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| 1 | Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome显示文摘Hutchinson-Gilford 早衰症候群(HGPS ) 和沃纳症候群(WS ) 是二最好描绘的人的 progeroid 症候群。HGPS 被一个点变化在 lamin A (LMNA ) 基因引起,导致截断的蛋白质 productprogerin 的生产。WS 被变化在 WRN 基因引起,编码 loss-of-function RecQ DNA helicase。这里,由基因编辑,我们创造了 isogenic 人的胚胎的干细胞(转换字符) 与异质接合(G608G/+) 或同型结合(G608G/G608G ) LMNA 变化和 biallelic WRN 大美人为为 HGPS 和 WS 致病建模,分别地。当转换字符和 endothelial 房间(EC ) 没介绍早熟的老朽的任何特征时, HGPS 间充质、 WS 间充质的干细胞(MSC ) 与不同动力学显示出联系老化的显型。当 HGPS-MSCs 展出了迟了发作的尖锐早衰 characterisitcs 时, WS-MSCs 有早发作的温和早衰显型。一起拿,我们的学习比较并且形成对照不同病理 underpinning 二早衰混乱,并且提供可靠干细胞为病理学、生理的老化识别新治疗学的策略的基于的模型。 | Zeming Wu Weiqi Zhang Moshi Song Wei Wang Gang Wei Wei Li Jinghui Lei Yu Huang Yanmei Sang Piu Chan Chang Chen Jing Qu Keiichiro Suzuki Juan Carlos Izpisua Belmonte Guang-Hui Liu | 2018 | Protein & Cell2018，9，4： | 15 |
| 2 | Zircon U–Pb and Hf isotopic study of Neoproterozoic granitic gneisses from the Alatage area, Xinjiang:constraints on the Precambrian crustal evolution in the Central Tianshan Block显示文摘The architecture and growth history of Precambrian crustal basements in the Central Tianshan Block play a key role in understanding the tectonic evolution of the Chinese Tianshan Orogenic Belt.In this study,we present precise LA-ICP-MS zircon U–Pb dating and LAMC-ICPMS zircon Hf isotopic data for two granitic gneisses from Alatage area in the Central Tianshan Block.The magmatic zircons from both samples yield similar protolith ages of 945±6 and 942±6 Ma,indicating that the early Neoproterozoic magmatism is prevailed in the Alatage area.These zircons have crustal Hf model ages of1.82–2.22 and 1.70–2.03 Ga,respectively,which are significantly older than their crystallization ages.It indicates that their parental magmas were derived from the reworking of ancient crust.However,we suggest that these Paleoproterozoic Hf model ages might result from mixing of continental materials with different ages in the Neoproterozoic crust.The inherited(detrital)zircon cores not only yield a wide age range of ca.989–1617 Ma,but also exhibit large Hf-isotope variations with Hf model ages of1.54–2.30 Ga.In particular,some 1.4–1.6 Ga zircons show high initial176Hf/177Hf ratios,consistent with those of depleted mantle,which indicates that the Mesoproterozoic event involved both reworking of older crust and generation of juvenile crust.The Central Tianshan Block has different Precambrian crustal growth history from the Tarim Craton.Therefore,it would not be a fragment of the Precambrian basement of the Tarim Craton. | Botao Huang Zhenyu He Keqing Zong Zeming Zhang | 2014 | Chinese Science Bulletin2014，59，1： | 12 |
| 3 | Single atom accelerates ammonia photosynthesis显示文摘Atomically dispersed metal has gained much attention because of the new opportunities they offer in catalysis. However, it is still crucial to understand the mechanism of single-atom catalysis at molecular level for expanding them to other more difficult catalytic reactions, such as ammonia synthesis from nitrogen. In fact, developing ammonia synthesis under ambient conditions to overcome the high energy consumption in well-established Haber-Bosch process has fascinated scientists for many years.Herein, we demonstrate that single Cu atom yields facile valence-electron isolation from the conjugated π electron cloud of p-CN. Electron spin resonance measurements reveal that these isolated valence electrons can be easily excited to generate free electrons under photo-illumination, thus inducing high efficient photo-induced ammonia synthesis under ambient conditions.The NH_3 producing rate of copper modified carbon nitride(Cu-CN) reached 186 μmol g^(-1) h^(-1) under visible light irradiation with the quantum efficiency achieved 1.01% at 420 nm monochromatic light. This finding surely offers a model to open up a new vista for the ammonia synthesis at gentle conditions. The introduction of single atom to isolate the valence electron also represents a new paradigm for many other photocatalytic reactions, since the most photoinduced processes have been successfully exploited sharing the same origin. | Pengcheng Huang Wei Liu Zhihai He Chong Xiao Tao Yao Youming Zou Chengming Wang Zeming Qi Wei Tong Bicai Pan Shiqiang Wei Yi Xie | 2018 | Science China Chemistry2018，61，9： | 8 |
