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| 1 | A mouse model for HBV immunotolerance and immunotherapy显示文摘一个适当小动物模型的缺乏仍然是一个主要障碍因为学习 immunotolerance 和 immunopathogenesis 由肝炎 B 病毒(HBV ) 导致了感染。在这研究,我们与 recombinant 在感染以后与持续 HBV viremia 报导一个老鼠模型带一个可复制的 HBV 染色体(AAV/HBV ) 的联系 adeno 的病毒(AAV ) 。类似于临床的 HBV 搬运人,感染 AAV/HBV 的老鼠为对 HBV 表面抗原(HBsAg ) 的抗体是 sero 否定的。有面对铝助手疫苗的常规 HBV 的免疫没能在这些老鼠对 HBV 得到有免疫力的回答。为了识别一支疫苗,那能潜在地围绕这忍耐, TLR9 收缩筋 CpG 作为一个助手被加到 HBsAg。有 HBsAg/CpG 的老鼠的种痘导致了 viremia,而且强壮的抗体生产和 T 房间回答的不仅清理。而且, DNA 复制和 HBV 的蛋白质表示显著地在 AAV/HBV-infected 鼠标的肝被减少。因此, AAV/HBV-infected 老鼠可以作为一个柔韧的模型被使用调查 HBV immunotolerance 并且为开发新奇免疫疗法根除的内在的机制 HBV 感染。 | Dan Yang Longchao Liu Danming Zhu Hua Peng Lishan Su Yang-Xin Fu Liguo Zhang | 2014 | Cellular & Molecular Immunology2014，11，1： | 25 |
| 2 | Ultrasound enhanced heterogeneous activation of peroxydisulfate by bimetallic Fe-Co/GAC catalyst for the degradation of Acid Orange 7 in water显示文摘Bimetallic Fe-Co/GAC(granular activated carbon) was prepared and used as heterogeneous catalyst in the ultrasound enhanced heterogeneous activation of peroxydisulfate(PS, S2O2-8) process. The effect of initial pH, PS concentration, catalyst addition and stirring rate on the decolorization of Acid Orange 7(AO7) was investigated. The results showed that the decolorization efficiency increased with an increase in PS concentration from 0.3 to 0.5 g/L and an increase in catalyst amount from 0.5 to 0.8g/L. But further increase in PS concentration and catalyst addition would result in an unpronounced increase in decolorization efficiency. In the range of 300 to 900 r/min, stirring rate had little effect on AO7 decolorization. The catalyst stability was evaluated by measuring decolorization efficiency for four successive cycles. | Chun Cai Liguo Wang Hong Gao Liwei Hou Hui Zhang | 2014 | Journal of Environmental Sciences2014，26，6： | 16 |
| 3 | Poly(lactic-co-glycolic acid)-based composite bone-substitute materials显示文摘Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics.Recently,poly(lactic-co-glycolic acid)(PLGA)-based artificial bone-substitute materials are attracting increasing attention as the benefit of their suitable biocompatibility,degradability,mechanical properties,and capabilities to promote bone regeneration.In this article,we comprehensively review the artificial bone-substitute materials made from PLGA or the composites of PLGA and other organic and inorganic substances,elaborate on their applications for bone regeneration with or without bioactive factors,and prospect the challenges and opportunities in clinical bone regeneration. | Duoyi Zhao Tongtong Zhu Jie Li Liguo Cui Zhiyu Zhang Xiuli Zhuang Jianxun Ding | 2021 | Bioactive Materials2021，6，2： | 14 |
| 4 | Molecular mechanism of SCARB2-mediatec attachment and uncoating of EV71显示文摘 | Minghao Dang Xiangxi Wang Quan Wang Yaxin Wang Jianping Lin Yuna Sun Xuemei Li Liguo Zhang Zhiyong Lou Junzhi Wang Zihe Rao | 2014 | Protein & Cell2014，5，9： | 13 |
| 5 | The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection显示文摘(EV71 ) Entero 病毒 71 引起手,脚,和嘴疾病(HFMD ) 并且偶尔导致严重神经病学的复杂并发症甚至死亡。(SCARB2 ) Scavenger 受体班 B 成员 2 是为 EV71 的功能的受体,调停病毒的附件,成为主观,和 uncoating。然而, SCARB2 上的 EV71 的准确有约束力的地点是未知的。在这研究,我们产生了绑在人然而并非老鼠 SCARB2 的 monoclonal 抗体(mAb ) 。它被称为 JL2,并且它能有效地禁止目标房间的 EV71 感染。用人和老鼠 SCARB2 的一套怪物,我们鉴别包含人的 SCARB2 的残余 77-113 的区域显著地作出贡献到 JL2 绑定。SCARB2-JL2 建筑群的结构表明 JL2 绑在包含 -helices 的 SCARB2 的顶端的区域 2, 5,和 14。我们的结果在 SCARB2 和 EV71 入口的分子的机制上为 EV71 提供新卓见进潜在的有约束力的地点。 | Xuyuan Zhang Pan Yang Nan Wang Jialong Zhang Jingyun Li Hao Guo Xiangyun Yin Zihe Rao Xiangxi wang Liguo Zhang | 2017 | Protein & Cell2017，8，8： | 10 |
