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| 1 | Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-KB signaling pathway and activating the PI3K/Akt/Nrf2 pathway显示文摘 | Si-tong LI Qi DAI Shu-xian ZHANG Ya-jun LIU Qiu-qiong YU Fei TAN Shu-hong LU Quan WANG Jian-wen CHEN He-qing HUANG Pei-qing LIU Min LI | 2018 | Acta Pharmacologica Sinica2018，39，8： | 43 |
| 2 | Assessment of duodenogastric reflux by combined continuous intragastric pH and bilirubin monitoring显示文摘AIM: To assess the diagnostic value of a combination of continuous intragastric pH and bilirubin monitoring in the detection of duodenogastric reflux (DGR), and the effects of diet on the bilirubin absorbance.METHODS: 30 healthy volunteers were divided into twogroups: standard diet group (Group 1) 18 cases, free diet group (Group 2) 12 cases. Each subjects were subjected to simultaneous 24 hour intragastric pH and spectrophotometric bilirubin concentration monitoring (Bilitec 2000).RESULTS: There was no difference of preprandial phasebilirubin absorbance between two groups. The absorbanceof postprandial phase was significantly increased in group 2than group 1. There was no difference between preprandialphase and postprandial phase absorbance in group 1.Postprandial phase absorbance was significantly higher ingroup 2. In a comparison of bile reflux with intragastric pHduring night time, there were 4 types of reflux:Simultaneous increase in absorbance and pH in only 19.6%, increase in bilirubin with unchanged pH 33. 3 %, pHincrease with unchanged absorbance 36. 3 %, and bothunchanged in 10. 8 %. Linear regression analysis showed nocorrelation between percertage total time of pH < 4 aridpercentage total time of absortance > 0. 14, r=0.068, P<0.05.CONCLUSION: Because of the dietary effect, highabsorbance fluids or foods should be avoided in detection.Intrsgastric pH and bilirubin monitoring separately predictthe presence of duodenal (and/or pancreatic) reflux and bilereflux. They can not substitute for each other. The detectionof DGR is improved if the two parameters are combinedsimultanoously. | Fei Dai Jun Gong Ru Zhang Jin-Yan Luo You-Ling Zhu Xue-Qin Wang,Department of Gastroenterology,Second Hospital of Xi’ an Jiaotong University,Xi’an 710004,Shaanxi Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 30 |
| 3 | Incubation and application of transgenic green fluorescent nude mice in visualization studies on glioma tissue remodeling显示文摘 | DONG Jun, DAI Xing-liang LU Zhao-hui FEI Xi-feng CHEN Hua ZHANG Quan-bin ZHAO Yao-dong WANG Zhi-min WANG Ai-dong LAN Qing HUANG Qiang | 2012 | Chinese Medical Journal2012，，24： | 17 |
| 4 | Motion simulation and test on threshed grains in tapered threshing and transmission device for plot wheat breeding based on CFD-DEM显示文摘Mechanization of field experiments is the only way to improve crop breeding and seed propagation effects.In order to further clarify and improve the working performance of tapered threshing device for plot breeding,and reduce the remaining seeds in the device,the numerical simulation was carried out on the motion process of materials in the longitudinal-axial tapered cylinder threshing and transmission device of the plot wheat breeding combine harvester based on CFD-DEM method.Simulation results showed that,threshing and transmission of particles and short stalks at axial direction could be realized under the influence of air flow.Meanwhile,the material transference and distribution rule and stream field distribution rule of air flow in the threshing and transmission device were obtained,the variations of velocity and displacement of particles and short stalks with time were obtained;the motion trajectories and forms of particles in different types of retention were also studied.At rotating speed of 1300-1600 r/min for the tapered threshing cylinder in the verification test,the particle retention rate in the enclosure was 0-0.13%,while in the simulation the particle retention rate in the enclosure was 0-0.11%,only a 0.02%difference between them.The results proved a favorable feasibility to simulate the working performance of the tapered threshing and transmission device for plot breeding through gas-solid coupling method. | Fei Dai Xuefeng Song Wuyun Zhao Zhengsheng Han Fengwei Zhang Shilin Zhang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，1： | 16 |