| 4 | Super-resolution fluorescence-assisted diffraction computational tomography reveals the threedimensional landscape of the cellular organelle interactome显示文摘The emergence of super-resolution(SR)fluorescence microscopy has rejuvenated the search for new cellular substructures.However,SR fluorescence microscopy achieves high contrast at the expense of a holistic view of the interacting partners and surrounding environment.Thus,we developed SR fluorescence-assisted diffraction computational tomography(SR-FACT),which combines label-free three-dimensional optical diffraction tomography(ODT)with two-dimensional fluorescence Hessian structured illumination microscopy.The ODT module is capable of resolving the mitochondria,lipid droplets,the nuclear membrane,chromosomes,the tubular endoplasmic reticulum,and lysosomes.Using dual-mode correlated live-cell imaging for a prolonged period of time,we observed novel subcellular structures named dark-vacuole bodies,the majority of which originate from densely populated perinuclear regions,and intensively interact with organelles such as the mitochondria and the nuclear membrane before ultimately collapsing into the plasma membrane.This work demonstrates the unique capabilities of SR-FACT,which suggests its wide applicability in cell biology in general. | Dashan Dong Xiaoshuai Huang Liuju Li Heng Mao Yanquan Mo Guangyi Zhang Zhe Zhang Jiayu Shen Wei Liu Zeming Wu Guanghui Liu Yanmei Liu Hong Yang Qihuang Gong Kebin Shi Liangyi Chen | 2020 | Light(Science & Applications)2020，9，1： | 7 |
| 5 | Synthesis,Characterization of Rare-Earth Metal Chlorides Bearing Indolyl-Based NCN Pincer Ligand and Their Catalytic Activity toward 1,4-cis Polymerization of Isoprene显示文摘A novel indolyl-based NCN pincer ligand precursor HL(HL=(1-(2-(CH_(2))_(4)NCH_(2)CH_(2))-3-(2,6-ipr_(2)C_(6)H_(3)N=CH)C_(8)H_(5)N))was rationally and precisely designed,and successfully prepared in a high yield.Lithiation of HL with ^(n)BuLi in n-hexane,followed by treatment with RECl_(3) in THF led to the isolation of rare-earth metal chlorides in monomeric form(κ^(3)-L)RECI_(2)(THF)(RE=Sc(2),Yb(3)),and dimeric form[(κ^(3)-L)RECI(THF)(μ-Cl)]_(2)(RE=Er(4),Y(5))bearing the novel indolyl-based NCN pincer ligand in designed pincer ligation depending on different metal ionic radii;and the chloride bridged rare-earth metal and lithium mixed complexes in form(κ^(2)-L)_(2)RE(μ-Cl)_(2)Li(THF)_(2)(RE=Y(6),Dy(7)).All complexes were fully characterized and their structures were determined.The diamagnetic complexes 2,5 and 6 were furtherly characterized by the NMR spectroscopic method.The catalytic activity studies revealed that the central metal ions,borates,aluminum alkyls,and ligation of the central metal ions have influences on catalytic activity,and regio-and stereoselectivity for the polymerization of isoprene.With cooperation of the cocatalysts,the pincer-type yttrium chloride 5 initiated the isoprene polymerization with a high activity producing polymers with high regio-and stereoselectivity(1,4-cis polymers up to 99.6%),and the Mn as high as 8.76×10^(5). | Zeming Huang Shaowu Wang Xiancui Zhu Yun Wei Qingbing Yuan Shuangliu Zhou Xiaolong Mu Hua Wang | 2021 | Chinese Journal of Chemistry2021，39，12： | 2 |
