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| 1 | Preliminary study on the production of transgenic mice harboring hepatitis B virus X gene显示文摘INTRODUCTIONDespiteoverwhelmingepidemiologicalevidencelinkingpersistentHepatitisBVirus(HBV)infectionandthedevelopmentofhepato... | ZHU Huan Zhang 1, CHENG Guo Xiang 2, CHEN Jian Qu 2, KUANG Shu Yuan 3, CHENG Yong 2, ZHANG Xin Li 1, Ll Hou Da 2, XU Shao Fu 2, SHI Jing Quan 1, QIAN Geng Sun 3 and GU Jian Ren 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 14 |
| 2 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 3 | A potential antitumor drug (arginine deiminase) reengineered for efficient oper- ation under physiological conditions 显示文摘 | ZHU LL VERMA R ROCCATANO D | 2010 | Chembioehem2010，11，16： | 1 |
| 4 | Neural mechanism of acupuncture - modulated gastric motility 显示文摘 | Ll Y Q Zhu B Rong P J | 2007 | World J Gastroenterol2007，13，5： | 1 |
| 5 | Directed evolution of an antitumor drug (arginine deialinase PpAD I) for in- creased activity at physiological pH显示文摘 | ZHU LL TEE KL ROCCATANO D | 2010 | Chembiochem2010，11，5： | 1 |
| 6 | Predicting functional motor potential in chronic stroke patients using diffusion tensor imaging 显示文摘 | Lindenberg R Zhu LL Ruber T | 2012 | Hum Brain Mapp2012，33，5： | 1 |
| 7 | Induction of a program gene expression during osteoblast differentiation with Strontium ranelate 显示文摘 | Zhu LL Zaidi S Peng Y | 2007 | Biochem Biophys Res Commun2007，355，2： | 1 |
| 8 | The optimal choice of medication administration route regarding intravenous, intramuscular, and subcutaneous injection 显示文摘 | Jin JF Zhu LL Chen M | 2015 | Patient Prefer Adherence2015，2，9： | 1 |
| 9 | SUCI02 inhibits the erbB-2 tyrosine kinase receptor signaling pathway and arrests the cell cycle in G1 phase in breast cancer cells 显示文摘 | Zhu XF Wang JS Cai LL | 2006 | Cancer Sci2006，97，1： | 1 |
| 10 | Lesion load of the corticospinal tract predicts motor impairment in chronic stroke 显示文摘 | Zhu LL Lindenberg R Alexander MP | 2010 | Stroke2010，41，5： | 1 |
| 11 | Evidence for altered hippocampal volume and metabolites in workers occupationally exposed to lead: a study by magnetic resonance imaging and ^1H magnetic resonance spectroscopy 显示文摘 | Jiang YM Long LL Zhu XY | 2008 | Toxicol Lett2008，181，2： | 1 |
| 12 | Pleural fluid soluble trig gering receptor expressed on myeloid cells-1 as a marker of bacterial infection: a meta-analysis显示文摘 | Summah H Tao LL Zhu YG | 2011 | BMC Infectious Dis- eases2011，11，1： | 1 |
| 13 | Gaining insight into the response logic of Saccharomyces cerevisiae to heat shock by combining expression profiles with metabolic pathways显示文摘 | Ye YR Zhu Y Pan L Li LL Wang XN Lin Y | | 0，，03： | 1 |
| 14 | Effects of electroacupuncture on pressor response to angiotensin-(1-7) by amino acid release in the rostral ventrolateral medulla显示文摘 | Wang J Shen LL Cao YX Zhu DN | 2003 | Acupunct Electrother Res2003，28，： | 1 |
| 15 | Evidence for altered hippocampal volume and metabolites in workers occupationally exposed to lead: a study by magnetic resonance imaging and ^1H magnetic resonance spectroscopy 显示文摘 | Jiang YM Long LL Zhu XY | 2008 | Toxicol Lett2008，181，2： | 1 |
| 16 | Coregulation of estrogen receptor by estrogen-inducible ERBB4/HER4 establishes a growth promoting autocrine signal in breast cancer 显示文摘 | Zhu Y Sullivan LL Nair SS | 2006 | Cancer Res2006，66，16： | 1 |
| 17 | Quantitative response of cell growth and Tuber polysaccharides biosynthesis by medicinal mushroom Chinese truffle Tuber sinense to metal ion in culture medium 显示文摘 | Tang YJ Zhu LL | 2008 | Bioresource Technology2008，99，16： | 1 |
| 18 | The effect of phloroglucinol on pain in first-trimester surgical abortion:a double-blind randomized controlled study显示文摘 | Zhuang Y Zhu X Huang LL | 2010 | Contraception2010，81，2： | 1 |
| 19 | Situational health education in patients with diabetes mellitus显示文摘 | Liu LL Zhu Y Dong Q | 2012 | Chin J Mod Nurs2012，18，31： | 1 |
| 20 | Structural integrity of corticospinal motor fibers predicts motor impairment in chronic stroke显示文摘 | Lindenherg R Renga V Zhu LL | 2010 | Neurology2010，74，4： | 1 |
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