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| 1 | Combined peripheral natural killer cell and circulating tumor cell enumeration enhance prognostic efficiency in patients with metastatic triple-negative breast cancer显示文摘Objective:Triple-negative breast cancer(TNBC)is a heterogeneous disease with poor prognosis.Circulating tumor cells(CTCs)are a promising predictor for breast cancer prognoses but their reliability regarding progression-free survival(PFS)is controversial.We aim to verify their predictive value in TNBC.Methods:In present prospective cohort study,we used the Pep@MNPs method to enumerate CTCs in baseline blood samples from 75 patients with TNBC(taken at inclusion in this study)and analyzed correlations between CTC numbers and outcomes and other clinical parameters.Results:Median PFS was 6.0(range:1.0–25.0)months for the entire cohort,in whom we found no correlations between baseline CTC status and initial tumor stage(P=0.167),tumor grade(P=0.783)or histological type(P=0.084).However,among those getting first-line treatment,baseline CTC status was positively correlated with ratio of peripheral natural killer(NK)cells(P=0.032),presence of lung metastasis(P=0.034)and number of visceral metastatic site(P=0.037).Baseline CTC status was predictive for PFS in first-line TNBC(P=0.033),but not for the cohort as a whole(P=0.118).This prognostic limitation of CTC could be ameliorated by combining CTC and NK cell enumeration(P=0.049).Conclusions:Baseline CTC status was predictive of lung metastasis,peripheral NK cell ratio and PFS in TNBC patients undergoing first-line treatment.We have developed a combined CTC-NK enumeration strategy that allows us to predict PFS in TNBC without any preconditions. | Xiaoran Liu Ran Ran Bin Shao Hope S.Rugo Yanlian Yang Zhiyuan Hu Zewen Wei Fengling Wan Weiyao Kong Guohong Song Hanfang Jiang Xu Liang Ruyan Zhang Ying Yan Guobing Xu Huiping Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 2 | Material exploration via designing spatial arrangement of octahedral units: a case study of lead halide perovskites显示文摘Halide perovskites have attracted tremendous attention as semiconducting materials for various optoelectronic applications.The functional metal-halide octahedral units and their spatial arrangements play a key role in the optoelectronic properties of these materials.At present,most of the efforts for material exploration focus on substituting the constituent elements of functional octahedral units,whereas designing the spatial arrangement of the functional units has received relatively little consideration.In this work,via a global structure search based on density functional theory(DFT),we discovered a metastable three-dimensional honeycomb-like perovskite structure with the functional octahedral units arranged through mixed edge-and comer-sharing.We experimentally confirmed that the honeycomb-like perovskite structure can be stabilized by divalent molecular cations with suitable size and shape,such as 2,2’-bisimidazole(BIM).DFT calculations and experimental characterizations revealed that the honeycomb-like perovskite with the formula of BIMPb2l6,synthesized through a solution process,exhibits high electronic dimensionality,a direct allowed bandgap of 2.1 eV,small effective masses for both electrons and holes,and high optical absorption coefficients,which indicates a significant potential for optoelectronic applications.The employed combination of DFT and experimental study provides an exemplary approach to explore prospective optoelectronic semiconductors via spatially arranging functional units. | Pengfei FU Sanlue HU Jiang TANG Zewen XIAO | 2021 | Frontiers of Optoelectronics2021，14，2： | 3 |
| 3 | Antimony doped Cs2SnCl6 with bright and stable emission显示文摘Lead halide perovskites,with high photoluminescence efficiency and narrow・band emission,are promising materials for display and lighting.However,the lead toxicity and environmental sensitivity hinder their potential applications.Herein,a new antimony・doped lead-free inorganic perovskites variant Cs2SnCl6:xSb is designed and synthesized.The perovskite variant Cs2SnCl6:xSb exhibits a broadband orange-red emission,with a photoluminescence quantum yield(PLQY)of 37%.The photoluminescence of Cs2SnCl6:xSb is caused by the ionoluminescence of Sb3+within Cs2SnCl6 matrix,which is verified by temperature dependent photoluminescence(PL)and PL decay measurements.In addition,the all inorganic structure renders Cs2SnCl6:xSb with excellent thermal and water stability.Finally,a white light-emitting diode(white-LED)is fabricated by assembling Cs2SnCl6:0.59%Sb,Cs2SnCl6:2.75%Bi and Ba2Sr2SiO4:Eu2+onto the commercial UV LED chips,and the color rendering index(CRI)reaches 81. | Jinghui LI Zhifang TAN Manchen HU Chao CHEN Jiajun LUO Shunran LI Liang GAO Zewen XIAO Guangda NIU Jiang TANG | 2019 | Frontiers of Optoelectronics2019，12，4： | 2 |
