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	题名	作者	年代	出处	被引量
1	Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure.	Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz	2021	Bioactive Materials2021，6，12：	7
2	Impact of the Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guidelines for Bone Metabolism and Disease in a Large Dialysis Network显示文摘	Ron Wald Francesca Tentori Hocine Tighiouart Philip G. Zager Dana C. Miskulin	2007	American Journal of Kidney Diseases2007，，2：	2
3	Thoracic outlet syndrome显示文摘	Huang JH Zager EL	2004	Neurosurgery2004，55，4：	1
4	Use of an oncolytic virus secreting GM-CSF as combined oncolytic and immunotherapy for treatment of colorectal and hepatic adenocarcinomas显示文摘	Sandeep Malhotra Teresa Kim Jonathan Zager Joseph Bennett Michael Ebright Michael D’Angelica Yuman Fong	2007	Surgery2007，，4：	1
5	Pathophysiology of peripheral nerve injury:a brief review显示文摘	Burnett M G Zager E L	2004	Neurosurg Focus2004，16，5：	1
6	Plasma and urine heine oxy- genase-1 in acute kidney injury显示文摘	Zager R A Johnson A C Becker K	2012	J AM Soc Nephrol2012，23，6：	1
7	Physiological pH effects on posthypoxic proximal tubular injury 显示文摘	Zager RA Schimpf BA Gmur DJ	1993	Circ Res1993，72，4：	1
8	Myoglobin depletes renal adenine nucleotide pools in the presence and absence of shock显示文摘	Zager RA	1991	Kidney1991，39，1：	1
9	Current diagnosis and management of retroperitoneal sarcoma显示文摘	Mullinax JE Zager JS Gonzalez RJ	2011	Cancer Control2011，18，17：	1
10	'U' curve association of blood pressure and mortality in hemodialysis patients 显示文摘	Zager P Nikolic J Brown R	1998	Kidney Int1998，54，：	1
11	“U” curve asscr-ciation of blood pressure and mortality in hemodialy-sis patients 显示文摘	Zager PG Nikolic J Brown RH	1998	Kidney Int1998，54，：	1
12	Troponin I and NT-proBNP and the association of systolic blood pressure with outcomes in incident hemodialysis patients:the Choices for Healthy Outcomes in Caring for ESRD(CHOICE) Study显示文摘	Shaft T Zager PG Sozio SM	2014	Am J Kidney Dis2014，64，3：	1
13	Effects of benthiocarb and butachlor on growth and nitrogen fixation by cyanobacteria显示文摘	Zager M Y	1990	Bull Environ Contam Toxicol1990，45，2：	1
14	Therapy for unreseetable recurrent and in-transit extremity melanoma显示文摘	Gimbel MI Delman KA Zager JS	2008	Cancer Control2008，15，3：	1
15	Ulnar nerve entrapment neu-ropathy at the elbow: simple decompression 显示文摘	Huang J H Samadani U Zager E L	2004	Neurosurgery2004，55，5：	1
16	Targeting the tran- scription factor Nrf2 to ameliorate oxidative stress and in- flammation in chronic kidney disease 显示文摘	Ruiz S Pergola PE Zager RA	2013	Kidney Int2013，83，6：	1
17	Hypocalcemia : A per- vasive metabolic abnormality in the critically ill 显示文摘	Zivin JR Gooley T Zager RA	2001	Am J Kidney Dis2001，37，4：	1
18	Thoracic outlet syndrome 显示文摘	Huang JH Zager EL	2004	Neurosurgery2004，55，：	1
19	Developmental well-being in offspring of women receiving cyclosporine post-renal transplant显示文摘	Stanley CW Gottileb R Zager R	1999	Transplant Proc1999，31，12：	1
20	Plasma andurinary heme oxygenase-1 in AKI 显示文摘	ZAGER R A JOHNSON AC BECKER K	2012	J Am Soc Nephrol2012，23，6：	1

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