| 5 | Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality显示文摘Severe fever with thrombocytopenia syndrome (SFTS),an emerging tick-borne infectious disease caused by a novel phlebovirus (SFTS virus, SFTSV), was listed among the top 10 priority infectious diseases by the World Health Organization due to its high fatality of 12%-50% and possibility of pandemic transmission. Currently, effective anti-SFTSV intervention remains unavailable. Here, by screening a library of FDA-approved drugs, we found that benidipine hydrochloride, a calcium channel blocker (CCB), inhibited SFTSV replication in vitro. Benidipine hydrochloride was revealed to inhibit virus infection through impairing virus internalization and genome replication. Further experiments showed that a broad panel of CCBs, including nifedipine, inhibited SFTSV infection. The anti-SFTSV effect of these two CCBs was further an a lyzed in a humanized mouse model in which CCB treatment resulted in reduced viral load and decreased fatality rate. Importantly, by performing a retrospective clinical investigation on a large cohort of 2087 SFTS patients, we revealed that nifedipine administration enhaneed virus clearance, improved clinical recovery, and remarkably reduced the case fatality rate by >5-fold. These findings are highly valuable for developing potential host-oriented therapeutics for SFTS and other lethal acute viral infections known to be inhibited by CCBs in vitro. | Hao Li Lei-Ke Zhang Shu-Fen Li Shao-Fei Zhang Wei-Wei Wan Yu-Lan Zhang Qi-Lin Xin Ke Dai Yuan-Yuan Hu Zhi-Bo Wang Xiang-Tao Zhu Yu-Jie Fang Ning Cui Pan-He Zhang Chun Yuan Qing-Bin Lu Jie-Ying Bai Fei Deng Geng-Fu Xiao Wei Liu Ke Peng | 2019 | Cell Research2019，29，9： | 15 |
| 6 | Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1显示文摘Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive triterpenoid extracted from Tripterygium wilfordii, shows effective anti-fibrotic and anti-inflammatory activities in multiple hepatic diseases. However, the exact molecular mechanisms of action and the direct protein targets of celastrol in the treatment of liver fibrosis remain largely elusive. Here, we discover that celastrol exerts anti-fibrotic effects via promoting the production of reactive oxygen species(ROS) and inducing ferroptosis in activated hepatic stellate cells(HSCs). By using activity-based protein profiling(ABPP) in combination with bio-orthogonal click chemistry reaction and cellular thermal shift assay(CETSA), we show that celastrol directly binds to peroxiredoxins(PRDXs), including PRDX1, PRDX2, PRDX4 and PRDX6,through the active cysteine sites, and inhibits their anti-oxidant activities. Celastrol also targets to heme oxygenase 1(HO-1) and upregulates its expression in activated-HSCs. Knockdown of PRDX1, PRDX2,PRDX4, PRDX6 or HO-1 in HSCs, to varying extent, elevated cellular ROS levels and induced ferroptosis. Taken together, our findings reveal the direct protein targets and molecular mechanisms via which celastrol ameliorates hepatic fibrosis, thus supporting the further development of celastrol as a promising therapeutic agent for liver fibrosis. | Piao Luo Dandan Liu Qian Zhang Fan Yang Yin-Kwan Wong Fei Xia Junzhe Zhang Jiayun Chen Ya Tian Chuanbin Yang Lingyun Dai Han-Ming Shen Jigang Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 14 |
