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| 1 | A Pricing Model for Big Personal Data显示文摘Big Personal Data is growing explosively. Consequently, an increasing number of internet users are drowning in a sea of data. Big Personal Data has enormous commercial value; it is a new kind of data asset. An urgent problem has thus arisen in the data market: How to price Big Personal Data fairly and reasonably. This paper proposes a pricing model for Big Personal Data based on tuple granularity, with the help of comparative analysis of existing data pricing models and strategies. This model is put forward to implement positive rating and reverse pricing for Big Personal Data by investigating data attributes that affect data value, and analyzing how the value of data tuples varies with information entropy, weight value, data reference index, cost, and other factors. The model can be adjusted dynamically according to these parameters. With increases in data scale, reductions in its cost,and improvements in its quality, Big Personal Data users can thereby obtain greater benefits. | Yuncheng Shen Bing Guo Yan Shen Xuliang Duan Xiangqian Dong Hong Zhang | 2016 | Tsinghua Science and Technology2016，21，5： | 19 |
| 2 | The Mechanism of Cortico-Striato-Thalamo-Cortical Neurocircuitry in Response Inhibition and Emotional Responding in Attention Deficit Hyperactivity Disorder with Comorbid Disruptive Behavior Disorder显示文摘The neurocircuitries that constitute the corticostriato-thalamo-cortical(CSTC) circuit provide a framework for bridging gaps between neuroscience and executive function in attention deficit hyperactivity disorder(ADHD), but it has been difficult to identify the mechanisms for regulating emotional problems from the understanding of ADHD comorbidity with disruptive behavior disorders(DBD). Research based on 'cool'' and 'hot''executive functional theory and the dual pathway models,which are thought of as applied response inhibition and delay aversion, respectively, within the neuropsychological view of ADHD, has shed light on emotional responding before and after decontextualized stimuli, while CSTC circuit-related domains have been suggested to explain the different emotional symptoms of ADHD with or without comorbid DBD. This review discusses the role of abnormal connections in each CSTC circuit, especially in the emotion circuit, which may be responsible for targeted executive dysfunction at the neuroscience level. Thus, the two major domains – abstract thinking(cool) and emotional trait(hot) – trigger the mechanism of onset of ADHD. | Yuncheng Zhu Xixi Jiang Weidong Ji | 2018 | Neuroscience Bulletin2018，34，3： | 12 |
| 3 | Oxygen and Hydrogen Isotopes of Waters in the Ordos Basin,China:Implications for Recharge of Groundwater in the North of Cretaceous Groundwater Basin显示文摘从 1988 年 1 月在 Ordos 盆从气象学的车站收集到 2005 年 12 月的几百件降水样品被用来建立一根本地大气的水线并且计算现代降水的加权的平均同位素的作文。氧和氢同位素,与为 δ
18 分别地, O 和 δD 在春天在冬季和富人被弄空,并且逐渐地在夏天和秋天减少,说明季节的效果是可观的。他们也证明南方部分和 Ordos 盆的北方部分之间的同位素的差别不是明显的,并且在中间的部分的同位素通常被弄空。32 件样品的同位素作文从浅地下水收集了(不到 150 m 的深度) 在到有为 δ
18 O 并且从 85 ‰到有为 δD 的 63 ‰的一般水准的 46 ‰。他们中的大多数与现代降水是相同的。22 中间、深的地下水的同位素作文(比 275 m 的深度大) 为 δ
18 O 并且从 89 ‰到有为 δD 的 76 ‰的一般水准的 63 ‰。一般水准珍视,说明是显著地不到那些现代降水中间、深的地下水在比较地更低的空气温度被再装。14 C 证明中间、深的地下水的 recharge 在迟了的更新世开始了。从八个湖收集的 13 件湖水样品的同位素定义一个本地蒸发趋势,与 3.77 的一个相对扁平的斜坡,并且证明湖水被现代降水和浅地下水主要喂。 | YANG Yuncheng SHEN Zhaoli WENG Dongguang HOU Guangcai ZHAO Zhenhong WANG Dong PANG Zhonghe | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 10 |
