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| 1 | Composition, source, mass closure of PM_(2.5) aerosols for four forests in eastern China显示文摘PM2.5 aerosols were collected in forests along north latitude in boreal-temperate, temperate, subtropical and tropical climatic zones in eastern China, i.e., Changbai Mountain Nature Reserve (CB), Dongping National Forest Park in Chongming Island (CM), Dinghu Mountain Nature Reserve (DH), Jianfengling Nature Reserve in Hainan Island (HN). The mass concentrations of PM2.5, organic carbon (OC), elemental carbon (EC), water soluble organic carbon (WSOC) as well as concentrations of ten inorganic ions (F-, Cl-, NO3-, SO42-, C2O42-, NH4+, Na+, K+, Ca2+, Mg2+) were determined. Aerosol chemical mass closures were achieved. The 24-hr average concentrations of PM2.5 were 38.8, 89.2, 30.4, 18 μg/m3 at CB, CM, DH and HN, respectively. Organic matter and EC accounted for 21%-33% and 1.3%-2.3% of PM2.5 mass, respectively. The sum of three dominant secondary ions (SO42-, NO3-, NH4+) accounted for 44%, 50%, 45% and 16% of local PM2.5 mass at CB, CM, DH and HN, respectively. WSOC comprised 35%-65% of OC. The sources of PM2.5 include especially important regional anthropogenic pollutions at Chinese forest areas. | Li Li Wu Wang Jialiang Feng Dongping Zhang Huaijian Li Zeping Gu Bangjin Wang Guoying Sheng Jiamo Fu | 2010 | Journal of Environmental Sciences2010，22，3： | 45 |
| 2 | Diurnal variations of polycyclic aromatic hydrocarbons associated with PM_(2.5) in Shanghai, China显示文摘Forty-eight daily time interval PM2.5 samples were collected from December 2006 to January 2008 in an urban site in Shanghai, China. Concentrations and compositions of polycyclic aromatic hydrocarbons (PAHs) were analyzed with GC-MS to study the diurnal and seasonal variations and to identify the main emitting sources. The diurnal variation of the PAHs concentrations was greater in the late autumn and winter sampling days, and was greatly influenced by meteorological conditions such as wind speed and ambient temperature. The concentration of PAHs in the mornings (6:30-10:00) increased distinctly, and was high in the late autumn and winter sampling days, indicating the contribution from vehicle emissions during rush hours. The diurnal variation of the high molecular weight PAHs did not seem to be controlled by the shift of gas-particle partitioning due to temperature variation, instead, it could be indicative of the variation in the source. Statistical analyses showed that the concentrations of PAHs were negatively correlated with temperature and wind speed, and positively correlated with relative humidity. Diagnostic ratios of PAHs suggested mixed emission sources of petroleum and coal/biomass combustion for PAHs in the PM2.5 in Shanghai. | Zeping Gu Jialiang Feng Wenliang Han Li Li Minghong Wu Jiamo Fu Guoying Sheng | 2010 | Journal of Environmental Sciences2010，22，3： | 13 |
| 3 | Oxygenation,inflammatory response and lung injury during one lung ventilation in rabbits using inspired oxygen fraction of 0.6 vs.1.0显示文摘Maintaining adequate oxygenation during one-lung ventilation(OLV) requires high inspired oxygen fraction(FiO_2).However,high FiO_2 also causes inflammatory response and lung injury.Therefore,it remains a great interest to clinicians and scientists to optimize the care of patients undergoing OLV.The aim of this study was to determine and compare oxygenation,inflammatory response and lung injury during OLV in rabbits using FiO_2 of 0.6 vs.1.0.After 30 minutes of two-lung ventilation(TLV) as baseline,30 rabbits were randomly assigned to three groups receiving mechanical ventilation for 3 hours:the sham group,receiving TLV with 0.6 FiO_2;the 1.0 FiO_2 group,receiving OLV with 1.0 FiO_2;the 0.6 FiO_2 group,receiving OLV with 0.6 FiO_2.Pulse oximetry was continuously monitored and arterial blood gas analysis was intermittently conducted.Histopathologic study of lung tissues was performed and inflammatory cytokines and the mRNA and protein of nuclear factor kappa B(NF-κB) p65 were determined.Three of the 10 rabbits in the 0.6 FiO_2 group suffered hypoxemia,defined by pulse oximetric saturation(SpO_2) less than 90%.Partial pressure of oxygen(PaO_2),acute lung injury(ALI) score,myeloperoxidase(MPO),tumor necrosis factor-a(TNF-α),interleukin-6(IL-6),mRNA and protein of NF-kB p65 were lower in the 0.6 FiO_2group than in the 1.0 FiO_2 group.In conclusion,during OLV,if FiO_2 of 0.6 can be tolerated,lung injury associated with high FiO_2 can be minimized.Further study is needed to validate this finding in human subjects. | Zeping Xu Lianbing Gu Qingming Bian Pengyi Li Lijun Wang Jingyuan Zhang Yanning Qian | 2017 | The Journal of Biomedical Research2017，31，1： | 7 |
