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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Marsdenia tenacissima extract restored gefitinib sensitivity in resistant non-small cell lung cancer cells显示文摘 | Han SY Zhao MB Zhuang GB Li PP | 2012 | Lung Cancer2012，75，1： | 1 |
| 3 | Expression of transcripts of interleukin-6 and related cytokines by human breast tumors,breast cancer cells,and adipose stromal cells 显示文摘 | Nichols JE Zhao Y | 1996 | Mol Cell Endocrinol1996，118，12： | 1 |
| 4 | Hydrophilic interaction liquid chromatography-tandem mass spectrometry determination of estrogen conjugates in human urine 显示文摘 | Qin F Zhao YY Sawyer MB | 2008 | Anal Chem2008，80，9： | 1 |
| 5 | Marsdenia tenacissima extract restored gefitinib sensitivity in resistant non-small cell lung cancer cells显示文摘 | Han SY Zhao MB Zhuang GB | 2012 | Lung Cancer2012，75，1： | 1 |
| 6 | Early cenozoic two-phase extension and late cenozoic thermal subsidence and inversion of theBohaiBasin, northernChina显示文摘 | Allen MB Macdonald DM Zhao X | 1997 | Marine and Petroleum Geology1997，14，78： | 1 |
| 7 | The application of nanotech- nology in cancer theranosties显示文摘 | Zheng MB Zhao PF Luo ZY | | Chinese Science Bulletin0，59，31： | 1 |
| 8 | Cracking of porcelain coatings bpnded to metal substrates of different modulus and hardness显示文摘 | Zhao H Hu X Bush MB | | 0，，05： | 1 |
| 9 | TNF-alpha knockout andminocycline treatment attenuates blood-brain barrier leakage in MPTP-treated mice显示文摘 | Zhao C Ling Z Newman MB | 2007 | Neurobiol Dis2007，26，1： | 1 |
| 10 | Coreosides A-D, C14-polyacetylene glycosides from the capitula of Coreopsis tinctoria and its anti-inflammatory activity against Cox-2显示文摘 | Zhang Y Shi SP Zhao MB | 2013 | Fitoterapia2013，87，： | 1 |
| 11 | Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer显示文摘 | Jones MB Krutzsch H Shu H Zhao Y Liotta LA Kohn EC | 2002 | Proteomics2002，2，1： | 1 |
| 12 | Marsdenia tenacissirna extract restored gefitinib sensitivity in resistant non-small cell lung cancer cells 显示文摘 | Han SY Zhao MB Zhuang GB | 2012 | Lung Cancer2012，75，1： | 1 |
| 13 | Rectification of skeletal muscle ryanodine re- ceptor mediated by FKS06 binding protein 显示文摘 | Ma J Bhat MB Zhao J | 1995 | Biophys J1995，6，： | 1 |
| 14 | PhaseⅡtrial of neoadjuvant exemestane in combination with celecoxib in postmenopausal women who have breast cancer显示文摘 | Lustberg MB Povoski SP Zhao W | 2011 | Clin Breast Cancer2011，11，4： | 1 |
| 15 | 显示文摘 | Tang MB Zhao DQ Pan M X | 2004 | J Phys D2004，37，： | 1 |
| 16 | CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis 显示文摘 | Wang L Zhao Z Meyer MB | 2014 | Cancer Cell2014，25，： | 1 |
| 17 | Transcatheter closure ofPerimembranous ventricular septal defects using a novel wire-maintaining technique显示文摘 | Gu MB You XH Zhao XX | 2010 | Catheter Carsiovasc Interv2010，75，1： | 1 |
| 18 | The innate immune response to Salmonella enterica serovar typhimurium by macrophages is dependent on TREM2-DAP12显示文摘 | Charles JF Humphrey MB Zhao XD | 2008 | Infect Immun2008，76，： | 1 |
| 19 | Phase II trial of neoadjuvant exemestane in combination with celecoxib in postmenopausal women who have breast cancer显示文摘 | Lustberg MB Povoski SP Zhao W | 2011 | Clin Breast Cancer2011，11，4： | 1 |
| 20 | A decomposition of total fac- tor productivity growth:The case of Chinese agricultural growth before and after reforms显示文摘 | Kalirajan K P Obwona MB Zhao S | 1996 | American Journal of Agri- cultural Economics1996，78，2： | 1 |
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