| 4 | High nitrogen application rate and planting density reduce wheat grain yield by reducing filling rate of inferior grain in middle spikelets显示文摘Excessive use of nitrogen fertilizer and high planting density reduce grain weight in wheat.However,the effects of high nitrogen and planting density on the filling of grain located in different positions of the wheat spikelet are unknown.A two-year field experiment was conducted to investigate this question and the underlying mechanisms with respect to hormone and carbohydrate activity.Both high nitrogen application and planting density significantly increased spike density,while reducing kernel number per spike and 1000-kernel weight.However,the effects of high nitrogen and high plant density on kernel number per spike and 1000-kernel weight were different.The inhibitory effect of high nitrogen application and high planting density on kernel number per spike was achieved mainly by a reduction in kernel number per spikelet in the top and bottom spikelets.However,the decrease in 1000-kernel weight was contributed mainly by the reduced weight of grain in the middle spikelets.The grain-filling rate of inferior grain in the middle spikelets was significantly decreased under high nitrogen input and high planting density conditions,particularly during the early and middle grain-filling periods,leading to the suppression of grain filling and consequent decrease in grain weight.This effect resulted mainly from inhibited sucrose transport to and starch accumulation in inferior grain in the middle spikelets via reduction of the abscisic acid/ethylene ratio.This mechanism may explain how high nitrogen application and high planting density inhibit the grain filling of inferior wheat grain. | Yang Liu Yuncheng Liao Wenzhao Liu | 2021 | The Crop Journal2021，9，2： | 9 |
| 5 | Adaptive Control Based on Neural Networks for an Uncertain 2-DOF Helicopter System With Input Deadzone and Output Constraints显示文摘In this paper, a study of control for an uncertain2-degree of freedom(DOF) helicopter system is given. The2-DOF helicopter is subject to input deadzone and output constraints. In order to cope with system uncertainties and input deadzone, the neural network technique is introduced because of its capability in approximation. In order to update the weights of the neural network, an adaptive control method is utilized to improve the system adaptability. Furthermore, the integral barrier Lyapunov function(IBLF) is adopt in control design to guarantee the condition of output constraints and boundedness of the corresponding tracking errors. The Lyapunov direct method is applied in the control design to analyze system stability and convergence. Finally, numerical simulations are conducted to prove the feasibility and effectiveness of the proposed control based on the model of Quanser's 2-DOF helicopter. | Yuncheng Ouyang Lu Dong Lei Xue Changyin Sun | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，3： | 9 |
| 6 | Population Genomic Analysis and De Novo Assembly Reveal the Origin of Weedy Rice as an Evolutionary Game显示文摘Crop weediness,especially that of weedy rice(Oryza sativa f.spontanea),remains mysterious.Weedy rice possesses robust ecological adaptability;however,how this strain originated and gradually formed proprietary genetic features remains unclear?Here,we demonstrate that weedy rice at Asian high latitudes(WRAH)is phylogenetically well defined and possesses unselected genomic characteristics in many divergence regions between weedy and cultivated rice.We also identified novel quantitative trait loci underlying weedy-specific traits,and revealed that a genome block on the end of chromosome 1 is associated with rice weediness.To identify the genomic modifications underlying weedy rice evolution,we generated the first de novo assembly of a high-quality weedy rice genome(WR04-6),and conducted a comparative genomics study between WR04-6 with other rice reference genomes.Multiple lines of evidence,including the results of demographic scenario comparisons,suggest that differentiation