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| 1 | A preliminary study of the failure mechanisms of cascading landslide dams显示文摘Landslide dams commonly form when mass earth or rock movements reach a river channel and cause a complete or partial blockage of the channel.Intense rainfalls can induce upstream flows along a sloping channel that significantly affect downstream landslide dams.If a series of landslide dams are collapsed by incoming mountain torrents(induced by intense rainfall),large debris flows can form in a very short period.Furthermore,the failure of these dams can amplify the magnitude and scale of debris flows in the flow direction.The catastrophic debris flows that occurred in Zhouqu County,China on 8 August 2010 were caused by intense rainfall and the upstream cascading failure of landslide dams along the gullies.Incorporating the role of outburst floods associated with the complete or partial failure of landslide dams is an interesting problem usually beyond the scope of analysis because of the inherent modeling complexity.To understand the cascading failure modes of a series of landslide dams,and the dynamic effect these failures have on the enlargement of debris flow scales,experimental tests are conducted in sloping channels mimicking field conditions,with the modeled landslide dams distributed along a sloping channel and crushed by different upstream flows.The failure modes of three different cascades of landslide dams fully or partially blocking a channel river are parametrically studied.This study illustrates that upstream flows can induce a cascading failure of the landslide dams along a channel.Overtopping is the primary failure mechanism,while piping and erosion can also induce failures for different constructed landslide dams.A cascading failure of landslide dams causes a gradually increasing flow velocity and discharge of the front flow,resulting in an increase in both diameter and percentage of the entrained coarse particles.Furthermore,large landslide blockages can act to enhance the efficiency of river incision,or conversely to induce aggradation of fluvial sediments,depending on the blockage factor of the landslide dams and upstream discharge. | Gordon G.D Peng Cui Xinghua Zhu Jinbo Tang Huayong Chen Qicheng Sun | 2015 | International Journal of Sediment Research2015，30，3： | 8 |
| 2 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 3 | Screen-imaging guidance using a modified portable video macroscope for middle cerebral artery occlusion显示文摘The use of operating microscopes is limited by the focal length.Surgeons using these instruments cannot simultaneously view and access the surgical field and must choose one or the other.The longer focal length (more than 1 000 mm) of an operating telescope permits a position away from the operating field,above the surgeon and out of the field of view.This gives the telescope an advantage over an operating microscope.We developed a telescopic system using screen-imaging guidance and a modified portable video macroscope constructed from a Computar MLH-10 × macro lens,a DFK-21AU04 USB CCD Camera and a Dell laptop computer as monitor screen.This system was used to establish a middle cerebral artery occlusion model in rats.Results showed that magnification of the modified portable video macroscope was appropriate (5-20 ×) even though the Computar MLH-10 × macro lens was placed 800 mm away from the operating field rather than at the specified working distance of 152.4 mm with a zoom of 1-40 ×.The screen-imaging telescopic technique was clear,life-like,stereoscopic and matched the actual operation.Screen-imaging guidance led to an accurate,smooth,minimally invasive and comparatively easy surgical procedure.Success rate of the model establishment evaluated by neurological function using the modified neurological score system was 74.07%.There was no significant difference in model establishment time,sensorimotor deficit and infarct volume percentage.Our findings indicate that the telescopic lens is effective in the screen surgical operation mode referred to as 'long distance observation and short distance operation' and that screen-imaging guidance using an modified portable video macroscope can be utilized for the establishment of a middle cerebral artery occlusion model and micro-neurosurgery. | Xingbao Zhu Junli Luo Yun Liu Guolong Chen Song Liu Qiangjin Ruan Xunding Deng Dianchun Wang Quanshui Fan Xinghua Pan | 2012 | Neural Regeneration Research2012，7，12： | 6 |
| 4 | Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis显示文摘Suppressor of cytokine signaling 3 (SOCS3) proteins,a member of SOCS family,are predominantly expressed in Th2 cells,and it has an important role in regulating the onset and maintenance of Th2-mediated allergic immune disease.1 SOCS can translocate from cytoplasm to nucleus when the level in cytoplasm increases,and localize to cell membrane where it binds to receptors.However,to our knowledge,there has been no documentation whether SOCS can transport to the intercellular space or circulating body fluids,let alone the subsequent biological significance.Signal transducer and activator of transcription (STAT) proteins,a group of transcription factor,are critical for mediating signals during Th1,Th2,Treg,and Th17 differentiation.Recent study demonstrated that STAT3 is not only required for the differentiation