| 6 | Refill friction stir spot welding of 5083-O aluminum alloy显示文摘In this work,refill friction stir spot welding(RFSSW) was used to weld 2 mm-thick 5083-O alloy.The Box–Behnken experimental design was used to investigate the effect of welding parameters on the joint lap shear property.Results showed that a surface indentation of 0.3 mm effectively eliminated the welding defects.Microhardness of the stir zone(SZ) was higher than that of the base material(BM) and the hardness decreased with increasing the heat input during welding.The optimum failure load of 7.72 k N was obtained when using rotating speed of 2300 rpm,plunge depth of 2.4 mm and refilling time of 3.5 s.Three fracture modes were obtained during the lap shear test and all were affected by the hook defect. | Zhiwu Xu Zhengwei Li Shude Ji Liguo Zhang | 2018 | Journal of Materials Science & Technology2018，34，5： | 10 |
| 7 | Proanthocyanidins Inhibit Seed Germination by Maintaining a High Level of Abscisic Acid in Arabidopsis thaliana显示文摘Proanthocyanidins (PAs) are the main products of the flavonoid biosynthetic pathway in seeds, but their biological function during seed germination is still unclear. We observed that seed germination is delayed with the increase of exogenous PA concentration in Arabidopsis. A similar inhibitory effect occurred in peeled Brassica napus seeds, which was observed by measuring radicle elongation. Using abscisic acid (ABA), a biosynthetic and metabolic inhibitor, and gene expression analysis by real-time polymerase chain reaction, we found that the inhibitory effect of PAs on seed germination is due to their promotion of ABA via de novo biogenesis, rather than by any inhibition of its degradation. Consistent with the relationship between PA content and ABA accumulation in seeds, PA-deficient mutants maintain a lower level of ABA compared with wild-types during germination. Our data suggest that PA distribution in the seed coat can act as a doorkeeper to seed germination. PA regulation of seed germination is mediated by the ABA signaling pathway. | Liguo Jia Qiuyu Wu Nenghui Ye Rui Liu Lu Shi Weifeng Xu Hui Zhi A. N. M. Rubaiyath Bin Rahman Yiji Xia Jianhua Zhang | 2012 | Journal of Integrative Plant Biology2012，54，9： | 9 |
| 8 | Design of Reflective Concentrator Model with Application for Concentrator Photovoltaic System显示文摘The nonuniform irradiation in the standard photovoltaic(PV) cells causes their relatively high series resistance,which results in a considerably lowered efficiency of PV cells.Currently the concentrator of uniform irradiation designed for concentrator photovoltaic is rare in China and lack sufficient theoretical research.In this paper,a systematic research on the solar reflective concentrator is conducted.A novel structure for a solar reflective concentrator is designed with the application of a flat mirror matrix to concentrate the sunlight for concentrator photovoltaic(CPV) systems.Sunlight beams are focused through the reflection of the mirror array on the solar cell to generate electricity.The concentrator is capable of producing much more uniform sunlight with a certain concentration ratio.The design scheme includes laying out the flat mirrors,optimizing the optical