between weedy rice and cultivated rice was initiated by genetic improvement of cultivated rice and that the essence of weediness arose through semi-domestication.A plant height model further implied that the origin of WRAH can be modeled as an evolutionary game and indicated that strategy-based selection driven by fitness shaped its genomic diversity. | Jian Sun Dianrong Ma Liang Tang Minghui Zhao Guangchen Zhangh Wenjia Wang Jiayu Song Xiang Li Zimeng Liu Wenxing Zhang Quan Xu Yuncheng Zhou Jianzhong Wu Toshio Yamamoto Fei Dai Yan Lei Song Li Gang Zhou Hongkun Zheng Zhengjin Xu Wenfu Chen | 2019 | Molecular Plant2019，12，5： | 9 |
| 7 | The Relationship Between Neuroimmunity and Bipolar Disorder:Mechanism and Translational Application显示文摘Neuroimmune system may be involved in the pathological process of bipolar disorder(BD),but the essential association is not fully understood.Accumulating evidence has shown that BD involves the activation of immune cells and the release of inflammatory substances in the central nerve system(CNS).Meanwhile,neuroimmune responses also interact with other hypothesis of the etiology of BD that are widely recognized,such as neurotransmitter systems,neuroendocrine systems,neurotrophic factors,and oxidative stress.Simultaneously,related genes and immune changes in peripheral blood vary with it.Overall,neuroimmunity may play an important role in the pathogenesis of BD,and the inflammatory cytokines,especially interleukin-6 and tumor necrosis factor-alpha,have potential value for the clinical diagnosis and prognosis of BD,as well as predicting the therapeutic effects of drugs.Large-scale studies are needed to extend the evidence on neuroimmunity in BD,and to examine its clinical value for applications such as early prediction and treatment. | Zhiang Niu Lu Yang Xiaohui Wu Yuncheng Zhu Jun Chen Yiru Fang | 2019 | Neuroscience Bulletin2019，35，4： | 8 |
| 8 | The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals显示文摘Dear Editor,Since the middle of December 2019,human-to-human transmission of novel coronavirus pneumonia(NCP,also called COVID-19)has occurred among close contacts[1].After the outbreak on January 21,2020,it was swiftly included among the Class B infectious diseases stipulated in the Law of the People’s Republic of China on the Prevention and Control of Infectious Diseases,and measures for prevention and control of Class A infectious diseases were adopted.At 21:27 on February 12,2020,the China News Network updated information to include epidemic data from the National Health Commission and official channels in Hong Kong,Macao,and Taiwan regions:the highest death rate was in Wuhan City(Table 1).Overload of inpatients at hospitals may play a negative role in the overall therapeutic effect and contribute to the death rate. | Yuncheng Zhu Liangliang Chen Haifeng Ji Maomao Xi Yiru Fang Yi Li | 2020 | Neuroscience Bulletin2020，36，3： | 6 |
| 9 | Groundwater Systems and Resources in the Ordos Basin,China显示文摘Ordos 盆是在西北的中国的大规模沉积的盆。到顶的从底部的 hydrostratigraphic 单位是 pre 寒武纪的变形岩石,更低的古生代的碳酸盐岩石,上面对中生代碎屑状的岩石和新生代存款古生代。全部的厚度直到 6000 m。三个地下水系统在 Ordos 盆是在场的,基于地质的设置,即石灰岩地区常见的地形地下水系统,白垩纪碎屑状的地下水系统和第四级的地下水系统。这份报纸系统地描述每个系统的地下水流动模式和对地下水资源的全面评价。 | HOU Guangcai LIANG Yongping SU Xiaosi ZHAO Zhenghong TAO Zhengping YIN Lihe YANG Yuncheng WANG Xiaoyong | 2008 | Acta Geologica Sinica(English Edition)2008，82，5： | 5 |
| 10 | MULTIPLICITY OF POSITIVE SOLUTIONS TO MULTIPOINT BOUNDARY VALUE PROBLEM WITH ONE-DIMENSIONAL p-LAPLACIAN显示文摘In this paper, we consider a multipoint boundary value problem for one-dimensional p-Laplacian. Using a fixed point theorem due to Bai and Ge, we study the existence of at least three positive solutions to the boundary value problem. In this problem, the nonlinear term explicitly involves a first-order derivative, which is different from some previous ones. | Zhiyu Zhang (Dept. of Math., Taiyuan Institute of Technology, Taiyuan 030008) Youfeng Zhang (Yuncheng Middle School, Yuncheng 044000, Shanxi) Fengqin Zhang (Dept. of Math., Yuncheng University, Yuncheng 044000, Shanxi) | 2010 | Annals of Differential Equations2010，26，4： | 4 |
