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| 1 | Prototype Design and Experimental Study on Locust Air-Posture Righting显示文摘 | Diansheng Chen Junmao Yin Kewei Chen Kai Zhao Benguang Zhang | 2014 | Journal of Bionic Engineering2014，11，3： | 7 |
| 2 | Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer显示文摘 | Jiang Kewei Lyu Liang Shen Zhanlong Zhang Jizhun Zhang Hui Dong Jianqiang Yan Yichao Liu Fangfang Wang Shan | 2014 | Chinese Medical Journal2014，，11： | 5 |
| 3 | The structural,electronic and magnetic properties of the 3d TM(V,Cr,Mn,Fe,Co,Ni and Cu) doped ZnO nanotubes:A first-principles study显示文摘We have performed the first-principles calculations onto the structural,electronic and magnetic properties of seven 3d transition-metal(TM=V,Cr,Mn,Fe,Co,Ni and Cu) atom substituting cation Zn in both zigzag(10,0) and armchair(6,6) zinc oxide nanotubes(ZnONTs).The results show that there exists a structural distortion around 3d TM impurities with respect to the pristine ZnONTs.The magnetic moment increases for V-,Cr-doped ZnONTs and reaches maximum for Mn-doped ZnONTs,and then decreases for Fe-,Co-,Ni-and Cu-doped ZnONTs successively,which is consistent with the predicted trend of Hund's rule for maximizing the magnetic moments of the doped TM ions.However,the values of the magnetic moments are smaller than the predicted values of Hund's rule due to strong hybridization between p orbitals of the nearest neighbor O atoms of ZnONTs and d orbitals of the TM atoms.Furthermore,the Mn-,Fe-,Co-,Cu-doped(10,0) and(6,6) ZnONTs with half-metal and thus 100% spin polarization characters seem to be good candidates for spintronic applications. | ZHANG JianMin GAO Dan XU KeWei | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，3： | 5 |
| 4 | Mechanism of Locust Air Posture Adjustment显示文摘 | Diansheng Chen Kewei Chen Ziqiang Zhang Benguang Zhang | 2015 | Journal of Bionic Engineering2015，12，3： | 5 |
| 5 | Analysis and comparison of three leg models for bionic locust robot based on landing buffering performance显示文摘Good landing buffering performance can reduce impact and vibration for the bionic locust jumping robot; thus, a landing buffer is important in evaluating the motion performance of the bionic locust robot. In particular, the legs of the robot are the main structures that realize the buffer; thus, its structure affects buffering performance. Three typical leg structure models are established based on the physiological analysis of the locust leg and research status, namely, bionic leg, multi-constraint leg, and arc legs. Kinematic and force analyses are conducted for these types of legs. Particularly, flexible deformation of leg link is considered in the analysis to describe the movement process accurately. In order to compare the buffering performance of these types of legs quantitatively, the performance indices with maximum buffering distance, the energy absorption capability, and the mechanical property are presented. Based on the performance indices, the structure parameters are analyzed and optimized. The buffering performance of the three leg structures is compared with the comprehensive performance of different structures in each best state. This study offers a quantitative analysis and comparison for different legs of bionic locust jumping robot based on landing buffering performance. Furthermore, a theoretical basis for future research and engineering applications is established. | ZHANG ZiQiang CHEN DianSheng CHEN KeWei | 2016 | Science China(Technological Sciences)2016，59，9： | 5 |
| 6 | Linear-grating hybridized electromagnetic-triboelectric nanogenerator for sustainably powering portable electronics显示文摘利用 nanogenerator 清除从我们的生活环境的机械精力是一个有效方法解决便携式的电子学的力量来源问题。我们报导线性栅栏的 hybridized 机械精力从滑动产生了的为清除的电磁摩擦电的 nanogenerator 打手势 sustainably 驱动某些便携式的电子学。hybridized nanogenerator 在结构的设计由滑块和一个定子组成,并且拥有 66 片断摩擦电 nanogenerator (TENG ) 和 9 片断在功能的设计的电磁的生成器(EMG ) 。在 hybridized nanogenerator 能交付的 20 m/s 2, 的滑动加速,最大值在 6 k 的一个装载电阻为 EMG 在 0.4 M 和 103.3 mW 的一个装载电阻为 TENG 102.8 mW 驱动。与有一个变压器的 TENG 和有一个力量管理电路的 EMG 的最佳的 hybridized 联合, 10 mF 电容器能容易在 20 s 被控告到 2.8 V。有 140 g 的轻重量和 12 厘米的小尺寸的包装 hybridized nanogenerator ?????? ? 丠? 楓?? | Kewei Zhang Ya Yang | 2016 | Nano Research2016，9，4： | 4 |
