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| 1 | Chinese Stroke Center Alliance:a national effort to improve healthcare quality for acute stroke and transient ischaemic attack:rationale,design and preliminary findings显示文摘Background In June 2015,the Chinese Stroke Association(CSA)initiated the Chinese Stroke Center Alliance(CSCA)to establish the national hospital-based stroke care quality assessment and improvement platform.This article outlines its objectives,operational structure,patient population,quality improvement(QI)intervention tools,data elements,data collection methodology and current patient and hospital data.Methods The CSCA is a national,hospital-based,multicentre,voluntary,multifaceted intervention and continuous QI initiative.This multifaceted intervention includes stroke centre development,written care protocols,workshops and a monitoring/feedback system of evidencebased performance measures.The data coordinating centre of the CSCA resides at the China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital.results As of July 2017,1576 hospitals in China have contributed detailed clinical information to serve as a benchmark for the stroke care quality of 433264 patients with acute stroke/transient ischaemic attacks(TIA),including 352572(81.38%)acute ischaemic stroke,30362(7.01%)TIA,42080(9.71%)spontaneous intracranial haemorrhage,5505(1.27%)subarachnoid haemorrhage and 2745(0.63%)not specified stroke.Conclusion The CSCA programme is designed to establish a continuous national stroke registry and help healthcare providers develop stroke centres and treat patients in a consistent manner in accordance with accepted national guidelines and,ultimately,improve patient outcomes.It supports the CSA mission to reduce stroke burden in China. | Yongjun Wang Zixiao Li Yilong Wang Xingquan Zhao Liping Liu Xin Yang Caiyun Wang Hongqiu Gu Fuying Zhang Chunjuan Wang Ying Xian David Z Wang Qiang Dong Anding Xu Jizong Zhao Chinese Stroke Center Alliance investigators | 2018 | Stroke & Vascular Neurology2018，3，4： | 38 |
| 2 | Preliminary research on Megalake Jilantai-Hetao in the arid areas of China during the Late Quaternary显示文摘我们识别了 geomorphological,在通过地调查并且通过地区性的遥感的分析的当前的 Jilantai 盐湖附近的高湖层次的沉积、生物的证据想象。在约 1060, 1050, 1044 和 1035 m a.s.l 的举起有四组海岸线,是在当前的盐湖上面的 37, 27, 21 和 12 m 分别地出现。沙和石子的沿岸的存款在在 1070 和 1080 m a.s.l 之间的举起被发现,比水流高的 47 ~ 57 m 腌湖表面,尽管 palaeoshoreline 地形仅仅在几个地点被保存。在 Herimuxini,在 Ulan Buh 荒芜的、典型湖的沉积和沙石子的北边缘上,沿岸的存款也发生在 1080 m a.s.l 并且在下面的举起。典型吐痰扩大的 A 11-km-long 从逐渐地在它的大拐弯上沿着黄河的南部的银行在一些沙石子石场从 1050 ~ 1035 m a.s.l 在举起减少的这条海岸线东方海岸线特征例如在水文学计量器车站和 Shilazhao 镇附近定位的那些,被识别。沿岸的存款 overlying 冲积的洪水的层在 Hangjin 在 Balagong 附近发生在沙石场县。也有沙滩岩石和沿岸的存款,沿着 Langshan-Yinshan 山的南部的山麓在几个地点在 cut-and-built 平台上保存。另外,揭示水下的三角洲沉积的侧面在 Wuhai 附近被识别,在黄河进入盆的地方。典型的湖沉积也在 Hetao 平原的东方结束在 Togtoh 站台存在。水的软体动物壳在沿岸的存款是普通的,包括 Corbicula 的几种,根值 lagotis, R。xauricularia 和 Gyraulus convexiusculus。Ostracode 壳能也在更好的沉积被识别。典型垂直 prograding 序列在湖的沉积很好被保存的露头是明显的。滚动波浪的卵石和沙滩岩石很通常在更高的举起在堤在侧面的顶上被保存。所有这些证据建议曾经有一个巨大的palaeo湖,用到达我们指的 ∼1080 m a.s.l 的最高的湖水平盖住 Jilantai 区域和 Hetao 平原的大多数部分巨大的 paleolake ,比现代的湖贝加尔湖大,作为“ Megalake Jilantai-Hetao ”. OSL 标明日期结果显示大湖以前形成了 ∼60 —50 ka,和在在 1060 和 1035 m a.s.l 之间的举起的四条海岸线多半从 ∼60 ∼50 ka 代表湖水平变化到早 Holocene。Megalake Jilantai-Hetao 的发现将多半影响黄河的发展的理解在期间晚第四级, Ulan Buh 和 Kubq 的进化抛弃,在这个区域的 neotectonism,并且可能地区性的气候的变化。 | CHEN FaHu FAN YuXin CHUN Xi D.B. MADSEN C.G. OVIATT ZHAO Hui YANG LiPing SUN Yang | 2008 | Chinese Science Bulletin2008，53，11： | 23 |