| 11 | Sortilin promotes macrophage cholesterol accumulation and aortic atherosclerosis through lysosomal degradation of ATP-binding cassette transporter A1 protein显示文摘Sortilin is closely associated with hyperlipidemia and the risk of atherosclerosis(AS).The role of sortilin and the underlying mechanism in peripheral macrophage are not fully understood.In this study,we investigated the effect of macrophage sortilin on ATP-binding cassette transporter A1(ABCA1)expression,ABCA1-mediated cholesterol efflux,and aortic AS.Macrophage sortilin expression was upregulated by oxidized low-density lipoproteins(ox-LDLs)in both concentration-and time-dependent manners.Its expression reached the peak level when cells were incubated with 50μg/ml ox-LDL for 24 h.Overexpression of sortilin in macrophage reduced cholesterol efflux,leading to an increase in intracellular total cholesterol,free cholesterol,and cholesterol ester.Sortilin was found to bind with ABCA1 protein and suppress macrophage ABCA1 expression,resulting in a decrease in cholesterol efflux from macrophages.The inhibitory effect of sortilin in cholesterol efflux was partially reversed by treatment with chloroquine,a lysosomal inhibitor.On the contrary,the ABCA1 protein level and ABCA1-mediated cholesterol efflux is increased by sortilin short hairpin RNA transfection.The fecal and biliary cholesterol 3H-sterol from cholesterol-laden mouse peritoneal macrophage was reduced by sortilin overexpression through lentivirus vector(LV)-sortilin in low-density lipoprotein receptor knockout mice,which was prevented by co-treatment with chloroquine.Treatment with LV-sortilin reduced plasma high-density lipoprotein and increased plasma ox-LDL levels.Accordingly,aortic lipid deposition and plaque area were exacerbated,and ABCA1 expression was reduced in mice in response to infection with LV-sortilin alone.These effects of LV-sortilin were partially reversed by chloroquine.Sortilin enhances lysosomal degradation of ABCA1 protein and suppresses ABCA1-mediated cholesterol efflux from macrophages,leading to foam cell formation and AS development. | Yuncheng Lv Jing Yang Anbo Gao Sha Sun Xilong Zheng Xi Chen Wei Wan Chaoke Tang Wei Xie Suyun Li Dongming Guo Tianhong Peng Guojun Zhao Liyuan Zhong | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 4 |
| 12 | A survey on vision-based UAV navigation显示文摘Research on unmanned aerial vehicles(UAV)has been increasingly popular in the past decades,and UAVs have been widely used in industrial inspection,remote sensing for mapping&surveying,rescuing,and so on.Nevertheless,the limited autonomous navigation capability severely hampers the application of UAVs in complex environments,such as GPS-denied areas.Previously,researchers mainly focused on the use of laser or radar sensors for UAV navigation.With the rapid development of computer vision,vision-based methods,which utilize cheaper and more flexible visual sensors,have shown great advantages in the field of UAV navigation.The purpose of this article is to present a comprehensive literature review of the vision-based methods for UAV navigation.Specifically on visual localization and mapping,obstacle avoidance and path planning,which compose the essential parts of visual navigation.Furthermore,throughout this article,we will have an insight into the prospect of the UAV navigation and the challenges to be faced. | Yuncheng Lu Zhucun Xue Gui-Song Xia Liangpei Zhang | 2018 | Geo-Spatial Information Science2018，21，1： | 4 |