| 7 | Three-dimensional bioprinting collagen/silk fibroin scaffold combined with neural stem cells promotes nerve regeneration after spinal cord injury显示文摘Many studies have shown that bio-scaffolds have important value for promoting axonal regeneration of injured spinal cord.Indeed,cell transplantation and bio-scaffold implantation are considered to be effective methods for neural regeneration.This study was designed to fabricate a type of three-dimensional collagen/silk fibroin scaffold (3D-CF) with cavities that simulate the anatomy of normal spinal cord.This scaffold allows cell growth in vitro and in vivo.To observe the effects of combined transplantation of neural stem cells (NSCs) and 3D-CF on the repair of spinal cord injury.Forty Sprague-Dawley rats were divided into four groups: sham (only laminectomy was performed),spinal cord injury (transection injury of T10 spinal cord without any transplantation),3D-CF (3D scaffold was transplanted into the local injured cavity),and 3D-CF + NSCs (3D scaffold co-cultured with NSCs was transplanted into the local injured cavity.Neuroelectrophysiology,imaging,hematoxylin-eosin staining,argentaffin staining,immunofluorescence staining,and western blot assay were performed.Apart from the sham group,neurological scores were significantly higher in the 3D-CF + NSCs group compared with other groups.Moreover,latency of the 3D-CF + NSCs group was significantly reduced,while the amplitude was significantly increased in motor evoked potential tests.The results of magnetic resonance imaging and diffusion tensor imaging showed that both spinal cord continuity and the filling of injury cavity were the best in the 3D-CF + NSCs group.Moreover,regenerative axons were abundant and glial scarring was reduced in the 3D-CF + NSCs group compared with other groups.These results confirm that implantation of 3D-CF combined with NSCs can promote the repair of injured spinal cord.This study was approved by the Institutional Animal Care and Use Committee of People’s Armed Police Force Medical Center in 2017 (approval No.2017-0007.2). | Ji-Peng Jiang Xiao-Yin Liu Fei Zhao Xiang Zhu Xiao-Yin Li Xue-Gang Niu Zi-Tong Yao Chen Dai Hui-You Xu Ke Ma Xu-Yi Chen Sai Zhang | 2020 | Neural Regeneration Research2020，15，5： | 14 |
| 8 | Alcohol consumption and metabolic syndrome among Shanghai adults: A randomized multistage stratified cluster sampling investigation显示文摘AIM: To examine the relations of alcohol consumption to the prevalence of metabolic syndrome in Shanghai adults. METHODS: We performed a cross-sectional analysis of data from the randomized multistage stratified cluster sampling of Shanghai adults, who were evaluated for alcohol consumption and each component of metabolic syndrome, using the adapted U.S. National Cholesterol Education Program criteria. Current alcohol consumption was defined as more than once of alcohol drinking per month. RESULTS: The study population consisted of 3953 participants (1524 men) with a mean age of 54.3 ± 12.1 years. Among them, 448 subjects (11.3%) were current alcohol drinkers, including 405 males and 43 females. After adjustment for age and sex, the prevalence of current alcohol drinking and metabolic syndrome in the general population of Shanghai was 13.0% and 15.3%, respectively. Compared with nondrinkers, the prevalence of hypertriglyceridemia and hypertension was higher while the prevalence of abdominal obesity, low serum high-density-lipoprotein cholesterol (HDL-C) and diabetes mellitus was lower in subjects who consumed alcohol twice or more per month, with a trend toward reducing the prevalence of metabolic syndrome. Among the current alcohol drinkers, systolic blood pressure, HDL-C, fastingplasma glucose, and prevalence of hypertriglyceridemia tended to increase with increased alcohol consumption. However, low-density-lipoprotein cholesterol concentration, prevalence of abdominal obesity, low serum HDL-C and metabolic syndrome showed the tendency to decrease. Moreover, these statistically significant differences were independent of gender and age.CONCLUSION: Current alcohol consumption is associated with a lower prevalence of metabolic syndrome irrespe- ctive of alcohol intake (g/d), and has a favorable influence on HDL-C, waist circumference, and possible diabetes mellitus. However, alcohol intake increases the likelihood of hypertension, hypertriglyceridemia and hyperglycemia. The clinical significance of these findings needs further investigation. | Jian-Gao Fan Xiao-Bu Cai Lui Li Xing-Jian Li Fei Dai Jun Zhu | 2008 | World Journal of Gastroenterology2008，14，15： | 13 |