| 4 | Evolution in physiochemical and cloud condensation nuclei activation properties of crop residue burning particles during photochemical aging显示文摘As a main form of biomass burning in agricultural countries, crop residue burning is a significant source of atmospheric fine particles. In this study, the aging of particles emitted from the burning of four major crop residues in China was investigated in a smog chamber.The particle size distribution, chemical composition and cloud condensation nuclei(CCN)activity were simultaneously measured. The properties of crop residue burning particles varied substantially among different fuel types. During aging, the particle size and mass concentration increased substantially, suggesting condensational growth by formation of secondary aerosols. The particle composition was dominated by organics. Aging resulted in considerable enhancement of organics and inorganics, with enhancement ratios of 1.24–1.44 and 1.33–1.76 respectively, as well as a continuous increase in the oxidation level of organics. Elevated CCN activity was observed during aging, with the hygroscopicity parameter κ varying from 0.16 to 0.34 for fresh particles and 0.19 to 0.40 for aged particles.Based on the volume mixing rule, the hygroscopicity parameter of organic components(κorg) was derived. κorgexhibited an increasing tendency with aging, which was generally consistent with the tendency of the O:C ratio, indicating that the oxidation level was related to the hygroscopicity and CCN activity of organic aerosols from crop residue burning. Our results indicated that photochemical aging could significantly impact the CCN activation of crop burning aerosols, not only by the production of secondary aerosols, but also by enhancing the hygroscopicity of organic components, thereby contributing to the aerosol indirect climate forcing. | Yan Ma Chao Chen Junfeng Wang Youling Jiang Zewen Zheng Hui Chen Jun Zheng | 2019 | Journal of Environmental Sciences2019，31，3： | 1 |
| 5 | Toward carbon neutrality:Uncovering constraints on critical minerals in the Chinese power system显示文摘China has set up its ambitious carbon neutrality target,which mainly relies on significant energy-related carbon emissions reduction.As the largest important contributing sector,power sector must achieve energy transition,in which critical minerals will play an essential role.However,the potential supply and demand for these minerals are uncertain.This study aims to predict the cumulative demand for critical minerals in the power sector under different scenarios via dynamic material flow analysis(DMFA),including total demands,supplies and production capacities of different minerals.Then,these critical minerals are categorized into superior and scarce resources for further analysis so that more detailed results can be obtained.Results present that the total minerals supply will not meet the total minerals demand(74260 kt)in 2060.Serious resource shortages will occur for several key minerals,such as Cr,Cu,Mn,Ag,Te,Ga,and Co.In addition,the demand for renewable energy will be nearly fifty times higher than that of fossil fuels energy,implying more diversified demands for various minerals.Finally,several policy recommendations are proposed to help improve the overall resource efficiency,such as strategic reserves,material substitutions,and circular economy. | Wendong Wei Zewen Ge Yong Geng Mingkun Jiang Zhujun Chen Wei Wu | 2022 | Fundamental Research2022，2，3： | 1 |
| 6 | Building Better Full Manganese‑Based Cathode Materialsfor Next‑Generation Lithium‑Ion Batteries显示文摘Lithium-manganese-oxides have been exploited as promising cathode materials for many years due to their environmental friendliness,resource abundance and low biotoxicity.Nevertheless,inevitable problems,such as Jahn-Teller distortion,manganese dissolution and phase transition,still frustrate researchers;thus,progress in full manganese-based cathode materials(FMCMs)has been relatively slow and limited in recent decades.Recently,with the fast growth of vehicle electrification and large-scale energy-storage grids,there has been an urgent demand to develop novel FMCMs again;actually,new waves of research based on FMCMs are being created.Herein,we systematically review the history of FMCMs,correctly describe their structures,evaluate the advantages and challenges,and discuss the resolution strategies and latest developments.Additionally,beyond FMCMs,a profound discussion of current controversial issues,such as oxygen redox reaction,voltage decay and voltage hysteresis in Li_(2)MnO_(3)-based cathode materials,is also presented.This review summarizes the effectively optimized approaches and offers a few new possible enhancement methods from the perspective of the electronic-coordination-crystal structure for building better FMCMs for next-generation lithium-ion batteries. | Jin Song Hangchao Wang Yuxuan Zuo Kun Zhang Tonghuan Yang Yali Yang Chuan Gao Tao Chen Guang Feng Zewen Jiang Wukun Xiao Tie Luo Dingguo Xia | 2023 | Electrochemical Energy Reviews2023，6，1： | 0 |
| 7 | Photothermal‑Triggered Structural Change of Nanofiber Scaffold Integrating with Graded Mineralization to Promote Tendon–Bone Healing显示文摘Scaffolds functionalized with graded changes in both fiber alignment and mineral content are more appealing for tendon-bone healing.This study reports the healing of rotator cuff injury using a heterogeneous nanofiber scaffold,which is associated with a structural gradating from aligned to random and an increasing gradient of mineral content in the same orientation.The photothermal-triggered structural change of a nanofiber scaffold followed by graded mineralization is key to constructing such scaffolds.This type of scaffold was found to be biocompatible and provide beneficial contact guidance in the manipulation of tendon-derived stem cell morphologies in vitro.Specifically,tenogenic and osteogenic differentiation of tendon-derived stem cells were simultaneously achieved using the fabricated scaffold.In vivo investigation also showed the improved healing of rabbit rotator cuff injuries based on immunohistochemical analysis and biomechanical investigation that indicates the promising potential of a dual-gradient nanofiber scaffold in clinical tendon-bone healing. | Chenghao Yu Tianrui Wang Hongcui Diao Na Liu Yi Zhang Hongyuan Jiang Peng Zhao Zhengyi Shan Zewen Sun Tong Wu Xiumei Mo Tengbo Yu | 2022 | Advanced Fiber Materials2022，4，4： | 0 |
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