pathway and the parameters of each mirror.The prototype of the CPV system was installed at Nanjing,China.In the configuration of the prototype,it is composed of 24 pieces parallelogram flat mirrors,which are arranged into a total reflective array of 5 rows and 5 columns.In comparison with the parabolic trough concentrator,the experimental measurements verify such design has high efficiency.The concentrator model of a flat mirror matrix and the proposed new design method will lay a solid foundation for designing the concentrator of uniform irradiation. | SU Zhongyuan ZHANG Yaoming JIA Minping SUN Liguo XU Feiyun WANG Jun | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 8 |
| 9 | Mathematical model of heat transfer for bloom continuous casting显示文摘A mathematical model for heat transfer during solidification in continuous casting of automobile steel,was established on researching under the influence of the solidifying process of bloom quality of CCM in the EAF steelmaking shop,at Shijiazhuang Iron and Steel Co.Ltd.Several steel grades were chosen to research,such as,40Cr and 42CrMo.According to the results of the high temperature mechanical property tests of blooms,the respective temperature curves for controlling the solidification of different steels were acquired,and a simulating software was developed.The model was verified using two methods,which were bloom pin- shooting and surface strand temperature measuring experiments.The model provided references for research on the solidifying proc- ess and optimization of a secondary cooling system for automobile steel.Moreover,it was already applied to real production.The calculated temperature distribution and solidification trend of blooms had offered a reliable theory for optimizing the solidifying process of blooms,increasing withdrawal speed,and improving bloom quality.Meanwhile,a new secondary cooling system was designed to optimize a secondary cooling water distribution,including choice and arrangements of nozzles,calculation of cooling water quantity,and so on. | Qing Liu Liangzhou Wang Liqiang Zhang Liguo Cao Xiuzhong Ding Mei Liang Yongge Qi | 2008 | Journal of University of Science and Technology Beijing2008，15，1： | 7 |
| 10 | Adjuvant radiotherapy in central hepatocellular carcinoma after narrow-margin hepatectomy:A 10-year real-world evidence显示文摘Objective:A prospective randomized control study investigated the feasibility and efficacy of adjuvant radiotherapy on patients with central hepatocellular carcinoma(HCC)after narrow-margin hepatectomy(<1 cm).This study presents an updated 10-year real-world evidence to further characterize the role of adjuvant radiotherapy.Methods:Patients with central HCC after narrow-margin hepatectomy(<1 cm)were prospectively assigned to adjuvant radiotherapy group and control group.Patients'outcome,adverse events,long-term recurrence and survival rates were investigated.Results:The 1-,5-,and 10-year recurrence-free survival(RFS)rates were 81.0%,43.9%,and 38.7%,respectively in adjuvant radiotherapy group and 71.7%,35.8%,and 24.2%,respectively in control group(log-rank test,P=0.09).The 1-,5-,and 10-year overall survival(OS)rates were 96.6%,54.7%,and 42.8%,respectively in adjuvant radiotherapy group and 90.2%,55.1%,and 30.0%,respectively in control group(log-rank test,P=0.20).The 1-,5-,and 10-year RFS rates for patients with small HCC(≤5 cm)were 91.1%,51.6%,and 48.4%,respectively in