|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting显示文摘Pediatric neuroblastomas(NBs)are heterogeneous,aggressive,therapy-resistant embryonal tumours that originate from cells of neural crest(NC)origin and in particular neuroblasts committed to the sympathoadrenal progenitor cell lineage.Therapeutic resistance,post-therapeutic relapse and subsequent metastatic NB progression are driven primarily by cancer stem cell(CSC)-like subpopulations,which through their self-renewing capacity,intermittent and slow cell cycles,drug-resistant and reversibly adaptive plastic phenotypes,represent the most important obstacle to improving therapeutic outcomes in unfavourable NBs.In this review,dedicated to NB CSCs and the prospects for their therapeutic eradication,we initiate with brief descriptions of the unique transient vertebrate embryonic NC structure and salient molecular protagonists involved NC induction,specification,epithelial to mesenchymal transition and migratory behaviour,in order to familiarise the reader with the embryonic cellular and molecular origins and background to NB.We follow this by introducing NB and the potential NC-derived stem/progenitor cell origins of NBs,before providing a comprehensive review of the salient molecules,signalling pathways,mechanisms,tumour microenvironmental and therapeutic conditions involved in promoting,selecting and maintaining NB CSC subpopulations,and that underpin their therapy-resistant,self-renewing metastatic behaviour.Finally,we review potential therapeutic strategies and future prospects for targeting and eradication of these bastions of NB therapeutic resistance,post-therapeutic relapse and metastatic progression. | Antonietta Rosella Farina Lucia Annamaria Cappabianca Veronica Zelli Michela Sebastiano Andrew Reay Mackay | 2021 | World Journal of Stem Cells2021，13，7： | 2 |
| 2 | Testing for Changing Shapes of Income Distribution: Italian Evidence in the 1990s from Kernel Density Estimates显示文摘 | Pittau M G Zelli R | 2004 | Empirical Eco- nomics2004，29，2： | 1 |
| 3 | ENVISAT RA-2 advanced radar altimeter instrument design and pre-launch performance assessment review显示文摘 | ZELLI C | 1999 | Acta Astronautica1999，44，712： | 1 |
| 4 | Itraconazole in the treatment of superficial cutaneous and mucosal Candida infections显示文摘 | Del Rosso JQ Zellis S Gupta AK | 1998 | J Am Osteopath Assoc1998，98，9： | 1 |
| 5 | Testing for changing shapes of income distribution: Italian evidence in the 1990s from kernel density estimates显示文摘 | Maria Grazia Pittau Roberto Zelli | 2004 | Empirical Economics2004，，2： | 1 |
| 6 | A dwindling middle class? Italian evidence in the 2000s显示文摘 | MASSARI R PITFAU M G ZELLI R | | 0，，： | 1 |
| 7 | Developments in satellite radar altimetry显示文摘 | Zelli C Impagnatiello F Alberti G | 1996 | Proceedings of SPIE1996，2958，： | 1 |
| 8 | The Institutional Fragmentationof Global Environmental Governance:Causes,Consequences,and Responses显示文摘 | Fariborz Zelli Harro van Asselt | | 0，，03： | 1 |
| 9 | Steel fibre treatment to improve bonds 显示文摘 | Mayfield B Zelly B 1973 | 1973 | Concrete1973，7，3： | 1 |
| 10 | The Institutional Fragmentation of Global Environmental Governance:Causes,Consequences,and Responses显示文摘 | Fariborz Zelli Harro van Asselt | | 0，，03： | 1 |
| 11 | The Fragmentation of Global Governance Architectures:A Framework for Analysis显示文摘 | Frank Biermann Philipp Pattberg Harro van Asselt Fariborz Zelli | | 0，，04： | 1 |
| 12 | ENVISAT RA-2 advanced radar altimeter instrument design and pre-launch performance assessment review 显示文摘 | ZELLI C | 1999 | Acta Astronuatica1999，44，： | 1 |
| 13 | Behavioral experience and social inference:Individual differences in aggressive experience and spontaneous versus deliberate trait inference显示文摘 | Zelli Arnaldo Cervone Daniel Huesmann L Rowell | 1996 | Social Cognition1996，14，2： | 1 |
| 14 | The Fragmentation of Global Governance Architectures:A Framework for Analysis显示文摘 | Frank Biermann Philipp Pattberg Harro van Asselt Fariborz Zelli | | 0，，04： | 1 |
| 15 | The Institutional Fragmentation of Global Environmental Governance:Causes,Consequences,and Responses显示文摘 | Fariborz Zelli Harro van Asselt | | 0，，03： | 1 |
| 16 | The Relation of Family Functioning to Violence Among Inner-City Minor-ity Youths显示文摘 | Gorman-Smith Deborah Tolan Patrick H Zelli Arnaldo | 1996 | J Family Psychol1996，10，2： | 1 |
| 17 | The Fragmentation of Global Govemance Architectures:A Framework for Analysis显示文摘 | Frank Biermann Philipp Pattberg Harro van Asselt Fariborz Zelli | | 0，，04： | 1 |
| 18 | The social-cognitive mechanisms regulating adolescents ' use of doping substances 显示文摘 | Lucidi F Zelli A Mallia L | 2008 | Journal of S~orts Sciences2008，26，5： | 1 |
| 19 | The Fragmentation of Global Governance Architectures:A Framework for Analysis显示文摘 | Frank Biermann Philipp Pattberg Harro van Asselt Fariborz Zelli | | 0，，04： | 1 |
| 20 | The relation of family functioning to violence among inner-city minority youths 显示文摘 | Gorman-Smith D Tolan P H Zelli A | 1996 | J Fam Psychol1996，10，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员