| 4 | SERK Receptor-like Kinases Control Division Patterns of Vascular Precursors and Ground Tissue Stem Cells during Embryo Development in Arabidopsis显示文摘During embryo development, the vascular precursors and ground tissue stem cells divide to renew them-selves and produce the vascular tissue, endodermal cells, and cortical cells. However, the molecular mech-anisms regulating division of these stem cells have remained largely elusive. In this study, we show that loss of function of SOMATIC EMBRYOGENESIS RECEPTOR-UKE KINASE (SERK) genes results in aberrant em-bryo development. Fewer cortical, endodermal, and vascular cells are generated in the embryos of serk1 serk2bak1 triple mutants. WUSCHEL-RELATED HOMBOBOX5 (WOXS) is ectopically expressed in vascular cells of serkl serk2 bak1 embryos. The first transverse division of vascular precursors in mid-globular em-bryos and second asymmetric division of ground tissue stem cells in early-heart embryos are abnormally altered to a longitudinal division. The embryo defects can be partially rescued by constitutively activated mitogen-activated protein kinase (MAPK) kinase kinase YODA (YDA) and MAPK kinase MKK5. Taken together, our results reveal that SERK-mediated signals regulate division patterns of vascular precursors and ground tissue stem cells, likely via the YDA-MKK4/5 cascade, during embryo development. | Huiqiang Li Zeping Cai Xiaojuan Wang Meizhen Li Yanwei Cui Nan Cui Fei Yang Mingsong Zhu Junxiang Zhao Wenbin Du Kai He Jing Yi Frans E.Tax Suiwen Hou Jia Li Xiaoping Gou | 2019 | Molecular Plant2019，12，7： | 7 |
| 5 | Cyclin-dependent Kinase 18 Promotes Oligodendrocyte Precursor Cell Differentiation through Activating the Extracellular Signal-Regulated Kinase Signaling Pathway显示文摘The correct differentiation of oligodendrocyte precursor cells(OPCs) is essential for the myelination and remyelination processes in the central nervous system.Determining the regulatory mechanism is fundamental to the treatment of demyelinating diseases. By analyzing the RNA sequencing data of different neural cells, we found that cyclin-dependent kinase 18(CDK18) is exclusively expressed in oligodendrocytes. In vivo studies showed that the expression level of CDK18 gradually increased along with myelin formation during development and in the remyelination phase in a lysophosphatidylcholine-induced demyelination model, and was distinctively highly expressed in oligodendrocytes. In vitro overexpression and interference experiments revealed that CDK18 directly promotes the differentiation of OPCs, without affecting their proliferation or apoptosis. Mechanistically, CDK18 activated the RAS/mitogen-activated protein kinase kinase1/extracellular signal-regulated kinase pathway, thus promoting OPC differentiation. The results of the present study suggest that CDK18 is a promising cell-type specific target to treat demyelinating disease. | Yuchen Pan Zeping Jiang Dingya Sun Zhenghao Li Yingyan Pu Dan Wang Aijun Huang Cheng He Li Cao | 2019 | Neuroscience Bulletin2019，35，5： | 4 |
| 6 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hf5wfnuxcu00k6065.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 7 | Experimental investigation of Z-pinch radiation source for indirect drive inertial confinement fusion显示文摘Z-pinch dynamic hohlraums(ZPDHs)could potentially be used to drive inertial confinement fusion targets.Double-or multishell capsules using the technique of volume ignition could exploit the advantages of ZPDHs while tolerating their radiation asymmetry,which would be unacceptable for a central ignition target.In this paper,we review research on Z-pinch implosions and ZPDHs for indirect drive targets at the Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics.The characteristics of double-shell targets and the associated technical requirements are analyzed through a one-dimensional computer code developed from MULTI-IFE.Some key issues regarding the establishment of suitable sources for dynamic hohlraums are introduced,such as soft X-ray power optimization,novel methods for plasma profile modulation,and the use of thin-shell liner implosions to inhibit the generation of prior-stagnated plasma.Finally,shock propagation and radiation characteristics in a ZPDH are presented and discussed,together with some plans for future work. | Zhenghong Li Zhen Wang Rongkun Xu Jianlun Yang Fan Ye Yanyun Chu Zeping Xu Faxin Chen Shijian Meng Jianmin Qi Qinyuan Hu Yi Qin Jiaming Ning Zhanchang Huang Linbo Li Shuqing Jiang | 2019 | Matter and Radiation at Extremes2019，4，4： | 1 |