of Th17,IL-6-activated STAT3 promotes Maf expression,a factor required for Th2 differentiation and production of IL-4.Furthermore,STAT3 was activated throughout Th2 cell differentiation and was indispensable for Th2 cytokine production and transcription factor expression.2 SOCS proteins were recognized to negatively regulate the JAK/STAT signaling pathway through the common SH2 domain.Since binding of the SH2 domain of SOCS3 is relatively specific to receptors for STAT3-activating cytokines,such as IL-6,granulocyte-colony stimulating factor,leptin,and leukemia inhibitory factor,the suppressive effect of SOCS3 has been shown to be relatively restricted to STAT3.3 In this report we demonstrate that the serum levels of SOCS3 and STAT3 were increased in childhood atopic dermatitis (AD) compared with controls.Furthermore,STAT3 is significantly positively correlated with Scoring Atopic Dermatitis (SCORAD) index. | Lyu Yani Zhu Lili Qi Ruiqun Xu Jing Di Zhenghong Chen Hongduo Gao Xinghua | 2014 | Chinese Medical Journal2014，，12： | 4 |
| 5 | Lowering reaction temperature: Electrochemical ammonia synthesis by coupling various electrolytes and catalysts显示文摘Ammonia is a vital emerging energy carrier and storage medium in the future hydrogen economy, even presenting relevant advantages compared with methanol due to the higher hydrogen content(17.6 wt% for ammonia versus 12.5 wt% for methanol). The rapidly growing demand for ammonia is still dependent on the conventional high-temperature and high-pressure Haber–Bosch process, which can deliver a conversion rate of about 10%–15%. However, the overall process requires a large amount of fossil fuels,resulting in serious environmental problems. Alternatively, electrochemical routes show the potential to greatly reduce the energy consumption, including sustainable energy sources and simplify the reactor design. Electrolytes perform as indispensable reaction medium during electrochemical processes, which can be further classified into solid oxide electrolytes, molten salt electrolytes, polymer electrolytes, and liquid electrolytes. In this review, recent developments and advances of the electrocatalytic ammonia synthesis catalyzed by a series of functional materials on the basis of aforementioned electrolytes have been summarized and discussed, along with the presentation and evaluation of catalyst preparation, reaction parameters and equipment. | Xinghua Guo Yunpei Zhu Tianyi Ma | 2017 | Journal of Energy Chemistry2017，26，6： | 4 |
| 6 | Flow dynamics and contact efficiency in a novel fast-turbulent fluidized bed with ring-feeder internals显示文摘The flow dynamics in a novel fast-turbulent fluidized bed(FTFB) with middle-upper expanding structure and two different ring-feeder internals(mixed and vortex ring-feeder) were studied to achieve a reduction in gasoline olefin production.Compared with a conventional circulating fluidized bed,the novel FTFB displayed unique characteristics and advantages.A higher solids holdup and more uniform solids holdup distribution existed in the diameter-expanding region,especially for the FTFB with vortex ring-feeder structure.A probability density distribution analysis indicated that the novel fluidized bed could reduce gas-solids segregation and enhance gas-solids interaction.A constant carbon dioxide tracer system was used to simulate the reactant gas distribution.The gas-solids contact efficiency was defined according to the solid dispersibility and the amount of gas covering the solid surface.Novel FTFB risers,especially those with vortex ring-feeders,have a much higher gas-solids contact efficiency than that of traditional risers. | Qiang Geng Ping Wang Xiaolin Zhu Xinghua You Chunyi Li | 2015 | Particuology2015，13，4： | 3 |
| 7 | Progress of the injection laser system of SG-Ⅱ显示文摘A high power laser system was used to drive the ignition of inertial confinement fusion(ICF), of which the high energy,the uniform focal spot, the accurate laser waveform, and the synchronization between the laser beams are key parameters.To accomplish this, global laser characteristics control should be assured, which was the main purpose of the injection laser system. In this paper, the key technological progress involved in the improvement of the performance of the injection laser of SG-II is reported, including frequency domain control, time domain control, near-field spatial shaping, preamplifier technology, and the optical parametric chirped pulse amplification pump source. | Wei Fan Youen Jiang Jiangfeng Wang Xiaochao Wang Dajie Huang Xinghua Lu Hui Wei Guoyang Li Xue Pan Zhi Qiao Chao Wang He Cheng Peng Zhang Wenfa Huang Zhuli Xiao Shengjia Zhang Xuechun Li Jianqiang Zhu Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，2： | 3 |