adjuvant radiotherapy group and 80.0%,36.6%,and 26.6%,respectively in control group(log-rank test,P=0.03).Landmark analysis demonstrated that patients with small HCC in adjuvant radiotherapy group had a significantly improved OS in second five years after treatment in comparison to patients in control group(log-rank test,P=0.05).Conclusions:Our updated results showed a sustained clinical benefit on reducing recurrence,improving longterm survival for small central HCC by adjuvant radiotherapy after narrow-margin hepatectomy.Long-term survival data also indicated that hepatectomy is an optimal treatment for selected patients with central HCC. | Weiqi Rong Weibo Yu Liming Wang Fan Wu Kai Zhang Bo Chen Chengli Miao Liguo Liu Songlin An Changcheng Tao Weihu Wang Jianxiong Wu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 6 |
| 11 | Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes显示文摘Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients. | Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 12 | 肿瘤浸润髓系细胞上表达的共抑制分子B7S1抑制抗肿瘤CD8 T细胞的功能显示文摘文章简介近年来,肿瘤免疫治疗蓬勃发展,为人类战胜癌症带来了一线曙光。阻断PD-1/PD-L1通路的抗体药物可以提高CD8 T细胞的抗肿瘤活性,疗效显著优于传统治疗手段。然而,只有小部分实体瘤病人可以对PD-1/PD-L1免疫治疗产生应答. | 黎静 Younghee Lee Yanjian Li Yu Jiang Huiping Lu Wenjuan Zang Xiaohong Zhao Liguo Liu Yang Chen Haidong Tan 杨志英 Michael Q Zhang Tak W.Mak Ling Ni 董晨 | 2019 | 科学新闻2019，0，2： | 6 |
| 13 | TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope显示文摘Ebolavirus 能与 50%90% 的死亡率在人引起出血性的发烧。当前,没有同意的疫苗和抗病毒的治疗是可得到的。人的 TIM1 为 EBOV 被看作一个附件因素,提高通过和位于病毒的信封的 PS 的相互作用的病毒的感染。然而,推理由 filovirus 位于 hTIM-1,然而并非另外的 PS 有约束力的受体的更好的用法下面,未知的遗体。我们第一在 vitro 表明了在 hTIM-1 和 EBOV GP 之间的一个直接相互作用并且决定了 hTIM-1 和 hTIM-4 的 Ig V 领域的水晶结构。在到 EBOV GP 的 hTIM-1 的有约束力的区域被怪物和变化试金印射,它基于结构的分析被设计。象点异种一样用 hTIM-1 和它的相当或相同的事物执行的 Pseudovirion 感染试金在 EBOV 细胞的入口验证了 GP 有约束力的地点和 EBOV GP-hTIM-1 相互作用的重要性的地点。 | Shuai Yuan Lei Cao Hui Ling Minghao Dang Yao Sun Xuyuan Zhang Yutao Chen Liguo Zhang Dan Su Xiangxi Wang Zihe Rao | 2015 | Protein & Cell2015，6，11： | 6 |
| 14 | A New Method of Wind Turbine Bearing Fault Diagnosis Based on Multi-Masking Empirical Mode Decomposition and Fuzzy C-Means Clustering显示文摘Based on Multi-Masking Empirical Mode Decomposition (MMEMD) and fuzzy c-means (FCM) clustering, a new method of wind turbine bearing fault diagnosis FCM-MMEMD is proposed, which can determine the fault accurately and timely. First, FCM clustering is employed to classify the data into different clusters, which helps to estimate whether there is a fault and how many fault types there are. If fault signals exist, the fault vibration signals are then demodulated and decomposed into different frequency bands by MMEMD in order to be analyzed further. In order to overcome the mode mixing defect of empirical mode decomposition (EMD), a novel method called MMEMD is proposed. It is an improvement to masking empirical mode decomposition (MEMD). By adding multi-masking signals to the signals to be decomposed in different levels, it can restrain low-frequency components from mixing in highfrequency components effectively in the sifting process and then suppress the mode mixing. It has the advantages of easy implementation and strong ability of suppressing modal mixing. The fault type is determined by Hilbert envelope finally. The results of simulation signal decomposition showed the high performance of MMEMD. Experiments of bearing fault diagnosis in wind turbine bearing fault diagnosis proved the validity and high accuracy of the new method. | Yongtao Hu Shuqing Zhang Anqi Jiang Liguo Zhang Wanlu Jiang Junfeng Li | 2019 | Chinese Journal of Mechanical Engineering2019，32，3： | 6 |
