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您的检索式：作者名="Zhangping LU"
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| 1 | Mapping knowledge domains analysis of research topics of doctoral dissertations on Library Science in Europe and the United States显示文摘Europe and the United States are considered to be the leaders in the field of Library Science research.Their doctoral dissertations have an irreplaceable role for studying and tracking the development of Library Science.In this study,3 973 doctoral dissertations in the database of PQDD from year1925 to 2013 are used as the research object.Keywords co-occurrence analysis and | Guoli YANG Jing LIU Manrong WANG Zhangping LU | 2015 | Journal of Library Science in China2015，，1： | 4 |
| 2 | Application of CGI in Cooperative Design Environment显示文摘The paper analyzes the principles and applications of CGI for collaborative design. The utility model possessing broad reference values is set up and its implementation techniques are presented in detail. | Xu Libo Lu Zhangping Institute of Graphic Technology, Jiangsu University, Zhenjiang 212013, China | 2002 | Computer Aided Drafting,Design and Manufacturing2002，12，1： | 0 |
| 3 | Metformin alleviates LTA-induced inflammatory response through PPARγ/MAPK/NF-κB signaling pathway in bovine mammary epithelial cells显示文摘Mastitis is a common inflammatory cow mammary infection;that causes significant economic loss in dairy industry.Given the interesting connection between metformin’s anti-inflammatory function and mastitis model induced by LTA in pbMECs,our objective was to prove that metformin was beneficial in suppressing proinflammatory response induced by LTA through modulation of mitogen-activated protein kinase(MAPK)and nuclear factor kappa B(NF-κB)signaling pathways and activation of peroxisome proliferator-activated receptor-γ(PPARγ)in pbMECs.The proliferation of cells and mRNA expression were measured using EdU assay and quantitative reverse transcriptase-polymerase chain reaction(qRT-PCR).Immunoblotting and immunofluorescence analysis were conducted to evaluate the expression of target proteins in inflammatory and anti-inflammatory responses to metformin and LTA.Finally,pbMECs were allowed to treat with the PPAR antagonist GW9662,and inflammatory markers were detected in the cells.Our results showed that LTA concentration at 100μg/mL significantly stimulated the MAPK14,IL-6 and IL-1βmRNA expressions compared to the control cells(P<0.05)in dose-dependent tests for LTA.Metformin suppressed the phosphorylation expressions of MAPK(ERK1/2,p38,and JNK)in LTA-stimulated pbMECs.Metformin also reduced the protein expression of NF-κB,interleukin-8(IL-8),interleukin-1β(IL-1β)and interleukin-6(IL-6)in pbMECs pretreated with LTA.Metformin administration activated PPARγphosphorylation by up-regulating the expression of PPARγin LTA-stimulated pbMECs.Treatment with GW9662 resulted in increased IL-6 expression,which was reversed by metformin.These findings collectively indicated that metformin act to attenuate LTA-stimulated inflammatory response in pbMECs by suppressing MAPK and NF-κB activation via a mechanism partially dependent on PPARγactivation.These results suggested that metformin could function as an anti-inflammatory drug in the treatment of mastitis. | ABDELAZIZ ADAM IDRISS ARBAB CHUNQING YIN XUBIN LU YAN LIANG ISMAIL MOHAMED ABDALLA AMER ADAM IDRIS TIANLE XU YONGJIANG MAO ZHANGPING YANG | 2022 | BIOCELL2022，46，11： | 0 |
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