| 8 | Suicide among the elderly in mainland China显示文摘 | Li Xia Zeping Xiao Shifu Xiao | | 0，，02： | 1 |
| 9 | Simulation of groundwater and nuclide transport in the near-field of the high-level radioactive waste repository with TOUGHREACT显示文摘In order to know the mechanism of groundwater transport and the variation of ion concentrations in the near-field of the high-level radioactive waste repository,the whole process was simulated by EOS3 module of TOUGHREACT.Generally,the pH and cation concentrations vary obviously in the near-field saturated zone due to interaction between groundwater and bentonite.Moreover,the simulated results showed that calcite precipitation could not cause obvious variations in the porosity of media in the near-filed if the chemical components and their concentrations of groundwater and bentonite pore water are similar to those used in this study. | LI Xun YANG Zeping ZHENG Zhihong WU Hongmei | 2008 | Chinese Journal Of Geochemistry2008，27，3： | 1 |
| 10 | Suicide among the elderly in mainland China显示文摘 | Xia LI Zeping XIAO Shifu XIAO | 2009 | Psychogeriatrics2009，，： | 1 |
| 11 | Field Efficacy Test of 22% Fipronil FS against Sugarcane Stem Borers and Thrips显示文摘[Objective] The paper was to explore the field efficacy of 22% fipronil FS against sugarcane stem borer and thrips( Baliothrips serratus Kobus).[Method]The field trial was conducted by foliar spraying of 22% fipronil FS and mixed broadcasting with fertilizer in 2014. [Result]Foliar spraying of 22%fipronil FS at the dose of 50 m L /667 m^2 had the best control effect against sugarcane stem borer,and the control effect at 90 d post administration was 70. 70%,significantly higher than that of control agent(61. 86%). Medium and high dose of 22% fipronil FS had better control effects against sugarcane thrips. [Conclusion] Considering control effects against sugarcane stem borers and thrips as well as sugarcane yield,it is recommended that 22% fipronil FS is sprayed at medium concentration(50 mL /667 m^2). | Wang Zeping Liu Lu Jiang Hongtao Zhang Gemin Huang Weihua Liang Qiang Duan Weixing Li Yijie Wei Jinju Qin Zhenqiang Huang Chenghua Lin Shanhai | 2016 | Plant Diseases and Pests2016，7，4： | 1 |
| 12 | Ion–Electron Coupling Enables Ionic Thermoelectric Material with New Operation Mode and High Energy Density显示文摘Ionic thermoelectrics(i-TE) possesses great potential in powering distributed electronics because it can generate thermopower up to tens of millivolts per Kelvin. However,as ions cannot enter external circuit, the utilization of i-TE is currently based on capacitive charge/discharge, which results in discontinuous working mode and low energy density. Here,we introduce an ion–electron thermoelectric synergistic(IETS)effect by utilizing an ion–electron conductor. Electrons/holes can drift under the electric field generated by thermodiffusion of ions, thus converting the ionic current into electrical current that can pass through the external circuit. Due to the IETS effect, i-TE is able to operate continuously for over 3000 min.Moreover, our i-TE exhibits a thermopower of 32.7 mV K^(-1) and an energy density of 553.9 J m^(-2), which is more than 6.9 times of the highest reported value. Consequently, direct powering of electronics is achieved with i-TE. This work provides a novel strategy for the design of high-performance i-TE materials. | Yongjie He Shaowei Li Rui Chen Xu Liu George Omololu Odunmbaku Wei Fang Xiaoxue Lin Zeping Ou Qianzhi Gou Jiacheng Wang Nabonswende Aida Nadege Ouedraogo Jing Li Meng Li Chen Li Yujie Zheng Shanshan Chen Yongli Zhou Kuan Sun | 2023 | Nano-Micro Letters2023，15，7： | 1 |
| 13 | Influences of Electrolytes on Soap-Free P(ST-MMA-AA) Emulsion Polymerization显示文摘 | Zeping LI Ronglong LI Yi DU Chengyou KAN Deshan LIU | 2005 | 复旦学报(自然科学版)2005，44，5： | 0 |
