whittal RM Zheng J Vederas JC Ross RP Hill C | 2010 | Proc Nat Acad Sci2010，107，： | 1 |
| 17 | JNK-AP-1 pathway involved in interleukin-1 β induced calcitonin gene-relatcd peptide secretion in human type Ilalveolar epithelial cells 显示文摘 | Li WJ Zheng S Tang CS | 2007 | Peptides2007，28，： | 1 |
| 18 | Nutritional status in Linxian, China: effects of season and supplementation 显示文摘 | Zheng SF Ershow AG Yang CS | 1989 | Int J Vitam Nutr Res1989，59，2： | 1 |
| 19 | The status of phos- phorylated p38 in esophageal squamous cell carcinoma 显示文摘 | Zheng ST Zhang CS Qin X | 2012 | Mol Biol Rep2012，39，5： | 1 |
| 20 | The-174 G to C polymorphism of interleukin-6 gene very rare in koreans显示文摘 | Lim CS Zheng S Kim YS | 2002 | Cytokine2002，19，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员