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| 1 | Neoadjuvant hyperfractionated accelerated radiotherapy plus concomitant 5-fluorouracil infusion in locally advanced rectal cancer: A phase Ⅱ study显示文摘AIM To evaluate the efficacy and tolerability of neoadjuvant hyperfractionated accelerated radiotherapy(HART)and concurrent chemotherapy in patients with locally advanced infraperitoneal rectal cancer. METHODS A total of 30 patients with histopathologically confirmed T2-3/N0+ infraperitoneal adenocarcinoma of rectum cancer patients received preoperative 42 Gy/1.5 Gy/18 days/bid radiotherapy and continuous infusion of 5-fluorouracil(325 mg/m^2). All patients were operated 4-8 wk after neoadjuvant concomitant therapy. RESULTS In the early phase of treatment, 6 patients had grade Ⅲ-Ⅳ gastrointestinal toxicity, 2 patients had grade Ⅲ-Ⅳ hematologic toxicity, and 1 patient had grade Ⅴ toxicity due to postoperative sepsis during chemotherapy. Only 1 patient had radiotherapy-related late side effects, i.e., grade Ⅳ tenesmus. Complete pathological response was achieved in 6 patients(21%), while near-complete pathological response was obtained in 9(31%). After a median follow-up period of 60 mo, the local tumor control rate was 96.6%. In 13 patients, distant metastasis occurred. Disease-free survival rates at 2 and 5 years were 63.3% and 53%, and corresponding overall survival rates were 70% and 53.1%, respectively.CONCLUSION Although it has excellent local control and complete pathological response rates, neoadjuvant HART concurrent chemotherapy appears to not be a feasible treatment regimen in locally advanced rectal cancer, having high perioperative complication and intolerable side effects. Effects of reduced 5-fluorouracil dose or omission of chemotherapy with the aim of reducing toxicity may be examined in further studies. | Zeynep Gural Sezer Saglam Serap Yucel Esra Kaytan-Saglam Oktar Asoglu Cetin Ordu Hediye Acun Rasul Sharifov Semen Onder Ahmet Kizir Ethem N Oral | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 3 |
| 2 | Glaucoma and the brain 显示文摘 | Yucel YH | 2001 | J Glaucoma2001，10，51： | 1 |
| 3 | Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients显示文摘 | Maegele M Lefering R Yucel N | 2007 | Injury2007，38，3： | 1 |
| 4 | Design and Implementation of a Personal Computer Authorization System using Color Detection 显示文摘 | F Yucel O Oral N Caglayan | 2011 | Electronics and Electrical Engineering2011，115，9： | 1 |
| 5 | Rupture of the pregnant uterus:a 9-year review显示文摘 | Ozdemir I Yucel N Yucel O | 2005 | Arch Gynecol Obstet2005，272，3： | 1 |
| 6 | Memantine protects neurons from shrinkage in the lateral geniculate nucleus in experimental glaucoma显示文摘 | Yucel Y H Gupta N Zhang Q | 2006 | Arch Ophthalmol2006，124，2： | 1 |
| 7 | Early cogulopathy in multiple iniury: an analysis from the German Trauma Registry on 872 patients显示文摘 | Maegele M Lefering R Yucel N | 2007 | Injury2007，38，29： | 1 |
| 8 | Oil price shocks and the US economy: where does the asymmetry originate? 显示文摘 | Balke N S Brown S P A Yucel M K | 2002 | Energy Journal2002，，23： | 1 |
| 9 | Early coagulopathy inmultiple injury:an analysis from the German Trauma Regis-try on 8724 patients显示文摘 | Maegele M Lefering R Yucel N | 2007 | Injury2007，38，3： | 1 |
| 10 | Prevalence and antibiotic resistance of Listeria species in meat products in Ankara, Turkey 显示文摘 | YUCEL N CITAK S ONDER M | 2005 | Food Microbiol2005，22，2： | 1 |
| 11 | Materials fabrication from Bombyx mori silk fibroin显示文摘 | ROCKWOOD D N PREDA R C YUCEL T | 2011 | Nature Protocols2011，6，10： | 1 |
| 12 | Hypospadias and anorectalmalformations mediated by defective Eph/ephrin signaling显示文摘 | Yucel S Dravis C Garcia N | 2007 | J Pediatr Urol2007，3，5： | 1 |
| 13 | Decolorization of sugar syrups using commercial and sugar beet pulp based activated carbons显示文摘 | MUDOGA H L YUCEL H KINCAL N S | 2008 | Bioresource technology2008，99，9： | 1 |
| 14 | Decolourization of sugarsyrups using commercial and sugar beet pulp based activated carbons显示文摘 | MUDOGA H L YUCEL H KINCAL N S | 2008 | Bioresource Technology2008，99，9： | 1 |
| 15 | Interactions between beta - lactoglobulin and dextran sulfate at near neutral pH and their effect on thermal stability 显示文摘 | Vardhanabhuti B Yucel U Coupland J N | 2009 | Food Hydrocolloids2009，23，6： | 1 |
| 16 | Humanglaucoma and neural degeneration in intracranial optic nerve,lateral geniculate nucleus,and visual cortex 显示文摘 | Gupta N Ang LC Nod de Tilly L Bidaisee L YUcel YH | 2006 | Br J Ophthal-mol2006，90，5： | 1 |
| 17 | Trauma Associated Severe Hemorrhage (TASH)-Score:probability of mass transfusion as surrogate for life threatening hemorrhage after multiple trauma显示文摘 | Yucel N Lefering R Maegele M | 2006 | J Trauma2006，，6： | 1 |
| 18 | Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients 显示文摘 | Maegele M Lefering R Yucel N | 2007 | Injury2007，38，3： | 1 |
| 19 | Central nervous system protection by resveratrol in streptozotocin-induced diabetic rats 显示文摘 | Ates O Cayli SR Yucel N | 2007 | Clin Neurosci2007，14，： | 1 |
| 20 | Central nervous system protection by resveratrol in streptozotocin-induced diabetic rats显示文摘 | Ates O Cayli SR Yucel N | 2007 | J Clin Neurosci2007，14，3： | 1 |
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