| 13 | High-entropy ferroelastic(10RE_(0.1))TaO_(4) ceramics with oxygen vacancies and improved thermophysical properties显示文摘The primary purpose of this work is to optimize the thermophysical properties of rare-earth tan-talate ceramics using the high-entropy effect.Here,the high-entropy rare-earth tantalate ceramic(Y_(0.1)Nd_(0.1)Sm_(0.1)Gd_(0.1)Dy_(0.1)Ho_(0.1)Er_(0.1)Tm_(0.1)Yb_(0.1)Lu_(0.1))TaO_(4)((10RE_(0.1))TaO_(4))is synthesized successfully.The lat-tice distortion and oxygen vacancy concentration are characterized firstly in the rare-earth tantalates.Notably,compared with single rare-earth tantalates,the thermal conductivity of(10RE_(0.1))TaO_(4) is reduced by 16%-45%at 100℃ and 22%-45%at 800℃,and it also presents lower phonon thermal conductivity in the entire temperature range from 100 to 1200℃.The phonon thermal conductivity(1.0-2.2 W m^(-1) K^(-1),100-1200℃)of(10RE_(0.1))TaO_(4) is lower than that of the currently reported high-entropy four-,five-and six-component rare-earth tantalates.This is the result of scattering by the ferroelastic domain,lattice distortion associated with size and mass disorder,and point defects,which target low-,mid-and high-frequency phonons.Furthermore,(10RE_(0.1))TaO_(4),as an improved candidate for thermal barrier coatings materials(TBCs),has a higher thermal expansion coefficient(10.5×10^(-6)K^(-1) at 1400℃),lower Young’s modulus(123 GPa)and better high-temperature phase stability than that of single rare-earth tantalates. | Jun Wang Xiaoyu Chong Liang Lv Yuncheng Wang Xiaolan Ji Haitao Yun Jing Feng | 2023 | Journal of Materials Science & Technology2023，，26： | 4 |
| 14 | Influence of water flow on gas hydrate accumulation at cold vents显示文摘感冒发泄是充满甲烷的液体渗出物发生的一个区域。这渗出物可以改变煤气的水合物的本地温度,咸度,和随后的累积。用一个运动煤气的水合物形成模型并且在在水合物理兹的南部的顶点的温度,咸度和液体流动的 situ 测量,我们在三个不同液体地点模仿煤气的水合物累积:蚌,细菌的地席,和气体解除地点。在蚌地点(毛孔水流动 < 20 kg m2 yr1 ) ,毛孔水移流几乎没在温度和咸度上有小影响。然而,咸度和温度被增加(山峰咸度 > 0.8 摩尔 kg1 ) 由引起水合物稳定性地区的底在 seafloor (mbsf ) 下面从 115 ~ 70 米逐渐地移动的煤气的水合物的形成。在蚌地点的煤气的水合物浸透相对高。在细菌的地席地点的水流动从 100 ~ 2500 kg m2 yr1 。水流动在咸度比海水的导致咸度结束到或稍微高压制增加(< 0.65 摩尔 kg1 ) 。热移流走水路,流动显著地增加温度,转移水合物稳定性地区的底到上面 50 或甚至 3 mbsf。煤气的水合物浸透在细菌的地席地点是相对低的。在煤气的分泌物地点,毛孔水流动能到达 1010 kg m2 yr1,并且温度能在 9 min 到达来源区域的。在煤气的分泌物地点没有煤气的水合物形成。我们的模拟分析因此表明更低的毛孔水流动将导致更低的咸度,更高的温度,和水合物稳定性地区的一个更浅的底。这接着导致更低的煤气的水合物形成率,更低的水合物浸透,并且最后不太煤气的水合物资源。 | CAO YunCheng SU Zheng CHEN DuoFu | 2013 | Science China Earth Sciences2013，56，4： | 3 |
| 15 | Hypothalamic-Pituitary-End-Organ Axes:Hormone Function in Female Patients with Major Depressive Disorder显示文摘Classic hypothalamic-pituitary-end-organ feedback loops–the hypothalamic-pituitary-adrenal axis(HPAA),hypothalamic-pituitary-thyroidal axis(HPTA),and hypothalamic-pituitary-gonadal axis(HPGA)–are associated with the neuroendocrine and immune systems in major depressive disorder(MDD).Female patients with MDD present with evident neuroendocrine and immunological changes.Glucocorticoid,thyroid hormone,and reproductive steroid levels fluctuate with menstrual cycles,which might lead to glucocorticoid receptor resistance,impairment of triiodothyronine conversion,and sex hormone secretion disorders.In this review,we summarize the independent and interactive functions of these three axes in female MDD patients.The similar molecular structure of steroids implies an interrelationship between the hypothalamic-pituitary-end-organ axes and the competitive inhibitory effects at the receptor level,especially when considering the HPAA and HPGA. | Yuncheng Zhu Xiaohui Wu Rubai Zhou Oliver Sie Zhiang Niu Fang Wang Yiru Fang | 2021 | Neuroscience Bulletin2021，37，8： | 3 |