| 3 | Sedimentary documents and Optically Stimulated Luminescence (OSL) dating for formation of the present landform of the northern Ulan Buh Desert,northern China显示文摘GPR reflecting sections and core profiles revealed that sand dunes of the northern Ulan Buh Desert are overlying shallow lacustrine or palustrine sediments. Optical dating results of sediments from three core profiles indicate that the area of the northern Ulan Buh Desert was still covered by the shallow lake or marsh during 8.4-6.4 ka, and eolian sand started to accumulate since around 2 ka. Such a result supports the idea that the present desert landform of the northern Ulan Buh Desert started to form since 2 ka, which was likely a response to the desertification caused by ruin of the Han Dynasty and the large-scale abandonment of farming of the Han nationality. Our research results are consistent with the previous archaeological studies, and support the idea that the Ulan Buh Desert is composed of two parts with different histories, i.e., the old southern Ulan Buh Desert and the young northern Ulan Buh Desert. | Fan YuXin Chen FaHu Fan TianLai Zhao Hui Yang LiPing | 2010 | Science China Earth Sciences2010，53，11： | 15 |
| 4 | Effect of Saccharomyces cerevisiae on alfalfa nutrient degradation characteristics and rumen microbial populations of steers fed diets with different concentrate-to-forage ratios显示文摘Live yeast(Saccharomyces cerevisiae) constitutes an effective additive for animal production;its probiotic effect may be related to the concentrate-to-forage ratio(CTFR).The objective of this study was to assess the effects of S.cerevisiae(SC) on fiber degradation and rumen microbial populations in steers fed diets with different levels of dietary concentrate.Ten Simmental × Local crossbred steers(450 ± 50 kg BW) were assigned to a control group or an SC group.Both groups were fed the same basal diet but the SC group received SC supplementation(8 × 10~9 cfu/h/d through the ruminal fistula)following a two-period crossover design.Each period consisted of four phases,each of which lasted 17 d:10 d for dietary adaptation,6 d for degradation study,and 1 d for rumen sample collection.From the 1^(st) to the 4^(th) phase,steers were fed in a stepwise fashion with increasing CTFRs,i.e.,30:70,50:50,70:30,and 90:10.The kinetics of dry matter and fiber degradation of alfalfa pellets were evaluated;the rumen microbial populations were detected using real-time PCR.The results revealed no significant(P> 0.05) interactions between dietary CTFR and SC for most parameters.Dietary CTFR had a significant effect(P< 0.01) on degradation characteristics of alfalfa pellets and the copies of rumen microorganism;the increasing concentrate level resulted in linear,quadratic or cubic variation trend for these parameters.SC supplementation significantly(P< 0.05) affected dry matter(DM) and neutral detergent fiber(NDF)degradation rates(c_(DM),c_(NDF)) and NDF effective degradability(ED_(NDF)).Compared with the control group,there was an increasing trend of rumen fungi and protozoa in SC group(P < 0.1);copies of total bacteria in SC group were significantly higher(P< 0.05).Additionally,percentage of Ruminobacter amylophilus was significantly lower(P< 0.05)but percentage of Selenomonas ruminantium was significantly higher(P< 0.05) in the SC group.In a word,dietary CTFR had a significant effect on degradation characteristics of forage and rumen microbial population.S.cerevisiae had positive effects on DM and NDF degradation rate or effective degradability of forage;S.cerevisiae increased rumen total bacteria,fungi,protozoa,and lactate-utilizing bacteria but reduced starch-degrading and lactate-producing bacteria. | Gengzhi Ding Ying Chang Liping Zhao Zhenming Zhou Liping Ren Qingxiang Meng | 2014 | Journal of Animal Science and Biotechnology2014，5，4： | 15 |
