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143篇 您的检索式:作者名="Zepeda"
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1The detrimental effects of lipopolysaccharideinduced neuroinflammation on adult hippocampal neurogenesis depend on the duration of the pro-inflammatory response显示文摘Adult hippocampal neurogenesis is a finely tuned process regulated by extrinsic factors. Neuroinflammation is a hallmark of several pathological conditions underlying dysregulation of neurogenesis. In animal models, lipopolysaccharide(LPS)-induced neuroinflammation leads to a neurogenic decrease mainly associated to the early inflammatory response. However, it is not well understood how the neuroinflammatory response progresses over time and if neurogenesis continues to be diminished during the late neuroinflammatory response. Moreover, it is unknown if repeated intermittent administration of LPS along time induces a greater reduction in neurogenesis. We administered one single intraperitoneal injection of LPS or saline or four repeated injections(one per week) of LPS or saline to young-adult mice. A cohort of new cells was labeled with three 5-bromo-2-deoxyuridine injections(one per day) 4 days after the last LPS injection. We evaluated systemic and neuroinflammation-associated parameters and compared the effects of the late neuroinflammatory response on neurogenesis induced by each protocol. Our results show that 1) a single LPS injection leads to a late pro-inflammatory response characterized by microglial activation, moderate astrocytic reaction and increased interleukin-6 levels. This response correlates in time with decreased neurogenesis and 2) a repeated intermittent injection of LPS does not elicit a late pro-inflammatory response although activated microglia persists. The latter profile is not accompanied by a continued longterm hippocampal neurogenic decrease. Hereby, we provide evidence that the neuroinflammatory response is a dynamic process that progresses in a milieu-dependent manner and does not necessarily lead to a neurogenic decrease, highlighting the complex interaction between the immune system and neurogenesis.Martha Pérez-Domínguez Evangelina ávila-Mu?oz Eduardo Domínguez-Rivas Angélica Zepeda 2019Neural Regeneration Research2019,14,5:2
2When all Work is Never Done:Time Allocation in US Family Farm Households显示文摘Kim J Zepeda L 2004Feminist Economics2004,10,1:1
3Impact of Al and Ti ions on the dispersion and performance of supported NiMo(W)/SBA-15 catalysts in the HDS and HYD reactions 显示文摘Olivasa A Zepeda T A 2009Catalysis Today2009,143,12:1
4Cap-independent translation of maize Hsp101显示文摘DINKOVA T D ZEPEDA H MARTINEZ-SALAS E 2005The Plant Journal2005,41,5:1
5Decrease of peritoneal inflammatory CD4+, CD8+, CD19+ lymphocy tes and apop- tosis of eosinophil s in a murine Taenia crassieeps infection显示文摘Nadia Zepeda San dra Solano Nata lia Copitin 2010Parasi- tol Res2010,107,:1
6Morphology and mechanical properties of foamed polyethylene-polypropylene blends显示文摘Tejeda Elias Herrera Sahagun Carlos Zepeda GonzalezNuNez Ruben 2005Journal of Cellular Plastics2005,41,5:1
7Functional reorgan-ization of visual cortex maps after ischemic lesions is accompaniedby changes in expression of cytoskeletal proteins and NMDA andGABAA receptor subunits显示文摘Zepeda A Sengpiel F Guaqnelli MA 2004Neurosci2004,24,8:1
8Integrating multi-product production and distribution in newspaper logistics 显示文摘Russell R Chiang WC Zepeda D 2008Com- puters Operations Research2008,35,9:1
9Impact of Al and Ti ions on the dispersion and performance of supported NiMo(W)/SBA-15 catalysts in the HDS and HYD reactions 显示文摘Olivas A Zepeda T A 2009Catalysis Today2009,143,:1
10Functional reorganization of visual cortex maps after ischemic lesions is accompanied by changes in expression of cytoskeletal proteins and NMDA and GABAA receptor subunits 显示文摘Zepeda A Sengpiel F Guagnelli MA 2004J Neurosci2004,24,:1
11Concept of compartmentalisation显示文摘Scott A Zepeda C Garber L 2006OIE Bulletin2006,2,:1
12Light chain deposition disease : novel biological insights and treatment advances 显示文摘Jimenez- Zepeda VH 2012Int J Lab Hematol2012,34,4:1
13The association of Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs in peptic ulcer disease 显示文摘Zapata Colindres J C Zepeda Gomez S Montano Loza A 2006Can J Gastroenterol2006,20,4:1
14Specific detection of Taenia saginata eggs by DNA hybridisation 显示文摘Flisser A Reid A Gareia Zepeda E 1988Lancet1988,2,8625:1
15Sensory analysis and consumer acceptance of irradiated boneless pork chops显示文摘LUCHSINGER S E KROPF D H GARCIA ZEPEDA C M 1996J Food Sci1996,61,6:1
16Drpl loss-of-func- tion reduces cardiomyocyte oxygen dependence protect, ing the heart from ischemia-reperfusion injury 显示文摘Zepeda R Kuzmicic J Parra V 2014J Cardiovasc Pharmacol2014,63,6:1
17菠萝的离体繁殖显示文摘Cesar Zepeda 邓家祺 1983热带作物译丛1983,,04:1
18显示文摘PAWELEC B CASTANO P ZEPEDA T A 2008Appl Surf Sci2008,254,13:1
19Integrating Multiproduct Production and Distribution in Newspaper Logistics显示文摘Russell R Cbiang Wen-Chyuan Zepeda D 2008Computers and Operations Research2008,35,5:1
20Prognostic significance of cutaneous depigmentation in Mexican patients with malignant melanoma显示文摘Rodriguez-Cuevas S Lopez-chavira A Zepeda del Rio G 1998Arch Med Res1998,29,2:1
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