| 9 | Simulation and test on separating cleaning process of flax threshing material based on gas-solid coupling theory显示文摘In order to further clarify and improve the working performance of separating cleaning device of flax threshing material,and study the motion law and characteristics of components of flax threshing material,in this paper,numerical simulation was carried out on the separating cleaning process of flax threshing material based on CFD-DEM method.Simulation results showed that the components of flax threshing material were separated and cleaned under the influence of airflow field,meanwhile,variation curves of quantity and mean velocity of flax seeds in the separating cleaning system were obtained.By referring to streamline distribution of gas-solid coupling,the quantity variation law of components of flax threshing material with time was explored and their motion curves and variation tendency of average velocity were studied.Verification test results showed that the cleaning rate of separating cleaning device for flax threshing material was 92.66%with 1.58%of total separation loss.Compared with simulation results,the test results were 1.34%and 0.93%lower,showing that it is feasible to apply the gas-solid coupling theory and method to simulate the separating and cleaning operation of flax threshing material. | Fei Dai Xuefeng Song Wenjuan Guo Wuyun Zhao Fengwei Zhang Shilin Zhang | 2020 | International Journal of Agricultural and Biological Engineering2020，13，1： | 13 |
| 10 | Knockdown of ecdysis-triggering hormone gene with a binary UAS/GAL4 RNA interference system leads to lethal ecdysis deficiency in silkworm显示文摘被触发蜕皮的荷尔蒙(ETH ) 是在大多数昆虫的蜕皮过程的一个集成因素,包括 Bombyx 粗腐殖质 i (蚕) 。在蚕理解 ETH 基因的函数,我们开发了一条有效途径到击倒在 vivo 的 ETH 的表达式成功地在另外的昆虫种类基于 RNA 干扰(RNAi ) 和是的一个二进制 UAS/GAL4 表达式系统使用了。二种转基因的蚕与这个方法被建立:有在 UAS 的控制下面的 ETH RNAi 顺序的受动器紧张和有编码的 GAL4 的使活跃之物紧张在 Bombyx 粗腐殖质 i 的控制下面定序细胞质的 actin3。由穿过二紧张,双 positive 转基因的蚕被获得,并且他们的 ETH 表示被发现比每个单身的积极转基因的父母的戏剧性地低。证明致命到双 positive 的严重蜕皮缺乏在 pharate 秒中间形态幼虫的阶段的转基因的蚕,当单个积极的转基因或野类型的蚕有正常蜕皮时。这条 UAS/GAL4 RNAi 途径提供一个方法在不同发展阶段学习内长的蚕基因的功能。 | Hongjiu Dai Li Ma Jue Wang Rongjing Jiang Zhugang Wang Jian Fei | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 12 |
| 11 | Consensus Problem of Heterogeneous Multi-agent Systems with Time Delay under Fixed and Switching Topologies显示文摘Consensus problem is investigated for heterogeneous multi-agent systems composed of first-order agents and second-order agents in this paper. Leader-following consensus protocol is adopted to solve consensus problem of heterogeneous multi-agent systems with time-varying communication and input delays. By constructing Lyapunov-Krasovkii functional, sufficient consensus conditions in linear matrix inequality(LMI) form are obtained for the system under fixed interconnection topology. Moreover, consensus conditions are also obtained for the heterogeneous systems under switching topologies with time delays. Simulation examples are given to illustrate effectiveness of the results. | Ping-Ping Dai Cheng-Lin Liu Fei Liu | 2014 | International Journal of Automation and computing2014，11，3： | 11 |
| 12 | Experimental cancer gene therapy by multiple anti-survivin hammerhead ribozymes显示文摘为癌症改进基因治疗的功效,我们设计了指向 survivin mRNA 的暴露的区域的四撞木鲛 ribozyme 侵入人体气管粘膜的病菌(到 R4 的 R1 ) 。除了在里面 vitro 描述,由教材扩展包括了劈开的顺序特性的一颗决心,为细胞增长并且为的试金在 vivo 肿瘤,生长被用来为 ribozyme 效率得分。survivin 表示的产生抑制经由 caspase-3-dependent 小径导致了有丝分裂的大祸和房间死亡。重要地, ribozyme 侵入人体气管粘膜的病菌的管理在一个 hepato 细胞的癌异种皮移植老鼠模型禁止了肿瘤生长。R1, R3 和 R4 ribozymes 的合作表示 synergistically 压制了 survivin 并且当这联合指向 survivin 抄本的所有主要形式,生产了大多数有势力反癌症效果。带在这份报告描述的多重撞木鲛 ribozymes 的侵入人体气管粘膜的病菌对癌症提供了柔韧的基因治疗策略。 | Qi Fei Hongyu Zhang Lili Fu Xinlan Dai Baomei Gao Min Ni Chao Ge Jinjun Li Xia Ding Yuwen Ke Xuebiao Yao Jingde Zhu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 10 |