| 15 | Human BDCA2^+CD123^+CD56^+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset显示文摘树枝状的房间(DC ) 包括二个机能上地不同的子集:plasmacytoid DC (pDCs ) 和 myeloid DC (mDCs ) 。pDCs 被专攻类型的快速、巨大的分泌物我响应通过使用费的 nucleic 酸的干扰素(IFN-I ) 相似受体(TLR )-7 或 TLR-9。在这份报告,我们描绘了 CD56 < 啜 class= “ a-plus-plus ” >+ DC 人口包括 CD123 和 BDCA2 表示典型 pDC 标记,但是生产与 pDCs 作比较的少得多 IFN-I。另外, CD56 < 啜 class= “ a-plus-plus ” > 和由介绍的染色体宽的 transcriptional 的 mDCs 然而并非 pDCs 的 + DC 簇。因此, CD56 < 啜 class= “ a-plus-plus ” >+ DC 机能上地由在 TLR4 刺激和 priming na 之上生产 IL-12 类似于 mDCs ? 没有优先的激活的 ve T 房间。这些数据建议 CD56 < 啜 class= “ a-plus-plus ” >+ DC 代表与一些 pDC 特征混合的一个新奇 mDC 子集。CD4 < 啜 class= “ a-plus-plus ” >+ CD56 < 啜 class= “ a-plus-plus ” >+ hematological 恶意作为 blastic plasmacytoid 被分类树枝状的房间瘤(BPDCN ) 由于它 pDCs 的典型分子的表示。然而,我们证明 BPDCN 接近 CD56 < 啜 class= “ a-plus-plus ” >+ DC 比由介绍的全球基因表示的 pDCs。因此,我们建议 CD4 < 啜 class= “ a-plus-plus ” >+ CD56 < 啜 class= “ a-plus-plus ” >+ 瘤可以是 CD56 的一个肿瘤对应物 < 啜 class= “ a-plus-plus ” >+ mDCs 然而并非 pDCs。 | Haisheng Yu Peng Zhang Xiangyun Yin Zhao Yin QuanxinG Shi Ya Cui Guanyuan Liu Shouli Wang Pier Paolo Piccaluga Taijiao Jiang Liguo Zhang | 2015 | Protein & Cell2015，6，4： | 6 |
| 16 | HIV-1 immunopathogenesis in humanized mouse models显示文摘在最近的年里,与人性化的免疫系统构造妄想的老鼠的技术显著地改善了。人的有免疫力的房间的多重系在与人的造血的干细胞被移植了的 immunodeficient 老鼠发展。更重要地,这些老鼠在免疫或微生物引起的感染之上装功能的体液、细胞的有免疫力的回答。人的免疫不全病毒类型(HIV-1 ) 我能在人性化的老鼠建立感染,导致 CD4 +T 房间弄空和伴随的 nonspecific 免疫者激活,它在 HIV-1-infected 人的病人模仿 immunopathology。这为学习 HIV-1 immunopathogenesis 并且为开发新奇基于免疫者的治疗的机制使人性化的老鼠成为一个最佳的模型。 | Liguo Zhang Lishan Su | 2012 | Cellular & Molecular Immunology2012，9，3： | 5 |
| 17 | Wavelet packet-based identification of complex oscillation in biological signals显示文摘Owing to the intrinsic nonlinearities of the system,a contracting mechanism,such as myogenic response,may induce different oscillatory patterns.Many specialists discussed the relations of oscillatory patterns with intrinsic control system or some pathological condition,but there is no single,well-defined criterion to achieve the identification of regular,stochastic,and chaotic activities.In this paper,we focus on the Mallat algorithm of wavelet packet and use it in the identification of the regular periodic,stochastic,and chaotic fluctuations.According to the specific frequency configuration of the chaos activity,we select proper layers of decomposition of wavelet packet and did fine segments to the frequency of signals.The frequency band of energy convergence could be recognized.The signal of periodic,stochastic,and chaotic could be distinguished depending on it.Numerical experiment is given to show its efficiency.Experiments on 12 babies' lung data have been done.This identification by means of wavelet packet could support the cardiologist or cerebral specialist to do more observation and deeper analysis to physic signals. | Zhang Shuqing Sarah K. Spurgeon Zhang Liguo Jin Mei John A. Twiddle Femando S. Schlindwein | 2008 | 仪器仪表学报2008，29，2： | 4 |
