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| 1 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 2 | Cyclophosphamide augments inflammation by reducing immunosuppression in a mouse model of aller- gic airway disease 显示文摘 | Yung CS Michael SR Margaret A | 2006 | Journal of Allergy and Clinical Immunology2006，117，3： | 1 |
| 3 | Impact of preoperative aortic cusp prolapse on long-term outcome after surgical closure of subarterial ventricular septal defect显示文摘 | Cheung YF Chiu CS Yung TC | 2002 | Ann Thorac Surg2002，73，2： | 1 |
| 4 | Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs显示文摘 | Zhou S Yung CS Cher GB | 2005 | Clin Phoarmacokinet2005，44，： | 1 |
| 5 | Mechanism-based inhibition of cytochrome P4503A4 by therapeutic drugs显示文摘 | Zhou S Yung CS Cher GB | 2005 | Clin Pharmacokinet2005，44，3： | 1 |
| 6 | Important role of cardiac spect imaging in patients undergoing percutaneous transluminal coronary angioplasty显示文摘ObjectiveToexaminetheutilizationandcontributionofcardiacperfusionscanstopatientsundergoingpercutaneoustransluminalcoronaryang... | Babington Chun kuen Yung, Wai Kwong Chan, Chiu Sun Yue, Wai Chau Fan, Kwok Fai Leung Amy Siu ling Fung and James Chi sang Chan Department of Radiology and Organ Imaging (Yung CK, Fan WC, Chan CS) & Department of Medicine and Geriatrics ( | 1999 | Chinese Medical Journal1999，，3： | 1 |
| 7 | Cyclophosphamide augments inflammation by reducing immunosuppression in a mouse model of allergic airway disease显示文摘 | Yung CS Michael SR Margaret A | 2006 | Journal of Allergy and Clinical Immunology2006，117，3： | 1 |
| 8 | Prospective randomized study of effect of somatostatin on rebleeding from esophageal vafices after endoscopic ligation 显示文摘 | Sung JY Chung CS Yung MY | 1995 | Lancet1995，346，： | 1 |
| 9 | Striatal information signaling and integration in globus pallidus :timing matters显示文摘 | Chan CS Surmeier DJ Yung WH | 2005 | Neurosignats2005，14，6： | 1 |
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