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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | A naturally occurring CD8^+CD122^+ T-cell subset as a memory-like Treg family显示文摘尽管有 CD4 + CD25 + 规章的 T 房间(Tregs ) 在过去的十年期间,在他们的临床的翻译以后的进步仍然保持停滞。增长证据建议那自然地发生的 CD8 + CD122 + T 房间也是有能力的 Tregs 禁止 T 房间回答并且象 alloimmunity 一样压制 autoimmunity。事实上,他们是像记忆的 Tregs 类似于一个中央记忆 T 房间(T 厘米 ) 显型。位于他们的抑制下面的机制仍然不好被理解,尽管他们可以包括 IL-10 生产。我们最近证明了那个规划 death-1 (PD-1 ) 表达式区分在之间规章并且存储器 CD8 + CD122 + T 房间和那 CD8 + CD122 + Tregs 经历更快的 homeostatic 增长并且比常规 CD4 + CD25 + Tregs。这些调查结果可以为在诊所加速有效 Treg 治疗打开调查的一根新线。在这评论,我们在 CD8 + CD122 + Treg 在诊所研究并且讨论他们的显型,在 autoimmunity 和 alloimmunity 的镇压角色,功能的要求,行动的机制和潜在的应用。 | Shanshan Li Qingfeng Xie Yuqun Zeng Chuan Zou Xusheng Liu Shouhai Wu Haixia Deng Yang Xu Xian C Li Zhenhua Dai | 2014 | Cellular & Molecular Immunology2014，11，4： | 6 |
| 3 | Effect of Sr on microstructure and aging behavior of Mg-14Li alloys | Bin Jiang a,b,c,Ying Zeng b,Hengmei Yin a,b,Ruihong Li a,b,Fusheng Pan a,b a National Engineering Research Center for Magnesium Alloys,Chongqing University,Chongqing 400030,China b College of Materials Science and Engineering,Chongqing University,Chongqing 400030,China c New Materials Center,Chongqing Academy of Science and Technology,Chongqing 401123,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 3 |
| 4 | Phylogenetic position of sponges in early metazoan evolution and bionic applications of siliceous sponge spicules显示文摘Sponges are the oldest and the simplest but not primitive multicellular animals. They represent the earliest evolutionary metazoan phylum still extant. It was a long and painful scientific process to posi-tion the most enigmatic and mysterious metazoan,the Porifera,into their correct phylogenetic place among the eukaryotes in general and multicellular animals in particular. As living fossils,sponges provide the best evidence for the early evolution of Metazoa. More recently,interest has been focused on the bionic applications of sponges' siliceous spicules,after the discovery of their unique structure and high fiber performance. In this review,the emergence of sponges,evolutionary novelties found in sponges,and the phylogenetic position of sponges in early metazoan evolution are highlighted. In ad-dition,the present state of knowledge on silicatein-mediated 'biosilica' formation in marine sponges,including the involvement of other molecules in silica metabolism and their potential application in nanobiotechnology and medicine,is given. | Werner E G MULLER WANG XiaoHong ZENG LingSen Heinz C SCHRODER | 2007 | Chinese Science Bulletin2007，52，22： | 3 |
| 5 | Alkane-assisted adsorption and assembly of phthalocyanines and porphyrins显示文摘 | Qiu X H Wang C Zeng Q D | | 0，，： | 2 |
| 6 | Image-adaptive watermarking using visual models显示文摘 | Podilchuk C I Zeng W | | 0，，： | 2 |
| 7 | Seed coat microsculpturing changes during seed development in diploid and amphidipoid Brassic species显示文摘 | ZENG C L WANG J B LIU A H | 2004 | Annals of Botany2004，93，： | 1 |
| 8 | A proximal method for pseudomonotone type variational-like inequalities显示文摘 | Schaible S Yao J C Zeng L C | 2006 | Taiwanese Journal of Mathematics2006，10，2： | 1 |
| 9 | YAG laser percussion drilling of a functional multi-layer thin plate 显示文摘 | WANG A H WANG W Y BAI Z K XIE C S ZENG D W SONG W L | 2007 | Optics & Laser Technology2007，39，： | 1 |
| 10 | A probabilistic reasoning-based decision support system for selecting remediation technologies for petroleum-contaminated sites 显示文摘 | HE L CHAN C W HUANG G H ZENG G M | 2006 | Expert Systems with Applications2006，30，4： | 1 |
| 11 | Hydrotherrnal synthesis of ZnO nanorods in the diameter regime of 50 nm显示文摘 | ZENG H C | 2003 | J Am Chem Soc2003，125，15： | 1 |
| 12 | In vivoFate ofUnimers and Micelles ofa Poly(ethylene glycol)-block-poly(caprolactone)Copolymer inMice Following IntravenousAdministration显示文摘 | Liu J Zeng F Allen C | 2007 | Eur J Pharm2007，65，3： | 1 |
| 13 | Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration显示文摘 | HUANG ZZ CHEN C ZENG Z | 2001 | FASEB J2001，15，1： | 1 |
| 14 | 显示文摘 | Liu B Zeng H C | 2003 | Am Chem Soc2003，125，15： | 1 |
| 15 | Sewage Sludge Conditioning withCoal Fly Ash by Sulfuric Aicd显示文摘 | CHEN C Y ZHANG P Y ZENG G M | 2010 | Chem Eng J2010，158，： | 1 |
| 16 | Attitudes of Ch-inesemedical students towardthe IIME GlobalMinimum Essential Require-ments显示文摘 | Zhang X Li X Wan X Zeng C Scott CS Schaad DC | 2004 | Teaching and Learning in Medicine2004，16，2： | 1 |
| 17 | Influence of exposure to imidacloprid on survi- vorship, reproduction and vitellin content of the carmine spider mite, Tetranychus cinnabarinus 显示文摘 | Zeng C X Wang J J | 2010 | Journal of Insect Science2010，10，20： | 1 |
| 18 | Disease surveillance based on spatial contact networks: A case study of Beijing 2003 SARS epidemic显示文摘 | Zeng D Chen H C Cao Z D | 2009 | IEEE Intelligent Systems2009，24，6： | 1 |
| 19 | Error bounds for approximation solution to nonlinear equations of strongly accretive operators in uniformly smooth Banach spaces显示文摘 | Zeng L C | 1997 | J Math Anal Appl1997，209，： | 1 |
| 20 | Image-adaptive watermarking using visual models显示文摘 | Podilchuk C J Zeng W J | 1998 | Selected Areas Communications1998，16，4： | 1 |
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