| 5 | Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes显示文摘Background The effect of cerebral small vessel disease(CSVD)and intracranial arterial stenosis(ICAS)on stroke outcomes remains unclear.Methods Data of 1045 patients with minor stroke or transient ischaemic attack(TIA)were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events(CHANCE)trial.We assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale(mRS)scores using ordinal logistic regression models.Results Among the 1045 patients,CSVD was present in 830 cases(79.4%)and ICAS in 460(44.0%).Patients with>1 ICAS segment showed the highest risk of new strokes(HR 2.03,95%CI 1.15 to 3.56,p=0.01).No association between CSVD and the occurrence of new strokes was found.The presence of severe CSVD(common OR(cOR)2.01,95%CI 1.40 to 2.89,p<0.001)and>1 ICAS segment(cOR 2.15,95%CI 1.57 to 2.93,p<0.001)was associated with higher mRS scores.Severe CSVD(HR 10.70,95%CI 1.16 to 99.04,p=0.04),but not ICAS,was associated with a higher risk of bleeding events.Six-point modified CSVD score improved the predictive power for bleeding events and disability.Interpretation CSVD is associated with more disability and bleeding events,and ICAS is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 months.CSVD and ICAS may represent different vascular pathologies and play distinct roles in stroke outcomes. | Huimin Chen Yuesong Pan Lixia Zong Jing Jing Xia Meng Yuyuan Xu Hongyi Yan Xingquan Zhao Liping Liu Hao Li S Claiborne Johnston Yongjun Wang Yilong Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 13 |
| 6 | Parameter estimation method based on parameter function surface显示文摘By analyzing the structure of the objective function based on error sum of squares and the information provided by the objective function, the essential problems in the current parameter estimation methods are summarized: (1) the information extracted from the objective function based on error sum of squares is unreasonable or even wrong for parameter estimation; and (2) the surface of the objective function based on error sum of squares is more complex than that of the parameter function, which indicates that the optimal parameter values should be searched on the surface of the parameter function instead of the objective function. This paper proposes the concept of sample intersection and demonstrates the uniqueness theorem of intersection point (namely the uniqueness of optimal parameter values). According to the characteristics of parameter function surface and Taylor series expansion, a parameter estimation method based on the sample intersection information extracted from parameter function surface (PFS method) was constructed. The results of theoretical analysis and practical application show that the proposed PFS method can avoid the problems in the current automatic parameter calibration, and has fast convergence rate and good performance in parameter calibration. | BAO WeiMin ZHANG XiaoQin ZHAO LiPing | 2013 | Science China(Technological Sciences)2013，56，6： | 13 |
| 7 | Modelling operation parameters of UAV on spray effects at different growth stages of corns显示文摘Currently,unmanned aerial vehicles(UAVs)were widely applied to spray for pest and disease control.However,spray effect can be further improved by setting operation parameters more reasonably and scientifically.Therefore,this study attempts to derive the relationship between operation parameters and spray effect.Different growth stages were distinguished by various corn heights.A six-rotor UAV was operated at different heights and velocities to test pesticides spray effects for corns at different growth stages.Different plant canopy coverage rate and penetrating coefficients were obtained,according to which,the effects on droplet deposition rate caused by different UAVs’operation parameters were analyzed.Droplet penetrating coefficients were applied as indexes to evaluate and select UAVs operation parameters for corns at different growth stages respectively.Mathematical models of droplet penetrating coefficients with UAVs operation parameters were established for corns at all growth stages.The determination coefficients(R2)of all models were greater than 0.90 and average relative errors were within 20%,which asserted high forecasting accuracy of droplet penetrating rate.With the help of the models,parameters like operating height away from the bottom of corns and UAVs velocities were further analyzed,which guided the optimization of parameter settings and selection of spray methods for corns at different growth stages. | Zheng Yongjun Yang Shenghui Zhao Chunjiang Chen Liping Yubin Lan Tan Yu | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 13 |