| 16 | Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects显示文摘Both opioids and nonsteroidal anti-inflammatory drugs(NSAIDS)produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain.Peripheral neuroinflammation(PN)is critical for initiation and development of inflammatory pain.A better understanding of molecular mechanisms underlying PN would facilitate the discovery of new analgesic targets and the development of new therapeutics.Emerging evidence suggests that peripheral sensory neurons are not only responders to painful stimuli,but are also actively engaged in inflammation and immunity,whereas the intrinsic regulatory mechanism is poorly understood.Here we report the expression of proton-selective ion channel Hv1 in peripheral sensory neurons in rodents and humans,which was previously shown as selectively expressed in microglia in mammalian central nervous system.Neuronal Hv1 was up-regulated by PN or depolarizing stimulation,which in turn aggravates inflammation and nociception.Inhibiting neuronal Hv1 genetically or by a newly discovered selective inhibitor YHV98-4 reduced intracellular alkalization and ROS production in inflammatory pain,mitigated the imbalance in downstream SHP-1-pAKT signaling,and also diminished pro-inflammatory chemokine release to alleviate nociception and morphine-induced hyperalgesia and tolerance.Thus,our data reveal neuronal Hv1 as a novel target in analgesia strategy and managing opioids-related side effects. | Qiansen Zhang Yimin Ren Yiqing Mo Peipei Guo Ping Liao Yuncheng Luo Jie Mu Zhuo Chen Yang Zhang Ya Li Linghui Yang Daqing Liao Jie Fu Juwen Shen Wei Huang Xuewen Xu Yanyan Guo Lianghe Mei Yunxia Zuo Jin Liu Huaiyu Yang Ruotian Jiang | 2022 | Cell Research2022，32，5： | 3 |
| 17 | Efficient fixation of CO_(2) into propylene carbonate with [BMIM]Br in a continuous-flow microreaction system显示文摘Utilization of carbon dioxide(CO_(2)) is of great significance in the development of CO_(2) absorption and the solution of greenhouse gas effect.Highly efficient conversion of CO_(2) into cyclic carbonate with green catalysts is essential for the more sustainable expansion of CO_(2) fixation.Traditional batch reactor is limited by low efficiency, high cost and low security. Meanwhile, continuous flow system showcased a myriad of virtues, including shortening the residence time from hours to seconds, and decreasing reaction temperature, and possessing the nature of easy industrial scale-up. In this paper, a continuous-flow microreaction system was developed to synthesis propylene carbonate(PC) from propylene oxide(PO) and CO_(2) using 1-butyl-3-methylimidazolium bromide([BMIM]Br) as catalyst. By observing the flow patterns inside microreaction system, the effects of reaction temperature, molar fraction of catalyst, operating pressure, residence time, molar ratio of CO_(2)/PO as well as recycling performance of catalyst on the overall performances were comprehensively evaluated into details. Under different reaction conditions,the flow patterns were set to vary between slug flow and annular flow. The results showed that the yield of propylene carbonate(PC) can reach99.7% at 140℃ and 3.0 MPa with the residence time of 166 s, while the recycling performance of the designed system greatly conforms the future trend of green chemistry. | Yuxin Wu Yuncheng Ding Jianhong Xu Yundong Wang Kathryn Mumford Geoffrey WStevens Weiyang Fei | 2021 | Green Energy & Environment2021，6，2： | 3 |
| 18 | Satisfiability and reasoning mechanism of terminological cycles in description logic vL显示文摘The current research works and the existing problems of terminological cycles in description logics are analyzed in this paper. Referring to the works of Baader F and Nebel B,we aim in a new direction. Firstly,description logic νL is defined,and the description graphs GT and GJ are redefined. A syntax condition for the satisfiability of membership relation is given. By using this syntax condition,we prove the following:The subsumption reasoning in νL with respect to gfp-model,lfp-model and descriptive model is polynomial. | WANG Ju JIANG YunCheng SHEN YuMing | 2008 | Science in China(Series F)2008，51，9： | 3 |