| 13 | Association between large artery stenosis,cerebral small vessel disease and risk of ischemic stroke显示文摘We aimed to assess the associations of large artery stenosis(LAS)and cerebral small vessel disease(CSVD)with the risk of ischemic stroke and to investigate their respective and combined contributions.In the prospective population-based Shunyi Study,1,082 stroke-free participants aged 55.9±9.1 years were included.Participants were followed for incident stroke throughout the study period(2013-2019).Total small vessel disease score was used to measure CSVD burden.Cervico-cerebral large artery stenosis was evaluated via brain magnetic resonance angiography and carotid ultrasound.We estimated the risk of ischemic stroke in relation to LAS and CSVD with Cox regression models.During a mean follow-up of 4.2 years,34 participants(3.1%)experienced at least one ischemic stroke.Severe LAS(≥50% stenosis versus no stenosis:HR=3.27(95%CI:1.31-8.18))and high CSVD burden(total small vessel disease score 2-4 versus 0 point:HR=12.73(4.83-33.53))were associated with increased stroke risk independently.In multivariate models,CSVD burden(7.72%)explained a larger portion of the variation in stroke risk than severity of LAS(3.49%).Our findings identified that both LAS and CSVD were associated with future ischemic stroke in asymptomatic subjects,while those with high CSVD burden deserve more attention in primary prevention of stroke. | Fei Han Ding-Ding Zhang Fei-Fei Zhai Jun Xue Jiang-Tao Zhang Shuang Yan Li-Xin Zhou Jun Ni Ming Yao Meng Yang Ming-Li Li Zheng-Yu Jin Qing Dai Shu-Yang Zhang Li-Ying Cui Yi-Cheng Zhu | 2021 | Science China(Life Sciences)2021，64，9： | 9 |
| 14 | Population Genomic Analysis and De Novo Assembly Reveal the Origin of Weedy Rice as an Evolutionary Game显示文摘Crop weediness,especially that of weedy rice(Oryza sativa f.spontanea),remains mysterious.Weedy rice possesses robust ecological adaptability;however,how this strain originated and gradually formed proprietary genetic features remains unclear?Here,we demonstrate that weedy rice at Asian high latitudes(WRAH)is phylogenetically well defined and possesses unselected genomic characteristics in many divergence regions between weedy and cultivated rice.We also identified novel quantitative trait loci underlying weedy-specific traits,and revealed that a genome block on the end of chromosome 1 is associated with rice weediness.To identify the genomic modifications underlying weedy rice evolution,we generated the first de novo assembly of a high-quality weedy rice genome(WR04-6),and conducted a comparative genomics study between WR04-6 with other rice reference genomes.Multiple lines of evidence,including the results of demographic scenario comparisons,suggest that differentiation between weedy rice and cultivated rice was initiated by genetic improvement of cultivated rice and that the essence of weediness arose through semi-domestication.A plant height model further implied that the origin of WRAH can be modeled as an evolutionary game and indicated that strategy-based selection driven by fitness shaped its genomic diversity. | Jian Sun Dianrong Ma Liang Tang Minghui Zhao Guangchen Zhangh Wenjia Wang Jiayu Song Xiang Li Zimeng Liu Wenxing Zhang Quan Xu Yuncheng Zhou Jianzhong Wu Toshio Yamamoto Fei Dai Yan Lei Song Li Gang Zhou Hongkun Zheng Zhengjin Xu Wenfu Chen | 2019 | Molecular Plant2019，12，5： | 9 |