| 6 | Rare-Earth Metal Alkyl Complexes with 3-Arylamido-Functionalized Indolyl Ligands:Synthesis,Characterization and Reactivity显示文摘A series of dinuclear rare-earth metal alkyl complexes{[μ-η^2:η^1:η^1-3-(LNCH)(CH2SiMe3)Ind]RE-(CH2SiMe3)(THF)}2(L^1=2-tBuC6H4,RE=Y,Gd,Dy,Er,Yb;L^2=2,4,6-Me3C6H2,RE=Dy,Er;Ind=indolyl)and{[μ-η^2:η^1:η^1-3-(LNCH2)Ind]RE(CH2SiMe3)(THF)}2(L^1,RE=Y,Dy,Er,Yb;L^2,RE=Er,Yb)bearing 3-arylamido functionalized indolyl ligands having diverse bonding modes with metal ions were synthesized either by the insertion reaction of the imino group to the RE-C bond or by the alkane elimination reaction.In the preparation of above complexes,rare-earth metal alkyl complexes{[μ-η^5:η^1:η^1-3-(L^2 NCH)(CH2SiMe3)Ind]Gd(CH2SiMe3)(THF)}2 with aμ-η^5:η^1:η^1 coordination mode to the gadolinium ion and{[μ-η^3:η^1:η^1-3-(L^2NCH2)Ind]Dy(CH2SiMe3)(THF)}2 with aμ-η^3:η^1:η^1 coordination mode to the dysprosium ion were unexpectedly isolated.The reactions of 3-(L^2N=CH)lnd with Er(CH2SiMe3)3(THF)2 at room temperature,generated a tetranuclear imino-indolyl erbium intermediate{[μ-η^1:η^1-3-(L^2N=CH)Ind]Er(CH2SiMe3)2(THF)}4,which can transform into the amido functionalized indolyl erbium complex in hot toluene.Moreover,the reactivities of the newly synthesized ytterbium complex with N-heterocyclic compounds were investigated,affording the corresponding products of the mixed pyridyl-indolyl,imidazolyl-indolyl,and ortho-metalated complexes.The yttrium complexes showed a high regioselectivity and steroselectivity for the isoprene polymerization with 1,4-trans selectivity up to 91.7%and 1,4-cis selectivity up to 96.1%in the presence of cocatalysts,respectively. | Xiancui Zhu Yuzhe Jiang Jun Chen Shaowu Wang Zeming Huang Shan Zhu Xu Zhao Wenrun Yue Jun Zhang Weikang Wu Xiangyang Zhong | 2020 | Chinese Journal of Chemistry2020，38，5： | 1 |
| 7 | Convenient and efficient access to tri-and tetra-substituted 4-fluoropyridines via a[3+2]/[2+1]cyclization reaction显示文摘A[3+2]/[2+1]cycloaddition reaction of gem–difluorocyclopropenes is presented,offering a mild and efficient approach to accessing tri-and tetra-substituted 4-fluoropyridines in moderate to good yields with excellent regioselectivity.Multiple synthetic applications,including process-scale reactions,modification of bioactive molecules,derivatization reactions and synthesis of the analogue of the PKM2 modulator,are subsequently described. | Xuejiao Tang Kun Liu Zeming Qu Junyan Zhan Rukui Zhu Fan Teng Lili Meng Yanmin Huang Chusheng Huang Yimiao He Qiang Zhu | 2022 | Chinese Chemical Letters2022，33，6： | 1 |
| 8 | Embedding Pd-Cu Alloy Nanoparticles in Shell of Surface-Porous N-Doped Carbon Nanosphere for Selective Hydrogenation of p-Chloronitrobenzene显示文摘Main observation and conclusion A catalyst PdxCuy/NC in which Pd-Cu alloy nanoparticles are superficially embeded in shell of surface-porous N-doped carbon nanosphere was successfully devised for p-chloronitrobenzene(p-CNB)selective hydrogenation.Bimetal ions were loaded in shell of a m-phenylenediamine derived core-shell polymer sphere and the catalyst was obtained after calcination under reducing atmosphere.The as synthesized catalyst exhibited high selectivity in hydrogenation of p-CNB to p-chloroaniline(p-CAN)(up to 98.8%)under full conversion and the performance was basically remained after 6 cyclic experiments.The reasons for the high selectivity were discussed based on the characterization results of catalyst.The interaction between N-doped support and metal atoms affected the electron distribution in alloy,electron-deficient Pd and electron-rich Cu,and thus improved hydrogenation selectivity.In addition,the alloy nanoparticles were distributed only in the porous shell of support,which benefits to prevent side reactions.This work described a scheme for tactfully designing catalyst for selective hydrogenation,which can provide experience and inspiration for relevant works and fields. | Yingcen Liu Wanyue Ye Hua Lin Caicheng Song Zeming Rong Rongwen Lu Hao Zhang He Huang Zhicheng Tang Shufen Zhang | 2021 | Chinese Journal of Chemistry2021，39，10： | 0 |