| 19 | Distribution of δ^(34)S and δ^(18)O in SO_4^(2-) in Groundwater from the Ordos Cretaceous Groundwater Basin and Geological Implications显示文摘The Ordos Cretaceous Groundwater Basin,located in an arid-semiarid area in northwestern China,is a large-style groundwater basin.SO_4^(2-) is one of the major harmful components in groundwater.Dissolved SO_4^(2-) concentrations,andδ^(34)S-SO_4^(2-) andδ^(18)O-SO_4^(2-) in groundwater from 14 boreholes and in gypsum from aquifer were analyzed.Results show that SO_4^(2-) in shallow groundwaters originates from precipitation,sulfide oxidation,and dissolution of stratum sulphate,with a big range ofδ^(34)S values,from-10.7‰to 9.2‰,and addition of SO_4^(2-) in deep groundwater results from dissolution of stratum sulphate,with biggerδ^(34)S values,from 7.8‰to 18.5‰,compared with those in shallow groundwater.This research also indicates that three types of sulphate are present in the strata,and characterized by highδ^(34)S values and highδ^(18)O values-style,highδ^(34)S values and middleδ^(18)O valuesstyle, middleδ^(34)S values and lowδ^(18)O values-style,respectively.Theδ^(34)S-SO_4^(2-) andδ^(18)O-SO_4^(2-) in groundwater have a good perspective for application in distinguishing different groundwater systems and determining groundwater circulation and evolution in this area. | YANG Yuncheng SHEN Zhaoli WEN Dongguang HOU Guangcai SHE Hongquan ZHAO Zhenhong WANG Dong LI Jingwen | 2010 | Acta Geologica Sinica(English Edition)2010，84，2： | 3 |
| 20 | Transcriptional control by HNF-1:Emerging evidence showing its role in lipid metabolism and lipid metabolism disorders显示文摘The present review focuses on the roles and underlying mechanisms of action of hepatic nuclear factor-1(HNF-1)in lipid metabolism and the development of lipid metabolism disorders.HNF-1 is a transcriptional regulator that can form homodimers,and the HNF-1αand HNF-1βisomers can form heterodimers.Both homo-and heterodimers recognize and bind to specific cis-acting elements in gene promoters to transactivate transcription and to coordinate the expression of target lipid-related genes,thereby influencing the homeostasis of lipid metabolism.HNF-1 was shown to restrain lipid anabolism,including synthesis,absorption,and storage,by inhibiting the expression of lipogenesis-related genes,such as peroxisome proliferator-activated receptorγ(PPARγ)and sterol regulatory element-binding protein-1/2(SREBP-1/2).Moreover,HNF-1 enhances the expression of various genes,such as proprotein convertase subtilisin/kexin type 9(PCSK9),glutathione peroxidase 1(GPx1),and suppressor of cytokine signaling-3(SOCS-3)and negatively regulates signal transducer and activator of transcription(STAT)to facilitate lipid catabolism in hepatocytes.HNF-1 reduces hepatocellular lipid decomposition,which alleviates the progression of nonalcoholic fatty liver disease(NAFLD).HNF-1 impairs preadipocyte differentiation to reduce the number of adipocytes,stunting the development of obesity.Furthermore,HNF-1 reduces free cholesterol levels in the plasma to inhibit aortic lipid deposition and lipid plaque formation,relieving dyslipidemia and preventing the development of atherosclerotic cardiovascular disease(ASCVD).In summary,HNF-1 transcriptionally regulates lipid-related genes to manipulate intracorporeal balance of lipid metabolism and to suppress the development of lipid metabolism disorders. | Fang Liu Xiao Zhu Xiaping Jiang Shan Li Yuncheng Lv | 2022 | Genes & Diseases2022，9，5： | 3 |
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