| 8 | Microstructure and temperature dependence of magnetic properties of CuO-added MnZn ferrites显示文摘MnZn ferrites with the chemical formula Mn0.68Zn0.25Fe2.07O4 have been prepared by a conventional ceramic technique. Then, the effects of CuO addition on the microstructure and temperature dependence of magnetic properties of MnZn ferrites were investigated by characterizing the fracture surface micrograph and measuring the magnetic properties over a temperature ranging from 25 to 120 C. The results show that the lattice constant and average grain size increase with the increase of CuO concentration. When the CuO concentration is below 0.07 wt.%, the initial permeability and saturation magnetic flux density increase monotonously, and the temperature of the secondary maximum peak in the curve of initial permeability versus temperature and the lowest power loss shift to a lower temperature with the increase of CuO concentra-tion. However, excessive CuO concentration (>0.07 wt.%) results in abnormal grain growth and porosity increase, which causes the initial permeability and saturation magnetic flux density decrease and the power loss increase at room temperature. Furthermore, the temperature of the secondary maximum peak in the curve of initial permeability versus temperature and the lowest power loss shift to a higher temperature. | LI Lezhong LAN Zhongwen ZHU Xinghua YU Zhong | 2011 | Rare Metals2011，30，3： | 3 |
| 9 | Pt-Re/rGO bimetallic catalyst for highly selective hydrogenation of cinnamaldehyde to cinnamylalcohol显示文摘In the present work, a series of Pt-based catalysts, alloyed with a second metal, i.e., Re, Sn, Er, La, and Y, and supported on activated carbon, ordered mesoporous carbon, N-doped mesoporous carbon or reduced graphene oxide(rGO), have been developed for selective hydrogenation of cinnamaldehyde to cinnamylalcohol. Re and rGO were proved to be the most favorable metal dopant and catalyst support, respectively. Pt_(50) Re_(50)/rGO showed the highest cinnamylalcohol selectivity of 89% with 94% conversion of cinnamaldehyde at the reaction conditions of 120 °C, 2.0 MPaH_2 and 4 h. | Zuojun Wei Xinmiao Zhu Xiaoshuang Liu Haiqin Xu Xinghua Li Yaxin Hou Yingxin Liu | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 2 |
| 10 | Polybrominated diphenyl ethers (PBDEs) and other flame retardants in the atmosphere and water from Taihu Lake, East China显示文摘 | Xinghua Qiu Tong Zhu Jianxin Hu | 2010 | Chemosphere2010，，10： | 2 |
| 11 | Susceptibility of patients with chronic obstructive pulmonary disease to heart rate difference associated with the short-term exposure to metals in ambient fine particles:A panel study in Beijing,China显示文摘Susceptibility of patients with chronic obstructive pulmonary disease(COPD)to cardiovascular autonomic dysfunction asso-ciated with exposure to metals in ambient fine particles(PM2.5,particulate matter with aerodynamic diameter≤2.5µm)remains poorly evidenced.Based on the COPDB(COPD in Beijing)panel study,we aimed to compare the associations of heart rate(HR,an indicator of cardiovascular autonomic function)and exposure to metals in PM2.5 between 53 patients with COPD and 82 healthy controls by using linear mixed-effects models.In all participants,the HR levels were significantly associated with interquartile range increases in the average concentrations of Cr,Zn,and Pb,but the strength of the associations differed by exposure time(from 1.4%for an average 9 days(d)Cr exposure to 3.5%for an average 9 d Zn exposure).HR was positively associated with the average concentrations of PM2.5 and certain metals only in patients with COPD.Associations between HR and exposure to PM2.5,K,Cr,Mn,Ni,Cu,Zn,As,and Se in patients with COPD significantly differed from those in health controls.Furthermore,association between HR and Cr exposure was robust in COPD patients.In conclusion,our findings indicate that COPD could exacerbate difference in HR following exposure to metals in PM2.5. | Ke Gao Xi Chen Xiaoying Li Hanxiyue Zhang Mengxiao Luan Yuan Yao Yifan Xu Teng Wang Yiqun Han Tao Xue Junxia Wang Mei Zheng Xinghua Qiu Tong Zhu | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
| 12 | The application of topology optimization on the quantitative description of the external shape of bone structure显示文摘 | Zhu Xinghua Gong He Gao Bingzhao | 2005 | Journal of Biomechanics2005，38，8： | 1 |
| 13 | The optimization approach for traffic rescue resource dispatch on express- way based on fuzzy programming 显示文摘 | Zhu Canghui Li Xinghua Chai Gan | 2010 | Fuzzy Informa- tion and Engineering2010，78，1： | 1 |
| 14 | Polybrominated diphenyl ethers (PBDEs) and other flame retardants in the atmosphere and water from Taihu Lake, East China显示文摘 | Xinghua Qiu Tong Zhu Jianxin Hu | 2010 | Chemosphere2010，，10： | 1 |
| 15 | Using the o, p-DDT/p, p-DDT ratio to identify DDT sources in China 显示文摘 | Qiu Xinghua Zhu Tong | 2010 | Chemosphere2010，81，： | 1 |
| 16 | Local hyperthermia could induce endogenous interferons gene expression via JAK- STATs signaling pathway in condyloma acuminate 显示文摘 | Zhu Lili Gao Xinghua Li Xiaodong | 2010 | Antiviral Research2010，88，2： | 1 |
| 17 | Removal of low-concentration formaldehyde in air by adsorption on activated carbon modified by hexamethylene diamine显示文摘 | Chanjuan Ma Xinghua Li Tianle Zhu | 2011 | Carbon2011，，8： | 1 |
| 18 | Evaluating the fate of p, p'-DDT in Tianjin, China using a non-steady-stale multimedia fugacity model 显示文摘 | LI Quanlin ZHU Tong QIU Xinghua | 2006 | Ecotoxicology and Environmental Safety2006，63，2： | 1 |
| 19 | On linearly topological structure and property of fuzzy normed linear space 显示文摘 | Xiao Jianzhong Zhu Xinghua | 2002 | Fuzzy sets and Systems2002，125，： | 1 |
| 20 | Paleomagnetic constraints on the tectonic history of the major blocks of China duing the Phanerozoic显示文摘 | Zhu Rixiang Yang Zhenyu Wu Hanning Ma Xinghua Huang Baochun Meng Zifang Fang Dajun | 1998 | Science in China Series D: Earth Sciences1998，，2： | 1 |
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