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| 1 | Lysine enhances the effect of amphotericin B against Candida albicans in vitro显示文摘Amphotericin B (AmB ) 是 Streptomyces nodosus 生产的多烯抗菌素并且被用于 > 在急性全身的真菌的感染的处理的 50 年。在现在的学习,我们表明了那离氨酸,必要氨基酸,能在 vitro 对 Candida albicans 提高 AmB 的效果,尽管离氨酸本身没施加杀菌剂效果。另外,有离氨酸的 AmB 的联合能独自与 AmB 相比对 Candida parapsilosis 和 Cryptococcus neoformans 提供一个提高的行动。离氨酸能也提高 caspofungin 或制霉菌素的抗真菌的效果。有 AmB 的离氨酸的联合的提高的效果为 biofilm 和 hypha 形成的预防被观察。而且,我们的结果证明那调停离氨酸的氧化损坏例如内长的反应的氧种类的产生,可以是在 AmB 上位于离氨酸的提高的效果下面的机制。我们的结果也证明那 CaMCA1 基因在增加 C 的敏感起一个重要作用。在 AmB 处理之上的 albicans 房间。和离氨酸使用 AmB 可以是为传播 candidiasis 的治疗的有希望的策略。 | Liuya Zhao Jingchen Jiang Zhenyu Zhu Zebin Liao Xiangwen Yao Yu Yang Yingying Cao Yuanying Jiang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 4 |
| 2 | A large-scale proteogenomic atlas of pear显示文摘Pear is an important fruit tree that is widely distributed around the world.The first pear genome map was reported from our laboratory approximately 10 years ago.To further study global protein expression patterns in pear,we generated pear proteome data based on 24 major tissues.The tissue-resolved profiles provided evidence of the expression of 17953 proteins.We identified 4294 new coding events and improved the pear genome annotation via the proteogenomic strategy based on 18090 peptide spectra with peptide spectrum matches>1.Among the eight randomly selected new short coding open reading frames that were expressed in the style,four promoted and one inhibited the growth of pear pollen tubes.Based on gene coexpression module analysis,we explored the key genes associated with important agronomic traits,such as stone cell formation in fruits.The network regulating the synthesis of lignin,a major component of stone cells,was reconstructed,and receptor-like kinases were implicated as core factors in this regulatory network.Moreover,we constructed the online database PearEXP(http://gffzz20aea264798e4804hxbfvcw5cwou06nb9.ffgz.tsg.suse.edu.cn)to enable access to the pear proteogenomic resources.This study provides a paradigm for in-depth proteogenomic studies of woody plants. | Peng Wang Xiao Wu Zebin Shi Shutian Tao Zhe Liu Kaijie Qi Zhihua Xie Xin Qiao Chao Gu Hao Yin Mengyu Cheng Xiaoyu Gu Xueying Liu Chao Tang Peng Cao Shaohang Xu Baojin Zhou Tingting Gui Yangyang Bian Juyou Wu Shaoling Zhang | 2023 | Molecular Plant2023，16，3： | 0 |
| 3 | An emerging plume head interacting with the Hawaiian plume tail显示文摘The Hawaiian-Emperor seamount chain has shown two subparallel geographical and geochemical volcanic trends,Loa and Kea,since-5 Ma,for which numerous models have been proposed that usually involve a single mantle plume sampling different compositional sources of the deep or shallow mantle.However,both the dramatically increased eruption rate of the Hawaiian hotspot since-5 Ma and the nearly simultaneous southward bending of the Hawaiian chain remain unexplained. | Lipeng Zhang Zebin Cao Robert E.Zartman Congying Li Saijun Sun Lijun Liu Weidong Sun | 2023 | The Innovation2023，4，2： | 0 |
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