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| 1 | Immunocytochemical identification and localization of APUD cells in the gut of seven stomachless teleost fishes显示文摘AIM To study the cell types,localization,distribution density and morphology of APUDcells in the intestinal mucosa of stomachlessteleost fishes.METHOD By using the peroxidase-antiperoxidase complex(PAP)immunocytochemical staining technique theidentification,localization and morphology ofimmunoreactive(IR)endocrine cells seattered inthe intestinal mucosa of grass carp(Cyenopharyngodon idellus),black carp(Mylopharyngodon piceus)and common carp(Cyprinus carpio)were investigated with 20kinds of antisera prepared against mammalianpeptide hormones of APUD cells,and likewise byusing avidin-biotin-peroxidase complex(ABC)method those of silver carp(Hypophthalmichthys molitrix),bighead(Aristichthys nobilis),silver crucian carp(Carassius gibelio)and bluntnose black bream(Megalobrama amblyocephala)were alsostudied with 5 different antisera.Thereplacement of the first antiserum by phosphatebuffered saline(PBS)was employed as a control.IR endocrine cells were counted with asquare-mesh ocular micrometer from 10 fieldsselected randomly in every section of each partof the intestine specimen.The average numberof IR endocrine cells per mm2 was counted toquantify their distribution density.RESULT Gastrin(GAS)-,Gastric inhibitorypeptide(GIP)-,glucagon(GLU)-,glucagon-likeimmunoreactants(GLI)-,bovine pancreaticpolypeptide(BPP)-,leucine-enkephalin(ENK)-and substance P(SP)-IR endocrine cells werefound in the gut of grass carp,black carp andcommon carp,and somatostatin(SOM)-IRendocrine cells were only seen in common carp.GAS-,GIP-and GLU-IR endocrine cells werefound in the intestinal mucosa of silver carp,bighead,silver crucian carp and bluntnose blackbream.Most of IR endocrine cells had the higherdistribution density in the foregut and midgut,and were longer in shape.They had a long apicalcytoplasmic process extended to the gut lumenand a basal process extended to adjacent cellsor basement membrane and touched with it.Sometimes,the basal cytoplasmic processformed an enlarged synapse-like structure in thecontiguous part with basement membrane.Thisphenomenon provided new morphologicalevidence for neuroendocrine and paracrinesecretory function of these enteroendocrinecells.CONCLUTION At least 8 kinds of IR endocrinecells were found in the gut of stomachlessteleost species for the first time in China.TheseIR endocrine cells scattering in the gut mucosabelong to the APUD system.Among them,thehormones secreted by SP-,ENK-,SOM-and GLU-IR endocrine cells belong to the peptides of dualdistribution in the brain and gut.This providednew evidence for the concept of brain-gutpeptide.According to the cell types,distribution density,morphologicalcharacteristics and variety in shape of APUDcells in the gut of stomachless teleost fishes,itis deemed that the digestive tract of fishes isalso an endocrine organ of great importance andcomplexity. | Pan QS Fang ZP Zhao YX | 2000 | World Journal of Gastroenterology2000，6，1： | 25 |
| 2 | Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai.显示文摘 | Zhang ZX Roman GC Hong Z Wu CB Qu QM Huang JB Zhou B Geng ZP Wu JX Wen HB Zhao H Zahner GE | 2006 | 中国生物学文摘2006，20，8： | 9 |
| 3 | Study of operator reliability in nuclear power plants显示文摘The study of the reliability of operator’s diagnosis and decision-making during abnormal events with HCR model has been introduced. A new approach has been proposed by the authors to deal with the classification of HIs. The modification of T0.5 by PSFs coefficients has been discussed. In addition, it is emphasized that T0. 5 and SD(σ) of response times can be used as a scale to predict and evaluate the reliability of crew/operator behavior. These processings provide improvement and refinement to HCR model and its practical application. The experiment for operator response time of Chinese NPP using a lull-scale simulator has proved the above-mentioned processings and presented the quantitative results of operator reliability in Chinese NPP. | Yang, MZ Gao, J Zhao, BQ Huang, XR Shen, ZP | 1997 | Chinese Science Bulletin1997，42，19： | 4 |