| 14 | Nanomeshed Si nanomembranes显示文摘One of the main challenges in stretchable electronics is to achieve high-performance stretchable semiconductors. Here, weintroduce an innovative concept of nanomeshed semiconductor nanomembrane which can be regarded almost as intrinsicallystretchable to conventional microelectronic layouts. By making a silicon film into homogeneous nanomeshes with spring-like nanotraces, we demonstrated a high electron mobility of 50 cm^(2)/V·s, and moderate stretchability with a one-time strain of 25% andcyclic strain of 14% after stretching for 1000 cycles, further improvable with optimized nanomesh designs. A simple analytic modelcovering both fractional material and trace sidewall surfaces well predicted the transport properties of the normally on siliconnanomesh transistors, enabling future design and optimizations. Besides potential applications in stretchable electronics, thissemiconductor nanomesh concept provides a new platform for materials engineering and is expected to yield a new family ofstretchable inorganic materials having tunable electronic and optoelectronic properties with customized nanostructures. | Xun Han Kyung Jin Seo Yi Qiang Zeping Li Sandra Vinnikova Yiding Zhong Xuanyi Zhao Peijie Hao Shuodao Wang Hui Fang | 2019 | npj Flexible Electronics2019，3，1： | 0 |
| 15 | Small-molecule agents for cancer immunotherapy显示文摘Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer therapy.They induce long-term tumor regression and overall survival benefit in many types of cancer.With the advances in our knowledge about the tumor immune microenvironment,remarkable progress has been made in the development of small-molecule drugs for immunotherapy.Small molecules targeting PRR-associated pathways,immune checkpoints,oncogenic signaling,metabolic pathways,cytokine/chemokine signaling,and immune-related kinases have been extensively investigated.Monotherapy of smallmolecule immunotherapeutic drugs and their combinations with other antitumor modalities are under active clinical investigations to overcome immune tolerance and circumvent immune checkpoint inhibitor resistance.Here,we review the latest development of small-molecule agents for cancer immunotherapy by targeting defined pathways and highlighting their progress in recent clinical investigations. | Fang Wang Kai Fu Yujue Wang Can Pan Xueping Wang Zeyu Liu Chuan Yang Ying Zheng Xiaopeng Li Yu Lu Kenneth Kin Wah To Chenglai Xia Jianye Zhang Zhi Shi Zeping Hu Min Huang Liwu Fu | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 16 | Clinical antitumor application and pharmacological mechanisms of Dahuang Zhechong Pill显示文摘Cancer still has elevated morbidity and mortality,which undoubtedly impacts the life quality of affected individuals.Remarkable advances have been made in cancer therapy,although the toxicities of traditional therapies remain an obvious challenge.Dahuang Zhechong Pill(DHZCP),developed by Zhongjing Zhang in the Synopsis of the Golden Chamber,represents an effective anticancer traditional Chinese medicine(TCM).In this review,it was found that DHZCP is therapeutically utilized in liver,lung,gastric,pancreatic and other cancers in clinic.Pharmacological evidence showed that its anti-tumor mechanisms mainly involve induced cell cycle arrest,apoptosis and autophagy,as well as suppressed tumor cell proliferation,obstructed angiogenesis and metastasis,enhanced immunity,and reversal of multidrug resistance.The present review provides a solid basis for the clinical application of DHZCP and may promote the wide use of TCM in clinical antitumor application. | Yingying Tian Beibei Ma Shangyue Yu Yilin Li Hailuan Pei Shiqiu Tian Xinyue Zhao Chuang Liu Zeping Zuo Zhibin Wang | 2023 | Chinese Herbal Medicines2023，15，2： | 0 |
| 17 | Noise canceled graphene-microcavity fiber laser sensor for ultrasensitive gas detection显示文摘Optical microcavities offer a promising platform for highly efficient light–matter interactions.Recently,the combination of microresonators and 2D materials in the nanoscale has further enriched the optoelectronics of microcavity geometries,spurring broad advances including lasers,nonlinear converters,modulators,and sensors.Here,we report the concept of compact dual-laser cogeneration in a graphene-microcavity fiber,which offers a way to cancel the optical common mode noises.Driven by a single 980 nm pump,orthogonally polarized laser lines are generated in a pair of degeneracy breaking modes.The two laser lines produce a heterodyne beat note at 118.96 MHz,with frequency noise down to 200 Hz~2∕Hz at 1 MHz offset,demonstrating a linewidth of 930 Hz in vacuum.This compact device enables on-line and label-free NH_(3) gas detection with high resolution,realizing a detection limit on a single pmol/L level,and a capability to quantitatively trace gas–graphene interactions.Such a combination of graphene optoelectronics and microcavity photonics demonstrates a novel physical paradigm for microlaser control and offers a new scheme for in situ chemical sensing. | YUCHEN WANG YIWEI LI YICHENG LI HAO ZHANG ZIHAN LIU YANHONG GUO ZEPING WANG JUN HE XUHAN GUO YIPING WANG BAICHENG YAO | 2023 | Photonics Research2023，11，8： | 0 |