| 7 | Capsaicin enhances the antitumor activity of sorafenib in hepatocellular carcinoma cells and mouse xenograft tumors through increased ERK signaling显示文摘Sorafenib,酷氨酸蛋白质 kinases 的一个小禁止者,当前是为先进 hepatocellular 癌(HCC ) 的治疗的标准化疗药。尽管 sorafenib 改进 HCC 病人的幸存,它的功效不是最佳的并且要求进一步的改进。Capsaicin,从类辣椒的红辣椒辣椒的主要活跃部件,是 TRPV1 隧道,而且显示 antitumor 活动的不仅收缩筋并且提高癌症房间的敏感到细胞毒素的药。在这研究,我们在 vitro 和异种皮移植肿瘤在 HCC 房间上调查了联合 sorafenib 和 capsaicin 的 antitumor 效果。有 capsaicin 的治疗 dose-dependently 独自分别地与 137, 108 和 140.7 mol/L 的 IC 50 价值禁止了 HCC 房间线 PLC/PRF/7, HuH7 和 HepG2 的增长。TRPV1 隧道的明显的表示都没在 3 根 HCC 房间线被检测, TRPV1 隧道 blockers 没减轻 capsaicin 的 cytotoxicity。由对比,显著地联合 capsaicin 和 sorafenib 在房间增长上提高了抑制,完成高级 synergistic 效果(超过 50% 的抑制率) 并且支持 HCC 房间 apoptosis。在有 PLC/PRF/5 异种皮移植的裸体老鼠,联合了 capsaicin 的管理,没有明显的粗野毒性, sorafenib 显著地独自与任何一个代理人相比在肿瘤生长上提高了抑制。机械学地, capsaicin (10-200 mol/L ) dose-dependently 在 PLC/PRF/5 房间增加了 phosphorylated 英皇家空军之阶级最低之兵(津贴) 的层次,因此导致在肿瘤房间上提高了 sorafenib 敏感和 synergistic 抑制。一起拿,我们的结果建议英皇家空军之阶级最低之兵的增加 capsaicin 的 phosphorylation 贡献 sorafenib,和 capsaicin 的提高的 antitumor 活动可能在为 HCC 的处理改进 sorafenib 的功效有用。 | Su-shan ZHANG Yu-hao NI Chen-ru ZHAO Zhen QIAO Hong-xia YU Lu-yao WANG Jin-yan SUN Chen DU Jia-haoZHANG Li-ying DONG KeWei WANG Jian-jun GAO | 2018 | Acta Pharmacologica Sinica2018，39，3： | 4 |
| 8 | Impact Analysis of Solar Irradiance Change on Precision Orbit Determination of Navigation Satellites显示文摘Solar radiation pressure is the main driving force and error source for precision orbit determination of navigation satellites.It is proportional to the solar irradiance,which is the'sun constant'.In regular calculation,the'solar constant'is regard as a constant.However,due to the existence of sunspots,flares,etc.,the solar constant is not fixed,the change in the year is about 1%.To investigate the variation of solar irradiance,we use interpolation and average segment modeling of total solar irradiance data of SORCE,establishing variance solar radiation pressure(VARSRP)model and average solar radiation pressure(AVESRP)model based on the built solar pressure model(SRPM)(constant model).According to observation data of global positioning system(GPS)and Beidou system(BDS)in 2015 and comparing the solar pressure acceleration of VARSRP,AVESRP and SRPM,the magnitude of change can reach 10-10 m/s^2.In addition,according to the satellite precise orbit determination,for GPS satellites,the results of VARSRP and AVESRP are slightly smaller than those of the SRPM model,and the improvement is between 0.1 to 0.5 mm.For geosynchronous orbit(GEO)satellites of BDS,The AVESRP and VARSRP have an improvement of 3.5 mm and 4.0 mm,respectively,based on overlapping arc,and SLR check results show the AVESRP model and the VARSRP model is improved by 2.3 mm and 3.5 mm,respectively.Moreover,the change of inclined geosynchronous orbit(IGSO)satellites and medium earth orbit(MEO)satellites is relatively small,and the improvement is smaller than 0.5 mm. | ZHANG Yan WANG Xiaoya XI Kewei SHAO Fan | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，6： | 4 |
| 9 | Analysis and Comparison of Two Jumping Leg Models for Bioinspired Locust Robot显示文摘 | Ziqiang Zhang Diansheng Chen Kewei Chen Hanlong Chen | 2016 | Journal of Bionic Engineering2016，13，4： | 4 |
| 10 | Numerical Study of the Intensity Correlation between Secondary Flow and Heat Transfer of Circle Tube-Finned Heat Exchanger with Vortex Generators显示文摘The application of vortex generators in tube-finned heat exchangers is very universal.The vortex generators can generate secondary flow,and as we all know secondary flow can obviously strengthen heat transfer.To use vortex generators much more efficiently in the circle tube-finned heat exchangers,the intensity correlation study between secondary flow and heat transfer is needed.22 different structures of circle tube-finned heat exchangers were numerically studied,including the plain fin cases and the cases with vortex generators.In addition,the influence of fin spacing,transverse and longitudinal tube pitch,heights and attack angle of vortex generators,positions of vortex generators and shape of vortex generators on heat transfer and fluid flow are studied,too.The non-dimensional parameter Se is applied to quantify the secondary flow intensity.The results show that Se can describe the secondary flow intensity very well.There is very close corresponding relationship between overall averaged Nu and volumetrically averaged Se for all the researched cases and the relational expression is obtained.However,there is no one-to-one correlation not only between Re and f but also between volumetrically averaged Se and f for all the studied cases. | Yong Guan Wanling Hu Yun Zhang Kewei Song Liangbi Wang | 2020 | Computer Modeling in Engineering & Sciences2020，，4： | 3 |