| 4 | Simultaneous multi-tear exclusion:an optimal strategy for type B thoracic aortic dissection initially proved by a single center's 8 years experience显示文摘背景 Endovascular 接枝stent 广泛地被用来对待胸的大动脉的 dissection.However ,很少信息都不关于跟随八年用为斯坦福的治疗的同时的多眼泪排除的经验打 B 胸的大动脉的解剖导致到1月2006,29日类型 B 胸的大动脉的解剖病人的从1998年9月的没有不利 events.Methods 的成功的大动脉的改变的多重 tears.This 报告细节的同时的排除的结果是可得到的( 24 个人, 5 | YUAN Liang-xi BAO Jun-min ZHAO Zhi-qing FENG Xiang OU Le-feng FENG Rui LU Qing-sheng MEI Zhi-jun JING Zai-ping Department of Vascular Surgery,Changhai Hospital,Second Military Medical University Institute of Vascular Surgery of Chinese People’s Liberation Army Clinic Center of Vascular Diseases of Shanghai National Key Department of Vascular Surgery of China Shanghai 200433,China (Yuan LX,Bao JM,Zhao ZQ,Feng X,Ou LF,Feng R,Lu QS,Mei ZJ and Jing ZP) | 2007 | Chinese Medical Journal2007，，24： | 3 |
| 5 | A novel recombinant fusion protein exhibited inhibitory activities on platelet aggregation and thrombin 显示文摘 | Hu ZL Zhao ZP Liang Y Li Y Chen GP | 2010 | Lett Drug Des Discovery2010，7，： | 1 |
| 6 | HERG K^+ channel blockade by the novel antiviral drug sophocarpine 显示文摘 | ZHAO XL QI ZP FANG C | 2008 | Biol Pharm Bull2008，31，6： | 1 |
| 7 | Tri-ortho-cresyl phosphate (TOCP) decreases the levels of cytoskeletal proteins in hen sciatic nerve 显示文摘 | Zhao XL Zhu ZP Zhang TL | 2004 | Toxicol Lett2004，152，： | 1 |
| 8 | Isolation and identi- fication of angiotensin-converting enzyme inhibitory peptides from egg white protein hydroiysates显示文摘 | Liu JB Yu ZP Zhao WZ | 2010 | Food Chem2010，122，： | 1 |
| 9 | Three - dimensional dis-crete element modeling of asphalt concrete: Sizeeffects of elements显示文摘 | Y Liu ZP You Y Zhao | 2012 | Construction Building Ma-terials2012，，37： | 1 |
| 10 | An experimental study and clinical pilot trials on Yttrium-90 glass microspheres through the hepatic for treatment of primary liver 显示文摘 | Yan ZP Lin G Zhao HY | 1993 | Cancer1993，72，11： | 1 |
| 11 | Advancement in endocrinetherapy for breast cancer显示文摘 | Deng ZP Ren H Zhao B | 2005 | J Mod Oncol2005，13，3： | 1 |
| 12 | Peptide derived from insulin with regadatory activity of dopamine transpextex 显示文摘 | Liu ZP Wang Y Zhao WJ | 2001 | Neuropharm acology2001，41，： | 1 |
| 13 | A new method to perpare chitosan membrance as a biomedical material 显示文摘 | Hu QL Fang ZP Zhao Y | 2001 | Chinese J Poly - Mer Science2001，19，5： | 1 |
| 14 | A powerful hybrid puc operon promoter tightly regulated by both of IPTG and low oxygen level 显示文摘 | Hu ZL Zhao ZP Pan Y Tu Y Chen GP | 2010 | Biochemistry2010，75，： | 1 |
| 15 | Comparative effects of sophocarpine and sophoridine on hERG K+ channel显示文摘 | Zhao XL Gu DF Qi ZP | 2009 | Eur J Pharmacol2009，607，： | 1 |
| 16 | Effect of 9-cisretinoic acid on growth and RXR expression in human breast cancer cells显示文摘 | Zhao Z Zhang ZP Soprano DR | 1995 | Exp Cell Res1995，219，2： | 1 |
| 17 | An experimental study and clinicalpilot trials on yttrium-90 glass microspheres through the hepaticartery for treatment of primary liver cancer显示文摘 | Yan ZP Lin G Zhao HY | 1993 | Cancer1993，72，11： | 1 |
| 18 | Starting sliding mode variable structure that coordinates the control and real-time optimization of dry dual clutch transmissions显示文摘 | Zhao ZG Jiang JL Yu ZP | 2013 | International Journal of Automotive Technology2013，14，6： | 1 |
| 19 | Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells显示文摘 | Zhao G Neeb ZP Leo MD | 2010 | J Gen Physiol2010，136，3： | 1 |
| 20 | Use of saline aquaculturewastewater to irrigate salt-tolerant Jerusalem artichoke and sunflower in semiarid coastal zones of China显示文摘 | Zhao GM Mehta SK Liu ZP | 2010 | Agricultural Water Management2010，97，： | 1 |
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