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您的检索式：作者名="Shaofang Fu"
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| 1 | Mutant p53 promotes cell spreading and migration via ARHGAP44显示文摘The tumor suppressor p53 protein is either lost or mutated in about half of all human cancers.Loss of p53 function is well known to influence cell spreading,migration and invasion.While expression of mutant p53 is not equivalent to p53 loss,mutant p53 can acquire new functions to drive cell spreading and migration via different mechanisms.In our study,we found that mutant p53 significantly increased cell spreading and migration when comparing with p53-null cells.RNA-Seq analysis suggested that Rho GTPase activating protein 44(ARHGAP44) is a new target of mutant p53,which suppressed AKHGAP44 transcription.ARHGAP44 has GAP activity and catalyze GTP hydrolysis on Cdc42.Higher level of GTP-Cdc42 was correlated with increase expression of mutant p53 and reduced ARHGAP44.Importantly,wt-ARHGAP44 but not mutant ARHGAP44(R291A) suppressed mutant p53 mediated cell spreading and migration.Bioinformatics analysis indicated lower expression of ARHGAP44 in lung carcinoma compared with normal tissues,which was verified by RT-qPCR using specimens from patients.More interestingly,ARHGAP44 mRNA level was lower in tumors with mutant p53 than those with normal p53.Collectively,our results disclose a new mechanism by which mutant p53 stimulates cell spreading and migration. | Jinjin Xu Jian Jiao Wei Xu Lei Ji Dongjie Jiang Shaofang Xie Syeda Kubra Xiaotao Li Junjiang Fu Jianru Xiao Bianhong Zhang | 2017 | Science China(Life Sciences)2017，60，9： | 4 |
| 2 | Multifunctional SnO2/3D graphene hybrid materials for sodium-ion and lithium-ion batteries with excellent rate capability and long cycle life显示文摘 | Jung-ln Lee Junhua Song Younghwan Cha Shaofang Fu Chengzhou Zhu Xiaolin Li Yuehe Lin Min-Kyu Song | 2017 | Nano Research2017，10，12： | 2 |
| 3 | Template-directed synthesis of nitrogen- and sulfur- codoped carbon nanowire aerogels with enhanced electrocatalytic performance for oxygen reduction显示文摘做的 Heteroatom,精确作文控制,和合理形态学设计是为在燃料房间为氧减小反应(ORR ) 生产新奇 nanocatalysts 的有效策略。此处,综合的一条划算的途径用一个难 templating 方法的 nitrogen-codoped 和 sulfur-codoped 碳 nanowire aerogels 被建议。aerogels 在碱的答案为 ORR 用热水的处理和碳化展览的联合准备了好催化活动。在在氮和硫先锋之间的最佳的退火温度和集体比率,结果的 aerogels 表演可比较的 electrocatalytic 活动到为 ORR 的商业 Pt/C 催化剂的。重要地,优化催化剂为甲醇转线路效果显示出更好长期的稳定性和令人满意的忍耐。这些 codoped aerogels 被期望在燃料房间有潜在的应用。 | Shaofang Fu Chengzhou Zhu Junhua Song Mark H. Engelhard Xiaolin Li Peina Zhang Haibing Xia Dan Du Yuehe Lin | 2017 | Nano Research2017，10，6： | 1 |
| 4 | Understanding Mechanistic Differences between 3-Diazoindolin-2-lmines and N-Sulfonyl-1,2,3-Triazoles in the Rh_(2)(ll)-Catalyzed Reactions with Nitrosoarenes显示文摘The employment of α-iminometallocarbenes to construct valuable N-containing compounds has attracted significant research interest.Herein,the nucleophilic addition of nitrosoarenes with the α-imino rhodium carbene species(I),which is derived from Rh_(2)(ll)-catalyzed denitrogenation of 3-diazoindolin-2-imines,to produce synthetically useful 2-iminoindolin-nitrones is described.Mechanistically,the N-attack of nitrosoarenes with the carbene site of I is proposed.For the analogous Rh_(2)(ll)-catalyzed reaction of nitrosoarenes with N-sulfonyl-1,2,3-triazoles reported by Li and co-workers(Org.Lett.2014,16,6394),however,the O-attack of nitrosoarenes with the carbene site of α-imino rhodium carbene species(II)is more favorable to occur than the N-attack.The subsequent transformation to yield the product of N-acylamidines is rationalized based on computational studies.The mechanistic differ-ences for the reactions of nitrosoarenes with a-imino rhodium carbene species I and II are discussed. | Rui Fu Luyao Kou Ke Gao Shaofang Zhou Xiaoguang Bao | 2021 | Chinese Journal of Chemistry2021，39，6： | 0 |
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