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| 1 | BH3-only proteins target BCL-xL/MCL-1,not BAX/BAK,to initiate apoptosis显示文摘It has been widely accepted that mitochondria-dependent apoptosis initiates when select BH3-only proteins(BID,BIM,etc.)directly engage and allosterically activate effector proteins BAX/BAK.Here,through reconstitution of cells lacking all eight pro-apoptotic BH3-only proteins,we demonstrate that all BH3-only proteins primarily target the anti-apoptotic BCL-2 proteins BCL-xL/MCL-1,whose simultaneous suppression enables membrane-mediated spontaneous activation of BAX/BAK.BH3-only proteins*apoptotic activities correlate with affinities for BCL-xL/MCL1 instead of abilities to directly activate BAX/BAK.Further,BID and BIM do not distinguish BAX from BAK or accelerate BAX/BAK activation following inactivation of BCL-xL/MCL-1.Remarkably,death ligandinduced apoptosis in cells lacking BH3-only proteins and MCL-1 is fully restored by BID mutants capable of neutralizing BCL-xL,but not direct activation of BAX/BAK.Taken together,our findings provide a'Membrane-mediated Permissive'model,in which the BH3-only proteins only indirectly activate BAX/BAK by neutralizing the anti-apoptotic BCL-2 proteins,and thus allowing BAX/BAK to undergo unimpeded,spontaneous activation in the mitochondrial outer membrane milieu,leading to apoptosis initiation. | Kai Huang Katelyn L.O'Neill Jian Li Wei Zhou Na Han Xiaming Pang Wei Wu Lucas Struble Gloria Borgstahl Zhaorui Liu Liqiana Zhang Xu Luo | 2019 | Cell Research2019，29，11： | 16 |
| 2 | Investigation of the thermomechanical properties of a plasma-sprayed nano- structured zirconia coating显示文摘 | Chen Huang Zhou Xiaming Ding Chuanxian | 2003 | Journal of the European Ceram- ic Society2003，23，9： | 1 |
| 3 | Particle in-flight behavior and its influence on the microstructure and mechani- cal properties of plasma-sprayed A1203 coatings 显示文摘 | Yin Zhijian Tao Shunyan Zhou Xiaming | 2008 | Journal of the European Ceramic Society2008，28，6： | 1 |
| 4 | Tribological properties of plasma sprayed Al/Al2O3 composite coatings显示文摘 | Zhijian Yin Shunyan Tao Xiaming Zhou | 2007 | Wear2007，263，712： | 1 |
| 5 | Investigation of the thermomechanical properties of a plasma-sprayed nanostructured zirconia coating显示文摘 | Chen Huang Zhou Xiaming Ding Chuanxian | 2003 | Journal of the European Ceramic Society2003，23，6： | 1 |
| 6 | Tribological properties of plasma sprayed Al/Al2O3 composite coatings显示文摘 | Yin Zhijian Tap Shunyan Zhou Xiaming | | 0，，： | 1 |
| 7 | The effect of ion implantation on the oxidation resistance of vacuum plasma sprayed CoNiCrA1Y coatings显示文摘 | Jiang Jie Zhao Huayu Zhou Xiaming | 2012 | Applied Surface Science2012，261，15： | 1 |
| 8 | Thermal conductivity of plasma sprayed Sm 2 Zr 2 O 7 coatings显示文摘 | Jianhua Yu Huayu Zhao Shunyan Tao Xiaming Zhou Chuanxian Ding | 2009 | Journal of the European Ceramic Society2009，，3： | 1 |
| 9 | Microstructure and mechanical properties of AI203-Cr203 composite coatings produced by atrnospheric plasma spraying 显示文摘 | Yang Kai Zhou Xiaming Zhao Huayu | 2011 | Surface & Coatings Technology2011，206，： | 1 |
| 10 | Sliding wear characteristics of plasma-sprayed Al2O3 and Cr2O3 coatings against copper alloy under severe conditions显示文摘 | Tao Shunyan Yin Zhijian Zhou Xiaming | 2010 | Tribol Int2010，43，： | 1 |
| 11 | Effect of the thick-ness on properties of Al2O3 coatings deposited by plasma spray-ing显示文摘 | Yin Zhijian Tao Shunyan Zhou Xiaming | 2011 | Materials Characterization2011，62，： | 1 |
| 12 | Microstructure and mechanical prperties of Al2O3-Al composite coatings deposited by plasma spraying显示文摘 | Yin Zhijian Tao Shunyan Zhou Xiaming | 2008 | Appl Surf Sci2008，254，： | 1 |
| 13 | Investigation of the thermomechanical properties of a plasma-sprayed nanostructured zirconia coating显示文摘 | CHEN Huang ZHOU Xiaming DING Chuanxian | 2003 | Journal of the European Ceramic Society2003，23，9： | 1 |
| 14 | Tribological properties of plasma sprayed Al/Al2O3 composite coatings 显示文摘 | Yin Zhijian Tao Shunyan Zhou Xiaming | 2007 | Wear2007，263，： | 1 |
| 15 | Effect of the thickness on properties of Al 2 O 3 coatings deposited by plasma spraying显示文摘 | Zhijian Yin Shunyan Tao Xiaming Zhou | 2010 | Materials Characterization2010，，1： | 1 |
| 16 | Tribological properties of plasma sprayed Al/Al 2 O 3 composite coatings显示文摘 | Zhijian Yin Shunyan Tao Xiaming Zhou Chuanxian Ding | 2007 | Wear2007，，7： | 1 |
| 17 | Preparation and characterization of plasma-sprayed Al/Al 2 O 3 composite coating显示文摘 | Zhijian Yin Shunyan Tao Xiaming Zhou Chuanxian Ding | 2007 | Materials Science & Engineering A2007，，1： | 1 |
| 18 | Microstructure and mechanical properties of Al 2 O 3 –Al composite coatings deposited by plasma spraying显示文摘 | Zhijian Yin Shunyan Tao Xiaming Zhou Chuanxian Ding | 2007 | Applied Surface Science2007，，： | 1 |
| 19 | Investigation of the thermal mechanical properties of a plasma-sprayed nanostructured zirconia coating 显示文摘 | Chen Huang Zhou Xiaming DING Chuanxian | 2003 | J Euro Ceram Soc2003，23，： | 1 |
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