| 8 | A point mutation resulting in a 13 bp deletion in the coding sequence of Cldf leads to a GA-deficient dwarf phenotype in watermelon显示文摘The dwarf architecture is an important and valuable agronomic trait in watermelon breeding and has the potential to increase fruit yield and reduce labor cost in crop cultivation.However,the molecular basis for dwarfism in watermelon remains largely unknown.In this study,a recessive dwarf allele(designated as Cldf(Citrullus lanatus dwarfism))was fine mapped in a 32.88 kb region on chromosome 09 using F2 segregation populations derived from reciprocal crossing of a normal line M08 and a dwarf line N21.Gene annotation of the corresponding region revealed that the Cla015407 gene encoding a gibberellin 3β-hydroxylase functions as the best possible candidate gene for Cldf.Sequence analysis showed that the fourth polymorphism site(a G to A point mutation)at the 3′AG splice receptor site of the intron leads to a 13 bp deletion in the coding sequence of Cldf in dwarf line N21 and thus results in a truncated protein lacking the conserved domain for binding 2-oxoglutarate.In addition,the dwarf phenotype of Cldf could be rescued by exogenous GA3 application.Phylogenetic analysis suggested that the small multigene family GA3ox(GA3 oxidase)in cucurbit species may originate from three ancient lineages in Cucurbitaceae.All these data support the conclusion that Cldf is a GA-deficient mutant,which together with the cosegregated marker can be used for breeding new dwarf cultivars. | Chunhua Wei Chunyu Zhu Liping Yang Wei Zhao Rongxue Ma Hao Li Yong Zhang Jianxiang Ma Jianqiang Yang Xian Zhang | 2019 | Horticulture Research2019，6，1： | 12 |
| 9 | Performance of wastewater sludge ecological stabilization显示文摘在这篇文章,废水污泥生态的稳定(WWSES ) 为污泥除去,矿化作用,和稳定,以及为被介绍滤处理。试验性的结果显示了那污泥的飞行员规模的二年不稳定的固体, triphenyltetrazolium 氯化物(TTC ) 脱氢酶活动(DHA ) ,和象指示物的含水量显示出污泥稳定的过程和学位。过程显示出的除去上的观察那弄干的污泥在二年系统操作以后到达了 20%50% 全部的固体的一个内容。第一年里的污泥 TTC-DHA 显然比第二年的低,并且 TTC-DHA 趋于随污泥的弄干的时间的增加减少。污泥的总氮,全部的磷,和器官的内容从顶逐渐地减少了到弄干的污泥层的底部。与与污水污泥对待的看台上的自然看台比较,单个射击显著地更高、粗糙蛋白质,粗糙的脂肪,和在在系统的芦苇根,茎,和叶子的粗糙的纤维内容比野芦苇的高,在系统(7.38%)的芦苇根的特别粗糙的蛋白质内容显然比野芦苇(3.29%)的高。 | CUI Yubo SUN Tieheng ZHAO Lihui JIANG Tingliang ZHANG Liping | 2008 | Journal of Environmental Sciences2008，20，4： | 12 |
| 10 | Recent Progress in Dual-Polarization Radar Research and Applications in China显示文摘Dual-polarization(dual-pol)radar can measure additional parameters that provide more microphysical information of precipitation systems than those provided by conventional Doppler radar.The dual-pol parameters have been successfully utilized to investigate precipitation microphysics and improve radar quantitative precipitation estimation(QPE).The recent progress in dual-pol radar research and applications in China is summarized in four aspects.Firstly,the characteristics of several representative dual-pol radars are reviewed.Various approaches have been developed for radar data quality control,including calibration,attenuation correction,calculation of specific differential phase shift,and identification and removal of non-meteorological echoes.Using dual-pol radar measurements,the microphysical characteristics derived from raindrop size distribution retrieval,hydrometeor classification,and QPE is better understood in China.The limited number of studies in China that have sought to use dual-pol radar data to validate the microphysical parameterization and initialization of numerical models and assimilate dual-pol data into numerical models are summarized.The challenges of applying dual-pol data in numerical models and emerging technologies that may make significant impacts on the field of radar meteorology are discussed. | Kun ZHAO Hao HUANG Mingjun WANG Wen-Chau LEE Gang CHEN Long WEN Jing WEN Guifu ZHANG Ming XUE Zhengwei YANG Liping LIU Chong WU Zhiqun HU Sheng CHEN | 2019 | Advances in Atmospheric Sciences2019，36，9： | 12 |