| 18 | Prediction of Large Structure Welding Residual Stress by Similitude Principles显示文摘On basis of the similitude principles, the conception of virtual simulative component and the auxiliary value of welding residual stress, which is deduced by the welding conduction theory, the relation of the welding residual stress between the simulative component and the practical component was attained. In order to verify the correctness of the relation, the investigation was done from the view of the welding experiment and the numerical simulation about the simulative component and the practical component. The results show that the distribution of welding residual stress of the simulative component is the same as that of the practical component. The ratio of welding residual stress attained by the experiment or the simulation method between the practical runner and the simulative component was compared with the ratio obtained by the similitude principles. Moreover, the error is less than 10%. This provides a new idea to predict the welding stress distribution of large practical structure by the contractible physical model, which is important for the welding experiment and the numerical simulation. | Shude Ji Liguo Zhang Xuesong Liu Jianguo Yang | 2009 | Journal of Materials Science & Technology2009，25，6： | 4 |
| 19 | Reversible Histone Acetylation Involved in Transcriptional Regulation of WT1 Gene显示文摘验证参与可逆嘘在人的 Wilm 的肿瘤的 transcriptional 规定的一 acetylation 1 基因(WT1 ) ,我们分析了角色嘘一 deacetylases (HDAC ) 并且嘘在这个 epigenetic 过程的一 acetyltransferase。检验的六 HDAC (HDAC1-6 ) , HDAC4 和 HDAC5 被发现有重要镇压在 WT1 记者基因的活动完成,由酶记者试金和量的即时反向的抄写聚合酶链反应揭示了试金。酶记者试金证明一 acetyltransferase p300 能在 WT1 记者的激活与转录因子 Sp1, c-Myb,和 Ets-1 抵抗 HDAC4/HDAC5-mediated 压抑和那 p300/CBP synergized 的 hist。染色质免疫降水实验证明 p300 支持 acetylation 水平嘘在 WT1 intronic 增强子的一 H3。把数据基于这些,我们为参与建议了一个假想模型可逆嘘在 WT1 基因的 transcriptional 规定的一 acetylation。这研究提供进一步的卓见进联系的 WT1 基因和 WT1 的 transcriptional 规定的机制疾病处理。 | Yangguang SHAO Jun LU Cao CHENG Liguo CUI Guoping ZHANG Baiqu HUANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 4 |
| 20 | Time-varying linear control for tiltrotor aircraft显示文摘Tiltrotor aircraft have three flight modes: helicopter mode, airplane mode, and transition mode. A tiltrotor has characteristics of highly nonlinear, time-varying flight dynamics and inertial/-control couplings in its transition mode. It can transit from the helicopter mode to the airplane mode by tilting its nacelles, and an effective controller is crucial to accomplish tilting transition missions. Longitudinal dynamic characteristics of the tiltrotor are described by a nonlinear Lagrangeform model, which takes into account inertial/control couplings and aerodynamic interferences.Reference commands for airspeed velocity and attitude in the transition mode are calculated dynamically by visiting a command library which is founded in advance by analyzing the flight envelope of the tiltrotor. A Time-Varying Linear(TVL) model is obtained using a Taylorexpansion based online linearization technique from the nonlinear model. Subsequently, based on an optimal control concept, an online optimization based control method with input constraints considered is proposed. To validate the proposed control method, three typical tilting transition missions are simulated using the nonlinear model of XV-15 tiltrotor aircraft. Simulation results show that the controller can be used to control the tiltrotor throughout its operating envelop which includes a transition flight, and can also deal with vertical gust disturbances. | Jing ZHANG Liguo SUN Xiangju QU Liuping WANG | 2018 | Chinese Journal of Aeronautics2018，31，4： | 4 |
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