| 11 | Inhibition of intracellular proton-sensitive Ca^(2+)-permeable TRPV3 channels protects against ischemic brain injury显示文摘Ischemic brain stroke is pathologically characterized by tissue acidosis, sustained calcium entry and progressive cell death. Previous studies focusing on antagonizing N-methyl-D-aspartate(NMDA) receptors have failed to translate any clinical benefits, suggesting a non-NMDA mechanism involved in the sustained injury after stroke. Here, we report that inhibition of intracellular proton-sensitive Ca^(2+)-permeable transient receptor potential vanilloid 3(TRPV3) channel protects against cerebral ischemia/reperfusion(I/R) injury. TRPV3 expression is upregulated in mice subjected to cerebral I/R injury. Silencing of TRPV3 reduces intrinsic neuronal excitability, excitatory synaptic transmissions, and also attenuates cerebral I/R injury in mouse model of transient middle cerebral artery occlusion(tMCAO). Conversely, overexpressing or re-expressing TRPV3 increases neuronal excitability, excitatory synaptic transmissions and aggravates cerebral I/R injury. Furthermore, specific inhibition of TRPV3 by natural forsythoside B decreases neural excitability and attenuates cerebral I/R injury. Taken together, our findings for the first time reveal a causative role of neuronal TRPV3 channel in progressive cell death after stroke, and blocking overactive TRPV3 channel may provide therapeutic potential for ischemic brain injury. | Xiaoling Chen Jingliang Zhang KeWei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 3 |
| 12 | Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 reveals unique conformation of fi nger 3 loop critical for channel function显示文摘In all six members of TRPV channel subfamily,there is an ankyrin repeat domain(ARD)in their intracellular N-termini.Ankyrin(ANK)repeat,a common motif with typi-cally 33 residues in each repeat,is primarily involved in protein-protein interactions.Despite the sequence similarity among the ARDs of TRPV channels,the struc-ture of TRPV3-ARD,however,remains unknown.Here,we report the crystal structure of TRPV3-ARD solved at 1.95Åresolution,which reveals six-ankyrin repeats.While overall structure of TRPV3-ARD is similar to ARDs from other members of TRPV subfamily;it,however,features a noticeable fi nger 3 loop that bends over and is stabilized by a network of hydrogen bonds and hydrophobic pack-ing,instead of being fl exible as seen in known TRPV-ARD structures.Electrophysiological recordings demonstrated that mutating key residues R225,R226,Q255,and F249 of fi nger 3 loop altered the channel activities and pharmacol-ogy.Taken all together,our findings show that TRPV3-ARD with characteristic fi nger 3 loop likely plays an im-portant role in channel function and pharmacology. | Di-Jing Shi Sheng Ye Xu Cao Rongguang Zhang KeWei Wang | 2013 | Protein & Cell2013，4，12： | 3 |
| 13 | Overexpression of N-cadherin is correlated with metastasis and worse survival in colorectal cancer patients显示文摘N-cadherin is related to the progression and metastases of several solid carcinomas.However,it was still unclear whether N-cadherin is overexpressed in colorectal malignant tumors that have stronger malignant tendency.In this study,we used immunohistochemistry to detect the expression patterns of N-cadherin in both the primary tumors and their normal mucosa tissues of 120patients with colorectal cancer.We revealed that N-cadherin was expressed in 78.3%(94/120)of colorectal tumor tissues and in only 9.2%(11/120)of paired distant normal mucosa tissues with a significant difference(P=0.000).The low,moderate,and high expression of N-cadherin protein was 42.5%,30.8%,and 26.7%,respectively.N-cadherin overexpression was associated