| 11 | LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing显示文摘(QS ) 在治安法官察觉到处理,细菌由利用响应许多环境暗示称为 autoinducers 的小发信号的分子调整基因表示。Autoinducer 2 (AI-2 ) ,表明分子的 QS 建议涉及 interspecies 通讯,被克否定、克积极的细菌的许多种类生产。在 Escherichia coli 和沙门氏菌 typhimurium,细胞外的 AI-2 被 lsr 操纵子编码的 transporter 进口进房间。lsr 操纵子在上游,有编码 LsrR 的分叉地抄录的基因,它以前被报导镇压 lsr 操纵子和自己的抄写。这里,我们第一次证明了 LsrR 镇压 lsr 操纵子和自己由的抄写对他们用胶化移动和 DNase 的倡导者直接有约束力我 footprinting 试金。牛乳糖记者试金进一步建议在 lsrR 和 lsrA 倡导者区域的二个主题为 LsrR 绑定是关键的。而且,与结论一致,那 phosphorylated AI-2 能在以前的研究减轻 LsrR 的压抑,我们 phospho-AI-2 显示的数据表演不能在 vitro 绑在它的自己的倡导者的 LsrR。 | Ting Xue Liping Zhao Haipeng Sun Xianxuan Zhou Baolin Sun | 2009 | Cell Research2009，19，11： | 11 |
| 12 | Association of elevated hs-CRP and multiple infarctions with outcomes of minor stroke or TIA: subgroup analysis of CHANCE randomised clinical trial显示文摘Background and purpose The relationship of high-sensitive C-reactive protein(hs-CRP)levels and infarction numbers with the prognosis of stroke is uncertain.This study evaluated the association of different hs-CRP levels and infarction numbers with the prognosis of acute minor ischaemic stroke or transient ischaemic attack(TIA).Methods A subset of 807 patients with both hs-CRP measurement and baseline MRI was included from the Clopidogrel in High-risk Patients with Acute Non-disabling Cerebrovascular Events trial.The primary efficacy outcome was the occurrence of an ischaemic stroke at the 1-year follow-up.Infarction numbers were classified as multiple acute infarctions(MAIs),single acute infarction and no acute infarction(NAI).The association between different hs-CRP levels with different infarction numbers and the risk of any outcome was analysed using multivariable Cox regression models.Results Among the 807 patients,84(10.4%)patients had a recurrent ischaemic stroke within 1 year.After adjustment for conventional confounding factors,patients with both elevated hs-CRP levels and MAIs were associated with approximately 4.7-fold of risk of ischaemic stroke within 1 year(16.7% vs 3.5%,HR 4.68,95% CI 1.54 to 14.23,p=0.007),compared with those with non-elevated hs-CRP levels and NAI.Similar results were observed for the composite events.Conclusions Combined elevated hs-CRP levels and MAIs may increase 1-year stroke risk stratification efficiency in patients with minor ischaemic stroke or TIA compared with using those markers alone,which indicated that the combination of inflammatory and imaging markers might improve the effectiveness of risk stratification concerning minor ischaemic stroke or TIA. | Guangyao Wang Jing Jing Jiejie Li Yuesong Pan Hongyi Yan Xia Meng Xingquan Zhao Liping Liu Hao Li David Z Wang Yongjun Wang Yilong Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 11 |
| 13 | Concurrent intracranial and extracranial artery stenosis and the prognosis of transient ischaemic symptoms or imaging-negative ischaemic stroke显示文摘Background and purpose Transient ischaemic attack(TIA),transient symptoms with infarction(TSI)and diffusion-weighted imaging(DWI)-negative acute ischaemic stroke(AIS)share similar aetiologies but are considered to have a rather benign prognosis.We intended to investigate the association between intracranial atherosclerotic stenosis(ICAS),extracranial atherosclerotic stenosis(ECAS)and the prognosis of patients with TIA,TSI and DWI-negative AIS.Methods Clinical and imaging data of eligible participants were derived from the Chinese Intracranial Atherosclerosis study,according to symptom duration,acute infarction on DWI and discharge diagnosis.Based on the severity and location of arterial atherosclerosis,we categorised the study population into four groups:no or<50% ICAS and no ECAS;≥50% ICAS but no ECAS;no or<50%ICAS with ECAS;and concurrent≥50% ICAS and ECAS.Using multivariable Cox regression