| 9 | Ammonium Impacts on Vibrations of Hydroxyl and Lattice of Phengite at High Temperature and High Pressure显示文摘Dehydration in hydrous phases of the downgoing slab controls water release processes in subduction zones. Interplay between volatiles in hydrous minerals has complicated the previous knowledge of their dehydration. Phengite is an essential mineral carrying both hydrogen and nitrogen to the deep Earth. To further understand the link between nitrogen and dehydration process of phengite at an atomic level, we here carry out high temperature and high pressure vibrational spectroscopic investigations on hydroxyl and lattice of ammonium-bearing and ammonium-free phengites. The results show that heating to 800 oC hardly influences hydroxyl bonding strength, whereas pressure induces strengthening of hydrogen bonding until 10 GPa. Moreover, hydrogen transits between the sites with increasing temperature and pressure. The lattice modes soften with increasing temperature and stiffen under compression. Ammonium has no effect on hydroxyl bonding strength, but hinders hydrogen transition at high temperatures and high pressures. Ammonium does not influence the lattice at high pressures either, but delays softening of the lattice at high temperatures. These data unveil behavior of hydroxyl and lattice in phengite at high temperature and high pressure, and also evaluate ammonium impacts, shedding new lights on dehydration processes of phengite during subduction. | Weihua Huang Yan Yang Zeming Qi Wendi Liu Zhongping Wang Yan Liu Qunke Xia | 2021 | Journal of Earth Science2021，32，5： | 0 |
| 10 | FTO stabilizes MIS12 and counteracts senescence显示文摘Dear Editor, N6-methyladenosine(m6A)is an abundant epitranscriptomic modification that regulates messenger RNA(mRNA)biology.The m6A modification regulates mRNA splicing,transport,stability,and translation through coordinated activities by methyltransferases(writers),binding proteins(readers),and demethylases(erasers)(Huang et al.,2020;Wu et al.,2020).Among m6A regulators,fat mass of obesity-associ-ated protein(FTO),is the first discovered eraser with RNA m6A demethylation activity(Jia et al.,2011).Since then,FTO has been reported to play m6A-dependent roles in a variety of physiological processes including adipogenesis,neuro-genesis and tumorigenesis(Fischer et al.,2009;Li et al.,2017;Huang et al.,2020).Consequently,FTO deficiency in mice leads to dramatic phenotypes,such as decreased fat mass and impaired brain development(Fischer et al.,2009;Li et al.,2017).Similarly,inhibition of FTO reduces tumori-genesis in multiple types of cancer models,while FTO is highly expressed in many cancers(Huang et al.,2020). | Sheng Zhang Zeming Wu Yue Shi Si Wang Jie Ren Zihui Yu Daoyuan Huang Kaowen Yan Yifang He Xiaoqian Liu Qianzhao Ji Beibei Liu Zunpeng Liu Jing Qu Guang-Hui Liu Weimin Ci Xiaoqun Wang Weiqi Zhang | 2022 | Protein & Cell2022，13，12： | 0 |
