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| 1 | Molecular analysis of germline t( 3 ;6) and t( 3 ; 12) associated with convention- al renal cell carcinomas indicates their rate - limiting role and supports the three - hit model of carcinogenesis 显示文摘 | Yusenko M V Nagy A Kovacs G | 2010 | Cancer genetics and cytogenetics2010，201，1： | 1 |
| 2 | Analysis of differentially ex-pressed mitochondrial proteins in ehromophobe renal cell carcinoma~ and renal oncocytomas by 2-D gel electrophoresis 显示文摘 | Yusenko MV Ruppert T Kovacs G | 2010 | Int J Biol Sci2010，6，3： | 1 |
| 3 | Molecular pathology of renal oncocyto-ma: a review显示文摘 | Yusenko M V | 2010 | Int J Urol2010，17，7： | 1 |
| 4 | Molecular pathology of renal oncocytoma:A review显示文摘 | Yusenko MV | 2010 | Int J Urol2010，17，60： | 1 |
| 5 | Molecular pathology of chromophobe renal cell carcinoma: a review 显示文摘 | Yusenko MV | 2010 | Int J Urol2010，17，7： | 1 |
| 6 | Metals@MOFs-loading MOFs with metal nanoparticles for hybrid functions显示文摘 | Meilikhov M Yusenko K Esken D Turner S Tendeloo G V Fischer R A | 2010 | European Journal of Inorganic Chemistry2010，2010，24： | 1 |
| 7 | Molecular pathology of renal oncocytoma:a review显示文摘 | Yusenko M V | 2010 | Int J Urol2010，17，7： | 1 |
| 8 | The Adsorbate Structure of Ferrocene Inside (X) ( MIL - 53 ) : A Powder X-Ray Diffraction Study 显示文摘 | Meilikhov M Yusenko K Fischer R A | 2009 | Dalton Transactions2009，，： | 1 |
| 9 | High resolution array CGH of metanephric adenomas: lack of DNA copy number changes显示文摘 | Szponar A Yusenko MV Kovacs G | 2010 | Histopathology2010，56，2： | 1 |
| 10 | Metals@ MOFs, loading MOFs with metal nanoparticles for hybrid functions 显示文摘 | MEILIKHOV M YUSENKO K ESKEN D | 2010 | European journal of inorganic chemistry2010，，24： | 1 |
| 11 | High-resolution array CGH of metanephric adenomas:lack of DNA copy number changes显示文摘 | Szponar A Yusenko MV Kovacs G | 2010 | Histo-pathology2010，56，2： | 1 |
| 12 | High-resolution array CGH of metanephric adenomas:lack of DNA copy number changes显示文摘 | Szponar A Yusenko MV Kovacs G | | 0，，02： | 1 |
| 13 | Molecular pathology of renal oncocytoma: a review显示文摘 | Yusenko M V | 2010 | Int J Urol2010，17，7： | 1 |
| 14 | Metals @ MOFs-loading MOFs with metal nanoparticles for hybrid functions显示文摘 | Meilikhov M Yusenko K Esken D | 2010 | European Journal of Inorganic Chemistry2010，44，： | 1 |
| 15 | Molecular pathology of renal oncocytoma:A review显示文摘 | Yusenko M V | | 0，，： | 1 |
| 16 | Unitarizable representations of quiv- ers显示文摘 | Weist T Yusenko K | 2013 | Algebras and Representation Theory2013，16，5： | 1 |
| 17 | MetalsoMOFs-Loading MOFs with metal nanoparticles for hybrid functions显示文摘 | Meilikhov M Yusenko K Esken D | | 0，，24： | 1 |
| 18 | Genomic profiling of papil- lary renal cell tumours identifies small regions of DNA alterations: a possible role of HNFIB in tumour development显示文摘 | Szponar A Yusenko MV Kuiper R | 2011 | Histopathology2011，58，： | 1 |
| 19 | Identifying CD82 (KAI1) as a marker for human ehromophobe renal cell carcinoma 显示文摘 | YUSENKO MV KOVACS G | 2009 | Histopathology2009，55，6： | 1 |
| 20 | Multimodal 4-arylchromene derivatives with microtubule-destabilizing,anti-angiogenic,and MYB-inhibitory activities显示文摘Aim:Efficient and readily available anticancer drugs are sought as treatment options.For this reason,chromene derivatives were prepared using the one-pot reaction and tested for their anticancer and anti-angiogenic properties.Methods:2-Amino-3-cyano-4-(aryl)-7-methoxy-4H-chromene compounds(2A-R)were repurposed or newly synthesized via a three-component reaction of 3-methoxyphenol,various aryl aldehydes,and malononitrile.We performed assays to study the inhibition of tumor cell growth[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromid(MTT)assay],effects on microtubules(immunofluorescence),cell cycle(flow-activated cell sorting analysis),angiogenesis(zebrafish model),and MYB activity(luciferase reporter assay).Fluorescence microscopy was applied for localization studies via copper-catalyzed azide-alkyne click reaction of an alkyne-tagged drug derivative.Results:Compounds 2A-C and 2F exhibited robust antiproliferative activities against several human cancer cell lines(50%inhibitory concentrations in the low nanomolar range)and showed potent MYB inhibition.The alkyne derivative 3 was localized in the cytoplasm after only 10 min of incubation.Substantial microtubule disruption and G2/M cell-cycle arrest were observed,where compound 2F stood out as a promising microtubule-disrupting agent.The study of anti-angiogenic properties showed that 2A was the only candidate with a high potential to inhibit blood vessel formation in vivo.Conclusion:The close interplay of various mechanisms,including cell-cycle arrest,MYB inhibition,and anti-angiogenic activity,led to identifying promising multimodal anticancer drug candidates. | Leonhard H.F.Kohler Sebastian Reich Maria Yusenko Karl-Heinz Klempnauer Gerrit Begemann Rainer Schobert Bernhard Biersack | 2023 | Cancer Drug Resistance2023，6，1： | 0 |
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