models,we analysed the relationship between the severity and distribution of large artery atherosclerosis and the prognosis of TIA,TSI and DWI-negative AIS.Results A total of 806 patients were included,67.3% of whom were male.The median age of the study participants was 63 years.Patients in the concurrent≥50% ICAS and ECAS subgroup had both a significantly higher 1-year recurrence rate(adjusted HR 3.4(95%CI 1.15 to 10.04),p=0.027)and a higher risk of composite vascular events(adjusted HR 3.82(95%CI 1.50 to 9.72),p=0.005).Conclusions Concurrent ICAS and ECAS is associated with a higher possibility of 1-year recurrent stroke or composite vascular events.Large artery evaluation is necessary to assess patients with transient ischaemic symptoms or DWI-negative AIS.Progress in shortening the time interval between symptom onset and large vessel evaluation is needed. | Yue Suo Jing Jing Yuesong Pan Weiqi Chen Hongyu Zhou Hao Li Yuehua Pu Liping Liu Xingquan Zhao Yilong Wang Xia Meng Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 10 |
| 14 | Crop Classification Using MODIS NDVI Data Denoised by Wavelet: A Case Study in Hebei Plain, China显示文摘Time-series Moderate Resolution Imaging Spectroradiometer (MODIS) Normalized Difference Vegetation Index (NDVI) data have been widely used for large area crop mapping.However,the temporal crop signatures generated from these data were always accompanied by noise.In this study,a denoising method combined with Time series Inverse Distance Weighted (T-IDW) interpolating and Discrete Wavelet Transform (DWT) was presented.The detail crop planting patterns in Hebei Plain,China were classified using denoised time-series MODIS NDVI data at 250 m resolution.The denoising approach improved original MODIS NDVI product significantly in several periods,which may affect the accuracy of classification.The MODIS NDVI-derived crop map of the Hebei Plain achieved satisfactory classification accuracies through validation with field observation,statistical data and high resolution image.The field investigation accuracy was 85% at pixel level.At county-level,for winter wheat,there is relatively more significant correlation between the estimated area derived from satellite data with noise reduction and the statistical area (R2 = 0.814,p < 0.01).Moreover,the MODIS-derived crop patterns were highly consistent with the map generated by high resolution Landsat image in the same period.The overall accuracy achieved 91.01%.The results indicate that the method combining T-IDW and DWT can provide a gain in time-series MODIS NDVI data noise reduction and crop classification. | ZHANG Shengwei LEI Yuping WANG Liping LI Hongjun ZHAO Hongbin | 2011 | Chinese Geographical Science2011，21，3： | 9 |
| 15 | Characteristics analysis of a novel centralized-driving flip-flow screen显示文摘During screening operation, blinding or clogging of screen perforations generally occurs to reduce the sieving capacity and efficiency. Recently, the flip-flow screening has been widely recognized as a feasible method to deal with the problem. In this paper, a novel centralized-driving flip-flow screen(CFS) was developed for the separation of fine and moist coal, and the key structures, namely, a centralized-driving mechanism and a quasi-circle beam mounted with the mat were designed for high reliability and stability. By means of a test on an experimental prototype, the effect of some factors, i.e., initial stretch and hardness of the polyurethane panel, respectively, and the rotation speed of the driving motor on the kinematic characteristic of the screen surface was investigated. Results show that without an initial stretch, the sieve mat generates the largest vibratory amplitude while the slacker the sieve mat initially is, the smaller amplitude it will accomplish. And an increase in the rotation speed could cause a rise in the vibratory amplitude. Unlike the two factors, the hardness does not have a definite effect on the kinematic performance, on which a further study is required. Finally, screening processing on a laboratory prototype was conducted to draw the conclusion that the developed CFS also has a high sieving efficiency for the fine and moist coal. | Peng Liping Li Fengming Dong Hailin Liu Chusheng Zhao Yuemin Duan Chenlong | 2014 | International Journal of Mining Science and Technology2014，24，2： | 9 |