| 11 | Unusual selective reactivity of the rare-earth metal complexes bearing a ligand with multiple functionalities显示文摘Ligands play a key role in controlling activity of organometallic complexes so that development of new ligands to overcome the challenge is the main topic of modern chemistry.The first example of 1,1-hydride migratory insertion and intramolecular redox reaction has been realized in this work by applying a new ligand in rare-earth metal chemistry.The novel rare-earth metal complexes L^(Mes)RECH2TMS(THF)(RE=Y(1a),Dy(1b),Er(1c),Yb(1d),L^(Mes)=1-(3-(2,6-iPr_(2)C_(6)H_(3)N=CH)C8H4N)-CH_(2)CH_(2)-3-(2-CH2–4,6-Me_(2)C_(6)H_(2))-(N(CH)_(2)NC),THF=tetrahydrofuran)bearing a ligand with imino,indolyl,NHC(N-heterocyclic carbene)multiple functionalities were synthesized and characterized.Treatment of complexes 1 with silanes(PhSiH3or PhSiH2Me or PhSiD3)selectively produced the unprecedented 1,1-hydride(or deuterated H)migratory insertion of the indolyl moiety of the novel unsymmetrical dinuclear rare-earth metal complexes 2.The complex 2a reacts with Ph_(2)C=O to give the selective C=O double bond insertion to the RE–Co-methylene-Mesbond product 3a which further reacts with another Ph_(2)C=O(or DMAP,4-N,N-dimethylaminopyridine)affording the novelμ-η^(2):η^(3)-dianionic 3-iminoindolyl dinuclear rare-earth metal complex 4a.The latter is formed through an unusual intramolecular redox reaction(through electron migration from the 2-carbanion of the indolyl ring to the imino motif)resulting in the re-aromatization of the indolyl ring. | Dongjing Hong Thayalan Rajeshkumar Shan Zhu Zeming Huang Shuangliu Zhou Xiancui Zhu Laurent Maron Shaowu Wang | 2023 | Science China Chemistry2023，66，1： | 0 |
| 12 | DNA repair-and nucleotide metabolism-related genes exhibit differential CHG methylation patterns in natural and synthetic polyploids (Brassica napus L.)显示文摘Polyploidization plays a crucial role in the evolution of angiosperm species.Almost all newly formed polyploids encounter genetic or epigenetic instabilities.However,the molecular mechanisms contributing to genomic instability in synthetic polyploids have not been clearly elucidated.Here,we performed a comprehensive transcriptomic and methylomic analysis of natural and synthetic polyploid rapeseeds(Brassica napus).Our results showed that the CHG methylation levels of synthetic rapeseed in different genomic contexts(genes,transposon regions,and repeat regions)were signi fi cantly lower than those of natural rapeseed.The total number and length of CHG-DMRs between natural and synthetic polyploids were much greater than those of CG-DMRs and CHH-DMRs,and the genes overlapping with these CHG-DMRs were signi fi cantly enriched in DNA damage repair and nucleotide metabolism pathways.These results indicated that CHG methylation may be more sensitive than CG and CHH methylation in regulating the stability of the polyploid genome of B.napus.In addition,many genes involved in DNA damage repair,nucleotide metabolism,and cell cycle control were significantly differentially expressed between natural and synthetic rapeseeds.Our results highlight that the genes related to DNA repair and nucleotide metabolism display differential CHG methylation patterns between natural and synthetic polyploids and reveal the potential connection between the genomic instability of polyploid plants with DNA methylation defects and dysregulation of the DNA repair system.In addition,it was found that the maintenance of CHG methylation in B.napus might be partially regulated by MET1.Our study provides novel insights into the establishment and evolution of polyploid plants and offers a potentialidea for improving the genomic stability of newly formed Brassica polyploids. | Liqin Yin Zhendong Zhu Liangjun Huang Xuan Luo Yun Li Chaowen Xiao Jin Yang Jisheng Wang Qiong Zou Lanrong Tao Zeming Kang Rong Tang Maolin Wang Shaohong Fu | 2021 | Horticulture Research2021，8，1： | 0 |