| 15 | Establishment and reliability evaluation of the design space for HPLC analysis of six alkaloids in Coptis chinensis(Huanglian) using Bayesian approach显示文摘Coptis chinensis(Huanglian) is a commonly used traditional Chinese medicine(TCM) herb and alkaloids are the most important chemical constituents in it. In the present study, an isocratic reverse phase high performance liquid chromatography(RP-HPLC) method allowing the separation of six alkaloids in Huanglian was for the first time developed under the quality by design(Qb D) principles. First, five chromatographic parameters were identified to construct a Plackett-Burman experimental design. The critical resolution, analysis time, and peak width were responses modeled by multivariate linear regression. The results showed that the percentage of acetonitrile, concentration of sodium dodecyl sulfate, and concentration of potassium phosphate monobasic were statistically significant parameters(P < 0.05). Then, the Box-Behnken experimental design was applied to further evaluate the interactions between the three parameters on selected responses. Full quadratic models were built and used to establish the analytical design space. Moreover, the reliability of design space was estimated by the Bayesian posterior predictive distribution. The optimal separation was predicted at 40% acetonitrile, 1.7 g·m L-1of sodium dodecyl sulfate and 0.03 mol·m L-1 of potassium phosphate monobasic. Finally, the accuracy profile methodology was used to validate the established HPLC method. The results demonstrated that the Qb D concept could be efficiently used to develop a robust RP-HPLC analytical method for Huanglian. | DAI Sheng-Yun XU Bing ZHANG Yi LI Jian-Yu SUN Fei SHI Xin-Yuan QIAO Yan-Jiang | 2016 | Chinese Journal of Natural Medicines2016，14，9： | 9 |
| 16 | Genome-wide association study dissects the genetic bases of salt tolerance in maize seedlings显示文摘Excess salinity is a natural stress that causes crop yield losses worldwide. The genetic bases of maize salt tolerance remain largely unknown. Here we investigated the survival rates of 445 maize natural accessions after salt treatments. A skewed distribution of the salttolerant phenotypes was observed in this population.Genome-wide association studies(GWAS) revealed 57 loci significantly associated with salt tolerance. Forty-nine candidate genes were detected from these loci. About10% of these genes were co-localized with loci from QTL mapping. Forty four percent of the candidate genes were involved in stress responses, ABA signaling,stomata division, DNA binding/transcription regulation and auxin signaling, suggesting that they are key genetic mechanisms of maize salt tolerance. Transgenic studies showed that two genes, the salt-tolerance-associatedgene 4(SAG4, GRMZM2 G077295) and SAG6(GRMZM2 G106056), which encode a protein transport protein and the double-strand break repair protein MRE11,respectively, had positive roles in plant salt tolerance,and their salt-tolerant haplotypes were revealed. The genes we identified in this study provide a list of candidate targets for further study of maize salt tolerance, and of genetic markers and materials that may be used for breeding salt-tolerance in maize. | Xi Luo Bingcai Wang Shan Gao Fei Zhang William Terzaghi Mingqiu Dai | 2019 | Journal of Integrative Plant Biology2019，61，6： | 8 |
| 17 | System integration of China's first PEMFC locomotive显示文摘In the face of growing environmental pollution,developing a fuel-cell-driven shunting locomotive is a great challenge in China for environmental protection and energy saving,which combines the environmental advantages of an electric locomotive with the lower infrastructure costs of a diesel-electric locomotive.In this paper,the investigation status and the development trend of the fuel-cell-driven shunting locomotive were introduced.Through innovation of the power system using fuel cells,an experiment prototype of a fuel-cell shunting locomotive was developed,which would reduce the effects on the environment of the existing locomotives.This was the first locomotive to use a proton exchange membrane fuel-cell(PEMFC) power plant in China.From October 2012,we started to test the fuel-cell power plant and further test runs on the test rail-line in Chengdu,Sichuan.The achieved encouraging results can provide fundamental data for the modification of the current individual fuel cell locomotives or further development of the fuel-cell hybrid ones in China. | WeiRong Chen Fei Peng Zhixiang Liu Qi Li Chaohua Dai | 2013 | Journal of Modern Transportation2013，21，3： | 7 |