| 16 | Activation of Rev-erbα attenuates lipopolysaccharide-induced inflammatory reactions in human endometrial stroma cells via suppressing TLR4-regulated NF-κB activation显示文摘Perturbation of the circadian rhythm damages the biological characteristics of cells and leads to their dysfunction. Rev-erbα, an important gene in the transcription-translation loop of circadian rhythm, is involved in regulating the balance between pro-inflammation and anti-inflammation. The disruption of this balance in human endometrial stroma cells (hESCs) destroys their biological behavior function in maintaining the menstrual cycle and embryonic implantation. Whether pharmacological modulation of Rev-erbα affects the inflammation of hESCs remains unclear. In this study, we treated hESCs with lipopolysaccharide (LPS) and found that LPS treatment increased the mRNA levels of pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-8, IL-18, and TNFα, and the secretion of IL-6. SR9009, a Rev-erbα agonist, significantly alleviated the LPS-induced production of pro-inflammatory cytokines in hESCs. Meanwhile, knockdown of Rev-erbα increased the expressions of IL-1β, IL-6, and IL-8, accompanied by an increased mRNA level of the core clock gene Bmal1. Western blot analysis showed that SR9009 inhibited the expression of toll-like receptor 4 (TLR4) and the activation of NF-κB induced by LPS. All these findings suggested that pharmacological activation of Rev-erbα attenuated the LPS-induced inflammatory response of hESCs by suppressing TLR4-regulated NF-κB activation. This study may provide a strategy for preventing inflammation-related endometrial dysfunction and infertility or recurrent implantation failure. | Weijie Zhao Liyuan Cui Xixi Huang Songcun Wang Dajin Li Liping Li Yan Sun Meirong Du | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 8 |
| 17 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 18 | Phase Evolution of Holocene Paleoenvironmental Changes in the Southern Yellow Sea: Benthic Foraminiferal Evidence from Core CO2显示文摘Assemblages of benthic foraminifera in a sediment core(C02)near the western margin of the southern Yellow Sea Mud were studied to decipher the phase evolution of Holocene paleoenvironmental changes associated with the Holocene marine transgression.It appears that during the early Holocene(11.2 10.1 kyr BP),the faunal was dominated by low salinity and shallow water species Cribrononion subincertum,Buccella frigida and Ammonia beccarii,reflecting a near coast depositional environment.A rapid increase of the relative abundance of Ammonia compressiuscula between 10.1 9.3 kyr BP indicates that the sea level rose rapidly during that time period.From 9.3 7.7 kyr BP,the benthic foraminiferal assemblage was dominated by high percentage of A.compressiscula,suggesting that the sea level was relatively stable.An obvious transition of benthic foraminifera,from the A.compressiuscula-dominated assemblage to an Ammonia ketienziensis-dominated assemblage,occurred between 7.7 6.2 kyr BP,possibly corresponding to a second sea level rapid rise period in the Yellow Sea during the Holocene.This transition may correspond to the gradually strengthened Yellow Sea warm current(YSWC)and finally is established the modern-type circulation in the Yellow Sea.It may also mark the formation of the Yellow Sea cold bottom water(YSCBW)during that period.Since then,the benthic foraminiferal assemblage based on core C02 was dominated by typical YSCBW species,A.ketienziensis,Astrononion italicum and Hanzawaia nipponica,at 6.2 4 kyr BP.A non-deposition period occurred since 4 kyr BP,which possibly related to the hydrology changes caused by the East Asia monsoon.The two obvious benthic foraminiferal transitions recorded in core C02 during the early and middle Holocene provide evidence that the Yellow Sea has undergone a two-phase rapid sea level rise during the Holocene marine transgression. | FANG Li XIANG Rong ZHAO Meixun ZHOU Liping LIU Jianguo ZHANG Lanlan | 2013 | Journal of Ocean University of China2013，12，4： | 8 |
