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您的检索式：作者名="Zhang Xiuning"
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| 1 | Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes显示文摘Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSCLC),characterized by the presence of epithelial and sarcoma-like components.The molecular and immune landscape of PSC has not been well defined.Methods:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA sequencing.We describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical outcomes.Results:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by KRAS.Interestingly,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC tumors.We identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and signaling.The Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized PSCs.Conclusions:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with prognosis.IM-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs. | Sahil Seth Runzhe Chen Yang Liu Junya Fujimoto Lingzhi Hong Alexandre Reuben Susan Varghese Carmen Behrens Tina McDowell Luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning Le Natalie I Vokes Chao Cheng John V.Heymach Don L.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang | 2024 | Cancer Innovation2024，3，3： | 0 |
| 2 | Acid Orange 7 degradation using methane as the sole carbon source and electron donor显示文摘Azo dyes are widely applied in the textile industry but are not entirely consumed during the dyeing process and can thus be discharged to the environment in wastewater.However,azo dyes can be degraded using various electron donors,and in this paper,Acid Orange 7(AO7)degradation performance is investigated using methane(CH4)as the sole electron donor.Methane has multiple sources and is readily available and inexpensive.Experiments using ^(13)C-labeled isotopes showed that AO7 degradation was coupled with anaerobic oxidation of methane(AOM)and,subsequently,affected by the initial concentrations of AO7.Higher concentrations of AO7 could inhibit the activity of microorganisms,which was confirmed by the long-term performance of AO7 degradation,with maximum removal rates of 8.94 mg/(L·d)in a batch reactor and 280 mg/(L·d)in a hollow fiber membrane bioreactor(HfMBR).High-throughput sequencing using 16S rRNA genes showed that Candidatus Methanoperedens,affiliated to ANME-2d,dominated the microbial community in the batch reactor and HfMBR.Additionally,the relative abundance of Proteobacteria bacteria(Phenylobacterium,Pseudomonas,and Geothermobacter)improved after AO7 degradation.This outcome suggested that ANME-2d alone,or acting synergistically with partner bacteria,played a key role in the process of AO7 degradation coupled with AOM. | Yanan Bai Xiuning Wang Fang Zhang Raymond Jianxiong Zeng | 2022 | Frontiers of Environmental Science & Engineering2022，16，3： | 0 |
| 3 | The Pavilion of the Center of InternationalCulture Exchange Is Reopened-Inauguration of NICE Choice Exhibition of Shanghai-Style Quality Cultural and Creative Products显示文摘The pavilion of the Center of International Culture Exchange, after three months of refurbishment,is now reopened. The philosophy behind this exhibition is "original design and inclusivity". Whiledemonstrating new techniques, materials, products and images of Shanghai style, the exhibition wantsevery product to tell a story about peop!e. This way, the combination of cultural exchanges and culturaltrade will lead to a win-win situation. | Zhang Xiuning Niu Gengshi | 2016 | China & The World Cultural Exchange2016，82，8： | 0 |
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