| 18 | Artificial Intelligence for Edge Service Optimization in Internet of Vehicles:A Survey显示文摘The Internet of Vehicles(IoV)plays a crucial role in providing diversified services because of its powerful capability of collecting real-time information.Generally,collected information is transmitted to a centralized resourceintensive cloud platform for service implementation.Edge Computing(EC)that deploys physical resources near road-side units is involved in IoV to support real-time services for vehicular users.Additionally,many measures are adopted to optimize the performance of EC-enabled IoV,but they hardly help make dynamic decisions according to real-time requests.Artificial Intelligence(AI)is capable of enhancing the learning capacity of edge devices and thus assists in allocating resources dynamically.Although extensive research has employed AI to optimize EC performance,summaries with relative concepts or prospects are quite few.To address this gap,we conduct an exhaustive survey about utilizing AI in edge service optimization in IoV.Firstly,we establish the general condition and relative concepts about IoV,EC,and AI.Secondly,we review the edge service frameworks for IoV and explore the use of AI in edge server placement and service offloading.Finally,we discuss a number of open issues in optimizing edge services with AI. | Xiaolong Xu Haoyuan Li Weijie Xu Zhongjian Liu Liang Yao Fei Dai | 2022 | Tsinghua Science and Technology2022，27，2： | 7 |
| 19 | Design and field test of crosswise belt type whole plastic-film ridging-mulching corn seeder on double ridges显示文摘In order to realize seedbed mechanization of whole plastic-film mulching on double ridges and to overcome the difficulty in crosswise belt type soil covering by whole plastic-film,a kind of crosswise belt type whole plastic-film ridging-mulching corn seeder on double ridges was designed in this study.The key components of the sample machine was designed and its working parameters of seedbed soil covering device,crosswise-belt soil covering mechanism and profiling sowing depth adjustment device were determined.After numerical simulation on the film edge and crosswise soil covering by whole plastic-film on double ridges by discrete element method,the velocity and displacement of the oscillating plate,and the variation rule of amount of covered soil with time were explored.Field test results show that,when the advancing velocity of the machine was 0.50 m/s,the qualified rate of soil width covered on film edge of the seedbed reached 96.1%,qualified rate of crosswise soil belt width was 94.5%,qualified rate of soil thickness on seedbed was 95.3%,qualified rate of sowing depth was 89.3%,qualified rate of spacing between crosswise soil belts reached 93.6%,which all met related standards in China and satisfied design requirements,and could realize seedbed mechanization of whole plastic-film mulching on double ridges.Comparison tests on working performances of practical soil covering show a basic consistence with the seedbed soil covering simulation,and verified the effectiveness of the soil covering model built by using discrete element method. | Fei Dai Wenjuan Guo Xuefeng Song Ruijie Shi Wuyun Zhao Fengwei Zhang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，4： | 7 |
| 20 | Mass Spectrometry-based Proteomics in Acute Respiratory Distress Syndrome: A Powerful Modality for Pulmonary Precision Medicine显示文摘 | Xue-Feng Xu Hua-Ping Dai Yan-Ming Li Fei Xiao Chen Wang | 2016 | Chinese Medical Journal2016，，19： | 7 |
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