| 19 | A semi-physical sediment yield model for estimation of suspended sediment in loess region显示文摘Sediment yield is a complex function of many environmental factors including climate,hydrology,vegetation,basin topography,soil types,and land cover.We present a new semi-physical watershed sediment yield model for the estimation of suspended sediment in loess region.This model is composed by three modules in slope,gully,and stream phases.For slope sediment yield,a balance equation is established based on the concept of hydraulic erosion capacity and soil erosion resistance capacity.According to the statistical analysis of watershed characteristics,we use an exponential curve to approximately describe the spatial variability of watershed soil erosion resistance capacity.In gully phase,the relationship between gully sediment concentration and flow velocity is established based on the Bagnold' stream power function.In the stream phase,we assume a linear dependence of the sediment volume in the reach on the weighted sediment input and output.The proposed sediment yield model is operated in conjunction with a conceptual hydrologic model,and is tested over 16 regions including testing grounds,and small,medium and large watersheds in the loess plateau region in the mid-reach of Yellow River.Our results indicate that the model is reasonable in structure and is able to provide a good simulation of sediment generation and transportation processes at both flood event scale and inter-annual time scale.The proposed model is generally applicable to the watersheds with soil texture similar to that of the loess plateau region in the Yellow River basin in China. | Wei Si Weimin Bao Peng Jiang Liping Zhao Simin Qu | 2017 | International Journal of Sediment Research2017，32，1： | 7 |
| 20 | Gastrointestinal bleeding during acute ischaemic stroke hospitalisation increases the risk of stroke recurrence显示文摘Objective Gastrointestinal(GI)bleeding in patients who had a stroke is strongly associated with a higher risk of death and loss of independence.However,it is unknown whether GI bleeding increases risk for recurrence of stroke.In this study,we assess the potential relationship between GI bleeding and stroke recurrence in patients within 12 months of an acute ischaemic stroke(AIS),using the China National Stroke Registry(CNSR).Methods This study included 22216 patients who had an ischaemic stroke included in the CNSR from 2007 to 2008.We analysed baseline patient characteristics,GI bleeding and outcomes of patients who had an AIS,specifically stroke recurrence at 3,6 and 12 months.We used multivariable logistic regression to evaluate a possible association between GI bleeding and stroke recurrence.results Of the 12415 patients included in our study,12.3%,15.5%and 17.7%had a stroke recurrence at 3,6 and 12 months,respectively.GI bleeding was an independent stroke recurrence risk factor in patients after ischaemic stroke at 3 months(adjusted OR 1.481,95%CI 1.118 to 1.962),6 months(adjusted OR 1.448,95%CI 1.106 to 1.896)and 12 months(adjusted OR 1.350;95%CI 1.034 to 1.763).Conclusion GI bleeding was associated with the increased risk of stroke recurrence after an AIS. | Wanliang Du Xingquan Zhao Yilong Wang Yuesong Pan Gaifen Liu Anxin Wang Ruijun Ji Liping Liu Hongqiu Gu Kehui Dong Penglian Wang Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 7 |
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