| 13 | Rhodium-catalyzed formal[4+3]annulation reaction of N-methoxybenzamides with gem–difluorocyclopropenes:A combination of experimental and theoretical studies显示文摘A rhodium-catalyzed[4+3]cycloaddition reaction between N-methoxybenzamides and gem–difluorocyclopropenes is described.The reaction offers a mild and efficient approach towards the synthesis of fluorinated 2 H-azepin-2-ones with broad substrate scope.A consecutive HOAc-assisted C–N bond formation and fluorine elimination are involved as key steps for success as illustrated by detailed DFT studies. | Yimiao He Limei Tian Xuexue Chang Zeming Qu Yanmin Huang Chusheng Huang Qing Sun Honggen Wang | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 14 | Graphene Quantum Dot‑Mediated Atom‑Layer Semiconductor Electrocatalyst for Hydrogen Evolution显示文摘The hydrogen evolution reaction performance of semiconducting 2H-phase molybdenum disulfide(2H-MoS_(2))presents a significant hurdle in realizing its full potential applications.Here,we utilize theoretical calculations to predict possible functionalized graphene quantum dots(GQDs),which can enhance HER activity of bulk MoS_(2).Subsequently,we design a functionalized GQD-induced in-situ bottom-up strategy to fabricate near atom-layer 2H-MoS_(2) nanosheets mediated with GQDs(ALQD)by modulating the concentration of electron withdrawing/donating functional groups.Experimental results reveal that the introduction of a series of functionalized GQDs during the synthesis of ALQD plays a crucial role.Notably,the higher the concentration and strength of electron-withdrawing functional groups on GQDs,the thinner and more active the resulting ALQD are.Remarkably,the synthesized near atom-layer ALQD-SO_(3)demonstrate significantly improved HER performance.Our GQD-induced strategy provides a simple and efficient approach for expanding the catalytic application of MoS_(2).Furthermore,it holds substantial potential for developing nanosheets in other transition-metal dichalcogenide materials. | Bingjie Hu Kai Huang Bijun Tang Zhendong Lei Zeming Wang Huazhang Guo Cheng Lian Zheng Liu Liang Wang | 2023 | Nano-Micro Letters2023，15，12： | 0 |
| 15 | Mafic Archean continental crust prohibited exhumation of orogenic UHP eclogite显示文摘The absence of ultrahigh pressure(UHP)orogenic eclogite in the geological record older than c.0.6 Ga is problematic for evidence of subduction having begun on Earth during the Archean(4.0-2.5 Ga).Many eclogites in Phanerozoic and Proterozoic terranes occur as mafic boudins encased within low-density felsic crust,which provides positive buoyancy during subduction;however,recent geochemical proxy analysis shows that Archean continental crust was more mafic than previously thought,having greater proportions of basalt and komatiite than modern-day continents.Here,we show via petrological modelling that secular change in the petrology and bulk composition of upper continental crust would make Archean continental terranes negatively buoyant in the mantle before reaching UHP conditions.Subducted or delaminated Archean continental crust passes a point of no return during metamorphism in the mantle prior to the stabilization of coesite,while Proterozoic and Phanerozoic terranes remain positively buoyant at these depths.UHP orogenic eclogite may thus readily have formed on the Archean Earth,but could not have been exhumed,weakening arguments for a Neoproterozoic onset of subduction and plate tectonics.Further,isostatic balance calculations for more mafic Archean continents indicate that the early Earth was covered by a global ocean over 1 km deep,corroborating independent isotopic evidence for large-scale emergence of the continents no earlier than c.3 Ga.Our findings thus weaken arguments that early life on Earth likely emerged in shallow subaerial ponds,and instead support hypotheses involving development at hydrothermal vents in the deep ocean. | Richard M.Palin James D.P.Moore Zeming Zhang Guangyu Huang Jon Wade Brendan Dyck | 2021 | Geoscience Frontiers2021，12，5： | 0 |
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