| 18 | Occurrence of Major Diseases and Insect Pests in Medium-term Growth Period of Sugarcane and The Diseases Resistance Evaluation in Guangxi显示文摘To figure out major diseases and insect pests of sugarcane and sugarcane resistance to diseases,the occurrence of major diseases and insect pests on 11 main sugarcane varieties in eight sugarcane producing areas of Guangxi was investigated during the medium-term growth period of sugarcane in 2015,and field resistance to smut and mosaic diseases was evaluated. The results showed that the dead heart rate( DHR) ranged from 0. 00% to 38. 55%; new-planting sugarcane of Guiliu 2 and ratoon sugarcane of Liucheng 05-136 suffered the most severe damage in Beihai city,and the DHR were 38. 55% and 37. 66%,respectively. The incidence rate of smut disease ranged from 0. 00% to 24. 89%. Ratoon sugarcane was more susceptible to smut than new-planting sugarcane among all investigated varieties. Variety ROC22 was most susceptible to smut,and performed moderate susceptibility. Guiliu 2 was the second susceptible and performed resistance,with the incidence rate of 7. 45%. The rest nine varieties had high resistance. Sugarcane mosaic disease occurred mildly in Guangxi,and the incidence rate ranged from 0. 39% to 7. 73%. ROC22,Guitang 42 and Guiliu 2 expressed moderate resistance and the rests exhibited resistance. Sugarcane in Nanning and Beihai suffered more severe damage than those in other producing areas. The field evaluation system of sugarcane resistance to borers was expected to be constructed. ROC22 was most susceptible to smut,compared with other main varieties. Mosaic diseases occurred lightly in Guangxi. Multi-location and multi-year observation are necessary for accurate evaluation of sugarcane resistance to smut and mosaic diseases. | Li Yijie Duan Weixing Huang Zhi Wang Zeping Li Wenjiao Wei Kaijun Lu Wenjuan Lin Shanhai | 2016 | Plant Diseases and Pests2016，7，3： | 0 |
| 19 | Progress in research on tumor microenvironment-based spatial omics technologies显示文摘Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information.It is characterized by the ability to visualize changes in molecular information and yields intuitive and vivid visual results.Spatial omics technologies include spatial transcriptomics,spatial proteomics,spatial metabolomics,and other technologies,the most widely used of which are spatial transcriptomics and spatial proteomics.The tumor microenvironment refers to the surrounding microenvironment in which tumor cells exist,including the surrounding blood vessels,immune cells,fibroblasts,bone marrow-derived inflammatory cells,various signaling molecules,and extracellular matrix.A key issue in modern tumor biology is the application of spatial omics to the study of the tumor microenvironment,which can reveal problems that conventional research techniques cannot,potentially leading to the development of novel therapeutic agents for cancer.This paper summarizes the progress of research on spatial transcriptomics and spatial proteomics technologies for characterizing the tumor immune microenvironment. | FANGMEI XIE NAITE XI ZEPING HAN WENFENG LUO JIAN SHEN JINGGENG LUO XINGKUI TANG TING PANG YUBING LV JIABING LIANG LIYIN LIAO HAOYU ZHANG YONG JIANG YUGUANG LI JINHUA HE | 2023 | Oncology Research2023，31，6： | 0 |
| 20 | The Evaluation of Visual Cadavers in Medical Laboratory: from Teaching to Practical Applications显示文摘Visual Cadavers is anemerging study method which promotes medical education and practical applications.It is benefited from other techniques and evaluated as having huge advantages,which is not only accelerating teaching and learning,but also improving scientific study,nevertheless,with limited cons. | Xinbozi XIONG Yanlin CHEN Zeping LI Xuezhong XIONG | 2018 | 国际感染病学(电子版)2018，7，4： | 0 |
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