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| 1 | Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame显示文摘导致的 pluripotent 的产生从体的细胞的茎(iPS ) 细胞被定义 reprogramming 抄写因素(TF ) 的同时的病毒的 transduction 成功地完成了。然而,这个过程为基因交货要求多重病毒的向量。作为结果,产生了 iPS 房间港口在他们的染色体的众多的病毒的集成地点。这能增加基因 mutagenesis 和 genomic 不稳定性的概率,并且介绍重要障碍给研究和 iPS 房间的临床的申请研究。在这篇论文,我们在场定义因素是的一个简单 lentivirus reprogramming 在系统经由自我劈开的 2A 序列熔化了在里面框架进一个单个开的读物框架(ORF ) 。一个 GFP 标记下游地被放 transgene 启用 transgene 表示追踪。我们证明这个 polycistronic 表示系统高效地产生 iPS 房间。产生 iPS 房间有正常 karyotypes 并且类似于鼠标在形态学和基因表示的胚胎的干细胞。而且,他们能在 vitro 并且在 vivo 试金在两个区分进三胚胎的细菌层的房间类型。显著地,大多数这些 iPS 房间仅仅怀有病毒的向量的一个单个拷贝。这个系统提供一个珍贵工具因为 iPS 房间的产生,和我们的数据建议在每个房间的 transduced reprogramming TF 的表示的平衡为 reprogramming 进程是必要的。更重要地,当由非集成的基因交货系统交付了时,这重新设计的单个 ORF 将没有基因修正便于人的 iPS 房间的有效产生。 | Lijian Shao Wei Feng Yan Sun Hao Bai Jun Liu Caroline Currie Jaejung Kim Rafael Gama Zack Wang Zhijian Qian Lucy Liaw Wen-Shu Wu | 2009 | Cell Research2009，19，3： | 12 |
| 2 | Dendritic Cells as a Pharmacological Target of Traditional Chinese Medicine显示文摘Dendritic cells (DCs) represent a heterogeneous population of professional antigen-presenting cells (APCs) that play a central role in the initiation and regulation of immune responses. There is considerable evidence that DCs can be used as therapeutic targets for pharmacological modulation of immune responses. Traditional Chinese medicine (TCM) has a long-standing history of using herbal medicine in the treatment of variety of human diseases. Many of the clinical effects of TCM have reportedly been attributed to the up- or down-regulation of immune responses. Accumulating evidence indicates that TCM and its components can interfere with immune responses at the earliest stage by targeting key functions of DCs. Here, we review those published studies of TCM with respect to their effects on immunobiological functions of DCs. Investigations based on both chemical entities derived from TCM as well as TCM herbal mixtures are presented. These studies suggest that various TCM herbal medicines have the capacity to inhibit or promote major functions of DCs, such as differentiation, maturation, cytokine production, survival, antigen uptake and presentation as well as trafficking. These studies have revealed novel biological effects of TCM and document the utility of this approach to discover novel biological modifier of DCfunctions derived from natural | Xin Chen Lu Yang O. M. Zack Howard Joost J. Oppenheim | 2006 | Cellular & Molecular Immunology2006，3，6： | 9 |
| 3 | Impact of Hepatopulmonary Syndrome on Quality of Life and Survival in Liver Transplant Candidates显示文摘 | Michael B. Fallon Michael J. Krowka Robert S. Brown James F. Trotter Steven Zacks Kari E. Roberts Vijay H. Shah Neil Kaplowitz Lisa Forman Keith Wille Steven M. Kawut | 2008 | Gastroenterology2008，，4： | 4 |
| 4 | TUNEL-positive gangline cells in human primary open-angle glaucoma 显示文摘 | Kerrigan LA Zack DJ Quigley HA | 1997 | Arch Ophthalmol1997，115，： | 2 |
| 5 | 危险性评估——气雾剂的安全性显示文摘2007年4月3日下午,欧莱雅公司安全、卫生、环保部经理Zack Mansdorf在巴黎气雾剂论坛上作了“危险性评估——气雾剂的安全性”的报告。现将报告择要刊登于下。 | Zack Mansdorf | 2007 | 气雾剂通讯2007，，3： | 2 |
| 6 | The SCL-90 factor structure in comorbid substance abusers显示文摘 | Zack M Toneatto T Streiner DL | 1998 | J Subst Abuse1998，10，1： | 1 |
| 7 | Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus,A/Vietnam/1203/04 (H5N1)显示文摘 | Yun N E Linde N S Zacks M A | 2008 | Virology2008，374，1： | 1 |
| 8 | An architecture for managing explicated knowledge 显示文摘 | Zack M | 1998 | Sloan Management Review1998，39，5： | 1 |
| 9 | Cough,fever and weight loss in a young male显示文摘 | Summer R Zacks J Ieong M | 2002 | Eur Respir J2002，19，6： | 1 |
| 10 | Applications of catastrophe theory for statistical modeling in the biosciences 显示文摘 | Cobb L Zacks S | 1985 | Journal of American Statistical Association1985，70，： | 1 |
| 11 | Developing a knowledge strategy显示文摘 | ZACK M | 1999 | California Management Review1999，41，3： | 1 |
| 12 | Assessment of the test-retest reliability of laboratory polysomnography显示文摘 | Levendowski D J Zack N Rao S | 2009 | Sleep Breath2009，13，20： | 1 |
| 13 | Evolution of a tourmaline-bearing lawsonite eclogite from the Elekda? area (Central Pontides, N Turkey): evidence for infiltration of slab-derived B-rich fluids during exhumation显示文摘 | Rainer Altherr Gültekin Topuz Horst Marschall Thomas Zack Thomas Ludwig | | 0，，： | 1 |
| 14 | Social stigmatization and hepatitis C virus infection显示文摘 | Zacks S Beavers K Theodore D | 2006 | Journal of Clinical Gastroenterology2006，40，3： | 1 |
| 15 | Studies of direct- ed forgetting in older adults 显示文摘 | Zacks RT1 Radvansky G Hasher L | 1996 | J Exp Psychol Learn Mere Cogn1996，22，1： | 1 |
| 16 | Retinal gan- glion cell morphology after optic nerve crush and experi- mental glaucoma显示文摘 | Kalesnykas G Oglesby EN Zack DJ | 2012 | Invest Ophthalmol Vis Sci2012，53，7： | 1 |
| 17 | Electroretinograms as an indicator of disease activity in birdshot retinochoroidopathy显示文摘 | Zacks D N Samson C M Loewenstein J | 2002 | Graefes Arch Clin Exp Ophthalmol2002，240，8： | 1 |
| 18 | Temporal Changes as Event Boundaries: Processing and Memory Consequences of Narrative Time Shifts 显示文摘 | Speer N K Zacks J M | 2005 | Journal of Memory and Language2005，53，1： | 1 |
| 19 | Developing a knowledge strategy 显示文摘 | ZACK M | 1999 | California Management Review1999，41，3： | 1 |
| 20 | Increased risk of large-bowel cancer in Crohn's disease with colonic involvement显示文摘 | Ekbom A Helmick C Zack M | 1990 | Lancet1990，336，8711： | 1 |
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