with advanced TNM stage,lymph nodes metastasis and distant metastasis(P<0.05).Patients with N-cadherin overexpressed showed the obvious lower overall survival rate than those with moderate and low expression,and patients with low expression had a better survival rate than those with moderate and high expression(P<0.05).In conclusion,high N-cadherin expression may lead to tumor aggressiveness and metastatic potential in colorectal cancer,and may prove to be a possible prognostic factor. | ZHUO HongQing JIANG KeWei DONG LingYi ZHU Yi Lü Liang Lü You ZHANG YanBin ZHANG Hui YE YingJiang WANG Shan | 2013 | Chinese Science Bulletin2013，58，28： | 2 |
| 14 | Structural and electronic properties of chiral single-wall copper nanotubes显示文摘The structural,energetic and electronic properties of chiral(n,m)(3≤n≤6,n/2≤m≤n)single-wall copper nanotubes(CuNTs)have been investigated by using projector-augmented wave method based on density-functional theory.The(4,3)CuNT is energetically stable and should be observed experimentally in both free-standing and tip-suspended conditions,whereas the(5,5)and(6,4)CuNTs should be observed in free-standing and tip-suspended conditions,respectively.The number of conductance channels in the CuNTs does not always correspond to the number of atomic strands comprising the nanotube.Charge density contours show that there is an enhanced interatomic interaction in CuNTs compared with Cu bulk.Current transporting states display different periods and chirality,the combined effects of which lead to weaker chiral currents on CuNTs. | DUAN YingNi ZHANG JianMin XU KeWei | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 2 |
| 15 | Advanced noble-metal-free bifunctional electrocatalysts for metal-air batteries显示文摘The sluggish reaction kinetics at the oxygen cathode is one of the important issues hindering the commercialization of the metal-air batteries.Although the noble metal can be used as the high-efficiency electrocatalyst to solve the problems to some extent,the high cost and scarcity of these noble-metal catalysts have limited their application in electrocatalysis.In this review,we discussed the mecha-nisms of the ORR and OER,and proposed the principles for the bifunctional electrocatalysts firstly,and then the state-of-the-art bifunctional catalysts,including carbon-based materials and transition-metal-based materials.On the basis of that,the self-supporting 3D noble-metal-free bifunctional ORR/OER catalysts were also discussed.Finally,the perspectives for the bifunctional electrocatalysts were discussed. | Wenhao Tang Boya Li Kewei Teng Xiaodong Wang Ruiping Liu Mengwei Wu Lei Zhang Pengfei Ren Junqing Zhang Ming Feng | 2022 | Journal of Materiomics2022，8，2： | 2 |
| 16 | Phosphatase activity and culture conditions of the yeast Candida mycoderma sp. and analysis of organic phosphorus hydrolysis ability显示文摘Orthophosphate is an essential but limiting macronutrient for plant growth. About 67%cropland in China lacks sufficient phosphorus, especially that with red soil. Extensive soil phosphorus reserves exist in the form of organic phosphorus, which is unavailable for root uptake unless hydrolyzed by secretory acid phosphatases. Thus, many microorganisms with the ability to produce phosphatase have been exploited. In this work, the activity of an extracellular acid phosphatase and yeast biomass from Candida mycoderma was measured under different culture conditions, such as p H, temperature, and carbon source. A maximal phosphatase activity of 8.47 × 105± 0.11 × 105U/g was achieved by C. Mycoderma in 36 hr under the optimal conditions. The extracellular acid phosphatase has high activity over a wide p H tolerance range from 2.5 to 5.0(optimum p H 3.5). The effects of different phosphorus compounds on the acid phosphatase production were also studied. The presence of phytin, lecithin or calcium phosphate reduced the phosphatase activity and biomass yield significantly. In addition, the p H of the culture medium was reduced significantly by lecithin. The efficiency of the strain in releasing orthophosphate from organic phosphorus was studied in red soil(used in planting trees) and rice soil(originating as red soil). The available phosphorus content was increased by 230% after inoculating20 days in rice soil and decreased by 50% after inoculating 10 days in red soil. This work indicates that the yeast strain C. mycoderma has potential application for enhancing phosphorus utilization in plants that grow in rice soil. | Mang Yan Liufang Yu Liang Zhang Yuexia Guo Kewei Dai Yuru Chen | 2014 | Journal of Environmental Sciences2014，26，11： | 2 |
