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| 1 | Preparation, microstructure and degradation performance of biomedical magnesium alloy fine wires显示文摘With the development of new biodegradable Mg alloy implant devices, the potential applications of biomedical Mg alloy fine wires are realized and explored gradually. In this study, we prepared three kinds of Mg alloy fine wires containing 4 wt% RE(Gd/Y/Nd) and 0.4 wt% Zn with the diameter less than 0.4 μm through casting, hot extruding and multi-pass cold drawing combined with intermediated annealing process. Their microstructures, mechanical and degradation properties were investigated. In comparison with the corresponding as-extruded alloy, the final fine wire has significantly refined grain with an average size of 3–4 μm, and meanwhile shows higher yield strength but lower ductility at room temperature. The degradation tests results and surface morphologies observations indicate that Mg–4Gd–0.4Zn and Mg–4Nd–0.4Zn fine wires have similar good corrosion resistance and the uniform corrosion behavior in SBF solution. By contrast, Mg–4Y–0.4Zn fine wire shows a poor corrosion resistance and the pitting corrosion behavior. | Jing Bai Lingling Yin Ye Lu Yiwei Gan Feng Xue Chenglin Chu Jingli Yan Kai Yan Xiaofeng Wan Zhejun Tang | 2014 | Progress in Natural Science:Materials International2014，24，5： | 3 |
| 2 | Characterization of the stress sensitivity of pores for different rank coals by nuclear magnetic resonance显示文摘 | Song Li Dazhen Tang Zhejun Pan Hao Xu Weiqiang Huang | 2013 | Fuel2013，，： | 1 |
| 3 | Evaluation of coalbed methane potential of different reservoirs in western Guizhou and eastern Yunnan, China显示文摘 | Li Song Tang Dazhen Pan Zhejun Xu Hao Guo Lele | 2015 | Fuel2015，139，： | 1 |
| 4 | Pharmacological mechanisms of Yishen Xingyang capsule in the treatment of oligoasthenospermia in rats显示文摘Objective:To investigate the therapeutic effects and pharmacological mechanisms of Yishen Xingyang capsule(YXC)in oligoasthenospermia(OA)rats.Methods:Forty-eight male SpragueeDawley rats were randomly divided into eight groups of six rats each:normal control(NC);model control(MC);three different positive drug(PD);and low-,medium-,and high-dose YXC groups.A rat model of OA was established by administering glucosides of Tripterygium wilfordii Hook.F(GTW).After YXC administration,penile erectile function was observed.The epididymis,blood,and testes of the rats were harvested for analysis of sperm quality,sex hormone levels,mitochondrial membrane potential,and the transforming growth factor(TGF)-b1/Smad signaling pathway.Results:Compared with that in the MC group,penile erectile function in the YXC groups and three PD groups increased(all P<.01).Moreover,sperm quality in the YXC groups and three PD groups improved(all P<.001).The levels of testosterone,follicle stimulating hormone,and luteinizing hormone in the three PD and YXC groups increased(all P<.05).The mitochondrial membrane potential in the three PD and YXC groups significantly improved(all P<.001).Furthermore,the YXC and three PD groups showed decreased TGF-b1 expression(all P<.05)compared with the MC group.The high-dose YXC group and three PD groups improved Smad2 and Smad4 expression(all P<.05).Conclusion:YXC improved penile erectile function and sperm quality in OA rats,and the underlying mechanism included increase in sex hormones,inhibition of sperm apoptosis,and regulation of the TGFb1/Smad signaling pathway.Meanwhile,this study provides a new effective drug option for the treatment of OA,which is beneficial to male reproductive health and social harmony. | Zhenghui Chang Xue Bai Yibo Tang Guimin Liu Dan Liu Xiaolei Fan Tianyang Tan Zhejun Liu Jinsheng Li Zhenquan Liu | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，1： | 0 |
| 5 | Comparative pharmacophore modeling of human adenosine receptor A1 and A3 antagonists显示文摘Adenosine receptors are promising therapeutic targets in drug discovery. In this study, three-dimensional pharmacophore models of human adenosine receptor A1 and A3 antagonists were developed based on 26 and 23 diverse compounds, respectively. The best A1 pharmacophore model (A 1 _Hopy1) consists of four features: one hydrogen bond donor, one hydrophobic point and two ring aromatics, while the best A 3 pharmacophore model (A3 _Hopy1) also has four features: one hydrogen bond acceptor, one hydrophobic point and two ring aromatics. The correlation coefficients were 0.840 for A 1 test set with 146 diverse compounds and 0.827 for A3 test set with 238 diverse compounds. In the simulated virtual screening experiments, high enrichment factors of 6.51 and 6.90 were obtained for A 1 _Hopy1 and A3 _Hopy1 models, respectively. Moreover, two models also showed high subtype-selectivity in the simulated virtual screening experiments. These results could be helpful for the discovery of novel potent and selective A 1 and A3 antagonists. | XU ZheJun CHENG FeiXiong LI Jie ZHOU YaDi SU Ni LI WeiHua LIU GuiXia TANG Yun | 2012 | Science China Chemistry2012，55，11： | 0 |
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