| 17 | First-principles study of the adsorption of oxygen atoms on copper nanowires显示文摘By using first-principles calculations,we have systematically investigated the structural stability and electronic properties of a single oxygen atom adsorbed on the surface of foursquare Cu nanowires for a wide range of adsorption sites.In view of binding energy maximization,we found that the long bridge site at the edge of the Cu nanowires is the most stable site for oxygen adsorption,which is always slightly energetically favorable compared with the hollow site at the surface.The electron transferring from Cu atoms to O adatom and a significant polarization indicate the O-Cu chemical bond,showing some degree of ionic character.In addition,the hybridization between O-2p and Cu-3d states implies the O-Cu bond which also shows some degree of covalence character.The main factors which affect the oxygen preferred adsorption site are analyzed from the local geometrical configurations and electronic properties. | MA LiangCai ZHANG JianMin XU KeWei | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，3： | 2 |
| 18 | Isolation of a strong matrix attachment region (MAR) and identification of its function in vitro and in vivo显示文摘Inclusion of MARs in transgene cassettes enhances their expression and reduces position-effect variations in the transgenic host. Four new MARs (TM2, TM3, AM1 and AM2) were isolated from tobacco and Arabidopsis by PCR method. The nuclei isolated from suspension-cultured cells of rice were used to prepare nuclear matrix. With a characterized MAR (TM1) as a positive control, the Matrix-MAR interactions were tested by an in vitro binding assay to identify the DNA sequences as MARs and their binding strength to nuclear matrix in vitro was compared. The results showed that TM2 and TM3 had stronger binding strength than TM1. To determine the functions of the four new MARs in vivo, binary vectors pBI121 carrying a uidA GUS reporter gene were modified with direct repeat MARs inserted on both sides of the reporter gene cassette and were transferred into tobaccos via Agrobacterium-mediated transformation procedure. Quantitative GUS assays of the transgenic tobaccos showed that when flanking a GUS reporter gene | Kewei Zhang Jianmei Wang Guodong Yang Xingqi Guo Fujiang Wen Decai Cui Chengchao Zheng | 2002 | Chinese Science Bulletin2002，47，23： | 2 |
| 19 | Stem cell therapy for Alzheimer’s disease:An overview of experimental models and reality显示文摘Alzheimer's disease(AD)is a neurodegenerative disorder.The pathology of AD is characterized by extracellular amyloid beta(Aβ)plaques,neurofibrillary tangles com-posed of hyperphosphorylated tau,neuronal death,synapse loss,and brain atrophy.Many therapies have been tested to improve or at least effectively modify the course of AD.Meaningful data indicate that the transplantation of stem cells can alleviate neuropathology and significantly ameliorate cognitive deficits in animal models with Alzheimer's disease.Transplanted stem cells have shown their inherent advantages in improving cognitive impairment and memory dysfunction,although certain weak-nesses or limitations need to be overcome.This review recapitulates rodent models for AD,the therapeutic efficacy of stem cells,influencing factors,and the underlying mechanisms behind these changes.Stem cell therapy provides perspective and chal-lenges for its clinical application in the future. | Chuan Qin Kewei Wang Ling Zhang Lin Bai | 2022 | Animal Models and Experimental Medicine2022，5，1： | 2 |
| 20 | Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-1ysine and its anti-nociceptive effects on inflammatory pain in rodents显示文摘 | Bo-chuan TENG Yan SONG Fan ZHANG Tian-yang MA Jin-Iong QI Hai-lin ZHANG Gang LI KeWei WANG | 2016 | Acta Pharmacologica Sinica2016，37，8： | 2 |
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